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Development Of Red Clover Necrotic Mosaic Virus As A Multifunctional Nanoparticle
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Book Synopsis Development of Red Clover Necrotic Mosaic Virus as a Multifunctional Nanoparticle by : Li Na Loo
Download or read book Development of Red Clover Necrotic Mosaic Virus as a Multifunctional Nanoparticle written by Li Na Loo and published by . This book was released on 2007 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: nanoparticle, development of Red clover necrotic mosaic virus, drug delivery tool.
Book Synopsis Development of Red Clover Necrotic Mosaic Virus as a Multifunctional Nanoparticle by :
Download or read book Development of Red Clover Necrotic Mosaic Virus as a Multifunctional Nanoparticle written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Red clover necrotic mosaic virus (RCNMV) is a member of the genus Dianthovirus and the family Tombusviridae. RCNMV is a plant virus with 180 identical capsid proteins (CP) arranged to form a T = 3 icosahedral symmetry. The capsid, with an outer diameter of 36 nm and an inner diameter of 17 nm, is enclosed to package two ssRNA: RNA-1 (3.9 kb) and RNA-2 (1.5 kb). In nature, a 20 nucleotide hairpin structure within the RNA-2 sequence trans-activator region forms a kissing loop complex with 8 nucleotides of the RNA-1 to serve as the origin of assembly (OAS). This pseudo-knot structure selectively recruits CP to initiate the virus assembly. In one of the research directions, an oligonucleotide mimic of the OAS sequence was attached to Au, CoFe2O4, and CdSe nanoparticles ranging from 3-15 nm, to trigger virus-like assembly by RCNMV CP. The formation of virus-like particles encapsidated nanoparticles was comparable in size to the native RCNMV. Attempts to encapsidate nanoparticles with diameters> 17 nm did not result in well-formed particles. The versatility of RCNMV capsid to package smaller cargo was explored. RCNMV experiences reversible swelling transition in a pH- and divalent ion-dependent manner. This transition leads to the reversible opening of pores (~13 Å) that permit infusion of molecules into the interior cavity. Comparison of three dyes, Rhodamine (positive charge), Luminarosine (neutral) and Fluorescein (negative charge) shows that infusion is controlled by electrostatic interactions. This method was applied to package an anticancer drug, Doxorubicin, within the capsid. The capability of the RCNMV capsid to deliver cargo into cancer cells was explored. Peptides from various serotypes of adenovirus were conjugated to the capsid to determine the internalization efficiency. The modified RCNMV was prepared with packaged molecules in the interior cavity and targeting peptide on the exterior surface. Intracellular uptake was studied both in terms of RCNMV interna.
Book Synopsis Recent Developments in Applied Microbiology and Biochemistry by : Viswanath Buddolla
Download or read book Recent Developments in Applied Microbiology and Biochemistry written by Viswanath Buddolla and published by Academic Press. This book was released on 2018-10-27 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Developments in Applied Microbiology and Biochemistry provides a comprehensive treatment and understanding on application oriented microbial concepts, giving readers insights into recent developments in microbial biotechnology and medical, agricultural and environmental microbiology. Discusses microbial proteomics and their importance in medical microbiology Explores emerging trends in the prevention of current global health problems, such as cancer and obesity Shows recent approaches in the production of novel enzymes from environmental samples by enrichment culture and metagenomics approaches Guides readers through the status and recent developments in analytical methods for the detection of foodborne microorganisms
Book Synopsis Plant Virus Nanoparticles as Targeting Agents: New Tools for Cell Biology by :
Download or read book Plant Virus Nanoparticles as Targeting Agents: New Tools for Cell Biology written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT KELLEY, RICHARD LEE. Plant virus nanoparticles as targeting agents: New tools for cell biology. (Under the direction of Stefan Franzen) In order to develop Red clover necrotic mosaic virus as a novel drug carrier to target specific cancer cells, the structure and viability of a prospective plant viral nanoparticle was studied. Initially, the assembly process of the virus was duplicated in vitro using transcript RNAs and capsid protein harvested from disassembled wild type virus. Using virus obtained by the preferred method of plant propagation, wild type virus was evaluated in vivo and gave no deleterious effects. The mice suffered no acute toxicity, no detected immune response and no evidence of biodistribution in any internal organs. With an understanding of preliminary toxicity, a formulation to target HeLa cells was produced to verify and expand on in vitro and in vivo testing results. The initial attempt at cell targeting visualization using a luciferin/luciferase luminescence indicator did not provide conclusive evidence of cellular uptake.
Book Synopsis Drug Delivery Technology Development in Canada by : Kishor M.Wasan
Download or read book Drug Delivery Technology Development in Canada written by Kishor M.Wasan and published by MDPI. This book was released on 2019-12-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Canada continues to have a rich history of ground-breaking research in drug delivery within academic institutions, pharmaceutical industry and the biotechnology community. Over the past 30 years, numerous Canadian-based biotechnology companies have been formed from the inventions conceived and developed within academic institutions that have led to the development of important drug delivery products that have enhanced the landscape of drug therapy in the treatment of cancer to infectious diseases. This Special Issue serves to highlight and capture the contemporary progress of drug delivery within the prevailing Canadian context. We invite articles on all aspects of drug delivery sciences from pre-clinical formulation development to human clinical trials that bring to light the world-class research currently undertaken in Canada for this Special Issue.
Book Synopsis Viral Nanoparticles by : Nicole F. Steinmetz
Download or read book Viral Nanoparticles written by Nicole F. Steinmetz and published by CRC Press. This book was released on 2019-08-21 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book overviews the applications of viral nanoparticles (VNPs) in areas ranging from materials science to biomedicine. It summarizes the many different VNP building blocks and describes chemistries that allow one to attach, entrap, or display functionalities on VNPs. The book outlines the strategies for the construction of 1-, 2-, and 3-D arrays, highlights the achievements in utilizing VNPs as tools for novel biosensors and nanoelectronic devices, and describes efforts in designing VNPs for biomedical applications, including their use as gene delivery vectors, novel vaccines, imaging modalities, and applications in targeted therapeutics.
Book Synopsis Plant Virus-Host Interaction by : R.K. Gaur
Download or read book Plant Virus-Host Interaction written by R.K. Gaur and published by Academic Press. This book was released on 2021-01-12 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Virus-Host Interaction: Molecular Approaches and Viral Evolution, Second Edition, provides comprehensive coverage of molecular approaches for virus-host interaction. The book contains cutting-edge research in plant molecular virology, including pathogenic viroids and transport by insect vectors, interference with transmission to control viruses, synergism with pivotal coverage of RNA silencing, and the counter-defensive strategies used by viruses to overcome the silencing response in plants. This new edition introduces new, emerging proteins involved in host-virus interactions and provides in-depth coverage of plant virus genes’ interactions with host, localization and expression. With contributions from leading experts, this is a comprehensive reference for plant virologists, molecular biologists and others interested in characterization of plant viruses and disease management. Introduces new, emerging proteins involved during the host-virus interaction and new virus strains that invade new crops through recombination, resorting and mutation Provides molecular approaches for virus-host interaction Highlights RNA silencing and counter-defensive strategies for disease management Discusses the socioeconomic implications of viral spread and mitigation techniques
Book Synopsis Proceedings of ISPMF 2018 - Plant Molecular Farming by : Anneli Ritala
Download or read book Proceedings of ISPMF 2018 - Plant Molecular Farming written by Anneli Ritala and published by Frontiers Media SA. This book was released on 2020-06-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Viral Diseases of Field and Horticultural Crops by : L. P. Awasthi
Download or read book Viral Diseases of Field and Horticultural Crops written by L. P. Awasthi and published by Elsevier. This book was released on 2023-09-20 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral Diseases of Field and Horticultural Crops details the fundamental and applied aspects of the viral diseases of field and horticultural crops. The book opens with a historical introduction to plant virology, important plant virologists, and landmarks. It continues with systematic coverage of viral diseases, their economic significance, disease symptoms, host range, mode of transmission, diagnostic techniques, geographic distribution, epidemiology, yield losses, and control and management of the disease. Contributions from an international group of virologists with a wide range of academic, research, professional, and specialized backgrounds in plant virology makes Viral Diseases of Field and Horticultural Crops a comprehensive and must-have resource for those engaged in the study and research of plant virology, microbiology, and plant pathology particularly viral diseases and their impact on field and horticultural crops. Provides virus characterization according to the disease pattern and symptoms they cause Covers viral diseases of cereals, oil seeds, legumes, commercial crops, spices and condiments, medicinal and aromatic crops, forage crops, vegetable crops, fruit crops, tree nuts, among others Discusses advances like applications in nanotechnology, molecular techniques for the detection and characterization of plant viruses, and the development of technologies for detecting plant viruses
Book Synopsis Handbook of Nanotechnology in Nutraceuticals by : Shakeel Ahmed
Download or read book Handbook of Nanotechnology in Nutraceuticals written by Shakeel Ahmed and published by CRC Press. This book was released on 2022-11-21 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology has been emerging as an important tool in the nutraceutical and food industries to improve the overall quality of life. Nanotechnology has established a new horizon by bestowing modified properties on nanomaterials and applying them to the production of nanoformulations, nutritional supplements, and the food industry. The Handbook of Nanotechnology in Nutraceuticals highlights the impact of nanotechnology on the food industries. The book focuses on the application of nanotechnology in nutraceuticals and the food industry to improve the overall quality of life. The book also addresses some important applications of nano-nutraceuticals in the treatment of different diseases, such as oxidative stress, cancer, neurodegenerative disorders, cardiovascular diseases, and so on. Features • Presents a scientometric approach to analyze the emergence of nano-nutraceuticals in cancer prevention and treatment • Examines various strategies employed to prepare nanocarrier systems, such as nanoparticles, nanostructure lipids, phospholipid-based nanocarriers, polysaccharide-based nanostructures, and metal nanoparticles • Discusses various regulatory issues related to nanotechnology and their application in different fields This book is a valuable reference for nanotechnologists, scientists, and researchers working in the field of food technology, food science, pharmaceuticals, and nutraceuticals.
Download or read book Protein Cages written by Brendan P. Orner and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume emphasizes new techniques to help understand protein cages and to apply them to a variety of technologies, highlighting the expertise of researchers based on three continents. Protein cages are currently inspiring diverse scientific disciplines and are therefore at the crossroads of extremely widely-scoped research, which is reflected in the detailed chapters of Protein Cages: Methods and Protocols. From nanomaterials studies and iron particles to computational strategies and Atomic Force Microscopy, the chapters herein collectively provide an introduction to the rich world of protein cage research and specific techniques to understand and exploit this fascinating class of proteins. Written in the highly successful Methods in Molecular Biology series format, chapters begin with an introduction to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Protein Cages: Methods and Protocols will help to inspire and further propel the current multi-disciplinary enthusiasm in studying and discovering new applications for protein cages.
Book Synopsis Nanostructures for Novel Therapy by : Denisa Ficai
Download or read book Nanostructures for Novel Therapy written by Denisa Ficai and published by Elsevier. This book was released on 2017-02-25 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructures for Novel Therapy: Synthesis, Characterization and Applications focuses on the fabrication and characterization of therapeutic nanostructures, in particular, synthesis, design, and in vitro and in vivo therapeutic evaluation. The chapters provide a cogent overview of recent therapeutic applications of nanostructured materials that includes applications of nanostructured materials for wound healing in plastic surgery and stem cell therapy. The book explores the promise for more effective therapy through the use of nanostructured materials, while also assessing the challenges their use might pose from both an economic and medicinal point of view. This innovative look at how nanostructured materials are used in therapeutics will be of great benefit to researchers, providing a greater understanding of the different ways nanomaterials could improve medical treatment, along with a discussion of the obstacles that need to be overcome in order to guarantee widespread availability. Outlines how the characteristics of nanostructures made from different materials gives particular properties that can be successfully used in therapeutics Compares the properties of different nanostructures, allowing medicinal chemists and engineers to select which are most appropriate for their needs Highlights new uses of nanostructures within the therapeutic field, enabling the discovery of new, more effective drugs
Download or read book Biofabrication written by Yi Cheng and published by Elsevier Inc. Chapters. This book was released on 2013-03-18 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrated circuits transformed our lives, and the potential for integrating biology with devices promises even greater transformations. A key question is how to effectively interface biological and microfabricated systems. Our approach is to “biofabricate” the biology-device interface using biological materials and mechanisms. Here, we review recent progress on three biofabrication approaches: the use of stimuli-responsive materials to recognize device-imposed electrical inputs to direct the assembly (i.e., to electrodeposit) of hydrogels; the use of enzymes to build structure by conjugating and crosslinking macromolecules; and the use of genetic techniques to engineer proteins for assembly. We further illustrate how these biofabrication approaches enable the biofunctionalization of previously fabricated microfluidic devices and suggest the potential for lab-on-chip analysis and the creation of experimental devices to study complex biological systems. We anticipate that the complementarity between biological and technological fabrication paradigms will provide broad opportunities to build structures that couple the power of electronics to the versatility of biology.
Book Synopsis Nanobiotechnology Applications in Plant Protection by : Kamel A. Abd-Elsalam
Download or read book Nanobiotechnology Applications in Plant Protection written by Kamel A. Abd-Elsalam and published by Springer Nature. This book was released on 2019-10-04 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiotechnology Applications in Plant Protection: Volume 2 continues the important and timely discussion of nanotechnology applications in plant protection and pathology, filling a gap in the literature for nano applications in crop protection. Nanobiopesticides and nanobioformulations are examined in detail and presented as powerful alternatives for eco-friendly management of plant pathogens and nematodes. Leading scholars discuss the applications of nanobiomaterials as antimicrobials, plant growth enhancers and plant nutrition management, as well as nanodiagnostic tools in phytopathology and magnetic and supramagnetic nanostructure applications for plant protection. This second volume includes exciting new content on the roles of biologically synthesized nanoparticles in seed germination and zinc-based nanostructures in protecting against toxigenic fungi. Also included is new research in phytotoxicity, nano-scale fertilizers and nanomaterial applications in nematology and discussions on Botyris grey mold and nanobiocontrol. This book also explores the potential effects on the environment, ecosystems and consumers and addresses the implications of intellectual property for nanobiopesticides. Further discussed are nanotoxicity effects on the plant ecosystem and nano-applications for the detection, degradation and removal of pesticides.
Book Synopsis Nanoparticles in Medicine by : Ashutosh Kumar Shukla
Download or read book Nanoparticles in Medicine written by Ashutosh Kumar Shukla and published by Springer Nature. This book was released on 2019-08-31 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the medical applications of inorganic nanoparticles. Nanomedicine is a relatively advanced field, which enhances the treatment of various diseases, offering new options for overcoming the problems associated with the use of conventional medicines. Discussing the toxicological and safety aspects associated with medical applications of nanoparticles, the book presents the latest research on topics such as emerging nanomaterials for cancer therapy, applications of nanoparticles in dentistry, and fluoride nanoparticles for biomedical applications, and also includes chapters on the use of nanoparticles such as silver and gold. /div
Book Synopsis Sustainable Solutions for Elemental Deficiency and Excess in Crop Plants by : Kumkum Mishra
Download or read book Sustainable Solutions for Elemental Deficiency and Excess in Crop Plants written by Kumkum Mishra and published by Springer Nature. This book was released on 2020-11-28 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of deficiency of essential elements and excess of toxic ones in crop plants. The metal deficiency and toxicity are the two sides of same problem that are threatening to sustainable agricultural growth. The book presents prospective strategies for the management of elemental nutrition of crop plants. Chapters are arranged in a manner so as to develop a lucid picture of the topic beginning from basics to advanced research. The content is supplemented with flow charts and figures to make it convenient for readers to holistically grasp the concepts. It will be a value addition for students, research scholars and professionals in understanding the basics as well latest developments in the area of metal deficiency and excess in crop plants.
Book Synopsis Encyclopedia of Virology by : Allan Granoff
Download or read book Encyclopedia of Virology written by Allan Granoff and published by Academic Press. This book was released on 1999-09-03 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the mate rial covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics.
