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Author : Rudi Edward DeKoker
Publisher :
ISBN 13 :
Total Pages : 496 pages
Book Rating : 4.F/5 ( download)
Download or read book Domain Structures and Hydrodynamics in Lipid Monolayers written by Rudi Edward DeKoker and published by . This book was released on 1996 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : K.S. Birdi
Publisher : Springer Science & Business Media
ISBN 13 : 0306468131
Total Pages : 391 pages
Book Rating : 4.3/5 (64 download)
Download or read book Self-Assembly Monolayer Structures of Lipids and Macromolecules at Interfaces written by K.S. Birdi and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-assembly monolayer (SAM) structures of lipids and macromolecules have been found to play an important role in many industrial and biological phenomena. This book describes two procedures, namely the STM and AFM, that are used to study SAMs at solid surfaces. K.S. Birdi examines the SAMs at both liquid and solid surfaces by using the Langmuir monolayer method. This book is intended for researchers, academics and professionals.
Author : T. Gutberlet
Publisher : Springer Science & Business Media
ISBN 13 : 3540675558
Total Pages : 320 pages
Book Rating : 4.5/5 (46 download)
Download or read book Lipid Bilayers written by T. Gutberlet and published by Springer Science & Business Media. This book was released on 2001 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: A general review of lipid bilayer structure and dynamics is given, including such current topics as the hydration of lipid bilayers, the superstructural behaviour of bilayers at different states of hydration and external conditions, the role and behaviour of lipid bilayers on fusion and rupture and the interaction of lipid bilayers with small organic molecules and additives and of protein lipid bilayer interactions. In addition, recent research on lipid interaction with proteins and other molecules in monolayers is reviewed, and the use of highly aligned samples under biologically relevant conditions and the benefits derived from such preparations are addressed. Finally, the latest approach in simulation of impurities within a lipid bilayer is introduced. This book will be a comprehensive review of the current state of biologically relevant model membrane systems which will become an indispensible reference for the "working biophysicist".
Author : Ole G. Mouritsen
Publisher : Springer Science & Business Media
ISBN 13 : 9783540232483
Total Pages : 296 pages
Book Rating : 4.2/5 (324 download)
Download or read book Life - As a Matter of Fat written by Ole G. Mouritsen and published by Springer Science & Business Media. This book was released on 2004-11-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a multi-disciplinary perspective on the physics of life and the particular role played by lipids and the lipid-bilayer component of cell membranes. Emphasizes the physical properties of lipid membranes seen as soft and molecularly structured interfaces. By combining and synthesizing insights obtained from a variety of recent studies, an attempt is made to clarify what membrane structure is and how it can be quantitatively described. Shows how biological function mediated by membranes is controlled by lipid membrane structure and organization on length scales ranging from the size of the individual molecule, across molecular assemblies of proteins and lipid domains in the range of nanometers, to the size of whole cells. Applications of lipids in nano-technology and biomedicine are also described.
Author :
Publisher : Academic Press
ISBN 13 : 0128033274
Total Pages : 393 pages
Book Rating : 4.1/5 (28 download)
Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information
Author :
Publisher : Elsevier
ISBN 13 : 0124199593
Total Pages : 238 pages
Book Rating : 4.1/5 (241 download)
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by and published by Elsevier. This book was released on 2014-07-18 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers. Gives a survey on recent theoretical as well as experimental results on lipid micro and nanonanostructures In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented
Author : Stanford University
Publisher :
ISBN 13 :
Total Pages : 506 pages
Book Rating : 4.F/5 ( download)
Download or read book Annual Commencement written by Stanford University and published by . This book was released on 1996 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ioannis Athanasopoulos
Publisher : Routledge
ISBN 13 : 1351447149
Total Pages : 366 pages
Book Rating : 4.3/5 (514 download)
Download or read book Free Boundary Problems written by Ioannis Athanasopoulos and published by Routledge. This book was released on 2019-11-11 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Free boundary problems arise in an enormous number of situations in nature and technology. They hold a strategic position in pure and applied sciences and thus have been the focus of considerable research over the last three decades. Free Boundary Problems: Theory and Applications presents the work and results of experts at the forefront of current research in mathematics, material sciences, chemical engineering, biology, and physics. It contains the plenary lectures and contributed papers of the 1997 International Interdisciplinary Congress proceedings held in Crete. The main topics addressed include free boundary problems in fluid and solid mechanics, combustion, the theory of filtration, and glaciology. Contributors also discuss material science modeling, recent mathematical developments, and numerical analysis advances within their presentations of more specific topics, such as singularities of interfaces, cusp cavitation and fracture, capillary fluid dynamics of film coating, dynamics of surface growth, phase transition kinetics, and phase field models. With the implications of free boundary problems so far reaching, it becomes important for researchers from all of these fields to stay abreast of new developments. Free Boundary Problems: Theory and Applications provides the opportunity to do just that, presenting recent advances from more than 50 researchers at the frontiers of science, mathematics, and technology.
Author : Sewwandi S. Rathnayake
Publisher :
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (984 download)
Download or read book A Biophysical Characterization of Protein-lipid Interactions of the Lipid Droplet Binding Protein, Perlipin 3 written by Sewwandi S. Rathnayake and published by . This book was released on 2016 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past, lipid droplets were considered as inert cell organelles that store cellular energy in the form of neutral lipids. But today, they are known as cell organelles carrying out a myriad of functions required for the sustenance of life. The structure of intracellular lipid droplets closely resembles that of extracellular particles called lipoproteins. Both structures contain a core of neutral lipids surrounded by a monolayer of phospholipids and proteins. However, their functional roles within living organisms are different, ie, lipoprotein particles transport neutral lipids extracellularly in an organism's circulatory system, whereas lipid droplets store neutral lipids intracellularly. These two structures differ in composition as well. However, literature shows that proteins found on the surface of lipoproteins and lipid droplets share a high degree of sequence and structural similarity. Although structural and functional details of lipoproteins and their components have been widely studied in the past, many structural and functional aspects of lipid droplets and their protein components are still unclear. This work describes the lipid binding properties of two structurally homologous proteins carrying amphipathic alpha helix bundles, apoLp-III and perilipin 3 which are found across two different biological systems, namely, lipoproteins in insects and lipid droplets in humans. Both these proteins are exchangeable in their lipid binding behavior. Studying the lipid interactions of the above proteins is of key importance to understand the basics of neutral lipid metabolism and lipid transport of multicellular organisms. Large quantities of recombinant proteins required for our biophysical characterization studies were expressed in E. coli cells and purified using a combination of chromatography techniques. In order to study the lipid interactions of apoLp-III and perilipin 3, we used Langmuir monolayers composed of various types of phospholipids. Our monolayer work revealed that apoLp-III by itself is a surface active protein and it appears to show a preference for saturated and highly ordered lipids. Consistent with earlier work we find that insertion of apoLp-III into fluid lipid monolayers is highest for diacylglycerol. The effective molecular shape of lipid molecules and the head group charge were also identified as important parameters that affect the lipid binding of ApoLp-III. We also investigated the interaction of full length perilipin 3 and three of its N-terminal truncation mutants with lipid monolayers. We observed that similar to apoLp-III, perilipin 3 is a surface active protein. The C-terminus of perilipin 3 shows strong preference for insertion into saturated, hence more-ordered lipid environments, similar to our previous data on apoLp-III. The C-terminal alpha helix bundle domain of perilipin 3 showed significantly different insertion properties compared to that of the full length protein and the other successively longer N-terminal truncation mutants. Addition of N-terminal sequences to the C-terminal alpha helix bundle domain reduced the lipid insertion ability of perilipin 3. Anionic lipids with negative spontaneous curvature facilitate lipid interaction and insertion of perilipin 3. Lipid monolayers created on the surface of hydrophobic planer chips (HPA) were used to study the kinetics of lipid binding interactions of apoLp-III and perilipin 3 through surface plasmon resonance. Our data show that for both apoLp-III and perilipin 3, lipid association and dissociation occur in a two --step process, suggesting conformational changes of the amphipathic alpha helices upon lipid interaction. These results thus shed important new insight into the protein--lipid interactions of a model exchangeable apolipoprotein with significant implications for its mammalian counterparts.
Author :
Publisher :
ISBN 13 :
Total Pages : 29 pages
Book Rating : 4.:/5 (727 download)
Download or read book Structure and Shear Response of Lipid Monolayers written by and published by . This book was released on 1990 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic monolayers and multilayers are both scientifically fascinating and technologically promising; they are, however, both complex systems and relatively inaccessible to experimental probes. In this Progress Report, we describe our X-ray diffraction studies, which have given us substantial new information about the structures and phase transitions in monolayers on the surface of water; our use of these monolayers as a unique probe of the dynamics of wetting and spreading; and our studies of monolayer mechanical properties using a simple but effective technique available to anyone using the Wilhelmy method to measure surface tension.
Author :
Publisher :
ISBN 13 :
Total Pages : 834 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2001 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Brasseur
Publisher : CRC Press
ISBN 13 : 1000694585
Total Pages : 349 pages
Book Rating : 4.0/5 (6 download)
Download or read book AMolecular Description of Biological Membrane Components by Computer Aided Conformational Analysis written by Robert Brasseur and published by CRC Press. This book was released on 2019-07-18 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990, the goal of these two volumes is to help fill the gap between theory and experiment in membrane science. Those involved with biochemistry, biophysics, pharmacology, and biology will find these volumes interesting and informative.
Author : Bin Liu
Publisher :
ISBN 13 :
Total Pages : 154 pages
Book Rating : 4.:/5 (973 download)
Download or read book Molecular Dynamics Studies of Lipid Monolayer and Bilayer Systems written by Bin Liu and published by . This book was released on 2016 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are a crucial ingredient of biomembranes in cells, and they play a pivotal role in many chemical and biological processes. Lipid based structures, such as lipid monolayers and lipid bilayers, both natural and artificial, are gaining their importance and popularity in drug delivery. In this thesis, our main interest is on using molecular modeling and atomistic molecular dynamics simulations to study lipid monolayers and bilayers, and their physical properties and interactions with an antibiotic molecule called daptomycin. This thesis is composed of the research results from two projects. The first project focuses on an atomistic molecular dynamcis study of lipid Langmuir monolayers composed of both pure zwitterionic dipalmitoylphosphatidylcholine (DPPC) and a mixture of DPPC and cationic cetyltrimethylammonium bromide (CTAB). The cationic CTAB lipids have been found to have significant condensing effect on the DPPC / CTAB monolayers, i.e., at the same surface tension or surface pressure, monolayers with higher CTAB molar fraction have smaller area per lipid. With this condensing effect, the DPPC / CTAB monolayers are also able to achieve negative surface tension without introducing buckling into the monolayer structure. The condensing effect is caused by the interplay between the cationic CTAB headgroups and the zwitterionic phosphatidylcholine (PC) headgroups which has electrostatic origin. Moreover, detailed analysis of the structural properties of the monolayers, such as the density profile analysis, hydrogen bonding analysis, chain order parameter calculations and radial distribution function calculations were also performed for better understanding of cationic DPPC/CTAB monolayers. A chapter is dedicated to the discussion of the mean and Gaussian curvatures of the pure DPPC and DPPC/CTAB mixture monolayers. In the second project, MD simulations were employed to study the atomistic details of the antimicrobial activities of daptomycin, a cyclic anionic lipopeptide which treats infections caused by Gram-positive bacteria, with emphasis on its interactions with a model bacteria membrane. Despite having itself a net negative charge, it is selective against negatively charged bacterial membranes. It has been established that daptomycin's antibiotic activity is based on targeting the bacterial membranes and that this antibacterial activity depends on calcium ions. Importantly, however, both the precise role of ions and the physical mechanisms responsible for daptomy-cin's action remain poorly understood. We investigate these issues using three types of molecular dynamics simulations: free energy calculations for a single daptomycin, unbiased simulations for daptomycin tetramers and micellation of daptomycin both in the absence and presence of calcium ions.
Author : Manual G. Verlarde
Publisher : Springer Science & Business Media
ISBN 13 : 1461307074
Total Pages : 1093 pages
Book Rating : 4.4/5 (613 download)
Download or read book Physicochemical Hydrodynamics written by Manual G. Verlarde and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1093 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains lecture notes and invited contributions presented at the NATO Advanced Study Institute and EPS Liquid State Conference on PHYSICOCHEMICAL HYDRODYNAMICS-PCH: INTERFACIAL PHENOMENA that were held July 1-15, 1986, in LA RABIDA (Huelva) SPAIN. Although we are aware of the difficulty in organizing the contents due to the broad and multidisciplinary aspects of PCH-Interfacial Phenomena, we have tried to accomodate papers by topics and have not followed the order in the presentation at the meetings. There is also no distinction between the ASI notes and Conference papers. We have done our best to offer a coverage as complete as possible of the field. However, we had difficulties coming from the fact that some authors were so busy that either did not find time to submit their contribution or did not have time to write a comprehensive paper. We also had to cope with very late arrivals, postdeadline valuable contributions that we felt had to be included here. Our gratitude goes to the NATO Scientific Affairs Division for its economic support and to the EPS Liquid State Committee for its sponsorship. Financial support also came from Asociacion Industrias Quimicas-Huelva (Spain), Caycit-Ministerio De Educacion Y Ciencia (Spain), Canon-Espana (Spain), Citibank-Espana (Spain), CNLS-Los Alamos Nat. Lab. (U. S. A. ), CSIC (Spain), EPS, ERT (Spain), ESA, Fotonica (Spain), IBM-Espana (Spain), Junta De Andalucia (Spain), NATO, NSF (U. S. A. ), ONR-London (U. S. A.
Author :
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)
Download or read book Proceedings written by and published by . This book was released on 1995 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Timothy Vernon Ratto
Publisher :
ISBN 13 :
Total Pages : 336 pages
Book Rating : 4.:/5 (65 download)
Download or read book Heterogeneities in Lipid Bilayers, Regulation, Structure, and Function written by Timothy Vernon Ratto and published by . This book was released on 2002 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 896 pages
Book Rating : 4.3/5 (91 download)
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1995 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt:
