Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Effects Of Conjugated Linoleic Acid Isomers On Eicosanoid Metabolism In Kidney And Liver Tissues Of Obese Zucker Rats
Download Effects Of Conjugated Linoleic Acid Isomers On Eicosanoid Metabolism In Kidney And Liver Tissues Of Obese Zucker Rats full books in PDF, epub, and Kindle. Read online Effects Of Conjugated Linoleic Acid Isomers On Eicosanoid Metabolism In Kidney And Liver Tissues Of Obese Zucker Rats ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Effects of Conjugated Linoleic Acid Isomers on Eicosanoid Metabolism in Kidney and Liver Tissues of Obese Zucker Rats by : Hong Shi
Download or read book Effects of Conjugated Linoleic Acid Isomers on Eicosanoid Metabolism in Kidney and Liver Tissues of Obese Zucker Rats written by Hong Shi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CLA -- Zucker rat -- eicosanoids -- tissues.
Book Synopsis Investigating the Isomer-specific Effects of Conjugated Linoleic Acid on Metabolic Syndrome, Hepatic Steatosis and Selected Mediators of Hepatic Lipid Metabolism in the Fa/fa Zucker Rat by : Danielle Marie Stringer
Download or read book Investigating the Isomer-specific Effects of Conjugated Linoleic Acid on Metabolic Syndrome, Hepatic Steatosis and Selected Mediators of Hepatic Lipid Metabolism in the Fa/fa Zucker Rat written by Danielle Marie Stringer and published by . This book was released on 2006 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism by : Amy Dianne Noto
Download or read book Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism written by Amy Dianne Noto and published by . This book was released on 2005 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats by : Nazanin Kazem Moosavi
Download or read book The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats written by Nazanin Kazem Moosavi and published by . This book was released on 2010 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Adiposity by Dietary Conjugated Linoleic Acid by : Xiaofang Xu
Download or read book Regulation of Adiposity by Dietary Conjugated Linoleic Acid written by Xiaofang Xu and published by . This book was released on 2002 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity by : Angela Ann Wendel
Download or read book Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity written by Angela Ann Wendel and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significant depletion of adipose in mice by CLA may contribute to the lipodystrophic-like effects that accompany. The final objective of this research was to determine mechanisms by which CLA reduces adipose mass. Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) were fed the control diet and received daily, intraperitoneal injections of 1 mg/kg BW recombinant leptin as a positive control for adipose depletion in ob/ob mice. The depletion of adipose tissue by CLA was accompanied by the acquirement of brown adipose-like characteristics, such as increased CPT-1b, PGC-1alpha, and UCP-1, in the white adipose of CLA-fed mice. This alteration may facilitate the reduction of adipose mass by increasing mitochondrial oxidation and energy dissipation. However, it appears that CLA does not increase UCP-1 through beta3AR signaling.
Book Synopsis Advances in Conjugated Linoleic Acid Research by : Jean-Louis Sébédio
Download or read book Advances in Conjugated Linoleic Acid Research written by Jean-Louis Sébédio and published by AOCS Publishing. This book was released on 2003 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Conjugated Linoleic Acid Research, Volume 2 is the second book in a series devoted entirely to conjugated linoleic acid. This book has updated information on the analysis, biochemistry and applications of conjugated fatty acids in an attempt to make Volume 2, in conjunction with Volume 1 (published in 1999), the most comprehensive, up-to-date sources of CLA-related information available today. Both scientific and commercial views are presented, with the same data sometimes interpreted differently.
Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Martin P. Yurawecz Publisher :The American Oil Chemists Society ISBN 13 :9781893997875 Total Pages :284 pages Book Rating :4.9/5 (978 download)
Book Synopsis Advances in Conjugated Linoleic Acid Research, Volume 3 by : Martin P. Yurawecz
Download or read book Advances in Conjugated Linoleic Acid Research, Volume 3 written by Martin P. Yurawecz and published by The American Oil Chemists Society. This book was released on 2006-09-29 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the chemistry, biological properties and healthful benefits of conjugated linoleic acid (CLA) continues to grow. The number of peer reviewed publications produced on CLA since the 2003 publication of Advances in Conjugated Linoleic Acid Research, Volume 2, has more than doubled. It is likely that CLA will be used in the future in many more studies related to diseases such as cancer, atherosclerosis, and diabetes. This text provides comprehensive coverage of this area of research. Sections include material on biosynthesis and metabolic processes, techniques of determination of individual isomers, diversity of CLA, and effects of CLA isomers in humans.
Book Synopsis Conjugated Linoleic Acid by : Yiyu Fang
Download or read book Conjugated Linoleic Acid written by Yiyu Fang and published by . This book was released on 1998 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effect of Different Conjugated Linoleic Acid Isomers on Lipid Metabolism and Body Composition by : Shama Vasanthi Joseph
Download or read book Effect of Different Conjugated Linoleic Acid Isomers on Lipid Metabolism and Body Composition written by Shama Vasanthi Joseph and published by . This book was released on 2010 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'objectif général de ce projet consiste à étudier les effets de différents isomères d'acide linoléique conjugué (ALC), soit l'isomère cis9, trans11 (c9, t11), et l'isomère trans10, cis12 (t10, c12) combinés ou non ensemble, ainsi qu'un mélange des isomères transi, cis10 (t8, c10) et c9, t11 sur le métabolisme lipidique et la composition corporelle à partir d'un modèle cellulaùe in vitro, d'un modèle animal et chez l'humain. Les résultats démontrent que le mélange t8, cl0+c9, t11 réduit l'accumulation de triglycérides (-26%) dans les (pré)adipocytes de souris 3T3-L1, comparativement à l'isomère c9, t11. Par ailleurs, le contenu en adiponectine des cellules traitées avec le mélange t8, cl0+c9, t11 est demeuré inchangé, indiquant une fonction cellulaire normale. Les hamsters Golden Syrian mâles nourris pendant 28 jours d'une diète hypercholestérolémique incorporant 2% d'un mélange d'ALC t8, c10+c9, t11 présentent également une masse grasse inférieure (-14%) à celle du groupe contrôle nourri à l'aide de la diète hypercholestérolémique sans ALC, confirmant ainsi nos précédents résultats obtenus avec les (pré)adipocytes de souche 3T3-L1. Les mécanismes sous-jacents demeurent à être élucidés. D'autre part, l'ALC t10, c12 combiné ou non avec l'isomère c9, t11 entraîne une diminution importante du contenu en triglycérides dans les (pré)adipocytes 3T3-L1 et en masse grasse chez les hamsters, mais s'accompagne d'effets délétères comme une diminution du niveau cellulaire d'adiponectine dans les (pré)adipocytes et une augmentation du poids du foie, du niveau du cholestérol non-HDL ainsi que de la concentration hépatique d'alanine transaminase chez les hamsters. Chez l'humain, la prise de 3.5g d'un supplément d'ALC à base de l'isomère c9, t11 ou d'un mélange 50:50 d'isomères c9, t11+t10, c12 pendant huit semaines n'entraîne de changement ni dans la composition corporelle ni dans la concentration des lipides plasmatiques. Aucun changement n'est également observé sur les paramètres d'inocuité testés. En conclusion, les résultats de ce projet doctoral montrent que, même si les suppléments d'ALC (c9, t11+t10, cl2) présentement disponibles sur le marché ne représentent pas une solution adéquate pour la perte de poids chez des hommes souffrant d'embonpoint, il poirrrait être intéressant d'explorer davantage le potentiel d'isomères d'ALC peu connus comme l'isomère t8, c10.
Book Synopsis Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) by : Wan Shen
Download or read book Anti-obesity Mechanisms of Conjugated Linoleic Acid (CLA) written by Wan Shen and published by . This book was released on 2015 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Overweight and obesity are the most widespread nutritional diseases in the U.S., which greatly increase chronic disease risks and mortality. Therefore, it is urgent to develop a relatively efficacious and safe strategy for the weight management. Consumption of conjugated linoleic acid (CLA) supplements or one of its isomers, trans-10, cis-12 (10,12) CLA, has consistently demonstrated reductions in body weight or body fat in human and animal studies. Our lab has demonstrated that 10,12 CLA triggered calcium release from endoplasmic reticulum in human primary adipocytes, which activated downstream inflammatory signaling, resulting in impaired uptake of glucose and fatty acid, and delipidation. However, the upstream signals responsible for these actions are unknown. Therefore, my Aim 1 investigated the upstream mechanism by which 10,12 CLA increases intracellular calcium and inflammatory signaling in human primary adipocytes. The results indicated that phospholipase C plays an important role in 10,12 CLA-mediated activation of intracellular calcium accumulation, inflammatory signaling, delipidation, and insulin resistance in human primary adipocytes. It has been demonstrated that 10,12 CLA increased mRNA levels and protein levels of cyclooxygenase-2 (COX-2) and pro-inflammatory prostaglandins, which have been linked to increased energy expenditure associated with white adipose tissue (WAT) browning and uncoupling of ATP synthesis. It also has been shown that relatively high doses of 10,12 CLA lead to more significant reductions in body fat, but cause a greater level of inflammation, insulin resistance, and steatosis in animals. Therefore, Aims 2 and Aim 3 determined the extent to which a relative low dose of 10,12 CLA or a CLA isomer mixture increases markers of browning in mice and its dependence in inflammatory signaling. In Aim 2, a low threshold dose of 10,12 CLA was found that prevented body fat accumulation with minimum metabolic side-effects in non-obese mice. It was also found that 10,12 CLA-induced browning in WAT was accompanied by increases in mRNA levels of COX-2 and other markers of inflammation. In Aim 3, a relatively low dose of 10,12 CLA reduced body fat and increased browning of WAT in overweight mice, which were independent of inflammatory signaling. Collectively, these findings provide critical insights for the development of reliable dietary strategies for people who take CLA as method to lose weight. However, we still do not know (i) if 10,12 CLA supplementation would effectively reduce body fat in overweight mice when they are continuously fed an American-type, high-fat diet; (ii) potential risks of impaired regulation of body temperature, inflammation, and steatosis due to 10,12 CLA consumption in high fat-fed mice; and (iii) potential mechanisms by which 10,12 CLA reduces body fat in high fat-fed mice."--Abstract from author supplied metadata.
Book Synopsis Differential Metabolic Effects in White and Brown Adipose Tissue by Conjugated Linoleic Acid Elicit Lipodystrophy-associated Hepatic Insulin Resistance by : Michael B. Stout
Download or read book Differential Metabolic Effects in White and Brown Adipose Tissue by Conjugated Linoleic Acid Elicit Lipodystrophy-associated Hepatic Insulin Resistance written by Michael B. Stout and published by . This book was released on 2011 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The prevalence of obesity has risen substantially throughout the world in recent decades. Nonsurgical treatments for reducing adiposity remain paramount to diminishing obesity and its associated comorbidities. Conjugated linoleic acid has received considerable attention due to its ability to reduce body weight and adiposity in a number of species. The mechanisms responsible for adipose depletion by conjugated linoleic acid remain controversial and are not completely understood. The first objective of this research was to determine if conjugated linoleic acid altered adipose phenotype by inducing adaptive thermogenesis and increasing oxidative capacity. In this study, conjugated linoleic acid dramatically reduced weight gain and adipose mass. Additionally, conjugated linoleic acid induced the expression of numerous genes involved in adaptive thermogenesis in epididymal white adipose tissue. Lipid droplet morphology was unchanged by conjugated linoleic acid treatment, although mitochondrial density was increased in epididymal white adipose tissue. Unexpectedly, whole body oxygen consumption and body temperatures were reduced and unchanged by conjugated linoleic acid treatment, respectively. We attributed these observations to a significant reduction in brown adipose tissue with a concomitant compensatory response in epididymal white adipose tissue. Our data suggest that significant reductions in brown adipose tissue by conjugated linoleic acid initiates white adipose adaptive thermogenesis as a means to maintain body temperature.
Book Synopsis Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition by : Madhuri Vemuri
Download or read book Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition written by Madhuri Vemuri and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis9, trans11-CLA and trans10, cis12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and other claimed health benefits. However supplementing CLA isomers, especially trans10, cis12-CLA has been shown to cause non alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) in several animal models. Here we have confirmed that supplementing 0.5% trans10, cis12-CLA to C57BL/6 mice for 8 weeks causes NAFLD and IR. When CLA diets were concomitantly supplemented with omega-3 fatty acids docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at 1.5% (w/w) for 8 weeks, DHA prevented CLA induced IR, while EPA was ineffective. Both EPA and DHA prevented CLA induced fatty liver. CLA also reduced the plasma leptin and adiponectin concentrations, and both EPA and DHA partially restored plasma leptin, but only DHA partially restored the plasma adiponectin. In another experiment, concomitant supplementation of CLA diets with 0.5% of flaxseed oil (rich in alpha linolenic acid) also prevented IR and decreased liver weights and lipids compared with those in CLA group. CLA supplementation also altered lipid profile in liver, decreasing n-6 and n-3 wt% and increasing n-6:n-3 ratio. Concomitant supplementation with flaxseed oil increased n-6 and n-3 polyunsaturated (PUFA) in liver lipids and decreased the n-6:n-3 ratio compared to that in CLA group. Supplementing 0.5% (w/w) of purified c9, t11- or trans10, cis12-CLA to mice for 8 weeks altered fatty acid profile of tissues differently. c9, t11-CLA diet reduced MUFA wt% in liver, adipose tissue, and spleen, and reduced the spleen n-3 PUFAs significantly while increasing the n-6 PUFA wt% in all tissues except heart. In contrast, trans10, cis12-CLA reduced both the n-6 and n-3 PUFA wt% in liver and heart however increased the wt% of n-3 PUFAs in spleen. Considering the adverse health effects of trans10, cis12-CLA and of mixtures of CLA isomers on NAFLD, IR and tissue fatty acids, human use of CLA supplements should not be recommended.
Book Synopsis The Effects of Fermented Soy and Soy Diets on Hepatic Lipid Composition in Zucker (fa/fa) Rats by : Rachel M. Cole
Download or read book The Effects of Fermented Soy and Soy Diets on Hepatic Lipid Composition in Zucker (fa/fa) Rats written by Rachel M. Cole and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Sixty million (30%) adults in the United States are considered obese. Obesity (Body Mass Index> 30 kg/m2) is an inflammatory disease that has its origin in diet. Obesity is the condition of accumulation of lipids in the adipose tissue and in non-adipose tissues such as the liver and muscle (eg. steatosis). The WHO-coordinated Cardiovascular Diseases and Alimentary Comparison Study (CARDIAC), a worldwide epidemiological study, found that those people who consumed soy had a significantly reduced risk of obesity than those who did not consume soy in their diets. The effects of fermented soy, soy, and casein diets on body weight of adipose mass and lipid composition of the liver in obese Zucker rats was studied. Thirty-nine male Zucker fatty rats, which are prone to hyperphagia, obesity, and insulin resistance, were randomized and placed in four groups, each group being fed a different diet. The diets were: 1) Casein diet (n=9); 2) Soy diet (n=10); 3) Fermented soy diet (n=10); 4) Mixture of soy and fermented soy (n=10). The differences in weight gain, food intake, changes in adipose mass and fat accumulation in the liver were examined. After feeding diets for ten weeks, the rats were euthanized and necropsy was performed. Weights of the removed organs were recorded. There were no effects of diets on food intake, body weight or adipose mass. All three soy diet groups had a significantly lower liver weight and liver to body weight ratio compared to the casein diet group. The casein diet group also had a significantly lower percentage of polyunsaturated fatty acids in the livers than both the soy and fermented soy diet groups. However, the casein diet group had a significantly higher percentage of monounsaturated fatty acids in the livers than all three of the soy diet groups. Both the fermented soy and soy diet groups had significantly higher amounts of omega-6 fatty acids in the livers than the casein diet group. Overall, fermented soy and soy diets did have an effect on hepatic lipid metabolism in Zucker fatty rats when compared to the casein diet.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1998 with total page 1848 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats PDF Online Free](https://books.google.com/books/content/images/frontcover/lAEengEACAAJ?fife=w200-h370)
