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Author : Emy Varughese
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book DEVELOPMENT OF A DOMESTIC ANIMAL MODEL OF ENDOMETRIOSIS. written by Emy Varughese and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kathy L. Sharpe-Timms
Publisher : Springer Nature
ISBN 13 : 3030518566
Total Pages : 111 pages
Book Rating : 4.0/5 (35 download)
Download or read book Animal Models for Endometriosis written by Kathy L. Sharpe-Timms and published by Springer Nature. This book was released on 2020-12-05 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology focuses on the need for and use of animal models when studying endometriosis. Covering models ranging from rodents to baboons, it explores novel mechanisms involved in the pathophysiology of endometriosis. Topics range from the role of miRNAs and environmental endocrine disrupters to pain and endometriosis-associated subfertility. Estimated to affect up to 10% of women, endometriosis is a widespread and in some cases debilitating disease. While studies on the pathophysiology of the disease and the development of treatments for endometriosis-associated subfertility are called for, acquiring appropriate tissues from women with and without endometriosis in combination with physiologically relevant in vitro and in vivo laboratory models is an essential aspect. However, control subjects with similar ages, living environments and medical histories, besides endometriosis, are hard to find and attaining suitable human reproductive tissues is linked to an ongoing ethical discussion, especially when studying embryos. Laboratory models like rodent and monkey models are therefore needed to fill the research gap and support hypothesis-driven, randomized, controlled experimental design studies. In this book we highlight the latest developments and findings in endometriosis research using animal models. The book was written for scientists, physicians and medical students working in the field of reproductive science, and for women with endometriosis.
Author : Yongye Huang
Publisher : Frontiers Media SA
ISBN 13 : 2832526888
Total Pages : 155 pages
Book Rating : 4.8/5 (325 download)
Download or read book Applying large animals for developmental study and disease modeling written by Yongye Huang and published by Frontiers Media SA. This book was released on 2023-06-21 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicola Maria Nowak
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 (314 download)
Download or read book Development and Evaluation of Two Mouse Models for Endometriosis Focused on the Involvement of the Immune System in Endometriosis Establishment written by Nicola Maria Nowak and published by . This book was released on 2008 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dev R. Chadha
Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.3/5 (91 download)
Download or read book Current Concepts in Endometriosis written by Dev R. Chadha and published by Wiley-Liss. This book was released on 1990 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a state-of-the-art analysis of recent developments in the study of the complex disease, endometriosis. It addresses new trends with a reappraisal of the use of therapeutic agents, particularly the new entrant LHRH analog. Among the aspects of the disease covered are prevalence, pathogenesis, histogenesis, diagnosis, classification, and medical and surgical management, with further attention given to such issues as the pros and cons of laparoscopic management of endometriosis with lasers, in vitro fertilization and embryo transfer, and Nafarelin, a new medical therapy. The book establishes a definition of optimal patient care based on the latest treatment techniques and presents innovative approaches to the often neglected area of preventive management. Finally, Current Concepts in Endometriosis indicates useful directions for future investigation of this perplexing disease.
Author : Heide Schatten
Publisher : John Wiley & Sons
ISBN 13 : 1118881605
Total Pages : 608 pages
Book Rating : 4.1/5 (188 download)
Download or read book Animal Models and Human Reproduction written by Heide Schatten and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that reflects the latest scientific research being done in human reproductive biology utilizing domestic animal models. Chapters on canine, equine, cow, pig, frog, and mouse models of reproduction reflect frontier research in placental biology, ovarian function and fertility, non-coding RNAs in gametogenesis, oocyte and embryo metabolism, fertilization, cryopreservation, signal transduction pathways, chromatin dynamics, epigenetics, reproductive aging, and inflammation. Chapters on non-human primate models also highlight recent advancements into such issues as human in vitro fertilization (IVF) and assisted reproductive technologies (ART). This book offers animal scientists, reproductive biology scientists, clinicians and practitioners, invaluable insights into a wide range of issues at the forefront of human reproductive health.
Author : Fabian Kiessling
Publisher : Springer
ISBN 13 : 3319422022
Total Pages : 871 pages
Book Rating : 4.3/5 (194 download)
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book The Cannabinoid Receptor CB1 Contributes to the Development of Ectopic Lesions in a Mouse Model of Endometriosis written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roxane Assaf
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (18 download)
Download or read book Porcupine-dependent Wnt Signaling in Endometriosis Development and Maintenance written by Roxane Assaf and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Endometriosis is a debilitating condition that affects over 10% of women and is characterized by the presence of endometrial tissue outside the uterus, most often in the pelvic cavity. It is thought to arise through retrograde menstruation where endometrial tissue is displaced into the peritoneal cavity where it implants and develops into lesions that can cause inflammation, tissue scarring, and it can subsequently result in pelvic pain in response to estrogen cycling. Although this disease affects a large number of women and impacts their quality of life, its underlying molecular mechanisms are not understood. Wnt signaling plays a role in uterine development and function. Specifically, Porcupine-dependent Wnt signaling is needed for the maintenance of endometrial glands and stromal proliferation. Some evidence suggests that Wnt signaling is aberrantly activated in patients' endometriosis lesions, but the pattern of its activation has not been established. We hypothesized that Porcupine-dependent Wnt signaling plays a role in the development and maintenance of endometriosis, and that it could be a potential therapeutic target. Using the auto-transplantation mouse model and a Tcf/Lef-LacZ construct, we characterized canonical Wnt signaling activation in endometriosis in vivo. We found that canonical Wnt signaling was activated in the endometrial epithelium of these endometriotic lesions. To assess the role of canonical Wnt signaling, reproductive tract-specific conditional Porcupine mutant female mice which do not secrete Wnt ligands in the uterus were used. No Wnt signaling activation was found in the lesions of Porcupine mutant, suggesting that in control mice, Wnt signaling is auto-activated by ligands that are secreted by the lesions themselves, and not by surrounding tissue. Additionally, in these mutants, endometriotic lesions developed with increased growth, which was not due to differences in cell proliferation rates but was rather associated with somewhat increased fibrosis. A similar result was observed when we treated wild-type mice with IWP-2, a Porcupine inhibitor, although this compound also resulted in lower levels of endometriosis-associated pain. Our findings therefore suggest that Porcupine-dependent Wnt signaling is activated in endometriosis and affects lesion size and endometriosis-associated pain." --
Author : Madhuri S. Salker
Publisher : Frontiers Media SA
ISBN 13 : 2889745228
Total Pages : 265 pages
Book Rating : 4.8/5 (897 download)
Download or read book Hype or Hope: New Frontiers in Endometrial Research written by Madhuri S. Salker and published by Frontiers Media SA. This book was released on 2022-02-25 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sophia Virani
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.:/5 (775 download)
Download or read book Role of Stromal Cell-derived Factor-1 in Neoangiogenesis in Endometriosis Lesions written by Sophia Virani and published by . This book was released on 2011 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endometriosis affects 5-10% of women and is characterized by the growth of endometrial tissue outside of the uterus. Treatment for endometriosis primarily focuses on symptom relief, is short term with severe side effects and often leads to recurrence of the condition. Establishing new blood supply is a fundamental requirement for endometriosis lesions growth. This has led to the idea that antiangiogenic therapy may be a successful approach for inhibiting endometriosis. Recent evidence indicates that endothelial progenitor cells (EPCs) contribute to neoangiogenesis of endometriotic lesions. These EPCs are recruited to the lesion site by stromal cell-derived factor-1 (SDF-1). We hypothesize that SDF-1 is central to the neoangiogenesis and survival of endometriotic lesions and that administration of SDF-1 blocking antibody will inhibit lesion growth by inhibiting angiogenesis in a murine model of endometriosis. Immunohistochemistry for SDF-1 and CD34 was performed on human endometriosis and normal endometrial samples. Quantification of SDF-1 and EPCs was performed in the blood of endometriosis patients and controls using ELISA and flow cytometry, respectively. A new mouse model of endometriosis was developed using BALB/c-Rag2-/-/IL2rg-/- mice to investigate role of SDF-1 in neoangiogenesis. Either SDF-1 blocking antibody or an isotype control was administered on a weekly basis for four weeks. Weekly samples of peripheral blood from mice were analyzed for SDF-1, other cytokines of interest and EPCs. Mice were euthanized at seven weeks to observe lesion growth and blood vessel development. Our results indicate overabundance of SDF-1 and CD34+ progenitor cells in human endometriotic lesions compared to eutopic endometrium. In the mouse model, SDF-1 and circulating EPC levels decreased from pre-treatment levels after one week, and remained constant over the course of the treatment in both SDF-1 blocking antibody and isotype control groups. In the SDF-1 blocking group, reduced vascularity of lesions, identified by immunofluorescence staining for CD31, was revealed compared to isotype controls. These findings suggest that SDF-1 may be responsible for CD34+ progenitor cell recruitment to the neoangiogenic sites in endometriosis. Blocking of SDF-1 reduces neovascularization of human endometriotic lesions in a mouse model. Further studies on blocking SDF-1 in combination with other antiangiogenic agents are needed.
Author :
Publisher : Academic Press
ISBN 13 : 0128151455
Total Pages : 3905 pages
Book Rating : 4.1/5 (281 download)
Download or read book Encyclopedia of Reproduction written by and published by Academic Press. This book was released on 2018-06-29 with total page 3905 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Reproduction, Second Edition, Six Volume Set comprehensively reviews biology and abnormalities, also covering the most common diseases in humans, such as prostate and breast cancer, as well as normal developmental biology, including embryogenesis, gestation, birth and puberty. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters also explore the latest advances in cloning, stem cells, endocrinology, clinical reproductive medicine and genomics. As reproductive health is a fundamental component of an individual’s overall health status and a central determinant of quality of life, this book provides the most extensive and authoritative reference within the field. Provides a one-stop shop for information on reproduction that is not available elsewhere Includes extensive coverage of the full range of topics, from basic, to clinical considerations, including evolutionary advances in molecular, cellular, developmental and clinical sciences Includes multimedia and interactive teaching tools, such as downloadable PowerPoint slides, video content and interactive elements, such as the Virtual Microscope
Author :
Publisher :
ISBN 13 :
Total Pages : 1272 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1990 with total page 1272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 1940 pages
Book Rating : 4.:/5 (319 download)
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Author : Douglas T. Carrell
Publisher : Springer
ISBN 13 : 3319178490
Total Pages : 242 pages
Book Rating : 4.3/5 (191 download)
Download or read book Biennial Review of Infertility written by Douglas T. Carrell and published by Springer. This book was released on 2015-06-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its fourth volume, the Biennial Review of Infertility brings together the most up-to-date research and clinical information on male and female infertility, emerging assisted reproductive techniques and evolving controversies in reproductive medicine. An impressive panel of contributors presents cutting-edge information in a clear and well-balanced manner. Volume 4 discusses hot topics in contemporary reproductive medicine, including stem cell technologies for male infertility, the current state of ovarian tissue cryopreservation and time-lapse video microscopy of embryos. The expanded section on controversies allows for point/counterpoint discussion between experts with differing opinions on topics like eSET and the use and role of dietary supplements in IVF cycles. Created to provide an ongoing appraisal of current knowledge, the Biennial Review of Infertility stimulates communication amongst all clinicians and researchers working to help couples resolve their infertility.
Author :
Publisher :
ISBN 13 :
Total Pages : 2616 pages
Book Rating : 4.3/5 (91 download)
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2616 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.3/5 (555 download)
Download or read book Journal of Reproduction and Fertility written by and published by . This book was released on 1995-05 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes the Proceedings of the Society for the Study of Fertility.
