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Author : Hung-Chi Cheng
Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.E/5 ( download)
Download or read book Dipeptidyl Peptidase IV (DPP IV) Mediates Lung Metastasis of Rat Breast Cancer Cells written by Hung-Chi Cheng and published by . This book was released on 2000 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book The Role of Dipeptidyl Peptidase IV in Lung Metastasis of Breast Cancer Cells written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our studies focused on (1) cloning and sequencing of wild-type endothelial DPP IV (wtDPP IV) and preparation of truncated DPP IV (tDPP IV); (2) identification of surface-associated fibronectin polymers (polyFN) as DPP IV ligand; (3) use of DPP IV Fischer 344/CRJ rats as protein-knock-outs in metastasis; and (4) identification of the DPP IV/FN binding domains. A lull-length clone of endothelial wtDPP IV was isolated from a rat lung cDNA library that was identical to hepatic DPP IV. Acid extraction of rat lung yielded a tDPP IV, which was an effective inhibitor of breast cancer cell adhesion to wtDPP IV and lung metastasis. The DPP IV ligand, polyFN, provides multiple binding sites for DPP IV, thereby allowing lung vascular arrest of cancer cells under hemodynamic conditions. Fischer 344/CRJ rats are unsuitable as DPP IV protein knock-out model, because lung endothelia leak expression of DPP IV and are able to support breast cancer cell arrest. The DPP IV binding domains of FN was localized to an N- terminal 30-kDa region and FN type III repeats 13 to 14. Three approximately equal size fragments of the extracellular domain of DPP IV were expressed as GST fusion proteins and are currently studied for FN binding.
Author : Ursula Günthert
Publisher : Springer Science & Business Media
ISBN 13 : 3642611079
Total Pages : 302 pages
Book Rating : 4.6/5 (426 download)
Download or read book Attempts to Understand Metastasis Formation I written by Ursula Günthert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas tasis research and to attempt to further understand the biol ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno logy compile the most recent developments on these meta stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.
Author : Robert C. Johnson
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.E/5 ( download)
Download or read book Lung Endothelial Cell Adhesion Molecules which Mediates Organ-specific Vascular Arrest of Lung Metastatic Cells written by Robert C. Johnson and published by . This book was released on 1992 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martin Hildebrandt
Publisher : Springer Science & Business Media
ISBN 13 : 0306479206
Total Pages : 360 pages
Book Rating : 4.3/5 (64 download)
Download or read book Dipeptidyl Aminopeptidases in Health and Disease written by Martin Hildebrandt and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Author : Kwang W. Jeon
Publisher : Elsevier
ISBN 13 : 0080495621
Total Pages : 316 pages
Book Rating : 4.0/5 (84 download)
Download or read book International Review of Cytology written by Kwang W. Jeon and published by Elsevier. This book was released on 2004-08-28 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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Publisher :
ISBN 13 :
Total Pages : 1836 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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ISBN 13 :
Total Pages : 956 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2000 with total page 956 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Norbert Voelkel
Publisher : John Wiley & Sons
ISBN 13 : 9780470747506
Total Pages : 532 pages
Book Rating : 4.7/5 (475 download)
Download or read book The Pulmonary Endothelium written by Norbert Voelkel and published by John Wiley & Sons. This book was released on 2009-08-25 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pulmonary Endothelium is a uniquely comprehensive compendium of our current knowledge of the pulmonary endothelium and is the first book dedicated specifically to the subject, offering insights into current and future approaches to management. The text provides the clinician with the most up-to-date information on one of the core physiological processes in airway disease and is an ideal point of reference for both postgraduates and professionals – specialist physicians in pulmonology and allergy and workers in biomedical and pharmaceutical research.
Author : Heidi Noels
Publisher : Frontiers Media SA
ISBN 13 : 2889198588
Total Pages : 165 pages
Book Rating : 4.8/5 (891 download)
Download or read book The CXCR4 Ligand/Receptor Family and the DPP4 Protease in High-Risk Cardiovascular Patients written by Heidi Noels and published by Frontiers Media SA. This book was released on 2016-06-27 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease (CVD) is the most common cause of morbidity and mortality worldwide, putting a major burden on life quality and social health care systems. Type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) have been identified as important risk factors for CVD, severely increasing the risk on e.g. myocardial infarction, and cardiovascular complications constitute the main cause of death in patients presenting with T2DM, CKD or a combination of both. As these pathologies are expected to rise alarmingly in the next decades, a better understanding of molecular and cellular mechanisms contributing to T2DM, CKD and CVD is required to improve prevention and treatment of these diseases. Furthermore, insight into the interplay between these pathologies and identification of molecular players interconnecting these comorbidities is of tremendous importance for optimal health management in the future. This Research Topic will focus on the chemokine receptor CXCR4 and its ligands CXCL12/SDF-1a and macrophage migration inhibitory factor (MIF) in the context of CVD and its link with T2DM and CKD, as well as address dipeptidyl peptidase-4 (DPP4) as an important protease destabilizing CXCL12. Chemokines and their receptors are important mediators of cell mobilization, recruitment and arrest, and also more broadly induce cell activation by triggering various intracellular signalling tracks. They control homeostatic conditions, but are also critically involved in inflammatory and pathological processes. Genome-wide association studies revealed single nucleotide polymorphisms connecting CXCL12 as well as MIF with CVD, and a role for both chemokines in T2DM and CKD has also been reported. In this review collection, current knowledge on molecular aspects of the CXCR4 ligand/receptor family and associated signalling pathways will be discussed. The physiological roles of CXCR4, CXCL12, MIF and DPP4 will be summarized, and recent findings on their function in pathological conditions of CVD, T2DM and CKD will be highlighted. This is combined with an extensive introduction providing insight into the pathologies of CVD, T2DM and CKD, discussing clinical features and common pathological aspects of these comorbidities on cellular and molecular level. Also, an overview of available animal models to study these diseases will be provided. This way, this Research Topic summarizes latest knowledge on this crucial molecular axis and its relationship with cardiovascular pathologies for both specialists and interested non-specialists and aims to stimulate further initiatives to unravel the mechanistic involvement of the CXCR4 ligand/receptor family in these morbidities, potentially paving the way for new therapeutical initiatives in the future.
Author :
Publisher :
ISBN 13 :
Total Pages : 568 pages
Book Rating : 4.:/5 (321 download)
Download or read book Mini Reviews in Medicinal Chemistry written by and published by . This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt:
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Publisher : Elsevier
ISBN 13 : 0080490883
Total Pages : 475 pages
Book Rating : 4.0/5 (84 download)
Download or read book Cell Surface Proteases written by and published by Elsevier. This book was released on 2003-05-03 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Proteases provides a comprehensive overview of these important enzymes that catalyze the hydrolysis of a protein as it degrades to a simpler substance. In the 1990s, an explosion of new discoveries shed light on the role of cell surface proteases and extended it beyond degradation of extracellular matrix components to include its influence on growth factors, cell signaling, and other cellular events. This volume unites the scientific literature from across disciplines and teases out unified themes of interactions between cell surface proteases and interconnecting cell surface-related systems -- including integrins and other adhesion molecules. Scientists and students involved in developmental biology, cell biology and disease processes will find this an indispensable resource.* Provides an overview of the entire field of cell surface proteases in a single volume* Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * A thematic volume in the longest-running forum for contemporary issues in developmental biology with over 30 years of coverage
Author :
Publisher :
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 1998 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: MBC online publishes papers that describe and interpret results of original research conserning the molecular aspects of cell structure and function.
Author : Pei-Hua Yang
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.3/5 (91 download)
Download or read book Targeting and Selectivity of Anticancer Prodrug written by Pei-Hua Yang and published by . This book was released on 2007 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ponnadurai Ramasami
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3111071642
Total Pages : 528 pages
Book Rating : 4.1/5 (11 download)
Download or read book Sustainable Chemistry Research written by Ponnadurai Ramasami and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-10-23 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book of proceedings is a collection of nineteen selected and peer-reviewed contributions from the Virtual Conference on Chemistry and its Applications (VCCA-2022). VCCA-2022 was held online from 8th to 12th August 2022. The theme of the conference was "Resilience and Sustainable Research through Basic Sciences". 500 participants from 55 countries participated in VCCA-2022. This volume 1 reflects the chapters covering chemical and biochemical aspects.
Author : David R. O'Reilly
Publisher :
ISBN 13 : 9780195091311
Total Pages : 366 pages
Book Rating : 4.0/5 (913 download)
Download or read book Baculovirus Expression Vectors written by David R. O'Reilly and published by . This book was released on 1994 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Baculoviruses have proven to be the most powerful and versatile eukaryotic expression vectors available. This unique laboratory manual is designed to help both beginning and experienced researchers construct and use baculovirus vector systems. It simplifies selection of the most appropriatebaculovirus vector design for a given problem, then describes each step of the implementation process--from vector construction to large-scale protein production. The book provides an understanding of how the vectors work; a biological overview of cells, viruses, plasmids, and promoters; guidelinesfor choosing optimum vectors; protocols for growing insect cells and recombinant viruses; methods of analyzing protein products and scaling up protein production; techniques for producing proteins in insect larvae; and easy-to-use maps charting available expression vectors. This comprehensiveapproach has many benefits for researchers and students alike. It allows them to understand how and why the vector system works and offers a rapid comparison of options for choosing the right virus, plasmid or promoter for vector design and construction, with a minimum amount of lost time. Themanual is an invaluable resource for every individual engaged in the production of proteins for any purpose.
Author : Shampa Chatterjee
Publisher : Academic Press
ISBN 13 : 0128054026
Total Pages : 477 pages
Book Rating : 4.1/5 (28 download)
Download or read book Immunity and Inflammation in Health and Disease written by Shampa Chatterjee and published by Academic Press. This book was released on 2017-08-31 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. - Conceptualizes the key features in natural products which can boost immune function and immune health - Explains the intricate mechanistic aspects and balance behind immune health - Presents the pathophysiology of several diseases associated with immune system disruption
