Cytokines And Pain

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Cytokines and Pain

Author : L.R. Watkins
Publisher : Springer
ISBN 13 : 3034887493
Total Pages : 248 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Cytokines and Pain by : L.R. Watkins

Download or read book Cytokines and Pain written by L.R. Watkins and published by Springer. This book was released on 2013-03-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.

Cytokines and Pain

Author : Waldiceu A. Verri
Publisher : Frontiers Media SA
ISBN 13 : 2889718603
Total Pages : 161 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Cytokines and Pain by : Waldiceu A. Verri

Download or read book Cytokines and Pain written by Waldiceu A. Verri and published by Frontiers Media SA. This book was released on 2021-12-28 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Emerging Technologies for Nutrition Research

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309174538
Total Pages : 729 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Emerging Technologies for Nutrition Research by : Institute of Medicine

Download or read book Emerging Technologies for Nutrition Research written by Institute of Medicine and published by National Academies Press. This book was released on 1997-09-03 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest of a series of publications based on workshops sponsored by the Committee on Military Nutrition Research, this book's focus on emerging technologies for nutrition research arose from a concern among scientists at the U.S. Army Research Institute of Environmental Medicine that traditional nutrition research, using standard techniques, centered more on complex issues of the maintenance or enhancement of performance, and might not be sufficiently substantive either to measure changes in performance or to predict the effects on performance of stresses soldiers commonly experience in operational environments. The committee's task was to identify and evaluate new technologies to determine whether they could help resolve important issues in military nutrition research. The book contains the committee's summary and recommendations as well as individually authored chapters based on presentations at a 1995 workshop. Other chapters cover techniques of body composition assessment, tracer techniques for the study of metabolism, ambulatory techniques for the determination of energy expenditure, molecular and cellular approaches to nutrition, the assessment of immune function, and functional and behavioral measures of nutritional status.

Inflammation and the Microcirculation

Author : D. Neil Granger
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1615041656
Total Pages : 99 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Inflammation and the Microcirculation by : D. Neil Granger

Download or read book Inflammation and the Microcirculation written by D. Neil Granger and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microcirculation is highly responsive to, and a vital participant in, the inflammatory response. All segments of the microvasculature (arterioles, capillaries, and venules) exhibit characteristic phenotypic changes during inflammation that appear to be directed toward enhancing the delivery of inflammatory cells to the injured/infected tissue, isolating the region from healthy tissue and the systemic circulation, and setting the stage for tissue repair and regeneration. The best characterized responses of the microcirculation to inflammation include impaired vasomotor function, reduced capillary perfusion, adhesion of leukocytes and platelets, activation of the coagulation cascade, and enhanced thrombosis, increased vascular permeability, and an increase in the rate of proliferation of blood and lymphatic vessels. A variety of cells that normally circulate in blood (leukocytes, platelets) or reside within the vessel wall (endothelial cells, pericytes) or in the perivascular space (mast cells, macrophages) are activated in response to inflammation. The activation products and chemical mediators released from these cells act through different well-characterized signaling pathways to induce the phenotypic changes in microvessel function that accompany inflammation. Drugs that target a specific microvascular response to inflammation, such as leukocyte-endothelial cell adhesion or angiogenesis, have shown promise in both the preclinical and clinical studies of inflammatory disease. Future research efforts in this area will likely identify new avenues for therapeutic intervention in inflammation. Table of Contents: Introduction / Historical Perspectives / Anatomical Considerations / Impaired Vasomotor Responses / Capillary Perfusion / Angiogenesis / Leukocyte-Endothelial Cell Adhesion / Platelet-Vessel Wall Interactions / Coagulation and Thrombosis / Endothelial Barrier Dysfunction / Epilogue / References

Cytokines and Pain

Author : Linda R. Watkins
Publisher : Birkhauser
ISBN 13 : 9780817658496
Total Pages : 225 pages
Book Rating : 4.6/5 (584 download)

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Book Synopsis Cytokines and Pain by : Linda R. Watkins

Download or read book Cytokines and Pain written by Linda R. Watkins and published by Birkhauser. This book was released on 1999 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Inflammation, 4 Volume Set

Author : Jean-Marc Cavaillon
Publisher : John Wiley & Sons
ISBN 13 : 3527338993
Total Pages : 1818 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

Nijkamp and Parnham's Principles of Immunopharmacology

Author : Michael J. Parnham
Publisher : Springer Nature
ISBN 13 : 3030108112
Total Pages : 888 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nijkamp and Parnham's Principles of Immunopharmacology by : Michael J. Parnham

Download or read book Nijkamp and Parnham's Principles of Immunopharmacology written by Michael J. Parnham and published by Springer Nature. This book was released on 2019-12-10 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.

Mechanisms of Neuroinflammation

Author : Gonzalo Emiliano Aranda Abreu
Publisher : BoD – Books on Demand
ISBN 13 : 9535134515
Total Pages : 320 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Mechanisms of Neuroinflammation by : Gonzalo Emiliano Aranda Abreu

Download or read book Mechanisms of Neuroinflammation written by Gonzalo Emiliano Aranda Abreu and published by BoD – Books on Demand. This book was released on 2017-08-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.

Acute Pain Management

Author : Raymond S. Sinatra
Publisher : Cambridge University Press
ISBN 13 : 0521874912
Total Pages : 729 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Acute Pain Management by : Raymond S. Sinatra

Download or read book Acute Pain Management written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2009-04-27 with total page 729 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides an overview of pain management useful to specialists as well as non-specialists, surgeons, and nursing staff.

Cytokine Storm Syndrome

Author : Randy Q. Cron
Publisher : Springer Nature
ISBN 13 : 303022094X
Total Pages : 607 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Cytokine Storm Syndrome by : Randy Q. Cron

Download or read book Cytokine Storm Syndrome written by Randy Q. Cron and published by Springer Nature. This book was released on 2019-09-09 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.

Acute Pain

Author : Lesley Bromley
Publisher : Oxford University Press
ISBN 13 : 0199234728
Total Pages : 205 pages
Book Rating : 4.1/5 (992 download)

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Book Synopsis Acute Pain by : Lesley Bromley

Download or read book Acute Pain written by Lesley Bromley and published by Oxford University Press. This book was released on 2010-06-03 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text covers the fundamentals of pain, the pharmacology of drugs used, and summarises the current evidence base for the management of acute pain. It provides practical direct clinical applications and strategies for the management of specific medical conditions in patient groups such as the elderly

Lung Inflammation in Health and Disease, Volume I

Author : Yong-Xiao Wang
Publisher : Springer Nature
ISBN 13 : 3030630463
Total Pages : 412 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Lung Inflammation in Health and Disease, Volume I by : Yong-Xiao Wang

Download or read book Lung Inflammation in Health and Disease, Volume I written by Yong-Xiao Wang and published by Springer Nature. This book was released on 2021-03-31 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory diseases are leading causes of death and disability globally, with about 65 million people suffering from COPD, and 334 million from asthma, the most common chronic disease. Each year, tens of millions of people develop and can die from from respiratory infections such as pneumonia and TB. Systemic inflammation may induce and exacerbate local inflammatory diseases in the lungs, and local inflammation can in turn cause systemic inflammation. There is increasing evidence of the coexistence of systemic and local inflammation in patients suffering from asthma, COPD, and other lung diseases, and the co-morbidity of two or more local inflammatory diseases often occurs. For example, rheumatoid arthritis frequently occurs together with, and promotes the development of, pulmonary hypertension. This co-morbidity significantly impacts quality of life, and can result in death for those affected. Current treatment options for lung disease are neither effective, nor condition-specific; there is a desperate need for novel therapeutics in the field. Additionally, the molecular and physiological significance of most major lung diseases is not well understood, which further impedes development of new treatments, especially in the case of coexistent lung diseases with other inflammatory diseases. Great progress has been made in recent years in many areas of the field, particularly in understanding the molecular geneses, regulatory mechanisms, signalling pathways, and cellular processes within lung disease, as well as basic and clinical technology, drug discovery, diagnoses, treatment options, and predictive prognoses. This is the first text to aggregate these developments. In two comprehensive volumes, experts from all over the world present state-of-the-art advances in the study of lung inflammation in health and disease. Contributing authors cover well-known as well as emerging topics in basic, translational, and clinical research, with the aim of providing researchers, clinicians, professionals, and students with new perspectives and concepts. The editors hope these books will also help to direct future research in lung disease and other inflammatory diseases, and result in the development of novel therapeutics.

Fundamentals of Inflammation

Author : Charles N. Serhan
Publisher : Cambridge University Press
ISBN 13 : 1139936670
Total Pages : 489 pages
Book Rating : 4.1/5 (399 download)

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Book Synopsis Fundamentals of Inflammation by : Charles N. Serhan

Download or read book Fundamentals of Inflammation written by Charles N. Serhan and published by Cambridge University Press. This book was released on 2010-04-26 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: The acute inflammatory response is the body's first system of alarm signals that are directed toward containment and elimination of microbial invaders. Uncontrolled inflammation has emerged as a pathophysiologic basis for many widely occurring diseases in the general population that were not initially known to be linked to the inflammatory response, including cardiovascular disease, asthma, arthritis, and cancer. To better manage treatment, diagnosis, and prevention of these wide-ranging diseases, multidisciplinary research efforts are underway in both academic and industry settings. This book provides an introduction to the cell types, chemical mediators, and general mechanisms of the host's first response to invasion. World-class experts from institutions around the world have written chapters for this introductory text. The text is presented as an introductory springboard for graduate students, medical scientists, and researchers from other disciplines wishing to gain an appreciation and working knowledge of current cellular and molecular mechanisms fundamental to inflammation.

Neuropathic Pain

Author : Cory Toth
Publisher : Cambridge University Press
ISBN 13 : 1107470439
Total Pages : 385 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Neuropathic Pain by : Cory Toth

Download or read book Neuropathic Pain written by Cory Toth and published by Cambridge University Press. This book was released on 2013-11-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Central or peripheral neuropathic pain can be caused by a wide range of injuries, infections and diseases such as: spinal cord injury, multiple sclerosis, stroke, herpes zoster, diabetes and cancer. Many of these pain syndromes are difficult to treat, representing a challenge for many neurologists not routinely trained in pain management. Written by an international team of experts in the field, Neuropathic Pain: Causes, Management and Understanding gives readers an in-depth understanding of the multitude of conditions causing neuropathic pain. Epidemiology, clinical diagnosis, pathophysiology, outcome measurement and the best evidence-based management of individual and general neuropathic pain conditions are also described in depth. A unique chapter, written from a patient's viewpoint, gives new insight into how chronic neuropathic pain affects the lives of those patients with the condition. This book is essential reading for all pain specialists, neurologists, psychiatrists and anesthesiologists who wish to better understand their patients' neuropathic pain.

The Resolution of Inflammation

Author : Adriano Rossi
Publisher : Springer Science & Business Media
ISBN 13 : 376437506X
Total Pages : 246 pages
Book Rating : 4.7/5 (643 download)

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Book Synopsis The Resolution of Inflammation by : Adriano Rossi

Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.