Efferocytosis

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Lipid-Activated Nuclear Receptors

Author : Matthew C. Gage
Publisher : Humana Press
ISBN 13 : 9781493991297
Total Pages : 220 pages
Book Rating : 4.9/5 (912 download)

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Book Synopsis Lipid-Activated Nuclear Receptors by : Matthew C. Gage

Download or read book Lipid-Activated Nuclear Receptors written by Matthew C. Gage and published by Humana Press. This book was released on 2019-04-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide range of state-of-the-art methodologies and detailed protocols currently used to study the actions that lipid-activated nuclear receptors and their co-regulators have in tissues and immune cell types considered classic metabolic “powerhouses”. This includes the liver, adipose tissue, and monocytes/macrophages present in these and other metabolic tissues. While the main focus is on the oxysterol receptor or Liver X Receptor (LXR), the majority of the methods described can be easily applied to multiple nuclear receptors, as well as to other tissues or cell types. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Lipid-Activated Nuclear Receptors: Methods and Protocols serves as an ideal guide for researchers pursuing the vital study of nuclear receptor biology and beyond.

Macrophages in inflammation and its resolution

Author : Heiko Mühl
Publisher : Frontiers E-books
ISBN 13 : 2889190730
Total Pages : 139 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Macrophages in inflammation and its resolution by : Heiko Mühl

Download or read book Macrophages in inflammation and its resolution written by Heiko Mühl and published by Frontiers E-books. This book was released on with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages were initially identified as a key element in the innate host response to infection and injury due to their phagocytic clearance and elimination of pathogenic and non-pathogenic entities. However, as macrophage research advanced it became clear that not only are these cells amenable to the acquisition of multiple plastic phenotypes during inflammatory responses to different pathogens, they also play a paramount role in the termination of inflammation and acquired immune responses. In addition, macrophages profoundly affect host physiology when they migrate to distant sites and differentiate to specialized cells, like foam cells, osteoclasts, adipose tissue- and tumor -associated macrophages and other macrophage-derived cell types. These processes are affected by the inflammation-resolution axis and can result in health threats, such as atherosclerosis, bone loss, obesity, fibrosis and cancer. This Research Topic issue will cover a wide range of topics in macrophage biology: 1. Macrophages in immune responses to pathogens 2. Macrophages in the termination of acute and acquired immunity. 3. The role of macrophages and their descendents in inflammation-associated pathologies. 4. Macrophage polarization and differentiation. Particular focus will be given to the modulation of macrophage phenotype and function following their encounter with apoptotic cells and the signaling cascades that govern these changes.

Apoptotic Cell Clearance in Health and Disease

Author : Estee Kurant
Publisher : Frontiers Media SA
ISBN 13 : 2889456889
Total Pages : 294 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Apoptotic Cell Clearance in Health and Disease by : Estee Kurant

Download or read book Apoptotic Cell Clearance in Health and Disease written by Estee Kurant and published by Frontiers Media SA. This book was released on 2018-12-27 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearance of apoptotic cells is essential for proper development, homeostasis and termination of immune responses in multicellular organisms. Thus, cellular and molecular players taking part in the sequential events of this process are of great interest. Research in the last 20 years has indicated that specific ligands and receptors take part in the attraction of immune cells toward apoptotic targets and in the interactions between apoptotic cells and professional as well as non-professional phagocytes that engulf them. Moreover, phagocytosis of apoptotic cells (efferocytosis) leads to significant phenotypic changes in the engulfing cells suggesting that it is a major fate-determining event for phagocytes. Particularly, efferocytosis has an important impact on the inflammation-resolution axis as well as embryonic development and tissue morphogenesis. Deficiencies in these processes can result in health threats, such as autoimmunity, atherosclerosis, bone loss, obesity, infertility, neurodegeneration, fibrosis and cancer. This eBook brings together 24 original research and review manuscripts that cover various aspects of apoptotic cell removal during normal development and homeostasis as well as in tumorigenesis and regenerative processes following injury.

Phagocytosis: Molecular Mechanisms and Physiological Implications

Author : Esther M. Lafuente
Publisher : Frontiers Media SA
ISBN 13 : 2889661474
Total Pages : 251 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Phagocytosis: Molecular Mechanisms and Physiological Implications by : Esther M. Lafuente

Download or read book Phagocytosis: Molecular Mechanisms and Physiological Implications written by Esther M. Lafuente and published by Frontiers Media SA. This book was released on 2020-12-03 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Protecting the Acutely Injured Lung: Physiologic, Mechanical, Inflammatory, and Translational Perspectives

Author : Gary Frank Nieman
Publisher : Frontiers Media SA
ISBN 13 : 2832502644
Total Pages : 241 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Protecting the Acutely Injured Lung: Physiologic, Mechanical, Inflammatory, and Translational Perspectives by : Gary Frank Nieman

Download or read book Protecting the Acutely Injured Lung: Physiologic, Mechanical, Inflammatory, and Translational Perspectives written by Gary Frank Nieman and published by Frontiers Media SA. This book was released on 2022-10-17 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Microenvironment

Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030731197
Total Pages : 548 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Tumor Microenvironment by : Alexander Birbrair

Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2021-10-18 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Apoptotic and Non-apoptotic Cell Death

Author : Shigekazu Nagata
Publisher : Springer
ISBN 13 : 3319239139
Total Pages : 186 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Apoptotic and Non-apoptotic Cell Death by : Shigekazu Nagata

Download or read book Apoptotic and Non-apoptotic Cell Death written by Shigekazu Nagata and published by Springer. This book was released on 2017-04-07 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on apoptotic and non-apoptotic programmed cell death, including necroptosis, pyroptosis, and ferroptosis, and presents recent findings in the field. It discusses the crucial role that apoptotic and non-apoptotic cell death play in various pathological conditions, such as skin diseases, inflammatory bowel diseases, and virus infections. Further, it highlights the mechanisms underlying the recognition and clearance of dead cells, and the subsequent biological responses triggered by phagocytosed macrophages and factors released from dying cells. Offering insights into cell death, it is a valuable resource for researchers and clinicians developing novel strategies to treat various diseases that are closely associated with cell death.

Phagocytosis

Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1837687390
Total Pages : 232 pages
Book Rating : 4.8/5 (376 download)

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Book Synopsis Phagocytosis by :

Download or read book Phagocytosis written by and published by BoD – Books on Demand. This book was released on 2023-08-02 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phagocytosis, as an innate immune defense mechanism, is the first process to respond to pathogens. It is also one of the initiating branches of an adaptive immune response. This book provides a comprehensive overview of phagocytosis and related cells in the immune response. It presents the basics of phagocytosis as well as discusses management and therapeutic strategies for infections.

Transport of Nutrients, Metabolites and Ions Linked to Bioenergetics: Relevance to Human Pathology

Author : Cesare Indiveri
Publisher : Frontiers Media SA
ISBN 13 : 2889716325
Total Pages : 237 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Transport of Nutrients, Metabolites and Ions Linked to Bioenergetics: Relevance to Human Pathology by : Cesare Indiveri

Download or read book Transport of Nutrients, Metabolites and Ions Linked to Bioenergetics: Relevance to Human Pathology written by Cesare Indiveri and published by Frontiers Media SA. This book was released on 2021-11-12 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phagocytosis and Phagosomes

Author : Roberto Botelho
Publisher : Humana
ISBN 13 : 9781493965793
Total Pages : 0 pages
Book Rating : 4.9/5 (657 download)

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Book Synopsis Phagocytosis and Phagosomes by : Roberto Botelho

Download or read book Phagocytosis and Phagosomes written by Roberto Botelho and published by Humana. This book was released on 2016-11-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details experimental approaches used to investigate phagocytosis and phagosome maturation. Chapters present methods and protocols on quantifying uptake and phagosome maturation using biophysical and biochemical approaches, proteomics, microscopy, and flow cytometry. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Phagocytosis and Phagosomes: Methods and Protocols aims to be an important resource for both experts in the field and for those investigators delving into phagocytosis and phagosome maturation for the first time.

Interplay Between Immunity and Fibrosis

Author : Anna-Maria Hoffmann-Vold
Publisher : Frontiers Media SA
ISBN 13 : 2889718336
Total Pages : 201 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Interplay Between Immunity and Fibrosis by : Anna-Maria Hoffmann-Vold

Download or read book Interplay Between Immunity and Fibrosis written by Anna-Maria Hoffmann-Vold and published by Frontiers Media SA. This book was released on 2021-12-20 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topic Editor Prof. Oliver Distler received financial support from Actelion, Bayer, Boehringer Ingelheim, Mitsubishi Tanabe Pharma companies. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

New Trends in Vascular Inflammation Research: From Biology to Therapy

Author : Masanori Aikawa
Publisher : Frontiers Media SA
ISBN 13 : 2889456374
Total Pages : 193 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis New Trends in Vascular Inflammation Research: From Biology to Therapy by : Masanori Aikawa

Download or read book New Trends in Vascular Inflammation Research: From Biology to Therapy written by Masanori Aikawa and published by Frontiers Media SA. This book was released on 2019-10-17 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The MIF Handbook

Author : Richard Bucala
Publisher : World Scientific
ISBN 13 : 9814335355
Total Pages : 399 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis The MIF Handbook by : Richard Bucala

Download or read book The MIF Handbook written by Richard Bucala and published by World Scientific. This book was released on 2012 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of the cytokine, macrophage migration inhibitory factor (MIF), in the immune response and in the immunopathogenesis of different inflammatory, autoimmune, and infectious disorders is now well established. The aim of this handbook is to provide an authoritative volume covering all aspects of MIF, from basic molecular biology to structure-function relationships, pathophysiology, genetics, and drug development. Recent studies continue to broaden considerably the role of MIF in both normal physiology and pathology, which range from such diverse areas as oncogenesis, cardiac physiology, and neurodevelopment. MIF's molecular mechanism of action in these contexts is becoming increasingly understood and the role of variant MIF alleles in different conditions continues to be defined. Unique structural features of the protein, such as an intrinsic catalytic activity, and the continuing elucidation of its receptor-dependent mechanism of action offer attractive opportunities for therapeutic intervention. This volume will provide a comprehensive synthesis of the state of the art of MIF science.

Apoptosis and Cancer

Author : Hugo Barcenilla
Publisher : Springer Nature
ISBN 13 : 1071625535
Total Pages : 215 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Apoptosis and Cancer by : Hugo Barcenilla

Download or read book Apoptosis and Cancer written by Hugo Barcenilla and published by Springer Nature. This book was released on 2022-09-10 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses methods used in the fields of molecular and cellular biology for detecting and studying cell death, especially in cancer and cancer therapy. Chapters in this book cover topics such as non-destructive, real-time Annexin V apoptosis assay; assessment of the immune response to tumor cell apoptosis and efferocytosis; mass cytometry assessment of cell phenotypes and signaling states in human whole blood; cell cycle analysis of ER stress and autophagy; and simultaneous detection of inflammasome activation and membrane damage during pyroptosis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Apoptosis and Cancer: Methods and Protocols is a valuable resource and practical guide for both novice and expert researchers looking into the “meaning of death.”

Regulation and Dysfunction of Apoptosis

Author : Yusuf Tutar
Publisher : BoD – Books on Demand
ISBN 13 : 183969193X
Total Pages : 184 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Regulation and Dysfunction of Apoptosis by : Yusuf Tutar

Download or read book Regulation and Dysfunction of Apoptosis written by Yusuf Tutar and published by BoD – Books on Demand. This book was released on 2022-04-06 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a comprehensive review of apoptotic cell death. It discusses the mechanism of apoptosis and emerging principles of drug resistance in cancer. The development of novel drug targets and drug delivery systems for inhibiting or inducing apoptosis are the ultimate goal. Further, upregulation of anti-apoptotic proteins and loss of pro-apoptotic proteins strongly favors apoptosis evasion. The ability of cancer cells to evade apoptosis is critical for the progression and clonal expansion of malignantly transformed cells. Defective apoptosis imparts proliferative advantage to cancer cells or cells with the potential to become cancerous. The mechanisms employed by cancer cells to evade apoptosis can be used in the strategic design of therapeutic regimens aimed at exploiting apoptotic signaling networks to ensure tumor-specific cell death. This book presents knowledge of the molecular mechanisms of defective apoptosis that could be translated into the development of novel therapeutic agents and therapeutic modalities for cancer treatment.

Macrophages: Biology and Role in the Pathology of Diseases

Author : Subhra K. Biswas
Publisher : Springer
ISBN 13 : 1493913115
Total Pages : 603 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Macrophages: Biology and Role in the Pathology of Diseases by : Subhra K. Biswas

Download or read book Macrophages: Biology and Role in the Pathology of Diseases written by Subhra K. Biswas and published by Springer. This book was released on 2014-11-12 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophages are a key component of the innate immune system and play an integral role in host defense and homeostasis. On one hand, these cells contribute to host defence by triggering inflammation, displaying microbicidal/tumoricidal properties, regulating the activation of adaptive immunity and promoting resolution of inflammation. On the other hand, they contribute to essential trophic functions such as neural patterning, bone morphogenesis and ductal branching in mammary glands. Thus, macrophages are extremely versatile cells that can respond efficiently to tissue micro environmental cues by polarizing to distinct phenotypes, depending on the functions they need to perform. Indeed, functional diversity and plasticity are hallmarks of these cells. Macrophages may also play a detrimental role. An overwhelming body of literature has indicated their crucial role in pathogenesis. The list includes sepsis, cancer, metabolic syndrome, immunodeficiency, auto-immune disease-virtually impacting every major pathology that we know. These observations have suggested macrophages and their related molecules as potential targets in therapeutic applications. Available evidence proclaims macrophages as a key player in homeostasis, host defense and disease. Crucial developments in the past few years call for a re-evaluation and update of our understanding of macrophages. The present book is an endeavour that attempts provide state-of-the art knowledge of these cells in health and disease.