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Author : Erling William Rud
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.:/5 (877 download)
Download or read book Defective Interfering Particles and Viral Interference written by Erling William Rud and published by . This book was released on 1989 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : W. Arber
Publisher : Springer Science & Business Media
ISBN 13 : 3642669565
Total Pages : 175 pages
Book Rating : 4.6/5 (426 download)
Download or read book Current Topics in Microbiology and Immunology written by W. Arber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Woo-Young Choi
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (872 download)
Download or read book Molecular Biological Characterization of Defective Interfering Particles of Vesicular Stomatitis Virus written by Woo-Young Choi and published by . This book was released on 1997 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hossein Sadrzadeh
Publisher : Elsevier
ISBN 13 : 0128034181
Total Pages : 478 pages
Book Rating : 4.1/5 (28 download)
Download or read book Endocrine Biomarkers written by Hossein Sadrzadeh and published by Elsevier. This book was released on 2017-09-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Biomarkers: Clinical Aspects and Laboratory Determination covers all the pre-analytical variables that can affect test results, both in the clinic and laboratory. Biomarkers of endocrine and bone diseases are discussed from both clinical and laboratory perspectives, and the authors elaborate on the teamwork-based app+roach between the clinician and the laboratory professional in the diagnosis and management of endocrine and bone disorders. Discussions include test utilization, laboratory measurement methods, harmonization and standardization, interpretation of results, and reference intervals. Each chapter ends with a discussion of one or two relevant cases with shared opinions from both a clinician and a clinical chemist. Each chapter also includes a summary box outlining key points and common pitfalls in the use of specific disease biomarkers and tests. Focuses on the traditional, current, and emerging clinical chemistry tests for endocrine and bone diseases, along with their application in individual clinical management Presents a brief discussion of each disorder and its respective interrelationships, along with laboratory methodologies that can be used to aid in evaluation of disorders Reviews common approaches to the measurement of the relevant hormones, with a special focus on measures that require a structured clinical testing scenario Reviews novel chemistry tests as potential means of future diagnostic tests Provides an overview of the current methodology and controversies in the concept of target lipid levels, paying particular attention to the role of clinical chemistry in helping to implement population health targets
Author : Jennifer Louten
Publisher : Academic Press
ISBN 13 : 0323914926
Total Pages : 412 pages
Book Rating : 4.3/5 (239 download)
Download or read book Essential Human Virology written by Jennifer Louten and published by Academic Press. This book was released on 2022-05-28 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essential Human Virology, Second Edition focuses on the structure and classification of viruses, virus transmission and virus replication strategies based upon type of viral nucleic acid. Several chapters focus on notable and recognizable viruses and the diseases caused by them, including influenza, HIV, hepatitis viruses, poliovirus, herpesviruses and emerging and dangerous viruses. Additionally, how viruses cause disease (pathogenesis) is highlighted, along with discussions on immune response to viruses, vaccines, anti-viral drugs, gene therapy, the beneficial uses of viruses, research laboratory assays and viral diagnosis assays. Fully revised and updated with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses, the book provides students with a solid foundation in virology. Focuses on human diseases and the cellular pathology that viruses cause Highlights current and cutting-edge technology and associated issues Presents real case studies and current news highlights in each chapter Features dynamic illustrations, chapter assessment questions, key terms, and a summary of concepts, as well as an instructor website with lecture slides, a test bank and recommended activities Updated and revised, with new chapters on coronaviruses, nonliving infectious agents, and notable non-human viruses
Author :
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (887 download)
Download or read book Quantification and Integration of the Multi-scale Effects of Defective Interfering Particles on Virus Infections written by and published by . This book was released on 2014 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defective interfering particles (DIPs) are virus mutants that lack essential genes for growth, but able to divert the viral proteins produced by an infectious virus, and thus, interfere with infectious virus production. The accumulating evidence about their presence in nature and the increasing interest in DIP-based vaccine formulations highlight the need for an accurate understanding of the effect of DIPs on virus growth at intracellular and cell-to-cell spread scale. To analyze the multi-scale effects of DIPs, we first tracked the intracellular growth of a recombinant vesicular stomatitis virus (VSV) in individual cells using fluorescence microscopy and quantified the effects of DIPs on intracellular virus production kinetics. Through a metric scoring the dose-dependent effects of DIPs in cells and their cell-to-cell variations, we identified two-fold higher degree of interference by DIPs in isolated cells than that in single cells within a population. Quantification of infection spread behavior revealed an induction in the diversity of spread patterns with increasing DIP input. Through a cellular automata model driven by the measured virus growth kinetics in individual cells, we found that the intracellular scale effects of DIPs and cell-to-cell variations play a major role in the formation of the diverse interfered spread patterns. Using the developed framework the DIP-induced interference was compared to the interference by a recombinant defective viral mutant that only lacks virus assembly proteins. Our findings suggested that during the DIP co-infections the competition at replication stage interferes mainly with the early growth delaying and reducing the intracellular virus activity, and thus decreasing extracellular virus production, which is further diminished by the competition at virus assembly stage. Despite this reduction in virus production, we observed that the enrichment of DIPs are limited by the growth of infectious virus suggesting the dependency of DIPs on infectious virus at all scales of virus infections. Overall, the insight provided by this work can guide future studies of the viral infectious disease progression in the presence of DIPs, while the developed framework sets a platform to investigate other microbial infections under the effects of different interfering substances, such as antiviral or antibacterial drugs and vaccines.
Author : Prerna Arora
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (122 download)
Download or read book Novel Production System for Influenza A Virus-derived Defective Interfering Particles and Analysis of Antiviral Activity written by Prerna Arora and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza A virus (IAV) increases morbidity and mortality rates and novel antivirals are needed to combat the virus. Errors of the viral polymerase lead to the generation of defective RNAs. These DI-RNAs may interfere with wild-type (wt) IAV infection and may be packaged into defective interfering particles (DIPs), which exhibit antiviral activity. DIPs inhibit IAV infection by competing with wt IAV for cellular and viral resources required for genome replication (replication interference) and by inducing interferon (IFN). DI-244 is a prototypic DI-RNA derived from IAV genomic segment 1 tha...
Author : Michael Varian Doyle
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 (318 download)
Download or read book Homologous and Heterologous Virus-induced Interference written by Michael Varian Doyle and published by . This book was released on 1973 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Roger Hull
Publisher : Academic Press
ISBN 13 : 0123848725
Total Pages : 1119 pages
Book Rating : 4.1/5 (238 download)
Download or read book Plant Virology written by Roger Hull and published by Academic Press. This book was released on 2013-10-31 with total page 1119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The seminal text Plant Virology is now in its fifth edition. It has been 10 years since the publication of the fourth edition, during which there has been an explosion of conceptual and factual advances. The fifth edition of Plant Virology updates and revises many details of the previous edition while retaining the important earlier results that constitute the field's conceptual foundation. Revamped art, along with fully updated references and increased focus on molecular biology, transgenic resistance, aphid transmission, and new, cutting-edge topics, bring the volume up to date and maintain its value as an essential reference for researchers and students in the field. Thumbnail sketches of each genera and family groups Genome maps of all genera for which they are known Genetic engineered resistance strategies for virus disease control Latest understanding of virus interactions with plants, including gene silencing Interactions between viruses and insect, fungal, and nematode vectors Contains over 300 full-color illustrations
Author : David S. Hui
Publisher : European Respiratory Society
ISBN 13 : 1849840709
Total Pages : 148 pages
Book Rating : 4.8/5 (498 download)
Download or read book SARS, MERS and other Viral Lung Infections written by David S. Hui and published by European Respiratory Society. This book was released on 2016-06-01 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viral respiratory tract infections are important and common causes of morbidity and mortality worldwide. In the past two decades, several novel viral respiratory infections have emerged with epidemic potential that threaten global health security. This Monograph aims to provide an up-to-date and comprehensive overview of severe acute respiratory syndrome, Middle East respiratory syndrome and other viral respiratory infections, including seasonal influenza, avian influenza, respiratory syncytial virus and human rhinovirus, through six chapters written by authoritative experts from around the globe.
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Ellen G. Strauss
Publisher : Elsevier
ISBN 13 : 0080553168
Total Pages : 476 pages
Book Rating : 4.0/5 (85 download)
Download or read book Viruses and Human Disease written by Ellen G. Strauss and published by Elsevier. This book was released on 2007-09-21 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text
Author : Najat Bdeir
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (126 download)
Download or read book A System for Production of Pure Influenza A Virus Defective Interfering Particles (DIPs) and Assessment of Their Antiviral Activity written by Najat Bdeir and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza A virus (IAV) epidemics and pandemics constitute a major threat to human health.The ability of IAV to rapidly acquire mutations can render antivirals and vaccines ineffective andnovel antiviral strategies are urgently needed. IAV particles harbor eight genomic RNA segmentsand defective interfering RNAs (DI RNAs) are naturally occurring byproducts of viral genomereplication. These RNAs interfere with replication of the WT RNAs and, upon packaging intodefective interfering particles (DIPs), can inhibit spread of WT IAV. It has been postulated thatDIPs interfere with IAV infection by...
Author : Yoshiyuki Nagai
Publisher : Springer Science & Business Media
ISBN 13 : 4431545565
Total Pages : 218 pages
Book Rating : 4.4/5 (315 download)
Download or read book Sendai Virus Vector written by Yoshiyuki Nagai and published by Springer Science & Business Media. This book was released on 2014-01-31 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sendai virus (SeV) is not just a mouse pathogen but is evolving into a cutting-edge component of biotechnology. SeV reverse genetics originating from a pure academic need to settle long-held questions in the biology and pathogenicity of nonsegmented negative strand RNA viruses (Mononegavirales) is about to bear the impressive fruit of multipurpose cytoplasmic (non-integrating) RNA vectors. This book brings together in one source the SeV biology revealed by conventional approaches and reverse genetics, the methods to construct the first-generation SeV vector and to generate safer versions, and the applications in medical settings that have left or are about to leave the laboratory bench. The applications, which already are diverse and have high medical impact, include use as vaccine vectors against AIDS and respiratory virus infections, creation of BioKnife to resect malignant tumors, induction of “footprint (transgene) free” pluripotent stem cells, and gene therapy for peripheral arterial disease. These achievements—which are just a few of many examples—were attainable only after rigorously incorporating the rich knowledge of SeV biology that has accumulated during the several decades since the discovery of the virus. Application of SeV vector is certain to expand greatly because of its extremely high performance in transgene expression and its remarkable target cell breadth.
Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)
Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Author : Najat Khodor Bdeir
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (126 download)
Download or read book A System for Production of Pure Influenza A Virus Defective Interfering Particles (DIPs) and Assessment of Their Antiviral Activity written by Najat Khodor Bdeir and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Influenza A virus (IAV) epidemics and pandemics constitute a major threat to human health.The ability of IAV to rapidly acquire mutations can render antivirals and vaccines ineffective andnovel antiviral strategies are urgently needed. IAV particles harbor eight genomic RNA segmentsand defective interfering RNAs (DI RNAs) are naturally occurring byproducts of viral genomereplication. These RNAs interfere with replication of the WT RNAs and, upon packaging intodefective interfering particles (DIPs), can inhibit spread of WT IAV. It has been postulated thatDIPs interfere with IAV infection by...
Author : Heinz Fraenkel-Conrat
Publisher : Springer Science & Business Media
ISBN 13 : 1461331293
Total Pages : 385 pages
Book Rating : 4.4/5 (613 download)
Download or read book Comprehensive Virology written by Heinz Fraenkel-Conrat and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: The time seems ripe for a critical compendium of that segment of the biological universe we call viruses. Virology, as a science, having passed only recently through its descriptive phase of naming and num bering, has probably reached that stage at which relatively few new truly new-viruses will be discovered. Triggered by the intellectual probes and techniques of molecular biology, genetics, biochemical cytology, and high resolution microscopy and spectroscopy, the field has experienced a genuine information explosion. Few serious attempts have been made to chronicle these events. This comprehensive series, which will comprise some 6000 pages in a total of about 18 volumes, represents a commitment by a large group of active investigators to analyze, digest, and expostulate on the great mass of data relating to viruses, much of which is now amorphous and disjointed, and scattered throughout a wide literature. In this way, we hope to place the entire field in perspective, and to develop an invalua ble reference and sourcebook for researchers and students at all levels. This series is designed as a continuum that can be entered anywhere, but which also provides a logical progression of developing facts and integrated concepts.
