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Author : Douglas Wayne Jackson
Publisher :
ISBN 13 :
Total Pages : 82 pages
Book Rating : 4.:/5 (198 download)
Download or read book Electrophoretic Studies of Human Alkaline Phosphatase written by Douglas Wayne Jackson and published by . This book was released on 1966 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Elizabeth Anne Stiene
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (291 download)
Download or read book Electrophoretic Studies of Leukocyte Alkaline Phosphatase written by Elizabeth Anne Stiene and published by . This book was released on 1969 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joyce Evelyn Nutt
Publisher :
ISBN 13 :
Total Pages : 167 pages
Book Rating : 4.:/5 (184 download)
Download or read book Studies of Human Alkaline Phosphatases by Isoelectric Focusing and Electrophoresis written by Joyce Evelyn Nutt and published by . This book was released on 1972 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert B. McComb
Publisher : Springer
ISBN 13 :
Total Pages : 1010 pages
Book Rating : 4.3/5 (91 download)
Download or read book Alkaline Phosphatase written by Robert B. McComb and published by Springer. This book was released on 1979-12 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt: There can be no doubt that alkaline phosphatase is one of the most extensively in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the ease and sensitivity with which its activity can be measured. Unfortunately, these wide-ranging but often superficial experimental studies have been followed up by intensive and systematic investigations in only a few limited areas of the biochemistry and chemical pathology of alkaline phosphatase. The result has been the accumulation of a scientific literature of intimidating proportions, and the inevitable rediscovery of already known facts about the enzyme. Scientists are taught early in their careers that, in the words of Sir John Herschel, "Hasty generalization is the bane of science. " Nevertheless, moments arrive in all spheres of scientific activity when generalization becomes essential, to codify and to select from the mass of data already accumulated, and to provide starting points for new developments and new lines of investigation. This is especially true in a field such as alkaline phosphatase research, in which very real dangers exist that the seeds of fundamental understanding will be lost amidst an unexamined harvest of empirical observations. The history of the study of alkaline phosphatase provides several instances when valuable generalizations have emerged. Occasionally, the conclusions drawn on the basis of available evidence were wrong; more frequently, they have stood the test of further experimentation, and always, they have provided new insights into the nature and proper ties of this enzyme.
Author : David D. Weaver
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.:/5 (36 download)
Download or read book Histochemical, Fluorometric and Electrophoretic Analysis of Human Leukocytic Alkaline Phosphatase written by David D. Weaver and published by . This book was released on 1966 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. M. Jones
Publisher :
ISBN 13 :
Total Pages : 170 pages
Book Rating : 4.:/5 (16 download)
Download or read book Immunological and Electrophoretic Studies on Dog Alkaline Phosphatase, with Particular Reference to Serum written by J. M. Jones and published by . This book was released on 1972 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John George Konrath
Publisher :
ISBN 13 :
Total Pages : 114 pages
Book Rating : 4.:/5 (222 download)
Download or read book Electrophoretic Analysis of Glucose-6-phosphate Dehydrogenase, Alkaline Phosphatase, and Protein of Rabbit Serum, Erythrocytes, and Intraocular Fluid written by John George Konrath and published by . This book was released on 1974 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : M. Gouldie
Publisher :
ISBN 13 :
Total Pages : 67 pages
Book Rating : 4.:/5 (15 download)
Download or read book Analysis of the Molecular Forms of Placental Alkaline Phosphatase Using Capillary Electrophoresis and HPLC written by M. Gouldie and published by . This book was released on 1995 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of Alkaline Phosphatase Inhibition by Metal Chelators Using Capillary Electrophoresis written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Alkaline phosphatase inhibition by metal chelators has been studied using capillary electrophoresis. The enzyme-inhibition assays were performed by electrophoretically mixing enzyme and inhibitor zones in a substrate filled capillary. Enzyme inhibition could be seen as a decrease in product formation as detected using laser-induced fluorescence. The enzyme-inhibition assays were adapted so they could be performed using a commercial CE system. Use of a commercial system is desirable for these assays due to ease of use and system features such as autosamplers and capillary and sampling cooling. This technique could prove useful for pharmaceutical industries as a screening tool for new drug therapies. Six metal chelators were studied as enzyme inhibitors using CE enzyme-inhibition assays. EDTA inhibition assays performed previously on a laboratory constructed CE system were compared to those using a commercial system. The assays performed on the commercial system showed irreversible inhibition at concentrations of 1.0 mM or less and activation at 2.0 mM. The opposite trend was seen with the laboratory constructed system. One hypothesis to explain this discrepancy is that two different water sources contained different concentrations of metal contaminants. The two water sources were used due to equipment failure making one source unavailable. The common metal chelators EGTA, NTA, and 1,10-phenanthroline all exhibited reversible inhibition of alkaline phophatase at concentrations of 0.08 to 2.0 mM. Crown ethers, which are not commonly used as enzyme inhibitors, were also studied. 12-crown-4 and 18-crown-6 both reversibly inhibited alkaline phophatase at concentrations of 0.08 to 0.3 mM. The reversible inhibition exhibited by the various chelators examined (excluding EDTA) could be due to a time dependent mechanism in which Zn2, which is required by ALP, is slowly removed, rendering the enzyme inactive. Alkaline phosphatase inhibition was also studied using on-column reagent addition. The enzyme was added on-column, through a gap reactor and mixed with the fluorescent enzyme substrate, Attophos, and zones of inhibitor. Theophylline, a reversible noncompetitive inhibitor, and sodium vanadate, a reversible competitive inhibitor were used. Enzyme inhibition could be easily seen as a decrease in product formation detected by laser-induced fluorescence.
Author : José Luis Millan
Publisher : John Wiley & Sons
ISBN 13 : 3527607471
Total Pages : 337 pages
Book Rating : 4.5/5 (276 download)
Download or read book Mammalian Alkaline Phosphatases written by José Luis Millan and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Author : John C. Griffiths
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)
Download or read book Clinical Enzymology written by John C. Griffiths and published by . This book was released on 1979 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : United States. Food and Drug Administration. Division of Microbiology
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.F/5 ( download)
Download or read book Bacteriological Analytical Manual written by United States. Food and Drug Administration. Division of Microbiology and published by . This book was released on 1969 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Luis Millán
Publisher : Humana
ISBN 13 : 9781493960316
Total Pages : 0 pages
Book Rating : 4.9/5 (63 download)
Download or read book Phosphatase Modulators written by José Luis Millán and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Robert B. McComb
Publisher : Springer Science & Business Media
ISBN 13 : 1461329701
Total Pages : 998 pages
Book Rating : 4.4/5 (613 download)
Download or read book Alkaline Phosphatase written by Robert B. McComb and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: There can be no doubt that alkaline phosphatase is one of the most extensively in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the ease and sensitivity with which its activity can be measured. Unfortunately, these wide-ranging but often superficial experimental studies have been followed up by intensive and systematic investigations in only a few limited areas of the biochemistry and chemical pathology of alkaline phosphatase. The result has been the accumulation of a scientific literature of intimidating proportions, and the inevitable rediscovery of already known facts about the enzyme. Scientists are taught early in their careers that, in the words of Sir John Herschel, "Hasty generalization is the bane of science. " Nevertheless, moments arrive in all spheres of scientific activity when generalization becomes essential, to codify and to select from the mass of data already accumulated, and to provide starting points for new developments and new lines of investigation. This is especially true in a field such as alkaline phosphatase research, in which very real dangers exist that the seeds of fundamental understanding will be lost amidst an unexamined harvest of empirical observations. The history of the study of alkaline phosphatase provides several instances when valuable generalizations have emerged. Occasionally, the conclusions drawn on the basis of available evidence were wrong; more frequently, they have stood the test of further experimentation, and always, they have provided new insights into the nature and proper ties of this enzyme.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309168708
Total Pages : 229 pages
Book Rating : 4.3/5 (91 download)
Download or read book Toxicologic Assessment of Jet-Propulsion Fuel 8 written by National Research Council and published by National Academies Press. This book was released on 2003-02-14 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report provides a critical review of toxicologic, epidemiologic, and other relevant data on jet-propulsion fuel 8, a type of fuel in wide use by the U.S. Department of Defense (DOD), and an evaluation of the scientific basis of DOD's interim permissible exposure level of 350 mg/m3
Author : Lars Beckman
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.3/5 (91 download)
Download or read book Isozyme Variations in Man written by Lars Beckman and published by . This book was released on 1966 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
