Author : Chudi O. Ndubaku
Publisher :
ISBN 13 :
Total Pages : 482 pages
Book Rating : 4.:/5 (131 download)
Book Synopsis Diastereoselective Nickel-catalyzed Reductive Coupling of Alkynes and Aldehydes and Application Towards the B-type Amphidinolides by : Chudi O. Ndubaku
Download or read book Diastereoselective Nickel-catalyzed Reductive Coupling of Alkynes and Aldehydes and Application Towards the B-type Amphidinolides written by Chudi O. Ndubaku and published by . This book was released on 2006 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of recently developed stereoselective nickel-catalyzed reductive coupling reactions of alkynes and aldehydes to the synthesis of complex natural product targets was explored. The "B-Type" amphidinolides were selected as ideal targets owing to their molecular complexity and the paucity of synthetically viable means for their total construction. The diastereoselective nickel-catalyzed reductive coupling of simple aryl-substituted alkynes and a-oxyaldehydes was developed and applied to the construction of the C15-C26 region of amphidinolide H3. ... Alternatively, the nickel-catalyzed reductive coupling reaction of 1,3-enynes and aldehydes was found to be a very effective way of installing the congested 1,3-diene moiety common to all members of this class of natural products. This methodology was further examined as a fragment coupling strategy for the syntheses of amphidinolides G3 and H4. This allowed for a highly convergent and functional group tolerant assembly of these ... molecules and, to date, stands as the most complicated setting for the application of the catalytic reductive coupling reaction.