Effects of Bone Morphogenetic Protein-2 and Parathyroid Hormone-related Peptide on Collagen XI During Skeletal Development

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ISBN 13 :
Total Pages : 81 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Effects of Bone Morphogenetic Protein-2 and Parathyroid Hormone-related Peptide on Collagen XI During Skeletal Development by : Neda Shefa

Download or read book Effects of Bone Morphogenetic Protein-2 and Parathyroid Hormone-related Peptide on Collagen XI During Skeletal Development written by Neda Shefa and published by . This book was released on 2015 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Long bones develop via endochondral ossification, a process in which cartilage precedes bone. During endochondral ossification prechondrogenic cells undergo proliferation and apoptose as cells of the periosteum differentiate into bone. The process of endochondral ossification is regulated by a group of endocrine as well as paracrine molecules that includes bone morphogenetic protein-2 (BMP-2) and parathyroid hormone-related peptide (PTHrP). Collagens are extracellular matrix molecules that are present in a spatiotemporal manner during endochondral ossification. Collagen XI alpha 1 (Col11a1) is a minor fibrillar collagen that is alternatively spliced during development and can result in up to eight different spliceforms. During endochondral ossification Col11a1 spliceforms have a distinct expression profile in the growing long bone. The significance of the different spliceforms has not been characterized. Here, I studied the effects of BMP-2 and PTHrP on the expression of Col11a1 in pre-chondrogenic mouse ATDC5 and pluripotent mouse C2C12 cells. I also investigated the role of different Col11a1 spliceforms in BMP-2-mediated C2C12 osteoblast differentiation. My results suggest a role for BMP-2 in regulating Col11a1 splicing and expression that includes the induction of exons 6A, 7, and 8. Further I show that while PTHrP alone did not affect Col11a1 expression, when combined with BMP-2, PTHrP was able to diminish BMP-2-induced Col11a1 expression. In addition, Col11a1 NTD[p6b-7] reduced BMP-2 activity in C2C12 cells while Col11a1 NTD[p7] did not have any significant effects. Col11a1 NTD[p6b-7] also reduced the expression of alkaline phosphatase and collagen 1 alpha 1 and increased the expression of Runx2 and osteocalcin while NTD[p7-8] induced the expression of osteocalcin, Runx2, and collagen alpha 1. When Col11a1 was knocked down, the expression of BMP-2-induced markers alkaline phosphatase, Runx2, osteocalcin, and collagen 1 alpha 1 were reduced at 24h post induction with BMP-2 suggesting a role for collagen XI alpha 1 during early osteoblast differentiation. In ATDC5 cells, I determined a role for PTHrP in the induction of collagen XI alpha 1 exons 6A, 7, and 8 during early chondrocyte differentiation and exon 6B during late chondrocyte differentiation. Overall the results of this project show a novel role for collagen XI alpha 1 in BMP-2-mediated osteoblast differentiation and also suggest a role for PTHrP in regulating collagen XI alpha splicing and expression during ATDC5 chondrocyte differentiation."--Boise State University ScholarWorks.

Modeling Bone Morphogenetic Protein Binding Peptide Action on Perfused Osteoblast Growth

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ISBN 13 :
Total Pages : 187 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Modeling Bone Morphogenetic Protein Binding Peptide Action on Perfused Osteoblast Growth by : Argus M. Sun

Download or read book Modeling Bone Morphogenetic Protein Binding Peptide Action on Perfused Osteoblast Growth written by Argus M. Sun and published by . This book was released on 2014 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Morphogenetic Protein-2 (BMP-2) is a growth factor in the TGF-β cytokine family, among other ubiquitous effects in development, it promotes bone mineralization by inducing osteoblast differentiation from precursor cells. This effect is the basis of its use as a therapeutic in procedures such as spinal fusion. However, because of its ubiquitous nature, side effects such as inflammation and swelling of surrounding tissues can be seen when the amount of BMP-2 implanted and released is not regulated. In the extracellular space, BMP-2 has numerous endogenous binding proteins. Among these is secreted phosphoprotein 24 (spp24). This protein can be modified in hopes of isolating the residues necessary to bind with BMP-2. This binding protein and its peptide derivatives can be used to modulate the release of BMP-2. Using a collagen sponge as a delivery vehicle, the rate and pattern of release can be analyzed. Collagen sponges can serve as tissue engineering scaffolds that can host cell growth. An analysis of growth factor release from implantable collagen sponges cannot ignore the effect of ingrowth of osteoblast precursor cells. To study BMP-2 release modulation by spp24 with cellular response as an output, a perfusion bioreactor can be used. Perfusion bioreactors immerse a scaffold in growth media, delivering nutrients and gases permitting cell growth. In the bioreactor efflux, the release of BMP-2 from the sponge can be quantified. A BMP-2 scaffold-bioreactor system has the advantage of being sufficiently well-characterized in terms of parameters to the point where simulation is possible. Furthermore, the designed bioreactor can be fabricated to verify the predictions made by simulation. Finally, the BMP-2 SMAD pathway can be used to create a cellular model to predict the response generated by BMP-2 release.

Osteogenesis Imperfecta

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Publisher : Academic Press
ISBN 13 : 0123977894
Total Pages : 578 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Osteogenesis Imperfecta by : Javaid Kassim

Download or read book Osteogenesis Imperfecta written by Javaid Kassim and published by Academic Press. This book was released on 2013-08-06 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI. Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta (OI) as will the importance of nutrition in managing the OI child and the OI adult Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI

The Growth Plate

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Publisher : IOS Press
ISBN 13 : 9781586032401
Total Pages : 312 pages
Book Rating : 4.0/5 (324 download)

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Book Synopsis The Growth Plate by : Irving M. Shapiro

Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Cumulated Index Medicus

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ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

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ISBN 13 :
Total Pages : 2036 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Pediatric Orthopedic Deformities, Volume 1

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Publisher : Springer
ISBN 13 : 3319205293
Total Pages : 807 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Pediatric Orthopedic Deformities, Volume 1 by : Frederic Shapiro

Download or read book Pediatric Orthopedic Deformities, Volume 1 written by Frederic Shapiro and published by Springer. This book was released on 2015-12-20 with total page 807 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental biology of normal bone and cartilage including histogenesis, molecular/gene and biomechanical aspects is updated and expanded. The book outlines the biology of: bone repair with differing mechanical environments; cartilage repair at articular and physeal sites; and distraction osteogenesis. The generously illustrated text provides an in-depth presentation of the interplay between normal developmental biology, abnormal pathologic states and the influence of operative and non-operative orthopedic interventions on childhood orthopedic deformity. Thirty-four principles underlying the development, progression and management of skeletal deformity in the growing child are defined. Orthopedic management including surgical treatment is discussed for: skeletal dysplasias; epiphyseal growth plate fracture-separations; lower extremity length discrepancies; and deformities of joints and epiphyses due to metabolic, inflammatory, infectious, hematologic, and neoplastic disorders. Treatments are related to extent of deformity, remodeling post-surgery and possible recurrence. This 2nd edition of Pediatric Orthopedic Deformities has been expanded to cover more regions and disorders and is being presented in 3 volumes.

Bone Pathology

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Publisher : Springer Science & Business Media
ISBN 13 : 1597453471
Total Pages : 419 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Bone Pathology by : Jasvir S. Khurana

Download or read book Bone Pathology written by Jasvir S. Khurana and published by Springer Science & Business Media. This book was released on 2009-12-02 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Rockwood and Wilkins' Fractures in Children

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451147961
Total Pages : 1059 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Rockwood and Wilkins' Fractures in Children by : James H. Beaty

Download or read book Rockwood and Wilkins' Fractures in Children written by James H. Beaty and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly revised, updated Seventh Edition of Rockwood and Wilkins' Fractures in Children offers a complete print and multimedia package: the established "gold-standard" reference on pediatric fractures and access to an integrated content website. The world's foremost authorities provide comprehensive coverage of all bone and joint injuries seen in children, thoroughly discuss alternative methods for treating each injury, and present their own preferred methods. This edition has a more international group of contributors, more tips and pearls in the authors' preferred method presentations, and expanded coverage of complications. New chapters cover casting, remodeling and what is unique about children's fractures; principles of physical examination of children with fractures; and treacherous children's fractures. A companion website contains the fully searchable text, an image bank, and videos of the ten most difficult procedures.

Cartilage

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Publisher : Springer
ISBN 13 : 3319295683
Total Pages : 275 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Cartilage by : Susanne Grässel

Download or read book Cartilage written by Susanne Grässel and published by Springer. This book was released on 2016-04-21 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This first volume provides a comprehensive overview on the basic composition and development of cartilaginous tissues followed by the description of the major signaling pathways which regulate cartilage morphogenesis and function. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage biology.

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

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Publisher : John Wiley & Sons
ISBN 13 : 0470623985
Total Pages : 559 pages
Book Rating : 4.4/5 (76 download)

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Book Synopsis Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism by : Juliet E. Compston

Download or read book Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism written by Juliet E. Compston and published by John Wiley & Sons. This book was released on 2009-12-22 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.

Encyclopedia of Bone Biology

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Publisher : Academic Press
ISBN 13 : 0128140828
Total Pages : 2390 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Bone Biology by :

Download or read book Encyclopedia of Bone Biology written by and published by Academic Press. This book was released on 2020-06-26 with total page 2390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Bone Biology, Three Volume Set covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles. Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field Includes multimedia features, cross-references and color images/videos

Biomaterials for Oral and Dental Tissue Engineering

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Publisher : Woodhead Publishing
ISBN 13 : 0081009674
Total Pages : 564 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Biomaterials for Oral and Dental Tissue Engineering by : Lobat Tayebi

Download or read book Biomaterials for Oral and Dental Tissue Engineering written by Lobat Tayebi and published by Woodhead Publishing. This book was released on 2017-07-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Oral and Dental Tissue Engineering examines the combined impact of materials, advanced techniques and applications of engineered oral tissues. With a strong focus on hard and soft intraoral tissues, the book looks at how biomaterials can be manipulated and engineered to create functional oral tissue for use in restorative dentistry, periodontics, endodontics and prosthodontics. Covering the current knowledge of material production, evaluation, challenges, applications and future trends, this book is a valuable resource for materials scientists and researchers in academia and industry. The first set of chapters reviews a wide range of biomaterial classes for oral tissue engineering. Further topics include material characterization, modification, biocompatibility and biotoxicity. Part Two reviews strategies for biomaterial scaffold design, while chapters in parts three and four review soft and hard tissues. Connects materials science with restorative dentistry Focuses on the unique field of intraoral tissues Highlights long-term biocompatibility and toxicity of biomaterials for engineered oral tissues

Diseases of the Kidney and Urinary Tract

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781793070
Total Pages : 1026 pages
Book Rating : 4.7/5 (93 download)

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Book Synopsis Diseases of the Kidney and Urinary Tract by : Robert W. Schrier

Download or read book Diseases of the Kidney and Urinary Tract written by Robert W. Schrier and published by Lippincott Williams & Wilkins. This book was released on 2007 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thoroughly updated Eighth Edition of this classic three-volume work provides the most comprehensive, current, and authoritative information on diseases of the kidney and urinary tract. This clinically oriented reference focuses on diagnosis and treatment of specific diseases, disorders, and complications and incorporates the basic science practicing physicians need to evaluate and manage the disease process. Each of the fourteen sections is written by internationally renowned contributors and provides coverage comparable to a complete book. The first two sections review renal basic science and describe current diagnostic tools. The remaining twelve sections cover various types of diseases, including hypertension, urological problems, and urinary tract concerns. Each disease-oriented section begins with an up-to-date review of pathophysiology and then focuses on specific diseases. This edition has new lead authors for more than 25 chapters, and separate chapters on heart disease and the kidney, liver disease and the kidney, and the nephrotic syndrome.

Phosphate Metabolism

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Publisher : Springer Science & Business Media
ISBN 13 : 1461342171
Total Pages : 611 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Phosphate Metabolism by : Shaul Massry

Download or read book Phosphate Metabolism written by Shaul Massry and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: We present to our readers the proceedings of the Second International Workshop on Phosphate. A short account of the history of the effort led to the Phosphate Workshops is appro priate and can be of interest to the reader. The idea for Phosphate Workshops was born in the early days of November, 1974. One of us (S. G. M. ) suggested the thought to a group of scientists gathered for a luncheon in one of the attrac tive small restaurants in Weisbaden, Germany. The purpose of the workshop was to bring together interested scientists to discuss the newer developments and the recent advances in the field of phosphate metabolism and the other related minerals. An Organizing Committee made of Shaul G. Massry (USA), Louis V. Avioli (USA), Philippe Bordier (France), Herbert Fleisch (Switzerland), and Eduardo Slatopolsky (USA) was formed. The First Workshop was held in Paris during June 5-6, 1975 and was hosted by Dr. Philippe Bordier. Its proceeding was already published. The Second Workshop took place in Heidelberg during June 28-30, 1976 and was hosted by Dr. Eberhard Ritz. Both of these workshops were extremely successful scientific endeavors, and the need for them was demonstrated by the great interest they generated among the scientific community. The Or ganizing Committee, therefore, decided to continue with the tradi tion to hold additional Workshops annually or every other year.

Inborn Errors of Development

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Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 1672 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Inborn Errors of Development by : Charles J. Epstein

Download or read book Inborn Errors of Development written by Charles J. Epstein and published by Oxford University Press, USA. This book was released on 2008 with total page 1672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Honored by the Association of American Publishers as the Best Medical Book of 2004, Inborn Errors is the definitive work on genetically caused abnormalities of human development. Despite the explosion in genetic advances, the causes of two-thirds of all birth defects remain unknown. However, we are on the brink of a revolution in this area, and Inborn Errors is at the forefront. It is the first book to connect the disease-causing gene to its biochemical pathway and to the structural/functional disorder. Mutations of the gene, the clinical picture, genetic counseling and prognosis, and any known treatments are discussed. For medical geneticists, genetic counselors, pediatricians, and developmental biologists, the book is a unique and groundbreaking reference.

Bioengineering and Translational Research for Bone and Joint Diseases

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Publisher : Frontiers Media SA
ISBN 13 : 2832501745
Total Pages : 298 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Bioengineering and Translational Research for Bone and Joint Diseases by : Weili Fu

Download or read book Bioengineering and Translational Research for Bone and Joint Diseases written by Weili Fu and published by Frontiers Media SA. This book was released on 2022-10-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: