Developmental And Gonadal Regulation Of Hypothalamic Pituitary Adrenal Axis Function In Adolescent And Adult Rats

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Developmental and Gonadal Regulation of Hypothalamic-pituitary-adrenal Axis Function in Adolescent and Adult Rats

Author : Matthew Green
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (124 download)

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Book Synopsis Developmental and Gonadal Regulation of Hypothalamic-pituitary-adrenal Axis Function in Adolescent and Adult Rats by : Matthew Green

Download or read book Developmental and Gonadal Regulation of Hypothalamic-pituitary-adrenal Axis Function in Adolescent and Adult Rats written by Matthew Green and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal (HPA) axis regulates the release of stress hormones and its function is dependent on various factors including prior exposure to stressors, circulating gonadal hormones, and developmental status. The overarching goal of this thesis was to uncover the potential mechanisms mediating developmental changes in HPA function and its regulation by gonadal hormones during adolescence and early adulthood. In Chapter 2, I found that pre-pubertal (postnatal day [P]35) and post-pubertal (P45) adolescents responded to an acute stressor with greater release of corticosterone (the main stress hormone in rodents) compared with adults (P75). To determine whether differences in corticosterone release were related to ongoing maturation of HPA feedback, I investigated glucocorticoid receptor (GR) activity and mRNA expression of receptors (Nr3c1, Nr3c2) and their co-chaperones (Fkbp5, Fkbp4, Bag1) in the hippocampus. I provide novel evidence that P35 males have more, not less, GR translocation from the cytosol to the nucleus in response to stress compared with P75 males. Gene expression remained relatively stable across development, except for Fkbp4, which codes for a pro-translocation protein and was up-regulated in P35 males relative to expression in P75 males. Thus, there are developmental shifts in the hormonal response to stress that are likely unrelated to GR activity in the hippocampus. In Chapter 3, I investigated whether differences in HPA function are explained by gonadal status; in adult males, testosterone reduces HPA function. Age-related differences in corticosterone release persisted when orchiectomized (OCX) males at each age were administered testosterone. Moreover, the effect of testosterone changed across the adolescent period; relative to those that got blank implants, testosterone had no effect on post-stress concentrations of corticosterone at P35, increased concentrations at P45, and tended to reduce concentrations at P75. Testosterone reduced expression of AVP in the PVN at all ages, but did not affect Fos (a marker of neuronal activation) expression. I hypothesized that the age-specific effects of testosterone on corticosterone were related to differential conversion to metabolites (e.g., estradiol), which I tested using androgen receptor (AR) and estrogen receptor (ER) antagonists (flutamide and tamoxifen, respectively) in the presence of testosterone or dihydrotestosterone (DHT). Testosterone produced a similar, albeit non-significant, age-specific pattern of effects on corticosterone as described above, and I found little evidence for effects of receptor antagonists. Androgens reduced post-stress concentrations of progesterone in all age groups, and flutamide prevented the effect. Together, this study provides evidence for developmental shifts in stress responses and their regulation by gonadal hormones. In Chapter 4, I examined the influence of estradiol on HPA function in adult female rats as a first step toward understanding developmental shifts. Ovariectomy (OVX) reduced post-stress concentrations of corticosterone compared with sham OVX and OVX females given estradiol alone or in combination with progesterone. I also found that OVX females had greater cytosolic expression of GR, possibly increasing sensitivity to corticosterone. In a second experiment, I found that progesterone partially mitigated the effect of estradiol on corticosterone release and that gene expression of stress hormone receptors (Nr3c1, Nr3c2), their co-chaperones (Fkbp5, Fkbp4, Bag1), and a co-activator (Src-1) did not change as a function of ovarian hormones. Together, these studies build on previous research investigating developmental and gonadal regulation of HPA activity and provide novel findings regarding potential mechanisms underlying their actions.

ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology

Author : Nicole Gallo-Payet
Publisher : Frontiers Media SA
ISBN 13 : 2889452328
Total Pages : 421 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology by : Nicole Gallo-Payet

Download or read book ACTH Action in the Adrenal Cortex: From Molecular Biology to Pathophysiology written by Nicole Gallo-Payet and published by Frontiers Media SA. This book was released on 2017-07-27 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: By stimulating adrenal gland and corticosteroid synthesis, the adrenocorticotropic hormone (ACTH) plays a central role in response to stress. In this Research Topic, a particular attention has been given to the recent developments on adrenocortical zonation; the growth-promoting activities of ACTH; the various steps involved in acute and chronic regulation of steroid secretion by ACTH, including the effect of ACTH on circadian rhythms of glucocorticoid secretion. The Research Topic also reviews progress and challenges surrounding the properties of ACTH binding to the MC2 receptor (MC2R), including the importance of melanocortin-2 receptor accessory protein (MRAP) in MC2R expression and function, the various intracellular signaling cascades, which involve not only protein kinase A, the key mediator of ACTH action, but also phosphatases, phosphodiesterases, ion channels and the cytoskeleton. The importance of the proteins involved in the cell detoxification is also considered, in particular the effect that ACTH has on protection against reactive oxygen species generated during steroidogenesis. The impact of the cellular microenvironment, including local production of ACTH is discussed, both as an important factor in the maintenance of homeostasis, but also in pathological situations, such as severe inflammation. Finally, the Research Topic reviews the role that the pituitary-adrenal axis may have in the development of metabolic disorders. In addition to mutations or alterations of expression of genes encoding components of the steroidogenesis and signaling pathways, chronic stress and sleep disturbance are both associated with hyperactivity of the adrenal gland. A resulting effect is increased glucocorticoid secretion inducing food intake and weight gain, which, in turn, leads to insulin and leptin resistance. These aspects are described in detail in this Research Topic by key investigators in the field. Many of the aspects addressed in this Research Topic still represent a stimulus for future studies, their outcome aimed at providing evidence of the central position occupied by the adrenal cortex in many metabolic functions when its homeostasis is disrupted. An in-depth investigation of the mechanisms underlying these pathways will be invaluable in developing new therapeutic tools and strategies.

The Hypothalamus-Pituitary-Adrenal Axis

Author :
Publisher : Elsevier
ISBN 13 : 0080559360
Total Pages : 413 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Hypothalamus-Pituitary-Adrenal Axis by :

Download or read book The Hypothalamus-Pituitary-Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. - Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle - Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later

The Promise of Adolescence

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309490111
Total Pages : 493 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Promise of Adolescence by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Promise of Adolescence written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-07-26 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

Developmental Psychopathology, Volume 2

Author : Dante Cicchetti
Publisher : John Wiley & Sons
ISBN 13 : 0470048190
Total Pages : 896 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Developmental Psychopathology, Volume 2 by : Dante Cicchetti

Download or read book Developmental Psychopathology, Volume 2 written by Dante Cicchetti and published by John Wiley & Sons. This book was released on 2006-03-31 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Psychopathology, Second Edition, contains in three volumes the most complete and current research on every aspect of developmental psychopathology. This seminal reference work features contributions from national and international expert researchers and clinicians who bring together an array of interdisciplinary work to ascertain how multiple levels of analysis may influence individual differences, the continuity or discontinuity of patterns and the pathways by which the same developmental outcomes may be achieved. This volume addresses theoretical perspectives and methodological.

Charney & Nestler's Neurobiology of Mental Illness

Author : Dennis S. Charney
Publisher : Oxford University Press
ISBN 13 : 019068142X
Total Pages : 1025 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis Charney & Nestler's Neurobiology of Mental Illness by : Dennis S. Charney

Download or read book Charney & Nestler's Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press. This book was released on 2018 with total page 1025 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years following publication of the DSM-5(R), the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney & Nestler's Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. No other book distills the basic science and underpinnings of mental disorders-and highlights practical clinical significance-to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and related bioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for the translation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit. Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5(R), which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Gender Differences at Puberty

Author : Chris Hayward
Publisher : Cambridge University Press
ISBN 13 : 9780521001656
Total Pages : 362 pages
Book Rating : 4.0/5 (16 download)

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Book Synopsis Gender Differences at Puberty by : Chris Hayward

Download or read book Gender Differences at Puberty written by Chris Hayward and published by Cambridge University Press. This book was released on 2003-07-31 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the emergence of gender difference, summarizing the most up-to-date interdisciplinary research.

Atlas of Histology of the Juvenile Rat

Author : George A Parker
Publisher : Academic Press
ISBN 13 : 0128026960
Total Pages : 464 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Atlas of Histology of the Juvenile Rat by : George A Parker

Download or read book Atlas of Histology of the Juvenile Rat written by George A Parker and published by Academic Press. This book was released on 2016-05-04 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. Written and edited by highly experienced, board-certified toxicologic pathologists Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies Detailed figure legends and chapter narratives present the salient features of each organ at each time interval Figures are available for further study via Elsevier’s Virtual Microscope, which allows viewing of microscopic images at higher magnification Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification

Toxicological Profile for Lead

Author :
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Lead by :

Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Ultrasonic Vocalization

Author : Stefan M Brudzynski
Publisher : Academic Press
ISBN 13 : 0128097736
Total Pages : 582 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Handbook of Ultrasonic Vocalization by : Stefan M Brudzynski

Download or read book Handbook of Ultrasonic Vocalization written by Stefan M Brudzynski and published by Academic Press. This book was released on 2018-04-27 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Ultrasonic Vocalization: Window into the Mammalian Brain, Volume 25, is an exhaustive resource on ultrasonic vocalizations in vertebrates, providing full coverage of all aspects of these vocalizations. The book also demonstrates the usefulness of ultrasonic vocalizations in studies of animal communication, sociobiological states, and in mammalian models of affective disorders, addictions and neurodevelopmental disorders, making it an indispensable resource for researchers using animal models. The book begins with the evolution of vocal communication before discussing mechanisms of ultrasound production, perception and the brain systems involved in emotional arousal that are responsible for the generation of vocalization and emotional states. In addition, the book covers studies of neuroactive agents and sociopsychological conditions that can regulate the outcome of ultrasonic vocalization and provide clues about animals’ internal states. Critically, the book also includes thorough coverage of pharmacological investigations using ultrasonic vocalizations, increasingly being utilized for studies in affective disorders, psychoses, addiction and alcoholism. No other book provides such extensive coverage of this rapidly growing field of study. Represents a multidisciplinary approach that incorporates evolution, communication, behavioral homeostasis, emotional expression and neuropsychiatric dysfunction Provides a systematic review of ultrasonic vocalizations in major groups of rodents widely used in laboratory research Discusses numerous other species across vertebrates that emit ultrasounds

Clinical Gynecology

Author : Eric J. Bieber
Publisher : Cambridge University Press
ISBN 13 : 1107040396
Total Pages : 1127 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Clinical Gynecology by : Eric J. Bieber

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Handbook of Sports Medicine and Science

Author : Dennis J. Caine
Publisher : John Wiley & Sons
ISBN 13 : 1118357574
Total Pages : 418 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Handbook of Sports Medicine and Science by : Dennis J. Caine

Download or read book Handbook of Sports Medicine and Science written by Dennis J. Caine and published by John Wiley & Sons. This book was released on 2013-07-18 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Handbook of Sports Medicine and Science series, published in conjunction with the Medical Commission of the International Olympic Committee, offers comprehensive and practical guidance on the training and medical care of competitive gymnasts. Written and edited by leading trainers, team doctors, coaches and other professionals with unparalleled experience in elite gymnastics, this book covers all the key aspects of caring for gymnasts, minimizing the unique risks these athletes face, and treating injuries when they happen. The book is organized into 4 sections covering: The evolution of gymnastics Growth and development Training and performance Sports medicine Individual chapters cover key topics such as energy needs and body weight management; biomechanics; psychology; the epidemiology of gymnastic injuries; treatment and rehabilitation of common injuries; injury prevention; and more. Endorsed by the International Gymnastics Federation (FIG), no other book offers such an in-depth look at the unique considerations and challenges that affect the growth, performance, training, and medical care of athletes in this demanding sport.

Hormones, Brain and Behavior

Author : Donald W. Pfaff
Publisher : Academic Press
ISBN 13 : 012532104X
Total Pages : 957 pages
Book Rating : 4.1/5 (253 download)

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Book Synopsis Hormones, Brain and Behavior by : Donald W. Pfaff

Download or read book Hormones, Brain and Behavior written by Donald W. Pfaff and published by Academic Press. This book was released on with total page 957 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Posttraumatic Stress Disorder

Author : J. Douglas Bremner
Publisher : John Wiley & Sons
ISBN 13 : 111835611X
Total Pages : 465 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Posttraumatic Stress Disorder by : J. Douglas Bremner

Download or read book Posttraumatic Stress Disorder written by J. Douglas Bremner and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Posttraumatic Stress Disorder: From Neurobiology to Treatment presents a comprehensive look at this key neuropsychiatric disorder. The text examines the neurobiological basis of post-traumatic stress and how our understanding of the basic elements of the disease have informed and been translated into new and existing treatment options. The book begins with a section on animal models in posttraumatic stress disorder research, which has served as the basis of much of our neurobiological information. Chapters then delve into applications of the clinical neuroscience of posttraumatic stress disorder. The final part of the books explores treatments and how our basic and clinical research is now being converted into treatment. Taking a unique basic science to translational intervention approach, Posttraumatic Stress Disorder: From Neurobiology to Treatment is an invaluable resource for researchers, students and clinicians dealing with this complex disorder.

Steroid Hormone Resistance

Author : George P. Chrousos
Publisher : Springer Science & Business Media
ISBN 13 : 1468451014
Total Pages : 436 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Steroid Hormone Resistance by : George P. Chrousos

Download or read book Steroid Hormone Resistance written by George P. Chrousos and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents the first attempt to present in one place the clinical syndromes and the pathophysiologic basis for the "resistance states" to each of the classes of steroid hormones. Glucocorticoids, mineralocorticoids, androgens, estrogens, progesterone and vitamin D have widely diverse roles ranging from the control of homeostasis to reproduction and bone formation. They are similar in that they share a chemical structure and that their action is in the cell nucleus where they induce transcription of specific genes leading to synthesis of function-specific proteins. Clinical syndromes of steroid hormone resistance to androgens (complete and partial testicular feminization), aldosterone (pseudo hypoaldosteronism) and vitamin D (vitamin D-dependent rickets type II) have been known for many years. Progesterone and glucocorticoid resistance syndromes have been described only recently. Resistance to estrogens has not been reported in man or in animals. It is hoped that a detailed reexamination of what is known about each of these conditions at the clinical and molecular levels will enhance our understanding of the function of these hormones and their mechanisms of action. New insight and research initiatives should result. G.P. Chrousos D.L. Loriaus M.B. Lipsett vii ACKNOWLEDGMENTS The contents of this volume are based in part on the proceedings of an International Conference held in Bethesda in the summer of 1984. This conference was sponsored by the National Institute of Child Health and Human Development, Bethesda, Maryland.

Diagnosis and Management of Ovarian Disorders

Author : Albert Altchek
Publisher : Elsevier
ISBN 13 : 008049451X
Total Pages : 595 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek

Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders.KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine

Polycystic Ovary Syndrome

Author : Andrea Dunaif
Publisher : Springer Science & Business Media
ISBN 13 : 1597451088
Total Pages : 361 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Polycystic Ovary Syndrome by : Andrea Dunaif

Download or read book Polycystic Ovary Syndrome written by Andrea Dunaif and published by Springer Science & Business Media. This book was released on 2008-01-12 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic basis. All four editors of this title are extremely prominent in the field of PCOS.