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Author : Séverine Oudin
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.:/5 (853 download)
Download or read book Effects of Mechanical Stretch on Human Bronchial Epithelial Cells written by Séverine Oudin and published by . This book was released on 2004 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Séverine Oudin
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.:/5 (718 download)
Download or read book Effect of Mechanical Stretch on Human Bronchial Epithelial Cells written by Séverine Oudin and published by . This book was released on 2004 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: L'objectif de cette thèse était d'identifier les mécanismes moléculaires et cellulaires qui transforment un stress mécanique en séquelle biochimique, dans le cadre d'une approche biologique de l'inflammation pulmonaire induite par la ventilation mécanique (VILI) observée chez les patients des soins intensifs de médecine. Il a été démontré que les cellules bronchiques humaines répondent au stress d'étirement en sécrétant l'interleukine (IL)-8, chimiokine importante dans le VILI. Cette sécrétion est due au moins en partie à une activation transcriptionnelle du gène de l'IL-8, laquelle est due à l'activation des voies de signalisations aboutissant à l'activation du facteur de transcription NF-kappaB. D'autre part, les voies de signalisation des MAP kinases, en particulier p38, participent aussi à l'activation des cellules bronchiques par l'étirement. Finalement, il a été établit que deux autres ARN messagers sont actives en sus de l'IL-8 au cours de l'étirement mécanique parmi les 588 ARNm testés : MCP-1 et GADD45.
Author : Ferranda Puig i Cotado
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (898 download)
Download or read book Effects of Mechanical Stimuli of Vibration and Stretch on Airway Epithelial Cells written by Ferranda Puig i Cotado and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Corey Garrett Holt
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (969 download)
Download or read book TNF-©{u008E}℗ł and Mechanical Stretch: Synergistic Damage to Alveolar Epithelial Cells written by Corey Garrett Holt and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute respiratory distress syndrome (ARDS) is difficult to treat and has a mortalitly rate of 40-60%. During ARDS, cytokine levels in the lungs are elevated and patients are treated with hyperoxia and mechanical ventilaion. Alone, these three factors can cause lung injury but the combination is thought to worsen lung damage. Using an over-distension model of lung injury, I investigated the effect of excessive mechanical stretch on a monolayer of murine alveolar epithelial cells (MLE-12) treated with the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α). Results show that monolayer damage, i.e., formation of cell-free areas, may begin as early as 30 minutes from the beginning of excessive stretch. Moreover, the cell-free area formation due to TNF-α and stretch together was 16% greater than the cell-free area formed due to either stimulus alone. Future studies are needed to elucidate the cause of this form of damage.
Author : Stephen Paul Arold
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (31 download)
Download or read book Effects of Cyclic Stretch on Surfactant Secretion and Cell Viability in Alveolar Epithelial Cells Grown in Culture written by Stephen Paul Arold and published by . This book was released on 2006 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Mechanical ventilation is vital among patients suffering from acute lung injury; however, studies have shown that it likely damages the lung through ventilator induced lung injury (VILI). VILI is thought to arise partly from the deleterious effects of non-physiologic forces imparted to the pulmonary epithelium. We have demonstrated that a novel ventilation strategy, "variable ventilation," whereby tidal volume is varied on a cycle-by-cycle basis, increases pulmonary surfactant content in rodents. We hypothesized that the variable stretch patterns enhanced surfactant secretion in the alveolar epithelial type II (AEII) cells. The broad goal of this study was to directly test this hypothesis. Here we describe the design and validation of a stretching device capable of delivering cyclic, biaxial strains to cells grown in culture including the novel stretch patterns required for this study. We utilized this device to characterize the effects of strain and underlying substratum on surfactant secretion and cell viability on the mouse lung epithelial-12 (MLE-12) cell line. Next, we cultured rat AEII cells and examined the combined effects of time duration and stretch magnitude on surfactant secretion and uptake, cell viability, and secretion of surfactant proteins. Finally, we stretched cultured AEII cells utilizing a "variable stretch" pattern mimicking those conditions thought to occur in-vivo during variable ventilation. We found that the MLE-12 cells did not exhibit surfactant secretion in response to stretch, however surfactant secretion was enhanced when grown on a fibronectin-like substratum in comparison with those grown on collagen I. While isolated AEII cells increased surfactant secretion in response to short periods of strain, 1 hour of cyclic stretch diminished surfactant secretion regardless of strain magnitude. Finally, variable stretch patterns applied to AEII increased surfactant secretion at high and moderate degrees of strain. This suggests ventilator strategies utilizing monotonous ventilation patterns may inhibit surfactant secretion in a clinical setting, whereas application of variable stretch may result in enhanced surfactant secretion into the alveolar space, possibly reducing VILI. These results may have a broader application to physiologic systems in general where purely periodic signals imposed by human intervention could have a detrimental effect on a system's natural function.
Author : Joyce Lee
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book The Effect of Mechanical Ventilation on Lung Epithelial Cell Fate written by Joyce Lee and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andre Kamkin
Publisher : Springer Science & Business Media
ISBN 13 : 9400720041
Total Pages : 247 pages
Book Rating : 4.4/5 (7 download)
Download or read book Mechanical Stretch and Cytokines written by Andre Kamkin and published by Springer Science & Business Media. This book was released on 2011-09-06 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.
Author : Roy Bicknell
Publisher : Cambridge University Press
ISBN 13 : 9780521559904
Total Pages : 156 pages
Book Rating : 4.5/5 (599 download)
Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Author : Didier Dreyfuss
Publisher : CRC Press
ISBN 13 : 1420019260
Total Pages : 776 pages
Book Rating : 4.4/5 (2 download)
Download or read book Ventilator-Induced Lung Injury written by Didier Dreyfuss and published by CRC Press. This book was released on 2006-03-21 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Cons
Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 1420091212
Total Pages : 566 pages
Book Rating : 4.4/5 (2 download)
Download or read book Mechanobiology Handbook written by Jiro Nagatomi and published by CRC Press. This book was released on 2011-03-15 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology—the study of the effects of mechanical environments on the biological processes of cells—has evolved from traditional biomechanics via the incorporation of strong elements of molecular and cell biology. Currently, a broad range of organ systems are being studied by surgeons, physicians, basic scientists, and engineers. These mechanobiologists aim to create new therapies and further biological understanding by quantifying the mechanical environment of cells and the molecular mechanisms of mechanically induced pathological conditions. To achieve these goals, investigators must be familiar with both the basic concepts of mechanics and the modern tools of cellular/molecular biology. Unfortunately, current literature contains numerous studies that misuse standard mechanical estimations and terminology, or fail to implement appropriate molecular analyses. Therefore, the Mechanobiology Handbook not only presents cutting-edge research findings across various fields and organ systems, but also provides the elementary chapters on mechanics and molecular analysis techniques to encourage cross-field understanding and appropriate planning. Aided by the continuous advancement of research tools in both mechanics and biology, more sophisticated experiments and analyses are possible—thus fueling the growth of the field of mechanobiology. Considering the complexity of the mechanics and the biology of the human body, most of the world of biomechanics remains to be studied. Since the field is still developing, the Mechanobiology Handbook does not force one unified theory, but brings out many different viewpoints and approaches to stimulate further research questions.
Author : Frederick H. Silver
Publisher : Springer Science & Business Media
ISBN 13 : 0387281762
Total Pages : 306 pages
Book Rating : 4.3/5 (872 download)
Download or read book Mechanosensing and Mechanochemical Transduction in Extracellular Matrix written by Frederick H. Silver and published by Springer Science & Business Media. This book was released on 2006-11-24 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only single authored text on biological polymers available for bioengineering and biomedical engineering students. The book describes the structure of polymers and how these molecules are put together to make the tissues of the body and also their role in surgical implants and in structural diseases. It provides essential reading for biomedical engineers, biologists, physicians, health care professionals and other biomedical researchers who are interested in understanding how physical forces affect the biology, physiology and pathophysiology of humans. The author is an expert on the effect of mechanical forces on extracellular matrix.
Author :
Publisher : Academic Press
ISBN 13 : 0128177659
Total Pages : 414 pages
Book Rating : 4.1/5 (281 download)
Download or read book Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders written by and published by Academic Press. This book was released on 2019-06-05 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters
Author : Galina Sud’ina
Publisher : Frontiers Media SA
ISBN 13 : 2832509452
Total Pages : 143 pages
Book Rating : 4.8/5 (325 download)
Download or read book Pharmacological Approaches Targeting Neutrophilic Inflammation: Volume II written by Galina Sud’ina and published by Frontiers Media SA. This book was released on 2022-12-22 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jiro Nagatomi
Publisher : CRC Press
ISBN 13 : 042981674X
Total Pages : 705 pages
Book Rating : 4.4/5 (298 download)
Download or read book Mechanobiology Handbook, Second Edition written by Jiro Nagatomi and published by CRC Press. This book was released on 2018-12-07 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology—the study of the effects of mechanics on biological events—has evolved to answer numerous research questions. Mechanobiology Handbook 2nd Edition is a reference book for engineers, scientists, and clinicians who are interested in mechanobiology and a textbook for senior undergraduate to graduate level students of this growing field. Readers will gain a comprehensive review of recent research findings as well as elementary chapters on solid mechanics, fluid mechanics, and molecular analysis techniques. The new edition presents, in addition to the chapters of the first edition, homework problem sets that are available online and reviews of research in uncovered areas. Moreover, the new edition includes chapters on statistical analysis, design of experiments and optical imaging. The editors of this book are researchers and educators in mechanobiology. They realized a need for a single volume to assist course instructors as a guide for didactic teaching of mechanobiology to a diverse student body. A mechanobiology course is frequently made up of both undergraduate and graduate students pursuing degrees in engineering, biology, or integrated engineering and biology. Their goal was to present both the elementary and cutting-edge aspects of mechanobiology in a manner that is accessible to students from many different academic levels and from various disciplinary backgrounds. Moreover, it is their hope that the readers of Mechanobiology Handbook 2nd Edition will find study questions at the end of each chapter useful for long-term learning and further discussion. Comprehensive collection of reviews of recent research Introductory materials in mechanics, biology, and statistics Discussion of pioneering and emerging mechanobiology concepts Presentation of cutting-edge mechanobiology research findings across various fields and organ systems End of chapter study questions, available online Considering the complexity of the mechanics and the biology of the human body, most of the world of mechanobiology remains to be studied. Since the field is still developing, the Mechanobiology Handbook raises many different viewpoints and approaches with the intention of stimulating further research endeavours.
Author : Ann Harris
Publisher : Cambridge University Press
ISBN 13 : 9780521559911
Total Pages : 204 pages
Book Rating : 4.5/5 (599 download)
Download or read book Epithelial Cell Culture written by Ann Harris and published by Cambridge University Press. This book was released on 1996-11-13 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains information and recipe-style techniques for culturing different types of epithelial cells.
Author : Masoud Mozafari
Publisher : Woodhead Publishing
ISBN 13 : 0128236108
Total Pages : 492 pages
Book Rating : 4.1/5 (282 download)
Download or read book Principles of Human Organs-on-Chips written by Masoud Mozafari and published by Woodhead Publishing. This book was released on 2023-01-17 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Human Organs-on-Chips covers all aspects of microfluidic organ-on-a-chip systems, from fabrication to application and commercialization. Organ-on-a-chip models are created to mimic the structural, microenvironmental and physiological functions of human organs, providing the potential to bypass some cell and animal testing methods. This is a useful platform with widespread applications, frequently in drug screening and pathological studies. This book offers a comprehensive and authoritative reference on microfluidic organs-on-chips, spanning all key aspects from fabrication methods, cell culture systems and cell-based analysis, to dedicated chapters on specific tissue types and their associated organ-on-a-chip models, as well as their use as disease models, drug screening platforms and more. Principles of Human Organs-on-Chips helps materials scientists and biomedical engineers to better understand the specific requirements and challenges in the design and fabrication of organ-on-a-chip devices. This book also bridges the knowledge gap between medical device design and subsequent clinical applications, allowing medical professionals to easily learn about related engineering concepts and techniques. Describes various microfluidic systems and fabrication methods Covers models and applications for a broad range of tissue types, including liver, eye, immune, gut, and more Offers an interdisciplinary approach, combining engineering techniques and clinical applications of organs-on-chips
Author : Jason X. -J. Yuan
Publisher : Springer Science & Business Media
ISBN 13 : 0387874291
Total Pages : 1640 pages
Book Rating : 4.3/5 (878 download)
Download or read book Textbook of Pulmonary Vascular Disease written by Jason X. -J. Yuan and published by Springer Science & Business Media. This book was released on 2011-03-24 with total page 1640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Pulmonary Vascular Diseases combines basic scientific knowledge on the pulmonary circulatory system at levels of the molecule, cell, tissue, and organ with clinical diagnosis and treatment of pulmonary vascular diseases. State-of-the-art techniques and their potential applications in research, diagnosis, and treatment of pulmonary vascular diseases are also covered.
