Current Perspectives In Micrornas Mirna

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Current Perspectives in microRNAs (miRNA)

Author : Shao-Yao Ying
Publisher : Springer Science & Business Media
ISBN 13 : 1402085338
Total Pages : 461 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Current Perspectives in microRNAs (miRNA) by : Shao-Yao Ying

Download or read book Current Perspectives in microRNAs (miRNA) written by Shao-Yao Ying and published by Springer Science & Business Media. This book was released on 2008-09-12 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 97% of the human genome is the non-coding DNA, which varies from one species to another, and changes in these sequences are frequently noticed to manifest clinical and circumstantial malfunction. Numerous non-protein-coding genes are recently found to encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded 17–25 nucleotide RNAs capable of interfering with intracellular messenger RNAs (mRNAs) that contain either complete or partial complementarity, are useful for the design of new therapies against cancer polymorphism and viral mutation. Currently over 1000 native miRNA species found in vertebrates and many more new miRNA homologs continue to be identified; however, most of their functions remain to be determined. In this book, many new perspectives of the miRNA research are reviewed and discussed, including their roles in stem cell maintenance, embryonic development, tissue differentiation, adult physiology, disease pathology, cancer research, viral infection, genetic engineering in plants, and utility in cosmetic applications. These new findings may not only provide significant insight into the various mechanisms of miRNAs but also offer a great opportunity in developing new therapeutic interventions.

MicroRNAs in Cancer

Author : César López-Camarillo
Publisher : CRC Press
ISBN 13 : 1466576766
Total Pages : 428 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis MicroRNAs in Cancer by : César López-Camarillo

Download or read book MicroRNAs in Cancer written by César López-Camarillo and published by CRC Press. This book was released on 2013-02-22 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and therapeutic targets as well as the potential use in translational medicine. Chapters present comprehensive and expert perspectives on the roles of miRNAs in most common cancers from bench to bedside applications and are written by an international team of renowned experts in the field.

MicroRNAs in Cancer Translational Research

Author : William C.S. Cho
Publisher : Springer Science & Business Media
ISBN 13 : 9400702981
Total Pages : 553 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis MicroRNAs in Cancer Translational Research by : William C.S. Cho

Download or read book MicroRNAs in Cancer Translational Research written by William C.S. Cho and published by Springer Science & Business Media. This book was released on 2011-01-25 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

MicroRNA Interference Technologies

Author : Zhiguo Wang
Publisher : Springer Science & Business Media
ISBN 13 : 364200489X
Total Pages : 198 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis MicroRNA Interference Technologies by : Zhiguo Wang

Download or read book MicroRNA Interference Technologies written by Zhiguo Wang and published by Springer Science & Business Media. This book was released on 2009-06-11 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.

MicroRNAs in Cancer Translational Research

Author : William C.S. Cho
Publisher : Springer
ISBN 13 : 9789400702974
Total Pages : 557 pages
Book Rating : 4.7/5 (29 download)

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Book Synopsis MicroRNAs in Cancer Translational Research by : William C.S. Cho

Download or read book MicroRNAs in Cancer Translational Research written by William C.S. Cho and published by Springer. This book was released on 2011-01-27 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) is a cutting-edge topic in the scientific and medical fields. This is a timely and specialized book focusing on the current understanding of miRNAs and the potential for their application in cancer diagnosis, prognosis, and therapeutic targets. It also provides discussion of the lessons learned from translational miRNA studies and exploration of the next steps required to advance this field. The unique book comprises 22 in-depth chapters by gathering unparalleled topics of interest in miRNAs by international team of world-renowned experts in the field. The first fifteen chapters provide comprehensive and expert perspectives on the most common cancers from bench to bedside applications, there is no current book structured in this cancer-oriented way. The next seven chapters providing thorough overviews of miRNAs and cancer stem cells; miRNAs in cancer invasion and metastasis; miRNAs in predicting radiotherapy and chemotherapy response; as well as expounding the role of miRNA in anti-cancer drug resistance and as blood-based cancer biomarkers. Furthermore, this book explicates the interplay of miRNAs in cancer metabolism and an update on the pioneering RNAi-based treatment approaches is also presented. This specialized book will contribute great to the scientific and medical community by providing the up-to-date discoveries of miRNAs and their important roles in cancer translational research.

MicroRNA

Author : Jaishree Paul
Publisher : CRC Press
ISBN 13 : 1351679872
Total Pages : 231 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis MicroRNA by : Jaishree Paul

Download or read book MicroRNA written by Jaishree Paul and published by CRC Press. This book was released on 2018-02-19 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the role of miRNA as therapeutic agents, the progress made in this direction and the problems that need to be addressed for miRNA based therapies to become successful. It also discusses the basic biology of miRNA sythesis, regulation, and their role in disease biology.

MicroRNA Cancer Regulation

Author : Ulf Schmitz
Publisher : Springer Science & Business Media
ISBN 13 : 9400755902
Total Pages : 352 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis MicroRNA Cancer Regulation by : Ulf Schmitz

Download or read book MicroRNA Cancer Regulation written by Ulf Schmitz and published by Springer Science & Business Media. This book was released on 2013-02-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and applications, together with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. We are sure that the emergence of high-throughput quantitative techniques will make this integrative approach absolutely necessary in the near future. This book will be a resource for researchers starting out with cancer microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology in cancer, and the state-of-the-art in computational microRNA biology.

MicroRNA Profiling in Cancer

Author : Yuriy Gusev
Publisher : CRC Press
ISBN 13 : 0429533721
Total Pages : 273 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis MicroRNA Profiling in Cancer by : Yuriy Gusev

Download or read book MicroRNA Profiling in Cancer written by Yuriy Gusev and published by CRC Press. This book was released on 2019-09-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents current advances in the emerging interdisciplinary field of microRNA research of human cancers from a unique perspective of quantitative sciences: bioinformatics, computational and systems biology, and mathematical modeling. This volume contains adaptations and critical reviews of recent state-of-the-art studies, ranging from technological advances in microRNA detection and profiling, clinically oriented microRNA profiling in several human cancers, to a systems biology analysis of global patterns of microRNA regulation of signaling and metabolic pathways. Interactions with transcription factor regulatory networks and mathematical modeling of microRNA regulation are also discussed.

RNAi and microRNA-Mediated Gene Regulation in Stem Cells

Author : Baohong Zhang
Publisher : Humana Press
ISBN 13 : 9781607617709
Total Pages : 240 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis RNAi and microRNA-Mediated Gene Regulation in Stem Cells by : Baohong Zhang

Download or read book RNAi and microRNA-Mediated Gene Regulation in Stem Cells written by Baohong Zhang and published by Humana Press. This book was released on 2011-08-24 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent stem cell research has revealed that miRNA and RNAi-mediated gene regulation is one of the vital determinates controlling the state of cell differentiation, with the small RNAs serving as key elements involved in regulatory network control of pluripotent cell fate determination. In RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications, expert authors from laboratories across the globe contribute an accessible compendium of up-to-date, proven methods focused on the study of the titular topic. Divided into three sections, the book first gives a brief introduction to RNAi and miRNAs in stem cells, with a focus on the current status of research and future perspectives, then it continues with detailed methods and protocols for RNAi screening, transfection, and the knockdown of specific genes and pathways in several animal species, including humans and mice, concluding with a section on recently developed methods for identification of miRNAs, including a general protocol for preparation and analysis of miRNA libraries for deep sequencing, knock down of a specific gene using miRNA-based shRNA, and miRNA expression analysis using qRT-PCR. Written in the highly successful Methods in Molecular BiologyTM series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes highlighting tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, RNAi and microRNA-Mediated Gene Regulation in Stem Cells: Methods, Protocols, and Applications serves as a valuable resource for scientists and aspiring graduate students interested in the intersection of RNAi, miRNA, and stem cell molecular biology and the exciting areas of medicine, including regenerative medicine, aging, cancer, and neurological disorders, that can be advanced through this expanding area of research.

MicroRNAs in Development

Author : Eran Hornstein
Publisher : Academic Press
ISBN 13 : 0123870380
Total Pages : 327 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis MicroRNAs in Development by : Eran Hornstein

Download or read book MicroRNAs in Development written by Eran Hornstein and published by Academic Press. This book was released on 2012-03-02 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume in the Current topics in Developmental Biology series concentrates on MicroRNAs in Development. It includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA. With an international team of authors, this volume is a must-have addition for researchers and students alike. Concentrates on microRNAs in development Includes chapters on such topics as miRNA networks in neuronal development, let-7 in development, and Hox networks and miRNA With an international team of authors, this volume is a must-have addition for researchers and students alike

MicroRNA and Cancer

Author : Wei Wu
Publisher : Humana Press
ISBN 13 : 9781607618621
Total Pages : 0 pages
Book Rating : 4.6/5 (186 download)

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Book Synopsis MicroRNA and Cancer by : Wei Wu

Download or read book MicroRNA and Cancer written by Wei Wu and published by Humana Press. This book was released on 2010-10-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tiny microRNAs (miRNAs) can have huge impacts on the regulation of a variety of genes and play crucial roles in the fundamental cellular processes. Recent miRNA studies change the landscape of cancer genetics by scrutinizing the alterations of genome-wide miRNA expressions in most common cancers and their regulatory functions during the development of cancer. The connections between miRNAs and cancer are widespread enough to warrant more comprehensive investigations in the systems biology perspective. In MicroRNA and Cancer: Methods and Protocols, internationally renowned experts provide the latest miRNA knowledge, the various techniques and methodologies currently available for cancer research application. Ranging from the fundamental concepts to practical applications, this book presents: • Overview of microRNA biogenesis, computational prediction of new miRNAs in the cancer genome, and miRNA-based therapeutic approaches for cancer treatment • Detailed experimental protocols in miRNA detection with novel and high-throughput technology, miRNA library cloning, miRNA epigenetic regulation, and miRNA pathway study • Stepwise computational and bioinformatic procedures for miRNA complex networks in cancer genomes with a variety of softwares and programs • Cross-cited notes on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge, MicroRNA and Cancer: Methods and Protocols serves researchers with the basic principles of experimental and computational methods for microRNA study in cancer research and provides a firm grounding for those who wish to further develop their own applications and tailor them to their own specific research needs.

Novel Perspectives in Micrornas

Author : Daniel Fletcher
Publisher : Murphy & Moore Publishing
ISBN 13 : 9781639877225
Total Pages : 0 pages
Book Rating : 4.8/5 (772 download)

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Book Synopsis Novel Perspectives in Micrornas by : Daniel Fletcher

Download or read book Novel Perspectives in Micrornas written by Daniel Fletcher and published by Murphy & Moore Publishing. This book was released on 2023-09-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) refers to a small single-stranded non-coding RNA molecule. It can be found in animals, plants and some viruses. miRNAs function in post-transcriptional regulation of gene expression and RNA silencing. They work through base-pairing along with complementary sequences in mRNA molecules. Several mammalian cell types contain a high concentration of miRNAs as circulating in extracellular fluid, which are released into body fluids such as blood and cerebrospinal fluid, and could be used as biomarkers in a variety of disorders. MiRNAs play a role in gene regulation and can also produce histone modifications and DNA methylation at promoter sites, which can affect the target gene expression. MiRNAs are important in modulating complex enzymatic cascades, such as the hemostatic blood coagulation system. The topics included in this book on microRNAs are of utmost significance and bound to provide incredible insights to the readers. Researchers and students engaged in the study of this molecule will be assisted by it.

MicroRNA in Development and in the Progression of Cancer

Author : Shree Ram Singh
Publisher : Springer
ISBN 13 : 9781493944910
Total Pages : 0 pages
Book Rating : 4.9/5 (449 download)

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Book Synopsis MicroRNA in Development and in the Progression of Cancer by : Shree Ram Singh

Download or read book MicroRNA in Development and in the Progression of Cancer written by Shree Ram Singh and published by Springer. This book was released on 2016-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: miRNAs are a class of endogenous, small non-protein coding RNA molecules (~ 22 nucleotides) which are novel post-transcriptional regulators of gene expression. Since we have hundreds of miRNAs, the major challenge is now to understand their specific biological function. In fact the experimental evidence suggests that signaling pathways could be ideal candidates for miRNA-mediated regulation. Several studies suggest that miRNAs affect the responsiveness of cells to signaling molecules such as WNT, Notch, TGF-β and EGFR. Altered expression of particular miRNAs has been implicated in the onset and development of cancer and could be used as potential biomarkers for the disease. Recently, many studies have found miRNAs have crucial regulatory roles in Cancer stem cells (CSCs) a kind of tumor initiating cells (TICs) and dormancy. Findings also suggest that DNA methylation may be important in regulating the expression of many miRNAs in several cancer initiating cells. Several miRNAs are known to either upregulated or downregulated in CSCs when compared to non-cancerous cells from the same tissues. CSCs are a small subpopulation of cells identified in a variety of tumors and involve in self-renewal, differentiation, chemoresistance and tumorigenesis. The volume will give a comprehensive account of important advancements in the area of miRNAs and cancer.

Clinical Bioinformatics

Author : Ronald Trent
Publisher : Humana
ISBN 13 : 9781493947003
Total Pages : 0 pages
Book Rating : 4.9/5 (47 download)

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Book Synopsis Clinical Bioinformatics by : Ronald Trent

Download or read book Clinical Bioinformatics written by Ronald Trent and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Clinical Bioinformatics, Second Edition, leading experts in the field provide a series of articles focusing on software applications used to translate information into outcomes of clinical relevance. Recent developments in omics, such as increasingly sophisticated analytic platforms allowing changes in diagnostic strategies from the traditional focus on single or small number of analytes to what might be possible when large numbers or all analytes are measured, are now impacting patient care. Covering such topics as gene discovery, gene function (microarrays), DNA sequencing, online approaches and resources, and informatics in clinical practice, this volume concisely yet thoroughly explores this cutting-edge subject. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Clinical Bioinformatics, Second Edition serves as an ideal guide for scientists and health professionals working in genetics and genomics.

RNA Biology

Author : Gunter Meister
Publisher : Wiley-VCH
ISBN 13 : 9783527322787
Total Pages : 0 pages
Book Rating : 4.3/5 (227 download)

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Book Synopsis RNA Biology by : Gunter Meister

Download or read book RNA Biology written by Gunter Meister and published by Wiley-VCH. This book was released on 2011-05-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with biologists, biochemists and other molecular scientists in mind, this volume meets the long-felt need for a textbook dedicated to the topic and recreates the excitement surrounding the scientific revolution sparked by the discovery of RNA interference in 1998. Students and instructors alike will profit from the author's exclusive first-hand knowledge, drawing on his breakthrough discoveries at the Tuschl lab at Rockefeller University. Gunter Meister abandons the traditionalist treatment of nucleic acids found in most biochemistry and molecular biology texts, adopting instead a modern approach in both concept and scope. The text is divided into three parts, on mRNA, non-coding RNA, and RNomics, and the author addresses the traditional roles of RNA in the transmission and regulation of genetic information, as well as the recently discovered functions of small RNA species in pathogen defense, cell differentiation and higher-level genomic regulation. All set to become the standard for teaching molecular science to biologists and biochemists.

MicroRNA

Author : Jaishree Paul
Publisher : CRC Press
ISBN 13 : 9781138054837
Total Pages : 202 pages
Book Rating : 4.0/5 (548 download)

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Book Synopsis MicroRNA by : Jaishree Paul

Download or read book MicroRNA written by Jaishree Paul and published by CRC Press. This book was released on 2018 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A CRC title, part of the Taylor & Francis imprint, a member of the Taylor & Francis Group, the academic division of T&F Informa plc."

Circulating MicroRNAs

Author : Nobuyoshi Kosaka
Publisher : Humana
ISBN 13 : 9781493962990
Total Pages : 0 pages
Book Rating : 4.9/5 (629 download)

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Book Synopsis Circulating MicroRNAs by : Nobuyoshi Kosaka

Download or read book Circulating MicroRNAs written by Nobuyoshi Kosaka and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: microRNAs (miRNAs) are small non-coding RNAs that regulate various biological phenomena, such as development and homeostasis. The dysregulation of miRNA leads to disease progression, particularly of cancer. In Circulating MicroRNAs: Methods and Protocols, expert researchers in the field detail recent advances in the isolation, purification and analysis of circulating miRNAs from a variety of sources for research. The book is divided into three main topics. The first section involves the study of secretory miRNAs in cell-cell communication, and the second, the study of circulating miRNAs in body fluids. The last describes the novel techniques used to study circulating miRNAs. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Circulating MicroRNAs: Methods and Protocols seeks to aid scientists in dealing with the recent advances of RNAi technology from the bench to the bedside.