Molecular Biology of Diabetes

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Publisher : Springer Science & Business Media
ISBN 13 : 1461202418
Total Pages : 411 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Molecular Biology of Diabetes by : Boris Draznin

Download or read book Molecular Biology of Diabetes written by Boris Draznin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Molecular and Cell Biology of Type 2 Diabetes and Its Complications

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Author :
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805566441
Total Pages : 270 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Molecular and Cell Biology of Type 2 Diabetes and Its Complications by : Francesco Belfiore

Download or read book Molecular and Cell Biology of Type 2 Diabetes and Its Complications written by Francesco Belfiore and published by Karger Medical and Scientific Publishers. This book was released on 1998-01-01 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume summarizes current research on type 2 diabetes, its etiology, pathogenesis and long-term vascular and neurological consequences, with special emphasis on molecular and biochemical mechanisms. Alterations in insulin secretion are comprehensively treated, focusing on the role of glucokinase as glucose sensor. Moreover, insulin action is analyzed with regard to both nonoxidative glucose utilization and glucose oxidation. Concerning the complications in chronic diabetes, topics covered include the effects of high glucose concentration on cellular and endothelial functions and on the glucose phosphorylation rate in non-insulin-sensitive tissues. Furthermore, the role of oxidative stress and advanced glycation end products as well as the significance of alterations in lipoprotein structure are considered. Finally, the pericyte loss in retinopathy and microalbuminuria as related to cardiovascular risk are discussed. Taken as a whole, the contributions included in this book represent a large body of information that will be of great interest to diabetologists, endocrinologists and internists interested in both the basic and clinical aspects of diabetes and its complications.

Molecular Nutrition and Diabetes

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Publisher : Academic Press
ISBN 13 : 0128017619
Total Pages : 400 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Molecular Nutrition and Diabetes by : Didac Mauricio

Download or read book Molecular Nutrition and Diabetes written by Didac Mauricio and published by Academic Press. This book was released on 2015-12-08 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes. Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition

Diabetes Mellitus and Molecular Biology

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Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.:/5 (215 download)

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Book Synopsis Diabetes Mellitus and Molecular Biology by : G. I. Bell

Download or read book Diabetes Mellitus and Molecular Biology written by G. I. Bell and published by . This book was released on 1990 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular and Cellular Biology of Diabetes Mellitus: Complications of diabetes mellitus

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Publisher :
ISBN 13 : 9780845142592
Total Pages : 168 pages
Book Rating : 4.1/5 (425 download)

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Book Synopsis Molecular and Cellular Biology of Diabetes Mellitus: Complications of diabetes mellitus by : Boris Draznin

Download or read book Molecular and Cellular Biology of Diabetes Mellitus: Complications of diabetes mellitus written by Boris Draznin and published by . This book was released on 1989 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion

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Publisher :
ISBN 13 : 9780845142578
Total Pages : 198 pages
Book Rating : 4.1/5 (425 download)

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Book Synopsis Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion by : Boris Draznin

Download or read book Molecular and Cellular Biology of Diabetes Mellitus: Insulin secretion written by Boris Draznin and published by . This book was released on 1989 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus

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Publisher : Academic Press
ISBN 13 : 0128002948
Total Pages : 513 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus by :

Download or read book Glucose Homeostatis and the Pathogenesis of Diabetes Mellitus written by and published by Academic Press. This book was released on 2013-12-24 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes mellitus is a disease with tremendous health and economic burden. A better understanding of how normal glucose homeostasis is maintained and the pathogenesis is important to identify new ways for diabetes treatment. This book addresses multiple aspects of this area of research. Written by experts in the field Informs on important topics related to the regulation of glucose homeostasis and the pathogenesis of diabetes mellitus, a field of intense research interest

Molecular and Cellular Biology of Diabetes Mellitus

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 9780471503934
Total Pages : 182 pages
Book Rating : 4.5/5 (39 download)

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Book Synopsis Molecular and Cellular Biology of Diabetes Mellitus by : Boris Draznin

Download or read book Molecular and Cellular Biology of Diabetes Mellitus written by Boris Draznin and published by John Wiley & Sons. This book was released on 1988-11-01 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in a three-part series, Insulin Secretion covers recent findings on the physiology and biochemistry of insulin release in both normal and diabetic states, highlighting the signal transduction system. This complex system includes traditional elements, such as hormone receptors, along with newly described components, such as G-proteins, intracellular kinases, and derivatives of the plasma membrane phospholipids. It reflects the various mechanisms by which hormones and nutrients interacting with B-cells influence the synthesis of insulin and islet cell secretory processes.

Animal Models in Diabetes Research

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Publisher : Humana Press
ISBN 13 : 9781627030670
Total Pages : 0 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Animal Models in Diabetes Research by : Hans-Georg Joost

Download or read book Animal Models in Diabetes Research written by Hans-Georg Joost and published by Humana Press. This book was released on 2012-08-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, human studies have made enormous contributions towards an understanding of the genetic basis of diabetes mellitus; however, most of the experimentation needed for the invention and testing of novel therapeutic approaches cannot be performed in humans. Thus, there is no alternative to appropriate animal models. In Animal Models in Diabetes Research, expert researchers explore the current status of the most important models and procedures in order to provide a timely resource in experimental diabetology. The first half of the volume serves as a comprehensive overview on our current knowledge of the pathogenesis and pathophysiology of diabetes in animal models through a series of reviews in model strains. The book then continues with vital, established protocols that are employed in the characterization and study of animal models of diabetes. As a volume in the highly successful Methods in Molecular BiologyTM series, this work contains the type of detailed description and key implementation advice necessary to achieve successful results. Authoritative and cutting-edge, Animal Models in Diabetes Research delivers essential content that will be an important resource to advance diabetes research in the years to come.

Diabetes Mellitus and Its Complications

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Publisher :
ISBN 13 :
Total Pages : 97 pages
Book Rating : 4.:/5 (594 download)

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Book Synopsis Diabetes Mellitus and Its Complications by : E. Adeghate

Download or read book Diabetes Mellitus and Its Complications written by E. Adeghate and published by . This book was released on 2001 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diabetes and the Endocrine Pancreas

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Publisher : Springer Science & Business Media
ISBN 13 : 9401163790
Total Pages : 168 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Diabetes and the Endocrine Pancreas by : W. Montague

Download or read book Diabetes and the Endocrine Pancreas written by W. Montague and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book attempts to explore the contribution that biochemistry has made, thus far, to our understanding of the endocrine pancreas and its relationship to diabetes mellitus. It was written with the aim of using an important clinical problem to illustrate, to medical students, that there are many aspects of the biochemistry taught in the early years which have direct relevance to clinical medicine. Furthermore, it is hoped that such information might provide biochemistry students with a frame work on which to base further studies. To this end a selection of recent references has been placed at the end of each chapter. In spite of considerable advances in our understanding of diabetes mellitus, it is still a disease which many physicians do not seem to com prehend. This is in part related to their lack of understanding of the molecular biology of the disease. Advances in this area have been dramatic in recent years and we are now able to offer a molecular basis for a rational approach to therapy. It may be therefore that this book will provide some physicians with the information they require to help them gain a deeper understanding of the disease. I hope that everyone who reads this book is able to capture some of the fascination that the islets of Langerhans hold for myself and the many other workers actively engaged in trying to unravel their mys teries.

Special Issue on Diabetes Mellitus and Its Complications: from Molecular Biology to Clinical Medicine

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Author :
Publisher :
ISBN 13 :
Total Pages : 97 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Special Issue on Diabetes Mellitus and Its Complications: from Molecular Biology to Clinical Medicine by : Ernest Adeghate

Download or read book Special Issue on Diabetes Mellitus and Its Complications: from Molecular Biology to Clinical Medicine written by Ernest Adeghate and published by . This book was released on 2001 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of Diabetes

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Author :
Publisher : Humana
ISBN 13 : 9780896032866
Total Pages : 432 pages
Book Rating : 4.0/5 (328 download)

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Book Synopsis Molecular Biology of Diabetes by : Boris Draznin

Download or read book Molecular Biology of Diabetes written by Boris Draznin and published by Humana. This book was released on 1994-09-02 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a rapidly evolving and extremely important area of medical science, it is often difficult for the student, teacher, and researcher to keep abreast of all the important advances. The purpose of Molecular Biology ofDiabetes, Parts I and II is to bring to these individuals the latest knowledge of diabetes-related research in a comprehensive, yet concise manner. To this end, we have assembled chapters, written by most of the world's experts in the field, that we believe compre hensively survey and synthesize a coherent understanding of the subject. Studies of the etiology of type I and type II diabetes are extremely exciting and essential, since we hope to one day prevent the disease using gene therapy. These aspects are covered in Molecular Biology of Diabetes: I. Autoimmunity and Genetics; Insulin Synthesis and Secretion. In type II diabetes, an abnormality in pancreatic secretion exists concomitantly with peripheral insulin resistance. This abnor mality of insulin secretion is believed to be related to a defect(s) in glucose sensing. Uncoupling of glucose sensing from insulin secre tion may be the crucial step in the pathogenesis of noninsulin-depen dent diabetes. In this volume, we have invited authors to describe their studies on all known factors affecting ~-cell function, including autoimmunity and genetics of diabetes, as well as molecular mecha nisms of insulin synthesis and secretion. In the last few years, the most rapidly advancing area of research in diabetes has been, in fact, related to insulin action.

Type 2 Diabetes

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Publisher : Humana
ISBN 13 : 9781493998807
Total Pages : 0 pages
Book Rating : 4.9/5 (988 download)

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Book Synopsis Type 2 Diabetes by : Claire J. Stocker

Download or read book Type 2 Diabetes written by Claire J. Stocker and published by Humana. This book was released on 2019-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition volume expands on the previous editions with updates on the commonly used techniques and analysis used by clinicians and scientists to study diabetes. The chapters in this book cover topics such as nutritional models of type 2 diabetes mellitus; the isolation and purification of rodent pancreatic islets of Langerhans; nitric oxide and redox state measurements in pancreatic beta cells; and primary adipocytes as a model for insulin sensitivity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Type 2 Diabetes: Methods and Protocols, Second Edition is a valuable resource for all researchers who are interested in learning more about this important and evolving field.

Diabetes

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Publisher : Springer Science & Business Media
ISBN 13 : 1461454417
Total Pages : 515 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Diabetes by : Shamim I. Ahmad

Download or read book Diabetes written by Shamim I. Ahmad and published by Springer Science & Business Media. This book was released on 2013-04-12 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is a complex disease and is also one of the most common. It is very difficult to reach an accurate estimate for the global prevalence of diabetes since the standards and methods of data collection vary widely in different parts of the world. In addition, many potential sufferers are not included in the count because according to an estimate about 50% of cases remain undiagnosed for up to 10 years. However, according to an estimate for 2010, globally, there are about 285 million people (amounting to 6.4% of the adult population) suffering from this disease. This number is estimated to increase to 439 million by 2030 if no cure is found. The general increase in life expectancy, leading to an ageing population, and the global rise in obesity are two main reasons for the increase. With the basic platform set, Editor presents his views and advice to the readers, especially to diabetic patients suffering from T2DM, on the basis of his observations and information collected from other diabetics.

Insulin

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Publisher : IRL Press
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.3/5 (97 download)

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Book Synopsis Insulin by : Frances M. Ashcroft

Download or read book Insulin written by Frances M. Ashcroft and published by IRL Press. This book was released on 1992 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes is caused by a partial or total lack of the hormone insulin, and is one of the world's major health problems. This book provides an accessible introduction to the current research into all aspects of the synthesis and action of insulin. In the last few years, there have been a number of crucial developments in the study of insulin at the molecular level. These are presented along with discussions of the pathology of diabetes, providing the first integrated account of insulin's physiological action and its significance in disease. Chapters have been assembled from a range of experts in the field, covering topics such as the insulin gene, insulin biosynthesis and secretion, the insulin receptor, and the genetic and immunological aspects of diabetes. Insulin: Molecular Biology to Pathology has been designed with the non-specialist in mind, and includes an extensive glossary of terms. It will enable both researchers and clinicians to gain new insights into unfamiliar areas and will be useful to anyone with an interest in this fascinating hormone.

Diabetes Mellitus in Children

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Publisher :
ISBN 13 : 9781416027539
Total Pages : 0 pages
Book Rating : 4.0/5 (275 download)

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Book Synopsis Diabetes Mellitus in Children by : Mark A. Sperling

Download or read book Diabetes Mellitus in Children written by Mark A. Sperling and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: