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Author : Joachim K. Seydel
Publisher :
ISBN 13 :
Total Pages : 349 pages
Book Rating : 4.:/5 (87 download)
Download or read book Drug-membrane Interactions written by Joachim K. Seydel and published by . This book was released on 2002 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joachim K. Seydel
Publisher : John Wiley & Sons
ISBN 13 : 3527616497
Total Pages : 367 pages
Book Rating : 4.5/5 (276 download)
Download or read book Drug-Membrane Interactions written by Joachim K. Seydel and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.
Author : S. Giatrellis
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128091835
Total Pages : 17 pages
Book Rating : 4.1/5 (28 download)
Download or read book Drug–biomembrane interaction studies written by S. Giatrellis and published by Elsevier Inc. Chapters. This book was released on 2013-10-31 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: DSC is a non-invasive experimental technique, which, besides other numerous applications, has been extensively applied in investigating the thermodynamic properties of synthetic and biological membranes. The calorimetric profiles of phase transitions of self-organized lipid membranes can provide valuable information about membrane interactions with biomolecules, pharmaceutical agents, other membranes, etc. The scope of this chapter is to review specific applications of DSC in studying membrane– nucleic acid interactions, which have attracted scientific attention for their biological relevance, as well as for their potential for biotechnological and pharmaceutical advances.
Download or read book Development of High-throughput Technologies for the Study of Drug-membrane Interactions written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R. Pignatello
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128091762
Total Pages : 39 pages
Book Rating : 4.1/5 (28 download)
Download or read book Drug–biomembrane interaction studies written by R. Pignatello and published by Elsevier Inc. Chapters. This book was released on 2013-10-31 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter will summarize recent information on cell membranes. Their structure, functions and the role of the various components are discussed, considering both their physiological tasks, such as mechanisms of drug internalization into cells, as well as membrane changes associated with or caused by particular disease states. Later chapters will discuss the possibility of testing biomembrane models to study their interaction with drugs and biological compounds.
Author : Callum Dickson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book In Silico Modelling of Membranes and Drug Membrane Interactions written by Callum Dickson and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R. Pignatello
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128091789
Total Pages : 23 pages
Book Rating : 4.1/5 (28 download)
Download or read book Drug–biomembrane interaction studies written by R. Pignatello and published by Elsevier Inc. Chapters. This book was released on 2013-10-31 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: DSC studies of the interaction between drugs or other biologically active compounds with biomembrane models has often been associated or integrated with other analytical methodologies. The information gained from various techniques can depict the different and complex elements that compose such interactions. This chapter will summarize some recent examples of successfully combining DSC with other physico-chemical methods, such as spectroscopy, chromatography, calorimetry, the Langmuir–Blodgett film technique and microscopy.
Author : Lorena Alvarez
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (14 download)
Download or read book Probing Lipid Membrane Interactions with Drug Molecules and Cationic Proteins Using Combined Experimental and Computational Analysis written by Lorena Alvarez and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lipid bilayer's integrity is essential for cell function as it acts as the primary barrier against external molecules like drugs and peptides, which can alter the bilayer's physical properties. This dissertation investigates how amphetamine (AMPH) and methamphetamine (METH), and the charged HIV1-TAT peptide impact the stability of lipid bilayers, using a home-built lipid bilayer apparatus that enables real-time monitoring through electrical and fluorescence measurements. Our findings indicate that AMPH and METH increase the lipid bilayer's ion permeability, with METH having a greater destabilizing effect. High concentrations of these stimulants, akin to levels in blood plasma of individuals with stimulant-related brain injuries, lead to pore formation in the bilayer. The extent of destabilization correlated with the drug concentration. We also studied the translocation dynamics of the charged HIV1-TAT peptide across the lipid bilayer. The analysis of current fluctuations showed that successful translocation of the TAT peptide is concentration-dependent, highlighting the significance of charge in inducing membrane deformation or pore formation. Additionally, molecular dynamic simulations were used to explore AMPH interactions with the lipid bilayer in greater detail. The results revealed AMPH's preferred orientation during interaction and its hydrophobic nature, as evidenced by the larger energy barrier encountered in the hydrophilic head group regions of the lipid bilayer. To complement these findings, we utilized surface-enhanced Raman spectroscopy (SERS) to estimate the concentrations of AMPH within lipid bilayers. The data showed a positive correlation between characteristic peak heights and AMPH concentrations. Moreover, whole-cell patch clamp measurements on neuronal cells were employed to examine AMPH's effects in a more intricate lipid environment. This research contributes to the understanding of how stimulants and charged peptides interact with lipid bilayers, which is vital for insights into their biological impacts and in developing therapeutic interventions.
Author : Julius Leo Zieleniecki
Publisher :
ISBN 13 :
Total Pages : 84 pages
Book Rating : 4.:/5 (851 download)
Download or read book In Vitro Drug-membrane Interactions Studied by Surface Analytic Methods written by Julius Leo Zieleniecki and published by . This book was released on 19?? with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. Wiśniewska-Becker
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128091770
Total Pages : 40 pages
Book Rating : 4.1/5 (28 download)
Download or read book Drug–biomembrane interaction studies written by A. Wiśniewska-Becker and published by Elsevier Inc. Chapters. This book was released on 2013-10-31 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological membranes consisting of two main components, lipids and proteins, have many important functions in cells. Membrane structure, physical and chemical properties of lipids and proteins, and interactions between them determine membrane functions such as the barrier separating a cell from its environment, selective transport, cell recognition, signalling and compartmentalization of cellular processes. To investigate membrane structure and dynamics, and the interactions between membrane components on a molecular level, simplified artificial models of biological membranes have been developed. Various biophysical techniques are used with these models to study membrane properties and their changes under different environmental factors. This chapter describes common membrane models and some of their applications. There are two groups of models: vesicular models (micelles, bicelles and liposomes) and planar ones (lipid monolayers, supported lipid bilayers, black lipid membranes). The advantages and disadvantages of both types are discussed as well as their usefulness for particular biophysical techniques.
Author : E. K. Rooney
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (597 download)
Download or read book Drug-membrane Interactions written by E. K. Rooney and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert B. Campbell
Publisher :
ISBN 13 :
Total Pages : 386 pages
Book Rating : 4.:/5 (433 download)
Download or read book Biophysical Properties of Catonic-phospholipid and Drug-membrane Interactions: Implications for Targeted Drug Delivery written by Robert B. Campbell and published by . This book was released on 1999 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Subramaniam Rameshkumar
Publisher :
ISBN 13 : 9783659977725
Total Pages : 224 pages
Book Rating : 4.9/5 (777 download)
Download or read book Electrochemical Studies on Drug-Membrane Interaction written by Subramaniam Rameshkumar and published by . This book was released on 2018-04-17 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Armelle Varnier Agasøster
Publisher :
ISBN 13 : 9788275580236
Total Pages : pages
Book Rating : 4.5/5 (82 download)
Download or read book Role of the phospholipid composition for the drug-membrane and protein-membrane interactions written by Armelle Varnier Agasøster and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christophe Chipot
Publisher : Springer Science & Business Media
ISBN 13 : 3540384472
Total Pages : 528 pages
Book Rating : 4.5/5 (43 download)
Download or read book Free Energy Calculations written by Christophe Chipot and published by Springer Science & Business Media. This book was released on 2007-01-08 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.
Author : Tom E. Peck
Publisher : Cambridge University Press
ISBN 13 : 0521704634
Total Pages : 360 pages
Book Rating : 4.5/5 (217 download)
Download or read book Pharmacology for Anaesthesia and Intensive Care written by Tom E. Peck and published by Cambridge University Press. This book was released on 2008-01-31 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has been thoroughly updated and expanded, with additional contributions from experts in the field, to include all new drugs available to the anaesthetist and intensive care specialist. Basic pharmacological principles are dealt with methodically and with many highly annotated diagrams and tables.
