Data Mining For Biomarker Discovery

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Data Mining for Biomarker Discovery

Author : Panos M. Pardalos
Publisher : Springer Science & Business Media
ISBN 13 : 1461421071
Total Pages : 256 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Data Mining for Biomarker Discovery by : Panos M. Pardalos

Download or read book Data Mining for Biomarker Discovery written by Panos M. Pardalos and published by Springer Science & Business Media. This book was released on 2012-02-11 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarker discovery is an important area of biomedical research that may lead to significant breakthroughs in disease analysis and targeted therapy. Biomarkers are biological entities whose alterations are measurable and are characteristic of a particular biological condition. Discovering, managing, and interpreting knowledge of new biomarkers are challenging and attractive problems in the emerging field of biomedical informatics. This volume is a collection of state-of-the-art research into the application of data mining to the discovery and analysis of new biomarkers. Presenting new results, models and algorithms, the included contributions focus on biomarker data integration, information retrieval methods, and statistical machine learning techniques. This volume is intended for students, and researchers in bioinformatics, proteomics, and genomics, as well engineers and applied scientists interested in the interdisciplinary application of data mining techniques.

Bioinformatics and Biomarker Discovery

Author : Francisco Azuaje
Publisher : John Wiley & Sons
ISBN 13 : 111996430X
Total Pages : 206 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Bioinformatics and Biomarker Discovery by : Francisco Azuaje

Download or read book Bioinformatics and Biomarker Discovery written by Francisco Azuaje and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to introduce biologists, clinicians and computational researchers to fundamental data analysis principles, techniques and tools for supporting the discovery of biomarkers and the implementation of diagnostic/prognostic systems. The focus of the book is on how fundamental statistical and data mining approaches can support biomarker discovery and evaluation, emphasising applications based on different types of "omic" data. The book also discusses design factors, requirements and techniques for disease screening, diagnostic and prognostic applications. Readers are provided with the knowledge needed to assess the requirements, computational approaches and outputs in disease biomarker research. Commentaries from guest experts are also included, containing detailed discussions of methodologies and applications based on specific types of "omic" data, as well as their integration. Covers the main range of data sources currently used for biomarker discovery Covers the main range of data sources currently used for biomarker discovery Puts emphasis on concepts, design principles and methodologies that can be extended or tailored to more specific applications Offers principles and methods for assessing the bioinformatic/biostatistic limitations, strengths and challenges in biomarker discovery studies Discusses systems biology approaches and applications Includes expert chapter commentaries to further discuss relevance of techniques, summarize biological/clinical implications and provide alternative interpretations

Data Mining for Biomarker Discovery

Author :
Publisher :
ISBN 13 : 9781461421085
Total Pages : 262 pages
Book Rating : 4.4/5 (21 download)

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Book Synopsis Data Mining for Biomarker Discovery by :

Download or read book Data Mining for Biomarker Discovery written by and published by . This book was released on 2012-02-12 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Data Mining for Genomics and Proteomics

Author : Darius M. Dziuda
Publisher : John Wiley & Sons
ISBN 13 : 0470593407
Total Pages : 348 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Data Mining for Genomics and Proteomics by : Darius M. Dziuda

Download or read book Data Mining for Genomics and Proteomics written by Darius M. Dziuda and published by John Wiley & Sons. This book was released on 2010-07-16 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining for Genomics and Proteomics uses pragmatic examples and a complete case study to demonstrate step-by-step how biomedical studies can be used to maximize the chance of extracting new and useful biomedical knowledge from data. It is an excellent resource for students and professionals involved with gene or protein expression data in a variety of settings.

Biomarkers in Drug Development

Author : Michael R. Bleavins
Publisher : John Wiley & Sons
ISBN 13 : 1118210425
Total Pages : 559 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Biomarkers in Drug Development by : Michael R. Bleavins

Download or read book Biomarkers in Drug Development written by Michael R. Bleavins and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover how biomarkers can boost the success rate of drug development efforts As pharmaceutical companies struggle to improve the success rate and cost-effectiveness of the drug development process, biomarkers have emerged as a valuable tool. This book synthesizes and reviews the latest efforts to identify, develop, and integrate biomarkers as a key strategy in translational medicine and the drug development process. Filled with case studies, the book demonstrates how biomarkers can improve drug development timelines, lower costs, facilitate better compound selection, reduce late-stage attrition, and open the door to personalized medicine. Biomarkers in Drug Development is divided into eight parts: Part One offers an overview of biomarkers and their role in drug development. Part Two highlights important technologies to help researchers identify new biomarkers. Part Three examines the characterization and validation process for both drugs and diagnostics, and provides practical advice on appropriate statistical methods to ensure that biomarkers fulfill their intended purpose. Parts Four through Six examine the application of biomarkers in discovery, preclinical safety assessment, clinical trials, and translational medicine. Part Seven focuses on lessons learned and the practical aspects of implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including data integration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or more leading experts, including scientists from biotechnology and pharmaceutical firms, academia, and the U.S. Food and Drug Administration. Their contributions offer pharmaceutical and clinical researchers the most up-to-date understanding of the strategies used for and applications of biomarkers in drug development.

Biological Data Mining

Author : Jake Y. Chen
Publisher : CRC Press
ISBN 13 : 1420086855
Total Pages : 736 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Biological Data Mining by : Jake Y. Chen

Download or read book Biological Data Mining written by Jake Y. Chen and published by CRC Press. This book was released on 2009-09-01 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: Like a data-guzzling turbo engine, advanced data mining has been powering post-genome biological studies for two decades. Reflecting this growth, Biological Data Mining presents comprehensive data mining concepts, theories, and applications in current biological and medical research. Each chapter is written by a distinguished team of interdisciplin

The Detection of Biomarkers

Author : Sibel A. Ozkan
Publisher : Academic Press
ISBN 13 : 0128230754
Total Pages : 615 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Detection of Biomarkers by : Sibel A. Ozkan

Download or read book The Detection of Biomarkers written by Sibel A. Ozkan and published by Academic Press. This book was released on 2021-12-05 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reliable, precise and accurate detection and analysis of biomarkers remains a significant challenge for clinical researchers. Methods for the detection of biomarkers are rather complex, requiring pre-treatment steps before analysis can take place. Moreover, comparing various biomarker assays and tracing research progress in this area systematically is a challenge for researchers. The Detection of Biomarkers presents developments in biomarker detection, including methods tools and strategies, biosensor design, materials, and applications. The book presents methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical, and therefore highly practical for use in clinical research scenarios. This volume situates biomarker detection in its research context and sets out future prospects for the area. Its 20 chapters offer a comprehensive coverage of biomarkers, including progress on nanotechnology, biosensor types, synthesis, immobilization, and applications in various fields. The book also demonstrates, for students, how to synthesize and immobilize biosensors for biomarker assay. It offers researchers real alternative and innovative ways to think about the field of biomarker detection, increasing the reliability, precision and accuracy of biomarker detection. - Locates biomarker detection in its research context, setting out present and future prospects - Allows clinical researchers to compare various biomarker assays systematically - Presents new methods, materials and procedures that are simple, precise, sensitive, selective, fast and economical - Gives innovative biomarker assays that are viable alternatives to current complex methods - Helps clinical researchers who need reliable, precise and accurate biomarker detection methods

Data Mining for Bioinformatics Applications

Author : He Zengyou
Publisher : Woodhead Publishing
ISBN 13 : 008100107X
Total Pages : 100 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Data Mining for Bioinformatics Applications by : He Zengyou

Download or read book Data Mining for Bioinformatics Applications written by He Zengyou and published by Woodhead Publishing. This book was released on 2015-06-09 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Data Mining for Bioinformatics Applications provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems, including problem definition, data collection, data preprocessing, modeling, and validation. The text uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems, containing 45 bioinformatics problems that have been investigated in recent research. For each example, the entire data mining process is described, ranging from data preprocessing to modeling and result validation. Provides valuable information on the data mining methods have been widely used for solving real bioinformatics problems Uses an example-based method to illustrate how to apply data mining techniques to solve real bioinformatics problems Contains 45 bioinformatics problems that have been investigated in recent research

Successes and New Directions in Data Mining

Author : Florent Masseglia
Publisher : IGI Global
ISBN 13 : 1599046458
Total Pages : 386 pages
Book Rating : 4.5/5 (99 download)

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Book Synopsis Successes and New Directions in Data Mining by : Florent Masseglia

Download or read book Successes and New Directions in Data Mining written by Florent Masseglia and published by IGI Global. This book was released on 2008-01-01 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book addresses existing solutions for data mining, with particular emphasis on potential real-world applications. It captures defining research on topics such as fuzzy set theory, clustering algorithms, semi-supervised clustering, modeling and managing data mining patterns, and sequence motif mining"--Provided by publisher.

Methodologies of Multi-Omics Data Integration and Data Mining

Author : Kang Ning
Publisher : Springer Nature
ISBN 13 : 9811982104
Total Pages : 173 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Methodologies of Multi-Omics Data Integration and Data Mining by : Kang Ning

Download or read book Methodologies of Multi-Omics Data Integration and Data Mining written by Kang Ning and published by Springer Nature. This book was released on 2023-01-15 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features multi-omics big-data integration and data-mining techniques. In the omics age, paramount of multi-omics data from various sources is the new challenge we are facing, but it also provides clues for several biomedical or clinical applications. This book focuses on data integration and data mining methods for multi-omics research, which explains in detail and with supportive examples the “What”, “Why” and “How” of the topic. The contents are organized into eight chapters, out of which one is for the introduction, followed by four chapters dedicated for omics integration techniques focusing on several omics data resources and data-mining methods, and three chapters dedicated for applications of multi-omics analyses with application being demonstrated by several data mining methods. This book is an attempt to bridge the gap between the biomedical multi-omics big data and the data-mining techniques for the best practice of contemporary bioinformatics and the in-depth insights for the biomedical questions. It would be of interests for the researchers and practitioners who want to conduct the multi-omics studies in cancer, inflammation disease, and microbiome researches.

Interactive Knowledge Discovery and Data Mining in Biomedical Informatics

Author : Andreas Holzinger
Publisher : Springer
ISBN 13 : 3662439689
Total Pages : 373 pages
Book Rating : 4.6/5 (624 download)

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Book Synopsis Interactive Knowledge Discovery and Data Mining in Biomedical Informatics by : Andreas Holzinger

Download or read book Interactive Knowledge Discovery and Data Mining in Biomedical Informatics written by Andreas Holzinger and published by Springer. This book was released on 2014-06-17 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the grand challenges in our digital world are the large, complex and often weakly structured data sets, and massive amounts of unstructured information. This “big data” challenge is most evident in biomedical informatics: the trend towards precision medicine has resulted in an explosion in the amount of generated biomedical data sets. Despite the fact that human experts are very good at pattern recognition in dimensions of = 3; most of the data is high-dimensional, which makes manual analysis often impossible and neither the medical doctor nor the biomedical researcher can memorize all these facts. A synergistic combination of methodologies and approaches of two fields offer ideal conditions towards unraveling these problems: Human–Computer Interaction (HCI) and Knowledge Discovery/Data Mining (KDD), with the goal of supporting human capabilities with machine learning./ppThis state-of-the-art survey is an output of the HCI-KDD expert network and features 19 carefully selected and reviewed papers related to seven hot and promising research areas: Area 1: Data Integration, Data Pre-processing and Data Mapping; Area 2: Data Mining Algorithms; Area 3: Graph-based Data Mining; Area 4: Entropy-Based Data Mining; Area 5: Topological Data Mining; Area 6 Data Visualization and Area 7: Privacy, Data Protection, Safety and Security.

Omics Technologies in Cancer Biomarker Discovery

Author : Xuewu Zhang
Publisher : CRC Press
ISBN 13 : 1498714005
Total Pages : 151 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Omics Technologies in Cancer Biomarker Discovery by : Xuewu Zhang

Download or read book Omics Technologies in Cancer Biomarker Discovery written by Xuewu Zhang and published by CRC Press. This book was released on 2011-03-10 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: The early detection of human cancer is still one of the great challenges in the battle against this disease. Single biomarkers are not likely to provide sufficient diagnostic power and multibiomarker assays should be developed in order to reach high diagnostic accuracy for cancer screening at the population level. Omics technologies are emerging ne

Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics

Author : Jiajie Peng
Publisher : Frontiers Media SA
ISBN 13 : 2889761746
Total Pages : 160 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics by : Jiajie Peng

Download or read book Data Mining and Statistical Methods for Knowledge Discovery in Diseases Based on Multimodal Omics written by Jiajie Peng and published by Frontiers Media SA. This book was released on 2022-06-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Some Recent Advances In Mathematics And Statistics - Proceedings Of Statistics 2011 Canada/imst 2011-fim Xx

Author : Yogendra P Chaubey
Publisher : World Scientific
ISBN 13 : 9814417998
Total Pages : 276 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Some Recent Advances In Mathematics And Statistics - Proceedings Of Statistics 2011 Canada/imst 2011-fim Xx by : Yogendra P Chaubey

Download or read book Some Recent Advances In Mathematics And Statistics - Proceedings Of Statistics 2011 Canada/imst 2011-fim Xx written by Yogendra P Chaubey and published by World Scientific. This book was released on 2013-03-14 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consists of a series of research papers presented at the conference Statistics 2011 Canada: 5th Canadian Conference in Applied Statistics held together with the 20th conference of the Forum for Interdisciplinary Mathematics titled, “Interdisciplinary Mathematical & Statistical Techniques”. These papers cover a wide range of topics from applications of Mathematics and Statistics such as Selection Bias in Surveys, Biomarker Discovery, Analysis of Earth Temperature, Supply Chain Management, Trimmed ANOVA, Zero-inflated Data, Non-Gaussian Time Series, and Stochastic Ordering; Classification, Nonparametric Test, and Jackknifed Ridge Estimator; Bayes Factor; Random Graphs and Error Correcting Codes; Meta Analysis; and National Health Plans and Risk Reduction through Supply Chain.The topics have been reviewed by experts in the field and the selected papers are expected to provide a topical resource on the subjects concerned.

Some Recent Advances in Mathematics and Statistics

Author : Yogendra P. Chaubey
Publisher : World Scientific
ISBN 13 : 981441798X
Total Pages : 276 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Some Recent Advances in Mathematics and Statistics by : Yogendra P. Chaubey

Download or read book Some Recent Advances in Mathematics and Statistics written by Yogendra P. Chaubey and published by World Scientific. This book was released on 2013 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume consists of a series of research papers presented at the conference Statistics 2011 Canada: 5th Canadian Conference in Applied Statistics held together with the 20th conference of the Forum for Interdisciplinary Mathematics titled, OC Interdisciplinary Mathematical & Statistical TechniquesOCO. These papers cover a wide range of topics from applications of Mathematics and Statistics such as Selection Bias in Surveys, Biomarker Discovery, Analysis of Earth Temperature, Supply Chain Management, Trimmed ANOVA, Zero-inflated Data, Non-Gaussian Time Series, and Stochastic Ordering; Classification, Nonparametric Test, and Jackknifed Ridge Estimator; Bayes Factor; Random Graphs and Error Correcting Codes; Meta Analysis; and National Health Plans and Risk Reduction through Supply Chain.The topics have been reviewed by experts in the field and the selected papers are expected to provide a topical resource on the subjects concerned.

Predictive Biomarkers in Oncology

Author : Sunil Badve
Publisher : Springer
ISBN 13 : 3319952285
Total Pages : 635 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Predictive Biomarkers in Oncology by : Sunil Badve

Download or read book Predictive Biomarkers in Oncology written by Sunil Badve and published by Springer. This book was released on 2018-12-06 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Precision/personalized or stratified medicine” refers to the tailoring of medical treatment or drug administration to the individual characteristics of each patient treatment. It does not literally mean that a pharmaceutical company makes a drug for an individual patient for consumption and treatment but rather means the ability to stratify (or classify) individuals into sub-populations that differ in their responsiveness to a specific drug. A marker that provides information on the likely response to therapy, i.e., either in terms of tumor shrinkage or survival of the patient is termed “predictive biomarker”. Despite their promise in precision medicine and the explosion of knowledge in this area, there is not a single source on this subject that puts all this evidence together in a concise or richly illustrated and easy to understand manner. This book provides a collection of ingeniously organized, well-illustrated and up-to-date authoritative chapters divided into five sections that are clear and easy to understand. Section one provides an overview of biomarkers, introduces the basic terminologies, definitions, technologies, tools and concepts associated with this subject in the form of illustrations/graphics, photographs and concise texts. Several recent biomarker endeavors that have been initiated and funded by the National Cancer Institute, National Institutes of Health, FDA and other International organizations are presented. Section two involves the signaling pathways controlling cell growth and differentiation altered in cancer. This section analyzes how predictive biomarkers are altered (expressed or amplified) across cancer types. Section three explores how predictive biomarkers play a role in patient stratification and tailored treatment in relationship to specific cancers. In addition, it includes discussion on the various precision medicine initiatives that are going on across the globe (e.g. TARGET, NCI-MATCH, BATTLE, SHIVA, etc.). Section four discusses: (a) how pharmaceutical companies validate predictive biomarker assays and accompanying companion diagnostics either internally or externally with partner companies such as central laboratories or clinical research organizations, and (b) how predictive biomarker tests fall under the oversight of US FDA, Centers for Medicare & Medicaid Services (CMS) and state laws. Section five wraps up novel agents and targets that are being used as targets for cancer therapeutics. The biomarkers associated with these protocols will also be presented. Throughout the book, sidebars, special interest boxes and illustrations are used to explain terms that are either newly introduced, uncommon, or specialized. Predictive Biomarkers in Oncology will serve as a definitive guide for practicing pathologists, oncologists, basic researchers, and personnel in the pharmaceutical or diagnostic industry interested in learning how “predictive biomarkers” are used in precision cancer therapy.

Integrating Biomedical Information

Author : Assa Reichert
Publisher : IOS Press
ISBN 13 : 9781586036140
Total Pages : 430 pages
Book Rating : 4.0/5 (361 download)

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Book Synopsis Integrating Biomedical Information by : Assa Reichert

Download or read book Integrating Biomedical Information written by Assa Reichert and published by IOS Press. This book was released on 2006 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organisations in health care are moving into the information age since two or three decades. Never was the pace of this movement as fast as today. "Integrating Biomedical Information: from e-Cell to e-Patient", the title of this EFMI publication, indicates the broad spectrum of Medical Informatics. Both concepts in the title are new - the result of data collection, data processing and information analysis. It is expected this data and information to be the knowledge base for a better understanding of mankind and also to assist us in making information (evidence) based decisions in health care. We expect that this will give us a better perspective of the human body, its functions and that it will ultimately lead us to better health care. Recent developments in clinical terminology construction have brought together specialists from different disciplines, such as Medicine, Computer Science, Philosophy, and Linguistics. Different genres of clinical terminologies co-exist: the former distinction between formal terminologies, classifications, vocabularies, nomenclatures and thesauri is increasingly being challenged by the notion of "ontology". There are controversies between linguistic approaches (aiming at representing term meanings) and ontological ones (which strive for a representation of biomedical reality). There is also an increasing quest for "good practice" recommendations for biomedical terminologies.) This book is the third volume of the EFMI STC conferences. This series is a subseries of the MIR-conferences published by IOS Press.