Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Disorazole C1 And New Analogs full books in PDF, epub, and Kindle. Read online Disorazole C1 And New Analogs ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Luca Lizzadro
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)
Download or read book (-)-disorazole C1 and New Analogs written by Luca Lizzadro and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kevin John Ralston
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Studies Towards the Total Synthesis of Disorazole C1 and Its Analogues written by Kevin John Ralston and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Helen Sarah Niblock
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (827 download)
Download or read book Synthesis of the C(1)-C(9) Fragment of Disorazole C1 and Novel Heterocyclic Analogues written by Helen Sarah Niblock and published by . This book was released on 2012 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: A highly convergent strategy for the synthesis of the antitubulin polyketide disorazole C1 is proposed based around the alkyne precursor I, featuring a novel Evans-Tishchenko/ring closing alkyne metathesis approach. Due to the inherent symmetry of the molecule this retrosynthesis leads to two fragments: a [beta]- hydroxyketone II and the oxazole C(1)-(9) fragment III. A review of previous syntheses of disorazole C1 and established structure activity relationships (SARs) highlights a gap in current knowledge relating to the role of the oxazole in tubulin binding. Therefore, the focus of this research has been towards developing new routes for the synthesis of the C(1)-C(9) fragment that can be adapted to the synthesis of heterocyclic analogues to further establish the SAR of disorazole C1. Chapter 2 focuses on a disconnection at the C(5)-C(6) bond and a novel synthesis of the racemic C(1)-C(9) fragment has been achieved via a lithiation of methyl 2- methyl-1,3-oxazole-4-carboxylate and coupling to aldehyde V. First generation asymmetric routes to the C(1)-C(9) fragment centred on i. a biomimetic amino acid condensation route via an oxazoline intermediate based on the precedent of Meyers et al. and ii. a C(4)-C(5) disconnection approach based around the epoxide VII; are discussed in chapter 3. A second generation C(4)-C(5) disconnection centred on the novel tosylate VIII is discussed in chapter 4. Attempts to synthesise the parent C(1)- C(9) oxazole fragment using the tosylate VIII via i. a palladium catalysed C-H activation of ethyl 4-oxazole carboxylate and ii. lithiation of oxazole are reported. Coupling of fragment VIII (X = OTs) with ethyl 1H-pyrazole-4-carboxylate and a CuAAC coupling of the azide derived from tosylate VIII with methyl propiolate has allowed the successful completion of the synthesis of pyrazole and triazole analogues of this fragment.
Author : Erum Akbar Hussain
Publisher : Elsevier
ISBN 13 : 0323915698
Total Pages : 304 pages
Book Rating : 4.3/5 (239 download)
Download or read book Oxazole, Isoxazole, Benzoxazole-Based Drug Discovery written by Erum Akbar Hussain and published by Elsevier. This book was released on 2024-09-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxazole, Isoxazole, Benzoxazole Based Drug Discovery offers complete coverage of oxazole and related molecules, both from natural and synthetic origin, with a focus on the reaction mechanisms, and medicinal, pharmacokinetic and computational aspects. New and contemporary methods of synthesis are discussed, with a special focus on green, environment-friendly procedures. Discussion of stereochemical studies, particularly on natural molecules, are included. Computational chemistry has emerged as an integral tool for drug discovery, hence this book explains how the drug candidate is established as suitable for clinical trials with the help of molecular docking and virtual screening modeling. This book offers a broad range of recent developments and detailed coverage of synthesis and biological activities of the drugs, and is an ideal reference guide to researchers working in organic and medicinal chemistry. - Presents detailed coverage of chemical structures and practical synthetic methods of oxazoles, isoxazoles and benzoxazoles in drug discovery - Includes green, environmentally-friendly novel synthetic methods and mechanistic insights - Features biological and computational aspects of the oxazoles family of drugs, including virtual screening and molecular docking
Author : David R. Klein
Publisher : John Wiley & Sons
ISBN 13 : 1119820839
Total Pages : 1395 pages
Book Rating : 4.1/5 (198 download)
Download or read book Organic Chemistry written by David R. Klein and published by John Wiley & Sons. This book was released on 2022 with total page 1395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry, 4th Edition provides a comprehensive, yet accessible treatment of all the essential organic chemistry concepts covered in a two-semester course. Presented with a skills-based approach that bridges the gap between organic chemistry theory and real-world practice, the book places special emphasis on developing their problem-solving skills through applied exercises and activities. It incorporates Klein's acclaimed SkillBuilder program which contains a solved problem that demonstrates a skill and several practice problems of varying difficulty levels�including conceptual and cumulative problems that challenge students to apply the skill in a slightly different environment. An up-to-date collection of literature-based problems exposes students to the dynamic and evolving nature of organic chemistry and its active role in addressing global challenges. The text is also enriched with numerous hands-on activities and real-world examples that help students understand both the "why" and the "how" behind organic chemistry.
Author : Mihnea-Alexandru Găman
Publisher : Elsevier
ISBN 13 : 0323859968
Total Pages : 487 pages
Book Rating : 4.3/5 (238 download)
Download or read book Antidotes to Toxins and Drugs written by Mihnea-Alexandru Găman and published by Elsevier. This book was released on 2023-11-25 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antidotes to Toxins and Drugs: From Natural Sources to Drug Discovery in Toxicology presents recent advances in the discovery of natural antidotes to toxins, drug intoxications and overdoses in pharmacology, drug discovery and toxicology. The text provides detailed information about toxins and their natural antidotes, along with the identification and screening of antidotes for drug intoxications and overdoses. Written by a global team of experts, it describes the potential uses of natural products in toxicology and their applications in medicine and in the pharmaceutical sciences. This book will be a key resource for drug developers, medicinal chemists and toxicologists, among others.Sections shine a particular focus on mechanisms of action, various principles in pharmacokinetics and pharmacodynamics terms, and possible sources and synthesis techniques for these phytochemicals. - Details recent advances in the discovery of natural antidotes from medicinal plants and phytochemicals - Includes advances in the discovery of antidotes to drug intoxications and overdoses - Describes modern screening assays for toxins and drug intoxications - Features information on recent advances in toxicology
Author :
Publisher :
ISBN 13 :
Total Pages : 886 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 886 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gordon Gribble
Publisher : Elsevier
ISBN 13 : 0443189404
Total Pages : 654 pages
Book Rating : 4.4/5 (431 download)
Download or read book Progress in Heterocyclic Chemistry written by Gordon Gribble and published by Elsevier. This book was released on 2023-01-10 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Heterocyclic Chemistry: Volume 34, the latest in this annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC), contains both highlights of the previous year's literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. Highlight chapters in Volume 34 are all written by leading researchers in their field, thus constituting a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2021. As with previous volumes in the series, Volume 34 will enable academic and industrial chemists and advanced students to keep abreast of developments in heterocyclic chemistry in a convenient way. - Recognized as the premiere review of heterocyclic chemistry - Includes contributions from leading researchers in the field - Provides a systematic survey of the important 2021 heterocyclic chemistry literature - Presents articles on new and developing topics of interest to heterocyclic chemist
Author : David J. Newman
Publisher : CRC Press
ISBN 13 : 1351643282
Total Pages : 650 pages
Book Rating : 4.3/5 (516 download)
Download or read book Chemical Biology of Natural Products written by David J. Newman and published by CRC Press. This book was released on 2017-09-22 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.
Author : Peter G. M. Wuts
Publisher : John Wiley & Sons
ISBN 13 : 1118589327
Total Pages : 1108 pages
Book Rating : 4.1/5 (185 download)
Download or read book Greene's Protective Groups in Organic Synthesis written by Peter G. M. Wuts and published by John Wiley & Sons. This book was released on 2012-12-20 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth Edition of Greene's Protective Groups in Organic Synthesis continues to be an indispensable reference for controlling the reactivity of the most common functional groups during a synthetic sequence. This new edition incorporates the significant developments in the field since publication of the third edition in 1998, including... New protective groups such as the fluorous family and the uniquely removable 2-methoxybenzenesulfonyl group for the protection of amines New techniques for the formation and cleavage of existing protective groups, with examples to illustrate each new technique Expanded coverage of the unexpected side reactions that occur with protective groups New chart covering the selective deprotection of silyl ethers 3,100 new references from the professional literature The content is organized around the functional group to be protected, and ranges from the simplest to the most complex and highly specialized protective groups.
Author : Yasushi Nishihara
Publisher : Springer Science & Business Media
ISBN 13 : 3642323685
Total Pages : 247 pages
Book Rating : 4.6/5 (423 download)
Download or read book Applied Cross-Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Author : David W Allen
Publisher : Royal Society of Chemistry
ISBN 13 : 1788018648
Total Pages : 410 pages
Book Rating : 4.7/5 (88 download)
Download or read book Organophosphorus Chemistry written by David W Allen and published by Royal Society of Chemistry. This book was released on 2020-04-15 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This annual review of the literature presents a comprehensive and critical survey of the vast field of study involving organophosphorus compounds, from phosphines and related P-C bonded compounds to phosphorus acids, phosphine chalcogenides and nucleotides. The Editors have added to the content with a timely chapter on the recent developments in green synthetic approaches in organophosphorus chemistry to reflect current interests in the area. With an emphasis on interdisciplinary content, this book is aimed at the worldwide organic chemistry and engineering research communities.
Author : Krishna C. Majumdar
Publisher : John Wiley & Sons
ISBN 13 : 3527634894
Total Pages : 648 pages
Book Rating : 4.5/5 (276 download)
Download or read book Heterocycles in Natural Product Synthesis written by Krishna C. Majumdar and published by John Wiley & Sons. This book was released on 2011-06-15 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap on the market, this handbook and ready reference is unique in its discussion of the usefulness of various heterocyclic systems in the synthesis of natural products. Clearly structured for easy access to the information, each chapter is devoted to a certain class of heterocycle, providing a tabular presentation of the natural products to be covered containing the particular heterocyclic ring system along with their biological profile, occurrence and most important physical properties, backed by the appropriate references. In addition, the application of the heterocyclic system to the synthesis of natural products ic covered in detail. Of great interest to organic, natural products, medicinal and biochemists, as well as those working in the pharmaceutical and agrochemical industry.
Author : Peter G. M. Wuts
Publisher : John Wiley & Sons
ISBN 13 : 1118905121
Total Pages : 1400 pages
Book Rating : 4.1/5 (189 download)
Download or read book Greene's Protective Groups in Organic Synthesis written by Peter G. M. Wuts and published by John Wiley & Sons. This book was released on 2014-08-08 with total page 1400 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable reference for any practicing synthetic organic ormedicinal chemist, this book continues the tradition ofGreene’s as comprehensive in the overall scope of coverage,providing the most relevant and useful examples to illustrate eachmethodology. • Presents valuable material, on the application ofprotective groups in organic chemistry, that is not easily found bycasual searching • Helps chemists to plan, investigate, and carry outorganic syntheses in an efficient manner • Adds over 2800 new references to update since thepublication of the last edition • Reviews of the prior edition: "An essential bible forthe library or personal bookshelf of chemists performing complexsynthesis." (CHOICE, May 2007) "...the most up-to-date compilationavailable...should be an integral part of all institutionallibraries...it is also highly recommended thatindividuals...maintain their own copy..." (Journal of MedicinalChemistry, March 8, 2007) "...continues to be a comprehensive guideto the techniques for the formation and cleavage of protectivegroups." (Journal of the American Chemical Society, January 31,2007)
Author : Yannick Landais
Publisher : Springer
ISBN 13 : 3319895214
Total Pages : 356 pages
Book Rating : 4.3/5 (198 download)
Download or read book Free-Radical Synthesis and Functionalization of Heterocycles written by Yannick Landais and published by Springer. This book was released on 2018-05-03 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments. The venerable Minisci reaction allows for direct access to functionalized heterocycles. This process has lately seen an interesting renaissance and is discussed in this volume. Addition of heteroatom-centered radicals onto unsaturated systems constitutes another powerful method to construct heterocycles. Examples of such a strategy are proposed along with the formation of various heterocycles relying on homolytic substitution at sulfur, phosphorus and selenium. Additionally free-radical functionalization of reactive functional groups including isonitriles, isothiocyanates and related unsaturated systems which offer a straightforward route towards useful aromatic and non-aromatic heterocycles are discussed. Finally, as metals are able to trigger single electron transfer both in reductive and oxidative modes this provides another possibility for the synthesis of heterocycles. Significant research efforts have focused on the use of samarium, copper and other metals to access a broad variety of heterocycles in a single pot process, starting from readily available raw material. Examples and mechanistic insights are discussed by experts in this area.
Author : Pierre Vogel
Publisher : John Wiley & Sons
ISBN 13 : 3527345329
Total Pages : 1386 pages
Book Rating : 4.5/5 (273 download)
Download or read book Organic Chemistry written by Pierre Vogel and published by John Wiley & Sons. This book was released on 2019-10-07 with total page 1386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the background, tools, and models required to understand organic synthesis and plan chemical reactions more efficiently Knowledge of physical chemistry is essential for achieving successful chemical reactions in organic chemistry. Chemists must be competent in a range of areas to understand organic synthesis. Organic Chemistry provides the methods, models, and tools necessary to fully comprehend organic reactions. Written by two internationally recognized experts in the field, this much-needed textbook fills a gap in current literature on physical organic chemistry. Rigorous yet straightforward chapters first examine chemical equilibria, thermodynamics, reaction rates and mechanisms, and molecular orbital theory, providing readers with a strong foundation in physical organic chemistry. Subsequent chapters demonstrate various reactions involving organic, organometallic, and biochemical reactants and catalysts. Throughout the text, numerous questions and exercises, over 800 in total, help readers strengthen their comprehension of the subject and highlight key points of learning. The companion Organic Chemistry Workbook contains complete references and answers to every question in this text. A much-needed resource for students and working chemists alike, this text: -Presents models that establish if a reaction is possible, estimate how long it will take, and determine its properties -Describes reactions with broad practical value in synthesis and biology, such as C-C-coupling reactions, pericyclic reactions, and catalytic reactions -Enables readers to plan chemical reactions more efficiently -Features clear illustrations, figures, and tables -With a Foreword by Nobel Prize Laureate Robert H. Grubbs Organic Chemistry: Theory, Reactivity, and Mechanisms in Modern Synthesis is an ideal textbook for students and instructors of chemistry, and a valuable work of reference for organic chemists, physical chemists, and chemical engineers.
Author : Gordon W. Gribble
Publisher : Springer
ISBN 13 : 364231791X
Total Pages : 456 pages
Book Rating : 4.6/5 (423 download)
Download or read book Metalation of Azoles and Related Five-Membered Ring Heterocycles written by Gordon W. Gribble and published by Springer. This book was released on 2012-07-09 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: T. L.S. Kishbaugh: Metalation of Pyrrole.- K.-S. Yeung: Furans and Benzofurans.- P. E. Alford: Lithiation-Based and Magnesation-Based Strategies for the Functionalization of Imidazole: 2001–2010.- L. Fu: Metalation of Oxazoles and Benzoxazoles.- S. Roy • S. Roy • G. W. Gribble: Metalation of Pyrazoles and Indazoles.- J. C. Badenock: Metalation Reactions of Isoxazoles and Benzisoxazoles.- Y.-J. Wu: Thiazoles and Benzothiazoles.- C. F. Nutaitis: Isothiazoles and Benzisothiazoles.- E. R. Biehl: Recent Advances in the Synthesis of Thiophenes and Benzothiophenes.- J. M. Lopchuk: Mesoionics.- J. M. Lopchuk: Azoles with 3-4 Heteroatoms.
