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Developing A New Water Soluble Porphyrin As A Potential Phtodynamic Cancer Therapy Agent
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Book Synopsis Developing a New Water-soluble Porphyrin as a Potential Photodynamic Cancer Therapy Agent by : Catherine Shirley
Download or read book Developing a New Water-soluble Porphyrin as a Potential Photodynamic Cancer Therapy Agent written by Catherine Shirley and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic cancer therapy (PDT) is a type of treatment involving the use of light in conjunction with a photosensitive agent- a chemical or series of chemicals designed for activation when exposed to light. This research project investigated the synthesis and identification of the novel photosensitive agent, H2TPP-Pro-OH. To create the water-soluble porphyrin, (S)-(+)-prolinol was added to the tetra-carboxyl porphyrin, H2TPPC, to form the final H2TPP-Pro-OH product. This compound was then purified using syringe filtration and column chromatography, and subsequently characterized using infrared (IR), nuclear magnetic resonance (NMR), and UV-vis spectroscopies. Finally, the utility of the material as a PDT agent was determined by examining the cytotoxicity of the H2TPP-Pro-OH product was determined using MTT assay on MDA-MB-231 triple negative breast cancer cells comparing dark and light exposure.
Book Synopsis Developing a New Water-soluble Porphyrin as a Potential Phtodynamic Cancer Therapy Agent by : Catherine Shirley
Download or read book Developing a New Water-soluble Porphyrin as a Potential Phtodynamic Cancer Therapy Agent written by Catherine Shirley and published by . This book was released on 2020 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment by : Joseph Earl Bradshaw
Download or read book Synthesis of a Novel Water-soluble Porphyrin Derivative for Use as a Potential Phototherapeutic Cancer Treatment written by Joseph Earl Bradshaw and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) agents are light-activated materials used for localized disease treatment. Porphyrins are classic representations of photosensitive agents. Identified by their large, planar molecular structure, porphyrins are centrally composed of four pyrrole rings. Through this project, the starting material, H2TPPC, a tetra-carboxylic acid porphyrin, was first synthesized and later modified through the addition of the amine, morpholin-2-ylmethanol. This multi-step synthesis resulted in the highly water-soluble porphyrin product H2TPP-MorphMeOH. Following this synthesis, the compound was purified using liquid chromatography, and then structurally identified and classified using infrared (IR), nuclear magnetic resonance (NMR), and UV-Vis spectroscopies. Lastly, to determine its utility as a potential PDT agent, the cytotoxicity of H2TPP-MorphMeOH was determined using an MTT assay on MDA-MB-231 triple negative breast cancer cells comparing exposure and absence of white light.
Book Synopsis Photodynamic Therapy Potential of a Novel Water-soluble Gallium Porphyrin by : Cammie York
Download or read book Photodynamic Therapy Potential of a Novel Water-soluble Gallium Porphyrin written by Cammie York and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy (PDT) has potential use in the treatment of cancer and other health disorders. PDT utilizes light and a photosensitive agent that once activated by light generates singlet oxygen that affects surrounding cells. Metalloporphyrins have been shown to accumulate in tumors as the result of preferential binding to low-density lipoproteins. Additionally, gallium(III) porphyrins have been shown to be effective potential photosensitizers for PDT. The goal of this research was to synthesize and characterize the novel photosensitive agent, GaTPP-DIPA, as a PDT agent. The GaTPP-DIPA was purified using column chromatography and characterized using IR, UV-Vis, and NMR spectroscopies, purity was determined using HPLC. Cytotoxicity testing of the GaTPP-DIPA using U87 glioblastoma cells in both light and dark conditions determined that novel material has potential as a next generation PDT agent.
Book Synopsis The Development of a New Water-soluble Zinc Porphyrin, ZnTPP-5AP, as Photodynamic Therapy Agent by : Kaylee Johnson
Download or read book The Development of a New Water-soluble Zinc Porphyrin, ZnTPP-5AP, as Photodynamic Therapy Agent written by Kaylee Johnson and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Developing Novel Water-soluble Porphyrins for Potential Use as Photosensitizers in Photodynamic Therapy by : Kayla R. Whittington
Download or read book Developing Novel Water-soluble Porphyrins for Potential Use as Photosensitizers in Photodynamic Therapy written by Kayla R. Whittington and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds by : Ravindra K Pandey
Download or read book Handbook Of Photodynamic Therapy: Updates On Recent Applications Of Porphyrin-based Compounds written by Ravindra K Pandey and published by World Scientific. This book was released on 2016-03-24 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of this book is to present the recent applications of photodynamic therapy (PDT) in treating cancer and other diseases. The limitations associated with current PDT agents, and the synthetic designs that have been used in various laboratories are also discussed. The utility of certain tumor-avid agent for cancer imaging (fluorescence, PET, MRI) is also summarized. The book also includes the use of delivery vehicles, including nanoparticles in improving the tumor-specificity of the desired agents. The book is basically focused on the translational approach of drug development. By providing certain specific examples, a clear concept of moving a 'product' from the bench to bed-side is also discussed.To have a clear concept of drug development the book is divided in three parts — Medicinal Chemistry, Mechanistic and Clinical studies. Each part includes the contributions from the leading scientists with extensive experience in the respective field. The handbook is assembled by renowned scientists Dr Dougherty, known as the father of PDT, Dr Kessel, well known for his contributions on mechanism of PDT and Dr Pandey for his inventions in developing improved agents for PDT and cancer-imaging.
Book Synopsis Synthesis of Water-soluble Porphyrin-dendron Conjugates for Targeted Photodynamic Therapy by : Francesca Bryden
Download or read book Synthesis of Water-soluble Porphyrin-dendron Conjugates for Targeted Photodynamic Therapy written by Francesca Bryden and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Porphyrin-based Agents and Their Applications in Cancer Imaging and Therapy by : Tracy Wei-Bin Liu
Download or read book Porphyrin-based Agents and Their Applications in Cancer Imaging and Therapy written by Tracy Wei-Bin Liu and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in the Biology, Therapy and Management of Melanoma by : Lester Davids
Download or read book Recent Advances in the Biology, Therapy and Management of Melanoma written by Lester Davids and published by BoD – Books on Demand. This book was released on 2013-02-13 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Recent Advances in the Biology, Therapy and Management of Melanoma brings up-to-date information regarding a number of aspects which culminate in illuminating potential targets in the fight against melanoma. This book is intended to be a reference book for both the scientific and clinical communities and brings complicated subject matter together in an easy, readable way. Undoubtedly fundamental scientific understanding has to then be translated to the clinic in order for us to make significant strides in eradicating melanoma. It is hoped that scientists, clinicians, students and residents find this book useful in their studies on melanoma and that it not only expands their perspectives and views on the field, but challenges them to forge ahead towards discovering the ultimate cure.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1991 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biomedical Photonics Handbook by : Tuan Vo-Dinh
Download or read book Biomedical Photonics Handbook written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shaped by Quantum Theory, Technology, and the Genomics RevolutionThe integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in
Book Synopsis Advances in Photodynamic Therapy by : Michael R. Hamblin
Download or read book Advances in Photodynamic Therapy written by Michael R. Hamblin and published by Artech House. This book was released on 2008 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: With today's focus on targeted and minimally invasive therapies, photodynamic therapy (PDT) is now being studied and used to combat many disease states and to investigate critical biological questions. This groundbreaking resource brings you the latest advances in photodynamic therapy and offers you a solid understanding of the design, delivery and dosimetry of the three basic ingredients of PDT - photosensitizers, light and oxygen. The book covers novel areas of mechanistic and innovative translational approaches. Moreover, it gives you an overview of the important medical applications of PDT, including approved treatments, clinical trials, and investigated therapies for cancer and non-malignant diseases.
Book Synopsis Biomedical Photonics Handbook, Second Edition by : Tuan Vo-Dinh
Download or read book Biomedical Photonics Handbook, Second Edition written by Tuan Vo-Dinh and published by CRC Press. This book was released on 2014-07-29 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Shaped by Quantum Theory, Technology, and the Genomics Revolution The integration of photonics, electronics, biomaterials, and nanotechnology holds great promise for the future of medicine. This topic has recently experienced an explosive growth due to the noninvasive or minimally invasive nature and the cost-effectiveness of photonic modalities in medical diagnostics and therapy. The second edition of the Biomedical Photonics Handbook presents recent fundamental developments as well as important applications of biomedical photonics of interest to scientists, engineers, manufacturers, teachers, students, and clinical providers. The third volume, Therapeutics and Advanced Biophotonics, focuses on therapeutic modalities, advanced biophotonic technologies, and future trends. Represents the Collective Work of over 150 Scientists, Engineers, and Clinicians Designed to display the most recent advances in instrumentation and methods, as well as clinical applications in important areas of biomedical photonics to a broad audience, this three-volume handbook provides an inclusive forum that serves as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of medical technologies. What’s New in This Edition: A wide variety of photonic biochemical sensing technologies has already been developed for clinical monitoring of early disease states and physiological parameters, such as blood pressure, blood chemistry, pH, temperature, and the presence of pathological organisms or biochemical species of clinical importance. Advanced photonic detection technologies integrating the latest knowledge of genomics, proteomics, and metabolomics allow sensing of early disease states, thus revolutionizing the medicine of the future. Nanobiotechnology has opened new possibilities for detection of biomarkers of disease, imaging single molecules and in situ diagnostics at the single-cell level. In addition to these state-of-the-art advancements, the second edition contains new topics and chapters including: • Fiber Optic Probe Design • Laser and Optical Radiation Safety • Photothermal Detection • Multidimensional Fluorescence Imaging • Surface Plasmon Resonance Imaging • Molecular Contrast Optical Coherence Tomography • Multiscale Photoacoustics • Polarized Light for Medical Diagnostics • Quantitative Diffuse Reflectance Imaging • Interferometric Light Scattering • Nonlinear Interferometric Vibrational Imaging • Nanoscintillator-Based Therapy • SERS Molecular Sentinel Nanoprobes • Plasmonic Coupling Interference Nanoprobes Comprised of three books: Volume I: Fundamentals, Devices, and Techniques; Volume II: Biomedical Diagnostics; and Volume III: Therapeutics and Advanced Biophotonics, this second edition contains eight sections, and provides introductory material in each chapter. It also includes an overview of the topic, an extensive collection of spectroscopic data, and a list of references for further reading.
Book Synopsis Photodynamic Therapy by : Thierry Patrice
Download or read book Photodynamic Therapy written by Thierry Patrice and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: For centuries, light has been used to cure various diseases. However, it is only recently that a new medical field has arisen. Photodynamic therapy (PDT), also known as photochemotherapy, is a fast growing technique which was initially devoted to cancer care but which is now recognised as a promising treatment technique in a variety of clinical fields. Written by recognised experts, Photodynamic Therapy provides a comprehensive explanation of what PDT is and how it has developed as a technique in areas such as the detection of lung cancer and applications in dermatology, gynaecology and neurosurgery. This book is ideal both as an introduction to PDT and as an informative text for those wishing to expand their knowledge. Practitioners in biological sciences, biotechnology and medicinal and pharmaceutical chemistry will find it an invaluable source of information.
Book Synopsis Photodynamic Therapy in Dermatology by : Michael H. Gold
Download or read book Photodynamic Therapy in Dermatology written by Michael H. Gold and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photodynamic therapy is a proven effective treatment of actinically damaged skin cells, nonmelanoma skin cancers, and acne and other pilosebaceous conditions. As an agent for general facial rejuvenatin it has untapped potential. The current state of PDT therapy and future applications are discussed in detail in this exciting new volume. Throughout, the focus is on evidence-based clinical uses of PDT, including pretreatment regimens, avoidance and management of complications, and posttreatment suggestions.
Book Synopsis Handbook of Industrial Water Soluble Polymers by : Peter A. Williams
Download or read book Handbook of Industrial Water Soluble Polymers written by Peter A. Williams and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural and synthetic water soluble polymers are used in a wide range of familiar industrial and consumer products, including coatings and inks, papers, adhesives, cosmetics and personal care products. They perform a variety of functions without which these products would be significantly more expensive, less effective or both. Written for research, development and formulation chemists, technologists and engineers at graduate level and beyond in the fine and specialty chemicals, polymers, food and pharmaceutical industries, the Handbook of Industrial Water Soluble Polymers deals specifically with the functional properties of both natural and synthetic water soluble polymers. By taking a function based approach, rather than a “polymer specific” approach the book illustrates how polymer structure leads to effect, and shows how different polymer types can be employed to achieve appropriate product properties.
