Dissecting Multiple Sequence Alignment Methods

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Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants

Author : Yuan-Ming Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832543693
Total Pages : 278 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants by : Yuan-Ming Zhang

Download or read book Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants written by Yuan-Ming Zhang and published by Frontiers Media SA. This book was released on 2024-01-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.

The Development and Application of Multi-Omics Integration Approaches to Dissecting Complex Traits in Plants

Author : Shang-Qian Xie
Publisher : Frontiers Media SA
ISBN 13 : 2889761355
Total Pages : 342 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis The Development and Application of Multi-Omics Integration Approaches to Dissecting Complex Traits in Plants by : Shang-Qian Xie

Download or read book The Development and Application of Multi-Omics Integration Approaches to Dissecting Complex Traits in Plants written by Shang-Qian Xie and published by Frontiers Media SA. This book was released on 2022-05-06 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Dissection of Complex Traits

Author : D.C. Rao
Publisher : Academic Press
ISBN 13 : 0080569110
Total Pages : 788 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Genetic Dissection of Complex Traits by : D.C. Rao

Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more

Genetic and Genomic Approaches to Dissect Nodulation in the Model Legume Medicago Truncatula

Author : Kavitha Tharmia Kuppusamy
Publisher :
ISBN 13 :
Total Pages : 278 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Genetic and Genomic Approaches to Dissect Nodulation in the Model Legume Medicago Truncatula by : Kavitha Tharmia Kuppusamy

Download or read book Genetic and Genomic Approaches to Dissect Nodulation in the Model Legume Medicago Truncatula written by Kavitha Tharmia Kuppusamy and published by . This book was released on 2005 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits

Author : Yuan-Ming Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889458342
Total Pages : 236 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits by : Yuan-Ming Zhang

Download or read book The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits written by Yuan-Ming Zhang and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.

Dissecting Complex Gene Families to Understand Their Roles in Climate-Resilience

Author : Mehanathan Muthamilarasan
Publisher : Frontiers Media SA
ISBN 13 : 2832535704
Total Pages : 181 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Dissecting Complex Gene Families to Understand Their Roles in Climate-Resilience by : Mehanathan Muthamilarasan

Download or read book Dissecting Complex Gene Families to Understand Their Roles in Climate-Resilience written by Mehanathan Muthamilarasan and published by Frontiers Media SA. This book was released on 2023-10-11 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Identification and Functional Dissection of Stress-responsive Genes in Cotton

Author : Jia-He Wu
Publisher : Frontiers Media SA
ISBN 13 : 2832506593
Total Pages : 415 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Identification and Functional Dissection of Stress-responsive Genes in Cotton by : Jia-He Wu

Download or read book Identification and Functional Dissection of Stress-responsive Genes in Cotton written by Jia-He Wu and published by Frontiers Media SA. This book was released on 2022-11-22 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Dissection of Complex Traits

Author : Andrew H. Paterson
Publisher : CRC Press
ISBN 13 : 0429525419
Total Pages : 384 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Molecular Dissection of Complex Traits by : Andrew H. Paterson

Download or read book Molecular Dissection of Complex Traits written by Andrew H. Paterson and published by CRC Press. This book was released on 2019-09-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi

Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment

Download Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment PDF Online Free

Author : Fabrizio Mattei
Publisher : Frontiers Media SA
ISBN 13 : 2832531377
Total Pages : 195 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment by : Fabrizio Mattei

Download or read book Organoids, organs-on-chip, nanoparticles and in silico approaches to dissect the tumorimmune dynamics and to unveil the drug resistance mechanisms to therapy in the tumor microenvironment written by Fabrizio Mattei and published by Frontiers Media SA. This book was released on 2023-08-03 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia

Author : Alfredo Iacoangeli
Publisher : Frontiers Media SA
ISBN 13 : 2889747050
Total Pages : 131 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia by : Alfredo Iacoangeli

Download or read book A Journey Through 50 Years of Structural Bioinformatics in Memoriam of Cyrus Chothia written by Alfredo Iacoangeli and published by Frontiers Media SA. This book was released on 2022-08-16 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cover image for this Research Topic was designed by Claire Marks.

Frontiers in Drug Design and Discovery: Volume 12

Author : M. Iqbal Choudhary
Publisher : Bentham Science Publishers
ISBN 13 : 9815165267
Total Pages : 242 pages
Book Rating : 4.8/5 (151 download)

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Book Synopsis Frontiers in Drug Design and Discovery: Volume 12 by : M. Iqbal Choudhary

Download or read book Frontiers in Drug Design and Discovery: Volume 12 written by M. Iqbal Choudhary and published by Bentham Science Publishers. This book was released on 2024-10-07 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This book series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. Volume 12 of this series brings together reviews covering homology modeling and anti-infective drug discovery. Topics included in this volume are: - Homology Modelling: A Computational Tool in Drug Design and Discovery - Anti-trypanosomatid Drugs/Candidates in Clinical Trials: What's New and What's Missing? - Nitroheterocyclics As Anti-Tuberculosis Agents: An Overview - SARS-CoV-2 Protease Inhibitors of Natural Origin: Current Scenario and Future Prospects as Anti-COVID-19 Agents.

Genetic Dissection of Important Traits in Aquaculture: Genome-scale Tools Development, Trait Localization and Regulatory Mechanism Exploration

Download Genetic Dissection of Important Traits in Aquaculture: Genome-scale Tools Development, Trait Localization and Regulatory Mechanism Exploration PDF Online Free

Author : Peng Xu
Publisher : Frontiers Media SA
ISBN 13 : 2889639142
Total Pages : 466 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Genetic Dissection of Important Traits in Aquaculture: Genome-scale Tools Development, Trait Localization and Regulatory Mechanism Exploration by : Peng Xu

Download or read book Genetic Dissection of Important Traits in Aquaculture: Genome-scale Tools Development, Trait Localization and Regulatory Mechanism Exploration written by Peng Xu and published by Frontiers Media SA. This book was released on 2020-07-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson's Disease

Author : Soraya Bardien
Publisher : Frontiers Media SA
ISBN 13 : 2889667456
Total Pages : 227 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson's Disease by : Soraya Bardien

Download or read book Celebrating the Diversity of Genetic Research to Dissect the Pathogenesis of Parkinson's Disease written by Soraya Bardien and published by Frontiers Media SA. This book was released on 2021-05-05 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: We would like to acknowledge Prof Rejko Krueger, from University of Luxembourg, who acted as a coordinator contributing to the preparation of the proposal for this Research Topic as part of the GEoPD.

Dissection of the Molecular Basis of Fatty Acid Composition in Oil Crops and Molecular Breeding of Oil Crops With Improved Fatty Acid Composition

Download Dissection of the Molecular Basis of Fatty Acid Composition in Oil Crops and Molecular Breeding of Oil Crops With Improved Fatty Acid Composition PDF Online Free

Author : Yong Xiao
Publisher : Frontiers Media SA
ISBN 13 : 2832506941
Total Pages : 175 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Dissection of the Molecular Basis of Fatty Acid Composition in Oil Crops and Molecular Breeding of Oil Crops With Improved Fatty Acid Composition by : Yong Xiao

Download or read book Dissection of the Molecular Basis of Fatty Acid Composition in Oil Crops and Molecular Breeding of Oil Crops With Improved Fatty Acid Composition written by Yong Xiao and published by Frontiers Media SA. This book was released on 2022-11-23 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Bioinformatics and Computational Biology

Author : Joao Carlos Setubal
Publisher : Springer Science & Business Media
ISBN 13 : 3540280081
Total Pages : 270 pages
Book Rating : 4.5/5 (42 download)

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Book Synopsis Advances in Bioinformatics and Computational Biology by : Joao Carlos Setubal

Download or read book Advances in Bioinformatics and Computational Biology written by Joao Carlos Setubal and published by Springer Science & Business Media. This book was released on 2005-07-14 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005. The 15 revised full papers and 10 revised extended abstracts presented together with 3 invited papers were carefully reviewed and selected from 55 submissions. The papers address a broad range of current topics in computational biology and bioinformatics.

Archaeology and Bioarchaeology of Anatomical Dissection at a Nineteenth-Century Army Hospital in San Francisco

Author : P. Willey
Publisher : University Press of Florida
ISBN 13 : 1683403487
Total Pages : 319 pages
Book Rating : 4.6/5 (834 download)

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Book Synopsis Archaeology and Bioarchaeology of Anatomical Dissection at a Nineteenth-Century Army Hospital in San Francisco by : P. Willey

Download or read book Archaeology and Bioarchaeology of Anatomical Dissection at a Nineteenth-Century Army Hospital in San Francisco written by P. Willey and published by University Press of Florida. This book was released on 2023-12-13 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: An archaeological site that tells a story of structural violence in medical research In 2010, a pit containing over 4,000 human skeletal elements was discovered at the site of the former Army hospital at Point San Jose in San Francisco. Local archaeologists determined that the bones, which were found alongside medical waste artifacts from the hospital, were remains from anatomical dissections conducted in the 1870s. As no records of these dissections exist, this volume turns to historical, archaeological, and bioarchaeological analysis to understand the function of the pit and the identities of the people represented in it. In these essays, contributors show how the remains discovered are postmortem manifestations of social inequality, evidence that nineteenth-century surgical and anatomical research benefited from and perpetuated structural violence against marginalized individuals. A volume in the series Bioarchaeological Interpretations of the Human Past: Local, Regional, and Global Perspectives, edited by Clark Spencer Larsen

Essentials of Bioinformatics, Volume II

Author : Noor Ahmad Shaik
Publisher : Springer Nature
ISBN 13 : 3030183750
Total Pages : 316 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Essentials of Bioinformatics, Volume II by : Noor Ahmad Shaik

Download or read book Essentials of Bioinformatics, Volume II written by Noor Ahmad Shaik and published by Springer Nature. This book was released on 2019-10-18 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.