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Dipeptidyl Aminopeptidases
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Book Synopsis Dipeptidyl Aminopeptidases by : Uwe Lendeckel
Download or read book Dipeptidyl Aminopeptidases written by Uwe Lendeckel and published by Springer Science & Business Media. This book was released on 2006-12-11 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Book Synopsis Dipeptidyl Aminopeptidases in Health and Disease by : Martin Hildebrandt
Download or read book Dipeptidyl Aminopeptidases in Health and Disease written by Martin Hildebrandt and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the International Conference on Dipeptidyl Aminopeptidases, held September 26-28, 2002, in Berlin, Germany. Dipeptidyl Aminopeptidases exert a potent modulatory role at an interface between immune mechanisms, metabolic responses and neuroendocrine pathways. Experimental models and clinical studies addressing the role of these enzymes and the effect of specific inhibitors pave the way to novel therapeutic concepts in immunology, rheumatology, oncology, reproductive medicine and diabetes. Leading experts in this field have contributed to this book which presents a state-of-the-art view on these enzymes, at a time when our understanding of their function is growing ever more rapidly and therapeutic options become imminent. The sections of the book focus on various topics: - Structure and function of dipeptidyl aminopeptidases, - DPP IV-like proteins, - Immune mechanisms and immune disorders, - Cancer and angiogenesis, - Diabetes and metabolism, - Therapeutic implications.
Download or read book Ectopeptidases written by Jürgen Langner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The idea to compile recent results on the ectoenzymes aminopeptidase N/CD13 and dipeptidylpeptidase IV/CD26 arose from the great interest given by readers world-wide to the two proceedings volumes edited by us in 1997 and 2000 (Ansorge and Langner, 1997; Langner and Ansorge, 2000). These volumes contained the presentations at two symposia held in Magdeburg (Germany) in 1996 and 1999 under the title "Cellular peptidases in immune functions and diseases", which was also the name of the Sonderforschungsbereich in Magdeburg, sponsored by the Deutsche Forschungsgemeinschaft between 1995 and 2001. Our groups in Magdeburg and Halle during the last two decades have provided results on these two enzymes in cells of the hematopoietic system that justify a review in an edited monograph like the present one (see the reviews by Kahne et at. , 1999; Lendeckel et at. ,1999; Riemann et at. , 1999). There are, however, many other groups in Europe, US and Japan which made important contributions to this field and particularly in topics improving the understanding of physiological and pathophysiological roles ofAPN/CD13 and DPIV/CD26. Therefore we decided to invite some of them to contribute reviews of their results to this book. Having worked for about 40 years in the field of proteolysis, for both of us to see the development of activities and knowledge from protein chemistry and enzymology to physiology and pathophysiology and even to therapy is very stimulating and fascinating. Of course, this development also reflects the dramatic improvement and refinement of methods.
Book Synopsis Industrial Enzymes by : Julio Polaina
Download or read book Industrial Enzymes written by Julio Polaina and published by Springer Science & Business Media. This book was released on 2007-05-16 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments in genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure. This volume reviews the most important types of industrial enzymes. In a balanced manner it covers three interrelated aspects of paramount importance for enzyme performance: three-dimensional protein structure, physicochemical and catalytic properties, and the range of both classical and novel applications.
Download or read book Dipeptidyl Aminopeptidases written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dipeptidyl Aminopeptidases by : Uwe Lendeckel
Download or read book Dipeptidyl Aminopeptidases written by Uwe Lendeckel and published by Springer. This book was released on 2008-11-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive volume on Dipeptidyl Aminopeptidases that can be marketed to a wide variety of disciplines, as well as to a variety of clinicians. Leading experts in the field contribute to this state-of-the-art view on these enzymes. This book comes at a time when our understanding of their function is growing ever more rapidly and therapeutic options have become imminent.
Book Synopsis Dipeptidyl-aminopeptidases and Aminopeptidases During Differentiation and Development of the Cellular Slime Mold D̲i̲c̲t̲y̲o̲s̲t̲e̲l̲i̲u̲m̲ D̲i̲s̲c̲o̲i̲d̲e̲u̲m̲ by : Samuel A. T. Chan
Download or read book Dipeptidyl-aminopeptidases and Aminopeptidases During Differentiation and Development of the Cellular Slime Mold D̲i̲c̲t̲y̲o̲s̲t̲e̲l̲i̲u̲m̲ D̲i̲s̲c̲o̲i̲d̲e̲u̲m̲ written by Samuel A. T. Chan and published by . This book was released on 1985 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Immunity and Inflammation in Health and Disease by : Shampa Chatterjee
Download or read book Immunity and Inflammation in Health and Disease written by Shampa Chatterjee and published by Academic Press. This book was released on 2017-08-31 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption
Book Synopsis X-prolyl Dipeptidyl Aminopeptidases from Saccharomyces Cerevisiae by : Maripaz Suárez Rendueles
Download or read book X-prolyl Dipeptidyl Aminopeptidases from Saccharomyces Cerevisiae written by Maripaz Suárez Rendueles and published by . This book was released on 1984 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell-surface Aminopeptidases by : Shigehiko Mizutani
Download or read book Cell-surface Aminopeptidases written by Shigehiko Mizutani and published by . This book was released on 2001 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers unique content for both basic and clinical scientists around the world with an interest in cell-surface peptidases. The book focuses on five cell-surface peptidases, namely neutral endopeptidase (NEP)/CD10, aminopeptidase N (APN)/CD13, aminopeptidase A (APA)/BP1, dipeptidyl peptidase IV (DPPIV)/CD26, and placental leucine aminopeptidase (PLAP)/insulin-regulated aminopeptidase (IRAP), which are members of the type II membrane-bound peptidase family. It reviews the recent progress in these peptidases as well as their peptide substrates, and explores their physiological and pathological significance. Key features include: a new insight into the regulation of blood pressure and peripheral vascular systems; research into a new mechanism for insulin-responsive glucose transport and its application for the treatment of diabetes; and understanding of the new mechanisms of cell-survival peptidase involvement in human tumor progression
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dipeptidyl-aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells by : Aaron Bettecken
Download or read book Dipeptidyl-aminopeptidases 8 and 9 Regulate Autophagy and Tamoxifen Response in Breast Cancer Cells written by Aaron Bettecken and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The cytosolic dipeptidyl-aminopeptidases 8 (DPP8) and 9 (DPP9) belong to the DPPIV serine proteases with the unique characteristic of cleaving off a dipeptide post-proline from the N-termini of substrates. To study the role of DPP8 and DPP9 in breast cancer, MCF-7 cells (luminal A-type breast cancer) and MDA.MB-231 cells (basal-like breast cancer) were used. The inhibition of DPP8/9 by 1G244 increased the number of lysosomes in both cell lines. This phenotype was more pronounced in MCF-7 cells, in which we observed a separation of autophagosomes and lysosomes in the cytosol upon DPP8/9 inhibition. Likewise, the shRNA-mediated knockdown of either DPP8 or DPP9 induced autophagy and increased lysosomes. DPP8/9 inhibition as well as the knockdown of the DPPs reduced the cell survival and proliferation of MCF-7 cells. Additional treatment of MCF-7 cells with tamoxifen, a selective estrogen receptor modulator (SERM) used to treat patients with luminal breast tumors, further decreased survival and proliferation, as well as increased cell death. In summary, both DPP8 and DPP9 activities confine macroautophagy in breast cancer cells. Thus, their inhibition or knockdown reduces cell viability and sensitizes luminal breast cancer cells to tamoxifen treatment
Book Synopsis Permuted Medical Subject Headings by : National Library of Medicine (U.S.)
Download or read book Permuted Medical Subject Headings written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Cloning, Expression and Distribution of the X-prolyl Dipeptidyl Aminopeptidase Gene from Lactobacillus Helveticus CNRZ 32 by : Gülhan Ünlü
Download or read book Molecular Cloning, Expression and Distribution of the X-prolyl Dipeptidyl Aminopeptidase Gene from Lactobacillus Helveticus CNRZ 32 written by Gülhan Ünlü and published by . This book was released on 1992 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aminopeptidases in Biology and Disease by : Nigel M. Hooper
Download or read book Aminopeptidases in Biology and Disease written by Nigel M. Hooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aminopeptidases in Biology and Disease provides a comprehensive review of the emerging role of aminopeptidases in a range of biological processes and disease situations. Processes as diverse as angiogenesis, antigen presentation, neuropeptide and hormone processing, pregnancy and reproduction, protein turnover, memory, inflammation, tumour growth, cancer and metastasis, blood pressure and hypertension all critically involve one or more aminopeptidases. The individual chapters have been written by experts in the field who have provided detailed accounts of the central roles played by various aminopeptidases in biology and disease.
Book Synopsis Characterization of a Dipeptidyl Aminopeptidase from Bovine Adrenal Medulla by : Elaine Kecorius
Download or read book Characterization of a Dipeptidyl Aminopeptidase from Bovine Adrenal Medulla written by Elaine Kecorius and published by . This book was released on 1986 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proteinases and Their Inhibitors by : V. Turk
Download or read book Proteinases and Their Inhibitors written by V. Turk and published by Elsevier. This book was released on 2014-05-23 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteinases and their Inhibitors: Structure, Function, and Applied Aspects documents the proceedings of an international symposium organized by the Department of Biochemistry, Jozef Stefan Institute, E. Kardelj University, Ljubljana, and the Department of Organic Chemistry and Biochemistry, Rudjer Boskovic Institute, Zagreb, held in Portoroz, Yugoslavia, September 29-October 3, 1980. The volume contains 34 papers that are organized into four parts. Part I on biological functions includes studies such as muscle protein breakdown in human catabolic state and age-dependent changes in intracellular protein turnover. The papers in Part II, which deals with properties and structure of enzymes, cover topics such as structures and biological functions of cathepsin B and L; and human erythrocytes peptidases. Part III is devoted to industrial applications, such as exogenous proteinases in dairy technology and the application of immobilized proteinases. Part IV on proteinase inhibitors includes papers on thiol inhibitors of proteases and and intracellular neutral proteinases and inhibitors. The papers in this volume provide new data, concepts, and visions which will not only prove useful, but will also stimulate further investigations of proteinases and their inhibitors.
