Development And Integration Of Informatic Tools For Qualitative And Quantitative Characterization Of Proteomic Datasets Generated By Tandem Mass Spectrometry

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Development and Integration of Informatic Tools for Qualitative and Quantitative Characterization of Proteomic Datasets Generated by Tandem Mass Spectrometry

Author : Rachel Michelle Adams
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.:/5 (112 download)

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Book Synopsis Development and Integration of Informatic Tools for Qualitative and Quantitative Characterization of Proteomic Datasets Generated by Tandem Mass Spectrometry by : Rachel Michelle Adams

Download or read book Development and Integration of Informatic Tools for Qualitative and Quantitative Characterization of Proteomic Datasets Generated by Tandem Mass Spectrometry written by Rachel Michelle Adams and published by . This book was released on 2013 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shotgun proteomic experiments provide qualitative and quantitative analytical information from biological samples ranging in complexity from simple bacterial isolates to higher eukaryotes such as plants and humans and even to communities of microbial organisms. Improvements to instrument performance, sample preparation, and informatic tools are increasing the scope and volume of data that can be analyzed by mass spectrometry (MS). To accommodate for these advances, it is becoming increasingly essential to choose and/or create tools that can not only scale well but also those that make more informed decisions using additional features within the data. Incorporating novel and existing tools into a scalable, modular workflow not only provides more accurate, contextualized perspectives of processed data, but it also generates detailed, standardized outputs that can be used for future studies dedicated to mining general analytical or biological features, anomalies, and trends. This research developed cyber-infrastructure that would allow a user to seamlessly run multiple analyses, store the results, and share processed data with other users. The work represented in this dissertation demonstrates successful implementation of an enhanced bioinformatics workflow designed to analyze raw data directly generated from MS instruments and to create fully-annotated reports of qualitative and quantitative protein information for large-scale proteomics experiments. Answering these questions requires several points of engagement between informatics and analytical understanding of the underlying biochemistry of the system under observation. Deriving meaningful information from analytical data can be achieved through linking together the concerted efforts of more focused, logistical questions. This study focuses on the following aspects of proteomics experiments: spectra to peptide matching, peptide to protein mapping, and protein quantification and differential expression. The interaction and usability of these analyses and other existing tools are also described. By constructing a workflow that allows high-throughput processing of massive datasets, data collected within the past decade can be standardized and updated with the most recent analyses.

Quantitative Proteomics by Mass Spectrometry

Author : Salvatore Sechi
Publisher : Springer Science & Business Media
ISBN 13 : 1597452556
Total Pages : 223 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Quantitative Proteomics by Mass Spectrometry by : Salvatore Sechi

Download or read book Quantitative Proteomics by Mass Spectrometry written by Salvatore Sechi and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a compendium of cutting-edge protocols for quantitative proteomics, and presents the most significant methods used in the field today. The focus on mass spectrometry (MS) is integral. Attention is given to state-of-the-art techniques for the characterization of the phosphoproteome and tandem MS for detection of inborn errors of metabolism. This volume is an indispensable resource in the search for novel biomarkers.

Mass Spectrometry Data Analysis in Proteomics

Author : Rune Matthiesen
Publisher : Springer Science & Business Media
ISBN 13 : 1597452750
Total Pages : 322 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Mass Spectrometry Data Analysis in Proteomics by : Rune Matthiesen

Download or read book Mass Spectrometry Data Analysis in Proteomics written by Rune Matthiesen and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an in-depth guide to the theory and practice of analyzing raw mass spectrometry (MS) data in proteomics. The volume outlines available bioinformatics programs, algorithms, and databases available for MS data analysis. General guidelines for data analysis using search engines such as Mascot, Xtandem, and VEMS are provided, with specific attention to identifying poor quality data and optimizing search parameters.

Proteome Informatics

Author : Conrad Bessant
Publisher : Royal Society of Chemistry
ISBN 13 : 1782626735
Total Pages : 429 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Proteome Informatics by : Conrad Bessant

Download or read book Proteome Informatics written by Conrad Bessant and published by Royal Society of Chemistry. This book was released on 2016-11-15 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of proteomics has developed rapidly over the past decade nurturing the need for a detailed introduction to the various informatics topics that underpin the main liquid chromatography tandem mass spectrometry (LC-MS/MS) protocols used for protein identification and quantitation. Proteins are a key component of any biological system, and monitoring proteins using LC-MS/MS proteomics is becoming commonplace in a wide range of biological research areas. However, many researchers treat proteomics software tools as a black box, drawing conclusions from the output of such tools without considering the nuances and limitations of the algorithms on which such software is based. This book seeks to address this situation by bringing together world experts to provide clear explanations of the key algorithms, workflows and analysis frameworks, so that users of proteomics data can be confident that they are using appropriate tools in suitable ways.

An Integrated Experimental and Computational Approach to Proteomics: Scaling from High Resolution Qualitative Analysis to Quantitative Measurements with Confidence Evaluation

Download An Integrated Experimental and Computational Approach to Proteomics: Scaling from High Resolution Qualitative Analysis to Quantitative Measurements with Confidence Evaluation PDF Online Free

Author : Chongle Pan
Publisher :
ISBN 13 : 9781109893304
Total Pages : 283 pages
Book Rating : 4.8/5 (933 download)

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Book Synopsis An Integrated Experimental and Computational Approach to Proteomics: Scaling from High Resolution Qualitative Analysis to Quantitative Measurements with Confidence Evaluation by : Chongle Pan

Download or read book An Integrated Experimental and Computational Approach to Proteomics: Scaling from High Resolution Qualitative Analysis to Quantitative Measurements with Confidence Evaluation written by Chongle Pan and published by . This book was released on 2006 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the research described here, a substantial advancement in both qualitative and quantitative proteomic measurements was achieved using an integrated experiment and computational approach. The improved proteomic measurements can help elucidate a range of biological processes.

Proteome Characterization and Proteomics

Author : Timothy D. Veenstra
Publisher : Academic Press
ISBN 13 : 0080569153
Total Pages : 445 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Proteome Characterization and Proteomics by : Timothy D. Veenstra

Download or read book Proteome Characterization and Proteomics written by Timothy D. Veenstra and published by Academic Press. This book was released on 2003-10-01 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The content of this volume is designed to reach a wide audience, including those involved with relevant technologies such as electrophoresis and mass spectrometry, to those interested in how proteomics can benefit research. A wide range of techniques are discussed, each specifically designed to address different needs in proteomic analysis. The concluding chapter discusses the important issue related to handling large amounts of data accumulated in proteomic studies. - Discusses proteomics in the postgenomic age - Includes various strategies for quantitative proteomics - Covers the role of MS in structural functional proteomics and proteomics in drug discovery and bioinformatics

Mass Spectrometry-Based Chemical Proteomics

Author : W. Andy Tao
Publisher : John Wiley & Sons
ISBN 13 : 1118970217
Total Pages : 448 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Mass Spectrometry-Based Chemical Proteomics by : W. Andy Tao

Download or read book Mass Spectrometry-Based Chemical Proteomics written by W. Andy Tao and published by John Wiley & Sons. This book was released on 2019-07-10 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROVIDES STRATEGIES AND CONCEPTS FOR UNDERSTANDING CHEMICAL PROTEOMICS, AND ANALYZING PROTEIN FUNCTIONS, MODIFICATIONS, AND INTERACTIONS—EMPHASIZING MASS SPECTROMETRY THROUGHOUT Covering mass spectrometry for chemical proteomics, this book helps readers understand analytical strategies behind protein functions, their modifications and interactions, and applications in drug discovery. It provides a basic overview and presents concepts in chemical proteomics through three angles: Strategies, Technical Advances, and Applications. Chapters cover those many technical advances and applications in drug discovery, from target identification to validation and potential treatments. The first section of Mass Spectrometry-Based Chemical Proteomics starts by reviewing basic methods and recent advances in mass spectrometry for proteomics, including shotgun proteomics, quantitative proteomics, and data analyses. The next section covers a variety of techniques and strategies coupling chemical probes to MS-based proteomics to provide functional insights into the proteome. In the last section, it focuses on using chemical strategies to study protein post-translational modifications and high-order structures. Summarizes chemical proteomics, up-to-date concepts, analysis, and target validation Covers fundamentals and strategies, including the profiling of enzyme activities and protein-drug interactions Explains technical advances in the field and describes on shotgun proteomics, quantitative proteomics, and corresponding methods of software and database usage for proteomics Includes a wide variety of applications in drug discovery, from kinase inhibitors and intracellular drug targets to the chemoproteomics analysis of natural products Addresses an important tool in small molecule drug discovery, appealing to both academia and the pharmaceutical industry Mass Spectrometry-Based Chemical Proteomics is an excellent source of information for readers in both academia and industry in a variety of fields, including pharmaceutical sciences, drug discovery, molecular biology, bioinformatics, and analytical sciences.

Computational and Statistical Methods for Protein Quantification by Mass Spectrometry

Author : Ingvar Eidhammer
Publisher : John Wiley & Sons
ISBN 13 : 111849377X
Total Pages : 290 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Computational and Statistical Methods for Protein Quantification by Mass Spectrometry by : Ingvar Eidhammer

Download or read book Computational and Statistical Methods for Protein Quantification by Mass Spectrometry written by Ingvar Eidhammer and published by John Wiley & Sons. This book was released on 2012-12-10 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive introduction to data analysis in quantitative proteomics This book provides all the necessary knowledge about mass spectrometry based proteomics methods and computational and statistical approaches to pursue the planning, design and analysis of quantitative proteomics experiments. The author’s carefully constructed approach allows readers to easily make the transition into the field of quantitative proteomics. Through detailed descriptions of wet-lab methods, computational approaches and statistical tools, this book covers the full scope of a quantitative experiment, allowing readers to acquire new knowledge as well as acting as a useful reference work for more advanced readers. Computational and Statistical Methods for Protein Quantification by Mass Spectrometry: Introduces the use of mass spectrometry in protein quantification and how the bioinformatics challenges in this field can be solved using statistical methods and various software programs. Is illustrated by a large number of figures and examples as well as numerous exercises. Provides both clear and rigorous descriptions of methods and approaches. Is thoroughly indexed and cross-referenced, combining the strengths of a text book with the utility of a reference work. Features detailed discussions of both wet-lab approaches and statistical and computational methods. With clear and thorough descriptions of the various methods and approaches, this book is accessible to biologists, informaticians, and statisticians alike and is aimed at readers across the academic spectrum, from advanced undergraduate students to post doctorates entering the field.

Integration of Tandem Mass Spectrometry and Ion Mobility Spectrometry for Protein Characterization and Structural Analysis

Author : Deepali Rathore
Publisher :
ISBN 13 : 9781339663456
Total Pages : 213 pages
Book Rating : 4.6/5 (634 download)

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Book Synopsis Integration of Tandem Mass Spectrometry and Ion Mobility Spectrometry for Protein Characterization and Structural Analysis by : Deepali Rathore

Download or read book Integration of Tandem Mass Spectrometry and Ion Mobility Spectrometry for Protein Characterization and Structural Analysis written by Deepali Rathore and published by . This book was released on 2016 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry (MS) based proteomics and intact protein analyses are important tools for the structural study of proteins and provide powerful methods for solving biochemical puzzles involving proteins. The work described in this dissertation is aimed at the development of novel, efficient, and information rich strategies for protein structure and sequence analysis. The approaches developed have been applied to analytes ranging from proteolytic peptides to large non-covalent protein complexes.

Development of Fully Automatable Multidimensional Liquid Chromatography (MDLC) with Online Tandem Mass Spectrometry for Shotgun Proteomics

Download Development of Fully Automatable Multidimensional Liquid Chromatography (MDLC) with Online Tandem Mass Spectrometry for Shotgun Proteomics PDF Online Free

Author : Pak-Wing Kong
Publisher : Open Dissertation Press
ISBN 13 : 9781361278932
Total Pages : pages
Book Rating : 4.2/5 (789 download)

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Book Synopsis Development of Fully Automatable Multidimensional Liquid Chromatography (MDLC) with Online Tandem Mass Spectrometry for Shotgun Proteomics by : Pak-Wing Kong

Download or read book Development of Fully Automatable Multidimensional Liquid Chromatography (MDLC) with Online Tandem Mass Spectrometry for Shotgun Proteomics written by Pak-Wing Kong and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Development of Fully Automatable Multidimensional Liquid Chromatography (MDLC) With Online Tandem Mass Spectrometry for Shotgun Proteomics" by Pak-wing, Kong, 江柏榮, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Proteomics is the systematic study of the proteome: the total protein expression of a cell or tissue under specified conditions. The multiplicity and complexity of proteins in cells requires sensitive, selective, and comprehensive methodologies for their distinction and characterization. Multidimensional liquid chromatography (MDLC) coupled with biological tandem mass spectrometry (MS/MS) is uniquely suited to fulfill those requirements and has become an indispensable tool in MS-based proteomics. Our laboratory has developed an online high-/low-pH reversed-phase/reversed-phase (RP-RP) LC system exhibiting fully automatable and reproducible performance. It is a promising alternative to the strong cation exchange/reversed-phase (SCX-RP) system commonly used in high-throughput comprehensive proteomics analyses. The first part of this Thesis (Chapter 2) describes the development of a variant of the high-/low-pH RP-RP platform-RP-SCX-RP-that integrates an additional SCX trap column between the two RP columns to enhance sample recovery. This new system allows the detection of larger numbers of hydrophilic peptides. Indeed, in the analyses of a lysate of Arabidopsis chloroplast proteins, it identified approximately 25% more non-redundant proteins than those identified using the previous version of the RP-RP system. The modified platform has been extended for the online removal of sodium dodecyl sulfate and other excess interference chemicals used in Isobaric Tags for Relative and Absolute Quantification (iTRAQ) reactions, thereby avoiding the need for time-consuming offline SCX clean-up prior to RP-RP separation in the quantitative proteomics analyses of crude biological samples at low-microgram levels. A novel online three-dimensional liquid chromatography (3DLC) system was derived from the RP-SCX-RP design, exhibiting remarkably enhanced orthogonality, resolution, and peak capacity. Peptides were separated in the first-dimension high-pH RP column based on their hydrophobicity, followed by sub-fractionation in the second-dimension SCX column, primarily based on charge; the third dimension was a typical low-pH RP separation, prior to MS analysis. The overall performance of the system was evaluated through analysis of a cell lysate of mouse embryonic fibroblasts. Relative to the two-dimensional high-/low-pH RP-RP system, the new 3D system yielded significant increases in the number of unique peptides and proteins identified, making it a good alternative to SCX-RP and high-/low-pH RP-RP as an efficient automated MDLC platform for high-throughput shotgun proteomics. An optimized and miniaturized variant of the three-dimensional LC platform was also developed. Its simplified setup and operation, by decreasing the number of six-port switching valves (from three to two) and the number of SCX fractionation steps, minimized both the potential sample loss and the total analysis time (by ca. 30%). Thus, a variety of novel, automatable, and robust RP-SCX-RP-based MDLC platforms have been developed for high-throughput qualitative and quantitative analysis. The performance of these systems complements conventional MDLC systems, with enhanced quality, quantity, reproducibility, and throughput of protein identification and quantification. DOI: 10.5353/th_b4819927 Subjects: Liquid chromatography Mass spectrometry

Clinical Proteomics

Author : Antonia Vlahou
Publisher : Springer Science & Business Media
ISBN 13 : 158829837X
Total Pages : 401 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Clinical Proteomics by : Antonia Vlahou

Download or read book Clinical Proteomics written by Antonia Vlahou and published by Springer Science & Business Media. This book was released on 2008-01-18 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, a select group of researchers has contributed their state-of-the-art methodologies on protein profiling and identification of disease biomarkers in tissues, microdissected cells and body fluids. The book integrates biochemistry, pathology, analytical technology, bioinformatics, and proteome informatics. Experimental approaches are thoroughly detailed and explained through a step-by-step instructional format that ensures successful results.

Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics

Author : Michael Kinter
Publisher : Springer
ISBN 13 : 9781461486657
Total Pages : 0 pages
Book Rating : 4.4/5 (866 download)

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Book Synopsis Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics by : Michael Kinter

Download or read book Application of Selected Reaction Monitoring to Highly Multiplexed Targeted Quantitative Proteomics written by Michael Kinter and published by Springer. This book was released on 2013-09-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A key experiment in biomedical research is monitoring the expression of different proteins in order to detect changes that occur in biological systems under different experimental conditions. The method that is most widely used is the Western blot analysis. While Western blot is a workhorse in laboratories studying protein expression and has several advantages, it also has a number of significant limitations. In particular, the method is semi-quantitative with limited dynamic range. Western blot focuses on a single protein per sample with only a small number of representative samples analyzed in an experiment. New quantitative tools have been needed for some time to at least supplement, & possibly replace, the Western blot. Mass spectrometric methods have begun to compete with Western blot for routine quantitative analyses of proteins. One of these methods is based on the tandem mass spectrometry technique of selected reaction monitoring (SRM), which is also called multiple reaction monitoring (MRM). Selected reaction monitoring is actually an older tandem mass spectrometry technique, first described in the late 70s, that is widely utilized in the quantitative analysis of small molecules like drugs & metabolites. The use of selected reaction monitoring for the quantitative analysis of proteins has a number of advantages. Most importantly, it is fundamentally quantitative with a wide dynamic range. The output of the analysis is a numerical result that can range over several orders of magnitude. Other advantages include sufficient specificity & sensitivity to detect low abundance proteins in complex mixtures. Finally, selected reaction monitoring can be multiplexed to allow the quantitative analysis of relatively large numbers of proteins in a single sample in a single experiment. This Brief will explain both the theoretical & experimental details of the selected reaction monitoring experiment as it is applied to proteins.

Development of a Software Package for the Quantitative Analysis of Proteomic Mass Spectrometry Datasets Labelled with Nitrogen-15

Author : Philip David Charles
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Development of a Software Package for the Quantitative Analysis of Proteomic Mass Spectrometry Datasets Labelled with Nitrogen-15 by : Philip David Charles

Download or read book Development of a Software Package for the Quantitative Analysis of Proteomic Mass Spectrometry Datasets Labelled with Nitrogen-15 written by Philip David Charles and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Proteomics Data Analysis

Author : Daniela Cecconi
Publisher : Humana
ISBN 13 : 9781071616437
Total Pages : 326 pages
Book Rating : 4.6/5 (164 download)

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Book Synopsis Proteomics Data Analysis by : Daniela Cecconi

Download or read book Proteomics Data Analysis written by Daniela Cecconi and published by Humana. This book was released on 2022-07-23 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thorough book collects methods and strategies to analyze proteomics data. It is intended to describe how data obtained by gel-based or gel-free proteomics approaches can be inspected, organized, and interpreted to extrapolate biological information. Organized into four sections, the volume explores strategies to analyze proteomics data obtained by gel-based approaches, different data analysis approaches for gel-free proteomics experiments, bioinformatic tools for the interpretation of proteomics data to obtain biological significant information, as well as methods to integrate proteomics data with other omics datasets including genomics, transcriptomics, metabolomics, and other types of data. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detailed implementation advice that will ensure high quality results in the lab. Authoritative and practical, Proteomics Data Analysis serves as an ideal guide to introduce researchers, both experienced and novice, to new tools and approaches for data analysis to encourage the further study of proteomics. Chapter 16 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Statistical Analysis of Proteomic Data

Author : Thomas Burger
Publisher : Springer Nature
ISBN 13 : 1071619675
Total Pages : 398 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Statistical Analysis of Proteomic Data by : Thomas Burger

Download or read book Statistical Analysis of Proteomic Data written by Thomas Burger and published by Springer Nature. This book was released on 2022-10-29 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the most important processing steps of proteomics data analysis and presents practical guidelines, as well as software tools, that are both user-friendly and state-of-the-art in chemo- and biostatistics. Beginning with methods to control the false discovery rate (FDR), the volume continues with chapters devoted to software suites for constructing quantitation data tables, missing value related issues, differential analysis software, and more. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice that leads to successful results. Authoritative and practical, Statistical Analysis of Proteomic Data: Methods and Tools serves as an ideal guide for proteomics researchers looking to extract the best of their data with state-of-the art tools while also deepening their understanding of data analysis.

Protein Analysis using Mass Spectrometry

Author : Mike S. Lee
Publisher : John Wiley & Sons
ISBN 13 : 1119359368
Total Pages : 282 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Protein Analysis using Mass Spectrometry by : Mike S. Lee

Download or read book Protein Analysis using Mass Spectrometry written by Mike S. Lee and published by John Wiley & Sons. This book was released on 2017-05-26 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis

Analysis of Protein Post-Translational Modifications by Mass Spectrometry

Author : John R. Griffiths
Publisher : John Wiley & Sons
ISBN 13 : 1119250889
Total Pages : 415 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Analysis of Protein Post-Translational Modifications by Mass Spectrometry by : John R. Griffiths

Download or read book Analysis of Protein Post-Translational Modifications by Mass Spectrometry written by John R. Griffiths and published by John Wiley & Sons. This book was released on 2016-10-12 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all major modifications, including phosphorylation, glycosylation, acetylation, ubiquitination, sulfonation and and glycation Discussion of the chemistry behind each modification, along with key methods and references Contributions from some of the leading researchers in the field A valuable reference source for all laboratories undertaking proteomics, mass spectrometry and post-translational modification research