Egfr Directed Therapy In Lung Cancer

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EGFR-Directed Therapy in Lung Cancer

Author : So Yeon Kim
Publisher : Cambridge University Press
ISBN 13 : 1009342320
Total Pages : 72 pages
Book Rating : 4.0/5 (93 download)

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Book Synopsis EGFR-Directed Therapy in Lung Cancer by : So Yeon Kim

Download or read book EGFR-Directed Therapy in Lung Cancer written by So Yeon Kim and published by Cambridge University Press. This book was released on 2023-01-26 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors (TKI) to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 (G719X), 20 (S768I), and 21 (L861Q) mutations. It also outlines the promising clinical applications of circulating tumor DNA (ctDNA).

Targeted Therapies for Lung Cancer

Author : Ravi Salgia
Publisher : Springer
ISBN 13 : 3030178323
Total Pages : 238 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia

Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners

Author : Marianne Davies
Publisher : Springer
ISBN 13 : 3030165507
Total Pages : 120 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners by : Marianne Davies

Download or read book Targeted Therapies in Lung Cancer: Management Strategies for Nurses and Practitioners written by Marianne Davies and published by Springer. This book was released on 2019-07-16 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to educate nurses and advanced practice providers (APP’s) about known mutations, availability of targeted therapy and the management of patients with non-small cell lung cancer (NSCLC). It will educate nurses and practitioners about the scope of therapy to assure safe and effective lung cancer treatment. In this era of personalized medicine, nurses and APP’s are responsible for guiding patients from diagnosis through treatment. This starts with the identification of patients that can benefit from these therapies, the key role of biopsy acquisition (ie. what to test, when and how often) and treatment selection based on the mutation identified. Readers will learn about the mechanisms of action, administration, potential adverse side effects and unique management strategies for these targeted agents. Lung cancer continues to be the leading cause of cancer death in the United States and worldwide. Recent advances in the identification of specific oncogenic mutations that drive cancer development, growth and metastasis have led to major paradigm shifts in lung cancer treatment. Sophisticated methods are required to identify specific mutations at the time of diagnosis. This book explains how molecularly targeted therapies have been developed that target these drivers. To date, several tyrosine kinase inhibitors have been approved to target the epidermal growth factor receptor (EGFR), EML4-ALK ,ROS1 and BRAF. Most recently, immune checkpoint inhibitors have been approved with some indication that efficacy may be enhanced for patients who overexpress PD-L1. While some driver mutations have been identified, there is ongoing investigation into additional mutations. In the case of driver mutations, lung cancers will develop resistance to therapy. This book provides nurses and APP’s with the mechanisms of resistance that have been identified such as T790 mutation and many others in the EGFR mutation, and shows how the next level of drug development is focused on identifying mechanisms of resistance and development of new agents that overcome these mutations. With this book in hand, nurses and practitioners will be able to navigate patients through this ever expanding field of lung cancer treatment.

Non-small Cell Lung Cancer Treatment

Author : Christian Manegold
Publisher :
ISBN 13 : 9783837412567
Total Pages : 190 pages
Book Rating : 4.4/5 (125 download)

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Book Synopsis Non-small Cell Lung Cancer Treatment by : Christian Manegold

Download or read book Non-small Cell Lung Cancer Treatment written by Christian Manegold and published by . This book was released on 2010 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Non-small Cell Lung Cancer

Author :
Publisher :
ISBN 13 : 9783036501307
Total Pages : 258 pages
Book Rating : 4.5/5 (13 download)

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Book Synopsis Non-small Cell Lung Cancer by :

Download or read book Non-small Cell Lung Cancer written by and published by . This book was released on 2021-12-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Guide to Targeted Therapies: EGFR mutations in NSCLC

Author : Federico Cappuzzo
Publisher : Springer
ISBN 13 : 3319030590
Total Pages : 75 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Guide to Targeted Therapies: EGFR mutations in NSCLC by : Federico Cappuzzo

Download or read book Guide to Targeted Therapies: EGFR mutations in NSCLC written by Federico Cappuzzo and published by Springer. This book was released on 2014-09-25 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guide to Targeted Therapies: EGFR Mutations in NSCLC is a speedy and up-to-date review, which discusses EGFR mutations, testing methods and technology, current and emerging therapies, and resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of EGFR gene mutations as well as a summary of current therapies will benefit from this succinct guide.

Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

Author : Vera Hirsh
Publisher : Frontiers Media SA
ISBN 13 : 2889453979
Total Pages : 95 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by : Vera Hirsh

Download or read book Update on the Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine written by Vera Hirsh and published by Frontiers Media SA. This book was released on 2018-01-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains a major cause of death in of both women and men in our society. Lung cancer treatment paradigms have changed enormously as we’ve started to understand the genetic complexity and the multiple driver mutations influencing the disease. Therapeutics directed towards, or to inhibit signaling pathways has resulted in increased life spans for our patients. Over the last two decades, we have gone from simple chemotherapy used to treat all, to a personalized medicine approach for the majority. For non-small cell lung cancer patients without driver mutations, the world of immune oncology has arrived. These improved long-term outcomes mean that now our lung cancer patients can live with their cancers, but without progression. The aim of this book is to catalogue the current state of knowledge for the many facets of advanced lung cancer. It describes current treatment approaches for driver mutations, rare mutations, and rare thoracic malignancies such as neuroendocrine tumors. Most importantly, this book addresses the topics of palliative treatment and care which allow our patients to enjoy longer survival with the highest quality of life. We hope you enjoy this e-book. The future is brighter for lung cancer patients and as lung cancer specialists; we finally feel sense optimism about treatment options for our patients.

Molecular Targeted Therapy of Lung Cancer

Author : Yuichi Takiguchi
Publisher : Springer
ISBN 13 : 9811020027
Total Pages : 327 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Molecular Targeted Therapy of Lung Cancer by : Yuichi Takiguchi

Download or read book Molecular Targeted Therapy of Lung Cancer written by Yuichi Takiguchi and published by Springer. This book was released on 2017-01-24 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also outlines the increasing necessity for new diagnostic technology and strategies for managing different adverse effects and novel methods for evaluating effectiveness and safety. Edited and authored by opinion leaders, Molecular Targeted Therapy of Lung Cancer provides a comprehensive overview of the disease and its treatments. It is a valuable resource for graduate students, post-doctoral fellows and faculty staff, as well as researchers involved in clinical and translational research on lung cancer, helping promote new ideas for further advances.

Advances in Systemic Therapy for Non-Small Cell Lung Cancer , An Issue of Thoracic Surgery Clinics

Author : Jessica Donington
Publisher : Elsevier Health Sciences
ISBN 13 : 0323791883
Total Pages : 137 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Advances in Systemic Therapy for Non-Small Cell Lung Cancer , An Issue of Thoracic Surgery Clinics by : Jessica Donington

Download or read book Advances in Systemic Therapy for Non-Small Cell Lung Cancer , An Issue of Thoracic Surgery Clinics written by Jessica Donington and published by Elsevier Health Sciences. This book was released on 2020-05-11 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Thoracic Surgery Clinics, guest edited by Drs. Jyoti Patel and Jessica Donington, is devoted to Advances in Systemic Therapy for Non-Small Cell Lung Cancer. Drs. Patel and Donington have assembled expert authors to review the following topics: Adjuvant and Neoadjuvant Immunotherapy; Combining Immunotherapy with Radiation in Lung Cancer; Adjuvant Chemotherapy; ALK Mutations; Molecular Targets Beyond the Big 3; Advances in Systemic Therapy; Liquid Biopsies in NSCLC; Combining Immunotherapy and Chemotherapy for NSCLC; ROS-1 Mutations; EGFR Mutations; and more!

Fast Facts: Non-Small-Cell Lung Cancer

Author : Mary O'Brien
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318070106
Total Pages : 148 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Fast Facts: Non-Small-Cell Lung Cancer by : Mary O'Brien

Download or read book Fast Facts: Non-Small-Cell Lung Cancer written by Mary O'Brien and published by Karger Medical and Scientific Publishers. This book was released on 2022-02-28 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite an overall decrease in tobacco use, lung cancer (80–85% of which is non-small-cell lung cancer [NSCLC]) is still the leading cause of cancer death in both men and women worldwide. Annual low-dose CT screening of high-risk individuals has the potential to detect early-stage tumors, which can usually be successfully treated with a combination of surgery, radiotherapy and chemotherapy and, in some cases, targeted therapy. However, most patients with NSCLC still present with advanced or metastatic disease. For these patients, initial therapy is guided by the tumor’s molecular characteristics and patient’s performance status. Targeted therapies have significantly improved clinical outcomes and, for some patients with no targetable genetic alterations, immunotherapy has demonstrated significant overall survival benefit. This insightful guide is designed to bring you up to speed with the latest developments and is important reading for all health professionals and medical trainees working in this fast-moving field. Table of Contents: • Prevention and screening • Diagnosis and staging • Surgery • Radiotherapy • Systemic therapy in non-metastatic NSCLC • Systemic therapy in advanced-stage/metastatic disease without a molecular driver • Personalized treatment in advanced NSCLC • Oligometastatic disease and brain metastases

Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC

Author : Anthony Faber
Publisher : Academic Press
ISBN 13 : 0128228342
Total Pages : 150 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC by : Anthony Faber

Download or read book Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC written by Anthony Faber and published by Academic Press. This book was released on 2023-01-30 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors Encompasses the current state of affairs in clinical trials to address resistance

Therapeutic Strategies in EGFR Mutant Lung Cancer

Author : Yaxiong Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832503802
Total Pages : 239 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Therapeutic Strategies in EGFR Mutant Lung Cancer by : Yaxiong Zhang

Download or read book Therapeutic Strategies in EGFR Mutant Lung Cancer written by Yaxiong Zhang and published by Frontiers Media SA. This book was released on 2022-11-03 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy

Author :
Publisher : Academic Press
ISBN 13 : 0128127384
Total Pages : 292 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy by :

Download or read book Protein Kinase Inhibitors as Sensitizing Agents for Chemotherapy written by and published by Academic Press. This book was released on 2018-11-21 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tyrosine Kinase Inhibitors as Sensitizing Agents for Chemotherapy, the fourth volume in the Cancer Sensitizing Agents for Chemotherapy Series, focuses on strategic combination therapies that involve a variety of tyrosine kinase inhibitors working together to overcome multi-drug resistance in cancer cells. The book discusses several tyrosine kinase inhibitors that have been used as sensitizing agents, such as EGFR, BCR-ABL, ALK and BRAF. In each chapter, readers will find comprehensive knowledge on the inhibitor and its action, including its biochemical, genetic, and molecular mechanisms' emphases. This book is a valuable source for oncologists, cancer researchers and those interested in applying new sensitizing agents to their research in clinical practice and in trials. Summarizes the sensitizing role of some tyrosine kinase inhibitors in existing research Brings recent findings in several cancer types, both experimental and clinically, with a particular emphases on underlying biochemical, genetic, and molecular mechanisms Provides an updated and comprehensive knowledge regarding the field of combinational cancer treatment

Lung Cancer, An Issue of Hematology/Oncology Clinics, E-Book

Author : Roy S. Herbst
Publisher : Elsevier Health Sciences
ISBN 13 : 0323496601
Total Pages : 249 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Lung Cancer, An Issue of Hematology/Oncology Clinics, E-Book by : Roy S. Herbst

Download or read book Lung Cancer, An Issue of Hematology/Oncology Clinics, E-Book written by Roy S. Herbst and published by Elsevier Health Sciences. This book was released on 2016-12-03 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics will focus on lung cancer; specifically, Genomics in lung cancer; Neoadjuvant and adjuvant therapy for NSCLC; Treatment of locally advanced NSCLC; First line systemic therapy for NSCLC; Second line chemotherapy and beyond for NSCLC; Treatment of EGFR mutant tumors; Treatment of ALK positive tumors; New targets in NSCLC; Immunotherapy; Advances in Small cell lung cancer; and many more!

The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine

Author : Vera Hirsh
Publisher : Frontiers Media SA
ISBN 13 : 2889195430
Total Pages : 142 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine by : Vera Hirsh

Download or read book The Treatment of Metastatic Non-small Cell Lung Cancer (NSCLC) in New Era of Personalised Medicine written by Vera Hirsh and published by Frontiers Media SA. This book was released on 2015-10-20 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer related mortality in Canada and USA. Majority of the patients present in advanced stage of the disease and of these only about 2% will be alive at 5 years. NSCLC is the most common form of lung cancer, accounting for approximately 87% of cases. Systemic chemotherapies have been used to treat metastatic NSCLC for decades, but the improvements of outcomes have reached a plateau. Recent advances in understanding signalling pathways for malignant cells, their interconections,the importance of various receptors and biomarkers and the interplay between various oncogenes have led to the development of targeted treatments that are improving both efficacy and safety of the treatments. Knowledge about the advantages of treatments with the targeted agents in metastatic NSCLC is growing rapidly. Combining various targeted agents or sequencing them properly will be important in the era of personalised medicine and overcoming development of the resistence to various targeted agents will be challenging. The importance of a team work,from the diagnosis through various treatments, to supportive care, from the interventional radiologists, pneumologists or surgeons, who have to obtain a satisfactory tumor tissue specimen, to pathologists, radiation and medical oncologists, to supportive care specialists, will be described in our publications. We will cover completely present and future approaches to personalised medicine in this rapidly evolving field of metastatic NSCLC.

Lung Cancer and Personalized Medicine

Author : Aamir Ahmad
Publisher : Springer
ISBN 13 : 3319242237
Total Pages : 228 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Lung Cancer and Personalized Medicine by : Aamir Ahmad

Download or read book Lung Cancer and Personalized Medicine written by Aamir Ahmad and published by Springer. This book was released on 2015-12-14 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

Lung Cancer E-Book

Author : Erin Alexis Gillaspie
Publisher : Elsevier Health Sciences
ISBN 13 : 0323695744
Total Pages : 355 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Lung Cancer E-Book by : Erin Alexis Gillaspie

Download or read book Lung Cancer E-Book written by Erin Alexis Gillaspie and published by Elsevier Health Sciences. This book was released on 2023-08-24 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Care of the lung cancer patient—screening, diagnosis, and treatment—has undergone recent dramatic changes due to technologic and research-driven advances. Lung Cancer: An Evidence-Based Approach to Multidisciplinary Management covers every aspect of this fast-changing field, including new screening guidelines, new practice standards, and new treatment advances that have led to higher survival rates. This practical, clinically oriented resource provides thorough, evidence-based coverage from experts in the field, including the increasingly important precision medicine approach in lung cancer planning and management. Discusses key topics such as small cell and non-small cell lung cancers; immunotherapy, molecular cohorts including ROS1, BRAF, HER2, Met, and NTRK; oligometastatic disease; and more. Covers individualized treatment plans for chemotherapy, radiotherapy, targeted biomarker-derived therapies, and new and emerging immunotherapies. Provides excellent visual guidance throughout, including algorithms, pathology specimens, anatomic drawings, and PET/CT and CT imaging for diagnosis and treatment planning. Features “Top 5 Clinical Pearls at the beginning of each chapter. Shares the experience and knowledge of medical oncologists, radiation oncologists, surgical oncologists, and thoracic radiologists for a real-world tumor board perspective.