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Development And Applications Of 4d Real Time Multi Functional Spectral Domain Optical Coherence Tomography
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Book Synopsis Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography by : Yan Wang
Download or read book Development and Applications of 4D Real-time Multi-functional Spectral-domain Optical Coherence Tomography written by Yan Wang and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 describes the construction and characterization of a multi-functional SD-OCT system at 1300nm. The axial resolution, lateral resolution, imaging depth, signal sensitivity drop-off, spectrometer efficiency, phase noise, system noise, polarization noise, computation of phase retardation, optic axis and diattenuation were characterized. Multiple samples were imaged to demonstrate each imaging facet (intensity, polarization and flow) of the system.
Book Synopsis Multi-scale Optical Coherence Tomography Imaging by : Michael Christopher Oliveira
Download or read book Multi-scale Optical Coherence Tomography Imaging written by Michael Christopher Oliveira and published by . This book was released on 2014 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: An optical modality capable of quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales coupled with sophisticated software for image reconstruction and quantitative analyses would be of great utility to scientists and engineers in the medical and life sciences fields. Currently, a combination of optical imaging techniques and software packages are needed to address the list of capabilities described previously. Optical coherence tomography is an optical imaging technique based on low coherence interferometry capable of measuring light backscattered from the sample at micrometer-level resolutions over millimeter-level penetration depths in biological tissue. Phase-sensitive extensions of OCT enable the functional assessment of biological tissue samples as well as the structural examination of samples down to the single-cell level. This dissertation describes the development and application of high-speed real-time multi-functional spectral-domain OCT (MF-SD-OCT) for structural and functional examination of biological samples across spatiotemporal scales. A discussion of the development of a GPU-accelerated high-speed MF-SD-OCT imaging system accompanied by demonstrations of the performance enhancements due to the GPU are presented initially. Next, the development of MF-SD-OCT-based quantitative methods for the structural and functional assessment and characterization and classification of biological tissue samples is discussed. The utility of these methods is demonstrated through structural, functional and optical characterization and classification of peripheral nerve and muscle tissue. The dissertation concludes with a discussion of the improvements made to spectral-domain optical coherence phase microscopy (SD-OCPM) to enable dynamic live cell imaging and the application of dynamic live cell SD-OCPM for morphological visualization of cheek epithelial cells and examination of functionally stimulated morphological changes in neurons. The work described in this dissertation demonstrates the versatility of OCT imaging technology to perform quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales, enabling the examination of native dynamic tissue and cellular physiology.
Book Synopsis Development of Spectral Domain Optical Coherence Tomography for in Vivo Functional Imaging of Biological Tissues by : Lin An
Download or read book Development of Spectral Domain Optical Coherence Tomography for in Vivo Functional Imaging of Biological Tissues written by Lin An and published by . This book was released on 2013 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography is a rapidly developing optical imaging modality capable of noninvasively providing depth resolved information of biological tissue at micrometer scale. Since its first report in 1991, it has made tremendous progress leading to successful applications in a number of fields, such as ophthalmology, gastroenterology, dermatology, dentistry, dermatology, cardiology, etc. According to [1], there are more than 15,000 OCT units that had been put into service in ophthalmic clinic by 2009, which represented approximately $1 billion market. The total amount paid by Medicare for OCT scans has increased from $1 billion per year in 2001 to $7 billion per year by 2008. The market size has kept growing in recent years. Reported in [2] by IBISWorld (an American research company), the OCT has achieved an annual growth rate of 27.4% since 2007. In 2012, the revenue is expected to be $478.4 million, which is 24.7% larger than last year. Despite the massive success, there are still several technical issues that need to be addressed, which could help the OCT technology to deliver even better imaging quality. In this thesis, we described several OCT technologies that can be used to double the imaging depth, realize functional vasculature imaging of biological tissue and increase the imaging speed of OCT system. Aim 1: Use of a scanner to introduce spatial frequency modulation to OCT spectral interferograms for in vivo full-range Fourier-domain optical coherence tomography. A novel method was developed that could easily introduce a modulation frequency onto the X-direction (i.e., B-scan) of the FDOCT scanning system, enabling full-range Fourier-domain Optical Coherence Tomography (frFDOCT). Compared to the conventional FDOCT system, the newly developed frFDOCT system can provide increased system sensitivity and deeper imaging depth. The previous technology that can achieve frFDOCT either needed multiple steps for data capturing, which is time consuming, or required additional components which increased the system's complexity. The newly developed method generates a modulation spatial frequency in the spectral interferogram by simply offsetting the probe beam at the X-scanner. In this way, the frFDOCT could be easily realized through applying a Hilbert transformation. Aim 2: Using optical micro-angiography to achieve in vivo volumetric imaging of vascular perfusion within human retina and choroids. Optical Micro-Angiography (OMAG) is a functional extension of FDOCT technology. It can achieve visualization of vasculature network of biological tissue. In order to apply the OMAG method to image vasculature map of human retina and choroid, a phase compensation algorithm was developed, which could minimize the motion artifacts generated by the movements of human eye and head. The original scanning protocol of OMAG method could only achieve ~2 mm x 2 mm scanning area on the retina, which is relatively small for clinical applications. To achieve large field of view of vasculature visualization of retina and choroid, multiple small areas of retina were sequentially scanned. After being processed, all the vasculature maps coming from small areas were stitched together to produce a vasculature map of the whole retina and choroid, which is comparable to Fluorescein Angiography. Aim 3: Developing ultrahigh sensitive optical micro-angiography to achieve micro vasculature imaging of biological tissue. Though the OMAG has been successfully applied for visualizing vasculature networks of different biological tissue, there are several problems that need to be solved, such as lower flow sensitivity, longer imaging time and so on. To improve the vasculature image quality, we developed ultrahigh sensitive OMAG (UHS-OMAG). Unlike conventional OMAG, UHS-OMAG applied the OMAG algorithm onto the slow direction of FDOCT scan (Y-direction). Because the time interval between adjacent B-frames is much longer than that between adjacent A-lines, UHS-OMAG can achieve much higher flow sensitivity compared to the conventional OMAG. In addition, the UHS-OMAG usually employed high frame rate (typically 300 frames per second) to achieve 3D scan, it cost much less time to finish one 3D scan compared to the traditional OMAG. However, when it was applied to visualize vasculature map of human tissue, the motion artifacts caused by the inevitable movements is still the biggest challenge. Based on the phase difference calculated from two adjacent B-frames, a new phase compensation algorithm was developed. The UHS-OMAG system was then applied onto human retina and skin to produce detailed micro vasculature networks. Aim 4: Developing ultrahigh speed Spectral Domain OCT system through sequentially controlling two high speed line scan CMOS cameras. Since the report of OCT technology, the imaging speed is always the hot topic along its development path. Though one branch of FDOCT technology, swept source OCT, can run at several megahertz, SSOCT is still not approved by FDA for human eye imaging. The development of spectral domain OCT is more attractive from a commercialization perspective. Two identical high speed line cameras were employed to build two home build high speed spectrometers. Through sequentially controlling the reading time period of two cameras, the imaging speed of the whole system could reach twice higher than the single camera system. The newly built 800 nm SDOCT system which can work at 500,000 Hz A-lines capturing speed was then used to achieve in vivo 3D imaging in both high speed and large field of view mode. In addition, through combining with the OMAG algorithm, the newly developed system is capable of providing detailed micro-vasculature imaging of human retina and optic nerve head.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis Development of Optical Coherence Tomography for Tissue Diagnostics by : Panomsak Meemon
Download or read book Development of Optical Coherence Tomography for Tissue Diagnostics written by Panomsak Meemon and published by . This book was released on 2010 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microvasculature can be found in almost every part of the human body, including the internal organs. Importantly, abnormal changes in microvasculature are usually related to pathological development of the tissue cells. Monitoring of changes in blood flow properties in microvasculature, therefore, provides useful diagnostic information about pathological conditions in biological tissues as exemplified in glaucoma, diabetes, age related macular degeneration, port wine stains, burn-depth, and potentially skin cancer. However, the capillary network is typically only one cell in wall thickness with 5 to 10 microns in diameter and located in the dermis region of skin. Therefore, a non-invasive flow imaging technique that is capable of depth sectioning at high resolution and high speed is demanded. Optical coherence tomography (OCT), particularly after its advancement in frequency domain OCT (FD-OCT), is a promising tool for non-invasive high speed, high resolution, and high sensitivity depth-resolved imaging of biological tissues. Over the last ten years, numerous efforts have been paid to develop OCT-based flow imaging techniques. An important effort is the development of phase-resolved Doppler OCT (PR-DOCT). Phase-resolved Doppler imaging using FD-OCT is particularly of interest because of the direct access to the phase information of the depth profile signal. Furthermore, the high speed capability of FD-OCT is promising for real time flow monitoring as well as 3D flow segmentation applications. However, several challenges need to be addressed; 1) Flow in biological samples exhibits a wide dynamic range of flow velocity caused by, for example, the variation in the flow angles, flow diameters, and functionalities. However, the improvement in imaging speed of FD-OCT comes at the expense of a reduction in sensitivity to slow flow information and hence a reduction in detectable velocity range; 2) A structural ambiguity so-called 'mirror image' in FD-OCT prohibits the use of maximum sensitivity and imaging depth range; 3) The requirement of high lateral resolution to resolve capillary vessels requires the use of an imaging optics with high numerical aperture (NA) that leads to a reduction in depth of focus (DOF) and hence the imaging depth range (i.e. less than 100 microns) unless dynamic focusing is performed. Nevertheless, intrinsic to the mechanism of FD-OCT, dynamic focusing is not possible. In this dissertation, the implementation of PR-DOCT in a high speed swept-source based FD-OCT is investigated and optimized. An acquisition scheme as well as a processing algorithm that effectively extends the detectable velocity dynamic range of the PR-DOCT is presented. The proposed technique increased the overall detectable velocity dynamic range of PR-DOCT by about five times of that achieved by the conventional method. Furthermore, a novel technique of mirror image removal called 'Dual-Detection FD-OCT' (DD-FD-OCT) is presented. One of the advantages of DD-FD-OCT to Doppler imaging is that the full-range signal is achieved without manipulation of the phase relation between consecutive axial lines. Hence the full-range DD-FD-OCT is fully applicable to phase-resolved Doppler detection without a reduction in detectable velocity dynamic range as normally encountered in other full-range techniques. In addition, PR- DOCT can utilize the maximum SNR ratio provided by the full-range capability. This capability is particularly useful for imaging of blood flow that locates deep below the sample surface, such as blood flow at deep posterior human eye and blood vessels network in the dermis region of human skin. Beside high speed and functional imaging capability, another key parameter that will open path for optical diagnostics using OCT technology is high resolution imaging (i.e. in a regime of a few microns or sub-micron). Even though the lateral resolution of OCT can be independently improved by opening the NA of the imaging optics, the high lateral resolution is maintained only over a short range as limited by the depth of focus that varies inversely and quadratically with NA. Recently developed by our group, 'Gabor-Domain Optical Coherence Microscopy' (GD-OCM) is a novel imaging technique capable for invariant resolution of about 2-3 [micrometers] over a 2 mm cubic field-of-view. This dissertation details the imaging protocol as well as the automatic data fusion method of GD-OCM developed to render an in-focus high-resolution image throughout the imaging depth of the sample in real time. For the application of absolute flow measurement as an example, the precise information about flow angle is required. GD-OCM provides more precise interpretation of the tissue structures over a large field-of-view, which is necessary for accurate mapping of the flow structure and hence is promising for diagnostic applications particularly when combined with Doppler imaging. Potentially, the ability to perform high resolution OCT imaging inside the human body is useful for many diagnostic applications, such as providing an accurate map for biopsy, guiding surgical and other treatments, monitoring the functional state and/or the post-operative recovery process of internal organs, plaque detection in arteries, and early detection of cancers in the gastrointestinal tract. Endoscopic OCT utilizes a special miniature probe in the sample arm to access tubular organs inside the human body, such as the cardiovascular system, the lung, the gastrointestinal tract, the urinary tract, and the breast duct. We present an optical design of a dynamic focus endoscopic probe that is capable of about 4 to 6 [micrometers] lateral resolution over a large working distance (i.e. up to 5 mm from the distal end of the probe). The dynamic focus capability allows integration of the endoscopic probe to GD-OCM imaging to achieve high resolution endoscopic tomograms. We envision the future of this developing technology as a solution to high resolution, minimally invasive, depth-resolved imaging of not only structure but also the microvasculature of in vivo biological tissues that will be useful for many clinical applications, such as dermatology, ophthalmology, endoscopy, and cardiology. The technology is also useful for animal study applications, such as the monitoring of an embryo's heart for the development of animal models and monitoring of changes in blood circulation in response to external stimulus in small animal brains.
Book Synopsis Handbook of Robotic and Image-Guided Surgery by : Mohammad Hossein Abedin Nasab
Download or read book Handbook of Robotic and Image-Guided Surgery written by Mohammad Hossein Abedin Nasab and published by Elsevier. This book was released on 2019-09-25 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Robotic and Image-Guided Surgery provides state-of-the-art systems and methods for robotic and computer-assisted surgeries. In this masterpiece, contributions of 169 researchers from 19 countries have been gathered to provide 38 chapters. This handbook is 744 pages, includes 659 figures and 61 videos. It also provides basic medical knowledge for engineers and basic engineering principles for surgeons. A key strength of this text is the fusion of engineering, radiology, and surgical principles into one book. - A thorough and in-depth handbook on surgical robotics and image-guided surgery which includes both fundamentals and advances in the field - A comprehensive reference on robot-assisted laparoscopic, orthopedic, and head-and-neck surgeries - Chapters are contributed by worldwide experts from both engineering and surgical backgrounds
Book Synopsis Real-time Microstructural and Functional Imaging and Image Processing in Optical Coherence Tomography by : Volker Westphal
Download or read book Real-time Microstructural and Functional Imaging and Image Processing in Optical Coherence Tomography written by Volker Westphal and published by . This book was released on 2002 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Optical Coherence Tomography and Its Non-medical Applications by : Michael Wang
Download or read book Optical Coherence Tomography and Its Non-medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.
Book Synopsis Optical Coherence Tomography by : Jianbing Xu
Download or read book Optical Coherence Tomography written by Jianbing Xu and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Optical Coherence Tomography: From System Design to Spectroscopic Applications" by Jianbing, Xu, 徐鉴冰, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Optical coherence tomography (OCT), as a newly developed imaging modality, has attracted significant attention due to its capability to obtain the cross-sectional information of biological tissues in a non-invasive way, with resolution in the range of several micrometers. The third-generation swept source OCT (SS-OCT), is superior in the speed, imaging range and signal-to-noise ratio (SNR) compared with the previous time-domain OCT (TD-OCT) and spectral domain OCT (SD-OCT), and therefore forms our research focus. In this thesis, for the first time, I investigate the deployment of Fourier domain mode-locked (FDML) swept laser by utilizing the bismuth-based erbium doper fiber (Bi-EDF) with a sweeping bandwidth of 81nm achieved. Following, fiber Raman amplifier (FRA) is also investigated by employing multiple Raman pumps. The tuning range is 111.8nm, which is much larger than the previous reported Raman pumped FDML in the 1550nm region. Imaging was performed to validate the feasibility of the proposed schemes for the SS-OCT applications, respectively. In addition to the FDML swept laser cavity design, speckle noise reduction is also of great importance in OCT, which can significantly improve the visibility of the obtained OCT images. I demonstrate two different speckle reduction methods for OCT applications, which are superior in suppressing speckle noise and reserving the one-dimensional (1D) and two-dimensional (2D) signal information, respectively. Applying the proposed wavelet domain compounding (WDC) and contourlet shrinkage method to despeckle the OCT images, the visibility of the OCT images was significantly improved, with negligible edge preservation compromise. Spectroscopic information is also of interest to many researchers as it provides additional spectroscopic contrast, which on one hand, will improve the visualization of the images, and on the other hand, will enable the classification of different tissue types and help the process of discrimination between invasive and noninvasive tumors. Compared with our previous reported work about dual-band spectroscopic OCT based on optical parametric amplifier (OPA) to generate another idler band, which will be used as the second band for dual-band spectroscopic analysis, I further extend the dual-band spectroscopic OCT to the endoscopic applications, and investigate the dual-band FDML swept laser configuration based on a custom-designed dual-channel driver to synchronize the two different wavelength bands, centered at 1310 and 1550 nm, respectively. OCT Images for different bands are captured and post-processed by coding the spectral difference in different colors. In short, in this thesis, the investigations of OCT range from system design, speckle reduction to the spectroscopic applications. All these research efforts will extend the current FDML techniques for a wide range of SS-OCT applications. These schemes may be useful in OCT swept laser source build up, speckle noise reduction, and the extension of spectroscopic analysis. DOI: 10.5353/th_b5317037 Subjects: Optical coherence tomography
Book Synopsis System Design for Frequency Quadrupling of Reference Clock for a Swept Source Spectral Domain Optical Coherence Tomography by : Karthick Santhanam
Download or read book System Design for Frequency Quadrupling of Reference Clock for a Swept Source Spectral Domain Optical Coherence Tomography written by Karthick Santhanam and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A real time system design to quadruple the frequency of the optical clock that is linear in the optical k-space domain is presented for a swept source spectral domain based polarization sensitive optical coherence tomography system. Advanced OCT imaging techniques have been developed in recent times to obtain high resolution images of retina that may help in early detection of glaucoma. Spatial resolution (sharper details) and depth of such images is of paramount importance. Use of a non-linear clocking system (that is linear in k-space domain) to acquire the sample is shown to be essential in avoiding loss of image resolution. The clock system described in this thesis represents an improvement over current clocking system in terms of faster and better acquisition of samples. The principle of operation and circuit implementation are described in this thesis. A fully functional hardware system has been developed and experimental results are recorded, presented and verified. By using the quadrupled frequency clock (linear in optical k-space domain) in the swept source spectral domain PS-OCT system, significant enhancement has been demonstrated in the axial resolution and depth range of acquired images.
Book Synopsis Development of Spectral Domain Optical Coherence Tomography for Pharmaceutical and Medical Application by : Yue Dong
Download or read book Development of Spectral Domain Optical Coherence Tomography for Pharmaceutical and Medical Application written by Yue Dong and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Diffuse Optical Tomography by : Huabei Jiang
Download or read book Diffuse Optical Tomography written by Huabei Jiang and published by CRC Press. This book was released on 2018-09-03 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an authority involved in the field since its nascent stages, Diffuse Optical Tomography: Principles and Applications is a long-awaited profile of a revolutionary imaging method. Diffuse Optical Tomography (DOT) provides spatial distributions of intrinsic tissue optical properties or molecular contrast agents through model-based reconstruction algorithms using NIR measurements along or near the boundary of tissue. Despite the practical value of DOT, many engineers from electrical or applied mathematics backgrounds do not have a sufficient understanding of its vast clinical applications and portability value, or its uncommon advantages as a tool for obtaining functional, cellular, and molecular parameters. A collection of the author’s research and experience, this book fuses historical perspective and experiential anecdotes with fundamental principles and vital technical information needed to successfully apply this technology—particularly in medical imaging. This reference finally outlines how to use DOT to create experimental image systems and adapt the results of laboratory studies for use in clinical applications including: Early-stage detection of breast tumors and prostate cancer "Real-time" functional brain imaging Joint imaging to treat progressive diseases such as arthritis Monitoring of tumor response New contrast mechanisms and multimodality methods This book covers almost every aspect of DOT—including reconstruction algorithms based on nonlinear iterative Newton methods, instrumentation and calibration methods in both continuous-wave and frequency domains, and important issues of imaging contrast and spatial resolution. It also addresses phantom experiments and the development of various image-enhancing schemes, and it describes reconstruction methods based on contrast agents and fluorescence DOT. Offering a concise description of the particular problems involved in optical tomography, this reference illustrates DOT’s fundamental foundations and the principle of image reconstruction. It thoroughly explores computational methods, forward mathematical models, and inverse strategies, clearly illustrating solutions to key equations.
Book Synopsis Enhanced Spectral Domain Optical Coherence Tomography for Pathological and Functional Studies by : Zhijia Yuan
Download or read book Enhanced Spectral Domain Optical Coherence Tomography for Pathological and Functional Studies written by Zhijia Yuan and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Photothermal Optical Coherence Tomography for in Vivo Imaging of Contrast Agents by : Jason Michael Tucker-Schwartz
Download or read book Development of Photothermal Optical Coherence Tomography for in Vivo Imaging of Contrast Agents written by Jason Michael Tucker-Schwartz and published by . This book was released on 2015 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Accelerating Fourier Domain Optical Coherence Tomography Using General Purpose Graphics Processing Units and Field Programmable Gate Arrays by : Jian Li
Download or read book Accelerating Fourier Domain Optical Coherence Tomography Using General Purpose Graphics Processing Units and Field Programmable Gate Arrays written by Jian Li and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fourier Domain Optical Coherence Tomography is an emerging biomedical imaging technology that provides ultra high resolution and a fast imaging speed. The complexity of the FD-OCT algorithm demands high processing power from the underlying platform. However, the scaling of faster data acquisition rates and 3D imaging on real time FD-OCT systems is quickly outpacing the performance growth of General Purpose Processors. Our research investigates the scalability of two potential platforms for accelerating FD-OCT -- GPGPUs and FPGAs. We implemented a FD-OCT system using a GPGPU as co-processor with 6.9x speed up. We also created a hardware processing engine using FPGAs, delivering over 2x the throughput rate over GPGPU with 1024- point FFT. Our analysis on the performance and scalability for both platforms shows that, while GPGPUs offer an easy and low cost solution for accelerating FD-OCT, FPGAs are more likely to match the long term demands for real-time, 3D FD-OCT.
Book Synopsis A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications by : Mengyang Liu
Download or read book A Study of Spectral Domain Optical Coherence Tomography and Photoacoustic Microscopy for Biometric and Biomedical Applications written by Mengyang Liu and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) has been widely used in biomedical imaging ever since its introduction. However, the application of OCT for biometrics is relatively new. This thesis demonstrates the feasibility of applying a spectral domain optical coherence tomography (SD-OCT) system to fingertip biometric information retrieval. The results show that SD-OCT is capable of retrieving Level 3 fingertip information. Combined with traditional Level 1 and 2 fingerprint information, which can also be easily acquired by SD-OCT, the proposed application shows potential for ultra-secure scenarios. Photoacoustic microscopy (PAM) is another imaging modality gaining considerable interest in the past decade. Different than OCT, it employs ultrasound detection for optically induced thermal expansion in tissue. Bovine articulate cartilage samples are imaged with a single wavelength PAM system using India ink as a contrast agent. The same samples were also imaged with SD-OCT. Image analysis shows that PAM produces excellent contrast between intact and fibrillated regions in cartilage while SD-OCT visualizes topological changes with fine spatial resolution. A spectroscopic PAM system is also developed using a tunable source based on supercontinuum generation in a photonic crystal fiber. Imaging experiments of tissue phantoms demonstrate the ability to differentiate various chromophores with unique absorption characteristics. Another spectroscopic PAM system is currently being developed, where the tunable source is based on stimulated Raman scattering. This new system is being studied and some preliminary results are given to demonstrate its advantages over the supercontinuum approach.
