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Author : Baohong Yuan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (71 download)
Download or read book Diffuse Optical Tomography and Fluorescence Diffuse Optical Tomography written by Baohong Yuan and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Huabei Jiang
Publisher : CRC Press
ISBN 13 : 1439847584
Total Pages : 366 pages
Book Rating : 4.4/5 (398 download)
Download or read book Diffuse Optical Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.
Author : An Jin
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (115 download)
Download or read book Sparse Reconstruction Methods in Fluorescence Diffuse Optical Tomography written by An Jin and published by . This book was released on 2012 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ying Mu
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (15 download)
Download or read book Development and Validation of Time-domain Diffuse Optical Tomographic Imaging and Multiplexed Fluorescence Mediated Tomography written by Ying Mu and published by . This book was released on 2016 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffuse optical tomography (DOT) and fluorescence molecule tomography (FMT) are emerging as important optical imaging tools for clinical and biomedical research. Two major outstanding challenge in DOT and FMT are i) the relatively low imaging resolution, which results from the high degree of photon scatter through biological tissue, and ii) the inability to image multiple fluorescent targets in deep tissue ("multiplexing") due to the relatively narrow wavelength region within which light is less attenuated and effectively transmitted through bulk tissue. In this dissertation, we explored the use of time-domain DOT and FMT imaging to address these problems. First, time-resolved (TR) measurement of early arriving photons from a pulse laser was studied as a method for improving resolution in diffuse optical imaging. The underlying concept is photons that arrive first ("early") at a detector from a pulsed laser incident on bulk tissue have experienced fewer scattering events and taken relatively straight paths. We developed and tested a time-domain diffuse optical imaging system consisting of a femetosecond titanium: sapphire laser and fast, single photon avalanche photodiode (SPAD) detectors, that had an extremely fast temporal response time of 59 ps. We validated that the SPAD allowed measurement of photon-density sensitivity function that were 65% narrower than the temporally un-gated case at very early times. This exceeded the performance achieved previously with photomultiplier-based systems and approached the theoretical maximum predicted by time-resolved Monte Carlo simulations. Following this work, we then developed a complete SPAD-based DOT scanner, in which an array of SPADs were used. We validated performance of the system in cylindrical and irregular shaped optical phantoms of approximately small animal size. We were able to accurately reconstruct the size and position of up to 4 absorbing inclusions in diffusive media for the first time, with increasing image quality at earlier times. Next, we developed a time-resolved multiplexed fluorescence tomography system, which allowed us to measure extremely rich multi-spectral and temporal fluorescence data sets from diffusing media. In combination with a recently developed two-stage de-mixing and image reconstruction algorithm we are able to simultaneously image as many as four (and in theory 5) red and near-infrared fluorophores with closely overlapping spectral and temporal profiles, doubling the information throughput of FMT systems. This instrument also allowed us to account for the wavelength-dependency of optical properties in bulk biological tissue, which is a major challenge in biological imaging. The unique multiplexing imaging capabilities of this technology will allow us to study development of gliomas in small animal models in ongoing work in our group.
Author : Alper Corlu
Publisher :
ISBN 13 :
Total Pages : 123 pages
Book Rating : 4.:/5 (259 download)
Download or read book Multi-spectral and Fluorescence Diffuse Optical Tomography of Breast Cancer written by Alper Corlu and published by . This book was released on 2007 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lu Zhou
Publisher :
ISBN 13 : 9781124351353
Total Pages : 300 pages
Book Rating : 4.3/5 (513 download)
Download or read book Adaptive Finite Element Methods for Fluorescence Diffuse Optical Tomography written by Lu Zhou and published by . This book was released on 2010 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Britton Chance
Publisher : SPIE-International Society for Optical Engineering
ISBN 13 : 9780819465474
Total Pages : 468 pages
Book Rating : 4.4/5 (654 download)
Download or read book Optical Tomography and Spectroscopy of Tissue VII written by Britton Chance and published by SPIE-International Society for Optical Engineering. This book was released on 2007 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theory/Algorithm/Modeling; Instrumentation and Technology I; Fluorescence Imaging/Spectroscopy (algorithm/model/tomography); Fluorescence Imaging/Image Reconstruction (Experimental); Instrumentation and Technology II; Fluorescence Imaging Technology I; Fluorescence Imaging Technology II; Fluorescence Imaging Technology III; Network for Translational Research in Optical Imaging: Breast Cancer Diffuse Optical Imaging; Breast II - Instrumentation & New Analysis Method; Breast III - Clinical Study; Pre-Clinical/Animal; Instrumentation and Technology III; Clinical/Human Subject Studies.
Author : Ali Behrooz
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (88 download)
Download or read book Multiplexed Fluorescence Diffuse Optical Tomography written by Ali Behrooz and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence tomography (FT) is an emerging non-invasive in vivo molecular imaging modality that aims at quantification and three-dimensional (3D) localization of fluorescent tagged inclusions, such as cancer lesions and drug molecules, buried deep in human and animal subjects. Depth-resolved 3D reconstruction of fluorescent inclusions distributed over the volume of optically turbid biological tissue using the diffuse fluorescent photons detected on the skin poses a highly ill-conditioned problem, as depth information must be extracted from boundary data. Due to this ill-posed nature of FT reconstructions, noise and errors in the data can severely impair the accuracy of the 3D reconstructions. Consequently, improvements in the signal-to-noise ratio (SNR) of the data significantly enhance the quality of the FT reconstructions. Furthermore, enhancing the SNR of the FT data can greatly contribute to the speed of FT scans. The pivotal factor in the SNR of the FT data is the power of the radiation illuminating the subject and exciting the administered fluorescent agents. In existing single-point illumination FT systems, the illumination power level is limited by the skin maximum radiation exposure levels. In this research, a multiplexed architecture governed by the Hadamard transform was conceptualized, developed, and experimentally implemented for orders-of-magnitude enhancement of the SNR and the robustness of FT reconstructions. The multiplexed FT system allows for Hadamard-coded multi-point illumination of the subject while maintaining the maximal information content of the FT data. The significant improvements offered by the multiplexed FT system were validated by numerical and experimental studies carried out using a custom-built multiplexed FT system developed exclusively in this work. The studies indicate that Hadamard multiplexing offers significantly enhanced robustness in reconstructing deep fluorescent inclusions from low-SNR FT data.
Author : Jean-Charles Baritaux
Publisher :
ISBN 13 :
Total Pages : 127 pages
Book Rating : 4.:/5 (782 download)
Download or read book Sparsity-Inducing Reconstruction Methods for Fluorescence Diffuse Optical Tomography written by Jean-Charles Baritaux and published by . This book was released on 2012 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiao Tong
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (835 download)
Download or read book Co-registration of Fluorescence Diffuse Optical Tomography (fDOT) with Positron Emission Tomography (PET) and Development of Multi-angle FDOT written by Xiao Tong and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis concerns the image processing of fluorescence diffuse optical tomography (fDOT), following two axes: FDOT image co-registration with PET (positron emission tomography) image and improvement of fDOT image reconstructions using mirrors to collect additional projections. It is presented in two parts:In the first part, an automatic method to co-register the fDOT images with PET images has been developed to correlate all the information from each modality. This co-registration method is based on automatic detection of fiducial markers (FM) present in both modalities. The particularity of this method is the use of optical surface image obtained in fDOT imaging system, which serves to identify the Z position of FM in optical images. We tested this method on a model of mice bearing tumor xenografts of MEN2A cancer cells that mimic a human medullary thyroid carcinoma, after a double injection of radiotracer [18F] 2-fluoro-2-Deoxy-D-glucose ( FDG) for PET imaging and optical fluorescent infrared tracer Sentidye. With the accuracy of our method, we can demonstrate that the signal of Sentidye is present both in the tumor and surrounding vessels.The fDOT reconstruction image quality is degraded along the Z axis due to a limited number of projections for reconstruction. In the second part, the work is oriented towards a new method of fDOT image reconstruction with a new multi-angle data acquisition system in placing two mirrors on each side of the animal. This work was conducted in collaboration with the CS Department of University College London (UCL), a partner of the European project FMT-XCT. TOAST software developed by this team was used as source code for the reconstruction algorithm, and was modified to adapt to the concerned problem. After several tests on the adjustment of program parameters, we applied this method on a phantom that simulating the biological tissue and on mice. The results showed an improvement in the reconstructed image of a semi-cylindrical phantom and the image of mouse kidney, for which the reconstruction of the mirrors geometry is better than that of conventional geometry without mirror. Nevertheless, we observed that the results were very sensitive to certain parameters, where the performance of reconstruction varies from one case to another. Future prospectives concern the optimization of parameters in order to generalize the multi-angle approach.
Author : Krishna Teja Tokala
Publisher :
ISBN 13 :
Total Pages : 63 pages
Book Rating : 4.:/5 (95 download)
Download or read book A Geometric-sensitivity-difference Algorithm for Fluorescence Diffuse Optical Tomography Reconstruction written by Krishna Teja Tokala and published by . This book was released on 2013 with total page 63 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence Diffuse Optical Tomography is an emerging non-invasive imaging technique. Here we have introduced an alternative approach for Fluorescence Diffuse Optical Tomography which optimizes the data model fit based on pairing of the source and detector such that one source is shared by two detectors or one detector is shared by two sources, which in comparison to the conventional data model fit which does not use any kind of pairing. This new reconstruction algorithm is called Geometric Sensitivity Difference (GSD) method which effectively reduces the variation of reconstruction sensitivity with respect to imaging depth. Here the GSD method for source sharing detector pairs is demonstrated using simulated continuous-wave measurements in an outer circular-array imaging geometry, of which the native sensitivity varies strongly with respect to the depth. The results of the GSD method are compared to that of two methods: one is the conventional baseline method which utilizes the native sensitivity and the second method is depth compensation algorithm (DCA) which employs active depth adaptive scheme which counteracts the dependence of reconstruction sensitivity with respect to imaging depth.
Author : Huabei Jiang
Publisher : Springer Nature
ISBN 13 : 3031100042
Total Pages : 135 pages
Book Rating : 4.0/5 (311 download)
Download or read book Fluorescence Molecular Tomography written by Huabei Jiang and published by Springer Nature. This book was released on 2022-09-13 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence Molecular Tomography: Principles and Applications is the first book to cover the underlying principles and practical applications of fluorescence molecular tomography (FMT) in a systematic manner. Using a tutorial approach, the text begins with an overview of the fundamentals of FMT and goes on to detail image reconstruction approaches (including linear and nonlinear reconstruction algorithms), FMT instrumentations (including time-domain, frequency-domain, and continuous-wave domain systems), and implementation of image-enhancing schemes (including both software and hardware approaches). Further chapters examine multimodal approaches combining photoacoustic tomography (PAT), computed tomography (CT), single-photon emission tomography (SPECT), and magnetic resonance imaging (MRI) and discuss bioluminescence tomography and miniaturized FMT from hand-held to endoscopic FMT. A final chapter looks at clinical applications and animal studies. This authoritative and practical guide will serve as a valuable reference for researchers, scientists, clinicians, and industry professionals. The first book dedicated to fluorescence molecular tomography (FMT); Covers underlying principles and practical applications; Written by a leading FMT research pioneer and expert.
Author : Tiffany C. Kwong
Publisher :
ISBN 13 : 9780355307481
Total Pages : 271 pages
Book Rating : 4.3/5 (74 download)
Download or read book A New Modality for High Resolution Diffuse Optical Imaging written by Tiffany C. Kwong and published by . This book was released on 2017 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: As one of the most sensitive in vivo molecular imaging modalities, fluorescence imaging has great potential to play an important role in preclinical and clinical studies. Indeed, in vivo fluorescence optical imaging extends across a wide range of applications, from cellular to organ levels. Unfortunately, in organ level applications, fluorescence imaging suffers from low spatial resolution due to the high scattering nature of biological tissue, especially in deep tissue (>1cm). Extensive effort has been spent to improve the spatial resolution of fluorescence tomography (FT). However, approaches such as integrating FT with other anatomic imaging modalities such as Magnetic Resonance Imaging (MRI) or computed tomography (CT) do not perform well if the fluorescent agent distribution within the medium cannot be defined in the anatomical image. There are also several techniques that attempt to modulate fluorescence signals using ultrasound to achieve higher spatial resolution. However, low modulation efficiency and extremely low signal to noise ratio (SNR) are the two primary factors that make the implementation of these techniques difficult.Consequently, the poor spatial resolution and subsequent low quantitative accuracy are the main obstacles preventing the widespread use of this powerful technique in pre-clinical and clinical settings. To overcome these limitations, the goal of this thesis is to develop an entirely new approach termed, "Temperature-modulated fluorescence tomography (TM-FT)", that can provide high resolution images at depths up to 6 cm without sacrificing the exceptional sensitivity of FT. In this innovative approach, FT is combined with temperature activatable fluorescence molecular probes (ThermoDots) and high intensity focused ultrasound (HIFU) which can provide localized heating of the tissue (only 3-5 °C) with high spatial resolution. The small size of the focal spot (~1.4 mm) allows imaging the distribution of these temperature sensitive agents with not only high spatial resolution but also high quantitative accuracy.This thesis will present the development of the first TM-FT system prototype including the instrumentation and system design, image reconstruction algorithm, and ThermoDots probe development. The feasibility of this method to provide superior spatial resolution and high quantitative accuracy is validated using simulations and experimentally demonstrated in phantom and ex vivo tissue.
Author : Yoko Hoshi
Publisher : MDPI
ISBN 13 : 3039361007
Total Pages : 246 pages
Book Rating : 4.0/5 (393 download)
Download or read book New Horizons in Time-Domain Diffuse Optical Spectroscopy and Imaging written by Yoko Hoshi and published by MDPI. This book was released on 2020-06-23 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jöbsis was the first to describe the in vivo application of near-infrared spectroscopy (NIRS), also called diffuse optical spectroscopy (DOS). NIRS was originally designed for the clinical monitoring of tissue oxygenation, and today it has also become a useful tool for neuroimaging studies (functional near-infrared spectroscopy, fNIRS). However, difficulties in the selective and quantitative measurements of tissue hemoglobin (Hb), which have been central in the NIRS field for over 40 years, remain to be solved. To overcome these problems, time-domain (TD) and frequency-domain (FD) measurements have been tried. Presently, a wide range of NIRS instruments are available, including commonly available commercial instruments for continuous wave (CW) measurements, based on the modified Beer–Lambert law (steady-state domain measurements). Among these measurements, the TD measurement is the most promising approach, although compared with CW and FD measurements, TD measurements are less common, due to the need for large and expensive instruments with poor temporal resolution and limited dynamic range. However, thanks to technological developments, TD measurements are increasingly being used in research, and also in various clinical settings. This Special Issue highlights issues at the cutting edge of TD DOS and diffuse optical tomography (DOT). It covers all aspects related to TD measurements, including advances in hardware, methodology, the theory of light propagation, and clinical applications.
Author : Fred S. Azar
Publisher : Artech House
ISBN 13 : 1596933089
Total Pages : 431 pages
Book Rating : 4.5/5 (969 download)
Download or read book Translational Multimodality Optical Imaging written by Fred S. Azar and published by Artech House. This book was released on 2008 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Supported with 119 illustrations, this milestone work discusses key optical imaging techniques in self-contained chapters; describes the integration of optical imaging techniques with other modalities like MRI, X-ray imaging, and PET imaging; provides a software platform for multimodal integration; presents cutting-edge computational and data processing techniques that ensure rapid, cost-effective, and precise quantification and characterization of the clinical data; covers advances in photodynamic therapy and molecular imaging, and reviews key clinical studies in optical imaging along with regulatory and business issues.
Author : Steen J. Madsen
Publisher : Springer Science & Business Media
ISBN 13 : 1461449782
Total Pages : 284 pages
Book Rating : 4.4/5 (614 download)
Download or read book Optical Methods and Instrumentation in Brain Imaging and Therapy written by Steen J. Madsen and published by Springer Science & Business Media. This book was released on 2012-11-13 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive up-to-date review of optical approaches used in brain imaging and therapy. It covers a variety of imaging approaches including diffuse optical imaging, laser speckle imaging, photoacoustic imaging and optical coherence tomography. A number of laser-based therapeutic techniques are reviewed, including photodynamic therapy, fluorescence guided resection and photothermal therapy. Fundamental principles and instrumentation are discussed for each imaging and therapeutic approach.
Author : Nicusor Iftimia
Publisher : John Wiley & Sons
ISBN 13 : 1118102711
Total Pages : 641 pages
Book Rating : 4.1/5 (181 download)
Download or read book Advances in Optical Imaging for Clinical Medicine written by Nicusor Iftimia and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides students, teachers, researchers and clinicians with a strong and established source of information on advanced optical technologies that show real promise of being translated to clinical use.
