Crystallization Of Molecular Glasses And Effect Of Polymer Additives On Crystallization In Amorphous Solid Dispersion

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Amorphous Solid Dispersions

Author : Navnit Shah
Publisher : Springer
ISBN 13 : 1493915983
Total Pages : 702 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Amorphous Solid Dispersions by : Navnit Shah

Download or read book Amorphous Solid Dispersions written by Navnit Shah and published by Springer. This book was released on 2014-11-21 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

Developing Solid Oral Dosage Forms

Author : Yihong Qiu
Publisher : Academic Press
ISBN 13 : 0128026375
Total Pages : 1178 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Developing Solid Oral Dosage Forms by : Yihong Qiu

Download or read book Developing Solid Oral Dosage Forms written by Yihong Qiu and published by Academic Press. This book was released on 2016-11-08 with total page 1178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more. - Written and edited by an international team of leading experts with experience and knowledge across industry, academia, and regulatory settings - Includes new chapters covering the pharmaceutical applications of surface phenomenon, predictive biopharmaceutics and pharmacokinetics, the development of formulations for drug discovery support, and much more - Presents new case studies throughout, and a section completely devoted to regulatory aspects, including global product regulation and international perspectives

Pharmaceutical Amorphous Solid Dispersions

Author : Ann Newman
Publisher : John Wiley & Sons
ISBN 13 : 1118455207
Total Pages : 502 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Pharmaceutical Amorphous Solid Dispersions by : Ann Newman

Download or read book Pharmaceutical Amorphous Solid Dispersions written by Ann Newman and published by John Wiley & Sons. This book was released on 2015-03-09 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world

Polymorphism in the Pharmaceutical Industry

Author : Rolf Hilfiker
Publisher : John Wiley & Sons
ISBN 13 : 3527697853
Total Pages : 645 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Polymorphism in the Pharmaceutical Industry by : Rolf Hilfiker

Download or read book Polymorphism in the Pharmaceutical Industry written by Rolf Hilfiker and published by John Wiley & Sons. This book was released on 2019-01-04 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

Pharmaceutical Amorphous Solid Dispersions

Author : Ann Newman
Publisher : John Wiley & Sons
ISBN 13 : 111890138X
Total Pages : 505 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Pharmaceutical Amorphous Solid Dispersions by : Ann Newman

Download or read book Pharmaceutical Amorphous Solid Dispersions written by Ann Newman and published by John Wiley & Sons. This book was released on 2015-02-27 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a roadmap from early to late stages of drug development, this book overviews amorphous solid dispersion technology – a leading platform to deliver poorly water soluble drugs, a major hurdle in today’s pharmaceutical industry. • Helps readers understand amorphous solid dispersions and apply techniques to particular pharmaceutical systems • Covers physical and chemical properties, screening, scale-up, formulation, drug product manufacture, intellectual property, and regulatory considerations • Has an appendix with structure and property information for polymers commonly used in drug development and with marketed drugs developed using the amorphous sold dispersion approach • Addresses global regulatory issues including USA regulations, ICH guidelines, and patent concerns around the world

Amorphous Drugs

Author : Marzena Rams-Baron
Publisher : Springer
ISBN 13 : 9783319891293
Total Pages : 230 pages
Book Rating : 4.8/5 (912 download)

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Book Synopsis Amorphous Drugs by : Marzena Rams-Baron

Download or read book Amorphous Drugs written by Marzena Rams-Baron and published by Springer. This book was released on 2019-06-06 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains theoretical and technological aspects of amorphous drug formulations. It is intended for all those wishing to increase their knowledge in the field of amorphous pharmaceuticals. Conversion of crystalline material into the amorphous state, as described in this book, is a way to overcome limited water solubility of drug formulations, in this way enhancing the chemical activity and bioavailability inside the body. Written by experts from various fields and backgrounds, the book introduces to fundamental physical aspects (explaining differences between the ordered and the disordered solid states, the enhancement of solubility resulting from drugs amorphization, physical instability and how it can be overcome) as well as preparation and formulation procedures to produce and stabilize amorphous pharmaceuticals. Readers will thus gain a well-funded understanding and find a multi-faceted discussion of the properties and advantages of amorphous drugs and of the challenges in producing and stabilizing them. The book is an ideal source of information for researchers and students as well as professionals engaged in research and development of amorphous pharmaceutical products.

Recent Progress in Solid Dispersion Technology

Author : Kohsaku Kawakami
Publisher :
ISBN 13 : 9783039215027
Total Pages : 1 pages
Book Rating : 4.2/5 (15 download)

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Book Synopsis Recent Progress in Solid Dispersion Technology by : Kohsaku Kawakami

Download or read book Recent Progress in Solid Dispersion Technology written by Kohsaku Kawakami and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amorphous solid dispersion (ASD) is a powerful formulation technology to improve oral absorption of poorly soluble drugs. Despite their being in existence for more than half a century, controlling ASD performance is still regarded as difficult because of ASD's natural non-equilibrium. However, recent significant advances in ASD knowledge and technology may enable a much broader use of ASD technology. This Special Issue, which includes 3 reviews and 6 original articles, focuses on recent progresses in ASD technology in hopes of helping to accelerate developmental studies in the pharmaceutical industry. In striving for a deep understanding of ASD non-equilibrium behavior, the Special issue also delves into and makes progress in the theory of soft-matter dynamics.

Structural Glasses and Supercooled Liquids

Author : Peter G. Wolynes
Publisher : John Wiley & Sons
ISBN 13 : 0470452234
Total Pages : 422 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Structural Glasses and Supercooled Liquids by : Peter G. Wolynes

Download or read book Structural Glasses and Supercooled Liquids written by Peter G. Wolynes and published by John Wiley & Sons. This book was released on 2012-04-10 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from 24 global experts in diverse fields, and edited by world-recognized leaders in physical chemistry, chemical physics and biophysics, Structural Glasses and Supercooled Liquids: Theory, Experiment, and Applications presents a modern, complete survey of glassy phenomena in many systems based on firmly established characteristics of the underlying molecular motions as deduced by first principle theoretical calculations, or with direct/single-molecule experimental techniques. A well-rounded view of a variety of disordered systems where cooperative phenomena, which are epitomized by supercooled liquids, take place is provided. These systems include structural glasses and supercooled liquids, polymers, complex liquids, protein conformational dynamics, and strongly interacting electron systems with quenched/self-generated disorder. Detailed calculations and reasoned arguments closely corresponding with experimental data are included, making the book accessible to an educated non-expert reader.

Binder and Polymer Assisted Powder Processing

Author : Randall M. German
Publisher : ASM International
ISBN 13 : 1627083197
Total Pages : 302 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Binder and Polymer Assisted Powder Processing by : Randall M. German

Download or read book Binder and Polymer Assisted Powder Processing written by Randall M. German and published by ASM International. This book was released on 2020-04-01 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Binder and Polymer Assisted Powder Processing is an engineering guide to powder-binder-based manufacturing methods. It covers the basic principles, current and emerging practices, implementation, and cost.

Handbook of Industrial Crystallization

Author : Allan Myerson
Publisher : Butterworth-Heinemann
ISBN 13 : 0080533515
Total Pages : 329 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Handbook of Industrial Crystallization by : Allan Myerson

Download or read book Handbook of Industrial Crystallization written by Allan Myerson and published by Butterworth-Heinemann. This book was released on 2002-01-08 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallization is an important separation and purification process used in industries ranging from bulk commodity chemicals to specialty chemicals and pharmaceuticals. In recent years, a number of environmental applications have also come to rely on crystallization in waste treatment and recycling processes.The authors provide an introduction to the field of newcomers and a reference to those involved in the various aspects of industrial crystallization. It is a complete volume covering all aspects of industrial crystallization, including material related to both fundamentals and applications. This new edition presents detailed material on crystallization of biomolecules, precipitation, impurity-crystal interactions, solubility, and design.Provides an ideal introduction for industrial crystallization newcomers Serves as a worthwhile reference to anyone involved in the fieldCovers all aspects of industrial crystallization in a single, complete volume

Thermal Analysis of Polymeric Materials

Author : Bernhard Wunderlich
Publisher : Springer Science & Business Media
ISBN 13 : 9783540236290
Total Pages : 918 pages
Book Rating : 4.2/5 (362 download)

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Book Synopsis Thermal Analysis of Polymeric Materials by : Bernhard Wunderlich

Download or read book Thermal Analysis of Polymeric Materials written by Bernhard Wunderlich and published by Springer Science & Business Media. This book was released on 2005-04-04 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of Contents Table of Contents 1 Atoms, small, and large molecules 2 Basics of thermal analysis 3 Dynamics of chemical and phase changes 4 Thermal analysis tools 5 Structure and properties of materials 6 Single component materials 7 Multiple component materials App. A.1 Table of thermal properties of linear macromolecules and related small molecules - the ATHAS data bank App. A.2 Radiation scattering App. A.3 Derivation of the Rayleigh ratio App. A.4 Neural network predictions App. A.5 Legendre transformations, Maxwell relations, linking of entropy and probability, and derivation of (dS/dT) App. A.6 Boltzmann distribution, harmonic vibration, complex numbers, and normal modes App. A.7 Summary of the basic kinetics of chemical reactions App. A.8 The ITS 1990 and the Krypton-86 length standard App. A.9 Development of classical DTA to DSC App. A.10 Examples of DTA and DSC under extreme conditions App. A.11 Description of an online correction of the heat-flow rate App. A.12 Derivation of the heat-flow equations App. A.13 Description of sawtooth-modulation response App. A.14 An introduction to group theory, definitions of configurations and conformations, and a summary of rational and irrational numbers App. A.15 Summary of birefringence and polarizing microscopy App. A.16 Summary of X-ray diffraction and interference effects App. A.17 Optical analog of electron double diffraction to produce Moire patterns.

Crystallization in Foods

Author : Richard W. Hartel
Publisher : Boom Koninklijke Uitgevers
ISBN 13 : 9780834216341
Total Pages : 342 pages
Book Rating : 4.2/5 (163 download)

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Book Synopsis Crystallization in Foods by : Richard W. Hartel

Download or read book Crystallization in Foods written by Richard W. Hartel and published by Boom Koninklijke Uitgevers. This book was released on 2001-03-31 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the food industry, controlling crystallization is a key factor in quality as it relates to texture, with some foods requiring the promotion of crystallization and others its prevention. In the first publication to focus specifically on this process as it applies to food, Crystallization in Foods covers fundamental principles in ice, sugar, and lipid crystallization, and their applications. Drawing on examples throughout of the practical use and impact of crystallization on food structure, texture, and quality; and enhanced with numerous equations and illustrations, Crystallization in Foods is a valuable resource for food engineers and other scientists working with crystallization in foods, particularly in the dairy, confectionery, frozen foods, and baked goods industries. In addition, this book may be of interest to scientists and other professionals in the personal care and cosmetics industry, which shares some of the same quality and texture concerns as the food industry.

Encyclopedia of Polymer Blends, Volume 3

Author : Avraam I. Isayev
Publisher : John Wiley & Sons
ISBN 13 : 3527653996
Total Pages : 528 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Encyclopedia of Polymer Blends, Volume 3 by : Avraam I. Isayev

Download or read book Encyclopedia of Polymer Blends, Volume 3 written by Avraam I. Isayev and published by John Wiley & Sons. This book was released on 2016-06-07 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete and timely overview of the topic, this Encyclopedia imparts knowledge of fundamental principles and their applications for academicians, scientists and researchers, while informing engineers, industrialists and entrepreneurs of the current state of the technology and its utilization. The most comprehensive source on polymer blends available on the market Offers a complete and timely overview of the topic Each article presents up to date research & development on a topic and its basic principles and applications, integrates case studies, laboratory and pilot plant experiments, and gives due reference to published and patented literature Equips academics, scientists and researchers with knowledge of fundamentals principles and their applications, and informs the engineers, industrialists and entrepreneurs about the state of the art technology and its applications

Polymer Morphology

Author : Qipeng Guo
Publisher : John Wiley & Sons
ISBN 13 : 1118452151
Total Pages : 472 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Polymer Morphology by : Qipeng Guo

Download or read book Polymer Morphology written by Qipeng Guo and published by John Wiley & Sons. This book was released on 2016-05-16 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on structure-property relationships, this book describes how polymer morphology affects properties and how scientists can modify them. The book covers structure development, theory, simulation, and processing; and discusses a broad range of techniques and methods. • Provides an up-to-date, comprehensive introduction to the principles and practices of polymer morphology • Illustrates major structure types, such as semicrystalline morphology, surface-induced polymer crystallization, phase separation, self-assembly, deformation, and surface topography • Covers a variety of polymers, such as homopolymers, block copolymers, polymer thin films, polymer blends, and polymer nanocomposites • Discusses a broad range of advanced and novel techniques and methods, like x-ray diffraction, thermal analysis, and electron microscopy and their applications in the morphology of polymer materials

Compendium of Polymer Terminology and Nomenclature

Author : Richard G Jones
Publisher : Royal Society of Chemistry
ISBN 13 : 1847559425
Total Pages : 465 pages
Book Rating : 4.8/5 (475 download)

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Book Synopsis Compendium of Polymer Terminology and Nomenclature by : Richard G Jones

Download or read book Compendium of Polymer Terminology and Nomenclature written by Richard G Jones and published by Royal Society of Chemistry. This book was released on 2009-01-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: The IUPAC system of polymer nomenclature has aided the generation of unambiguous names that re ect the historical development of chemistry. However, the explosion in the circulation of information and the globalization of human activities mean that it is now necessary to have a common language for use in legal situations, patents, export-import regulations, and environmental health and safety information. Rather than recommending a ‘unique name’ for each structure, rules have been developed for assigning ‘preferred IUPAC names’, while continuing to allow alternatives in order to preserve the diversity and adaptability of nomenclature. Compendium of Polymer Terminology and Nomenclature is the only publication to collect the most important work on this subject into a single volume. It serves as a handy compendium for scientists and removes the need for time consuming literature searches. One of a series issued by the International Union of Pure and Applied Chemistry (IUPAC), it covers the terminology used in many and varied aspects of polymer science as well as the nomenclature of several di erent types of polymer including regular and irregular single-strand organic polymers, copolymers and regular double-strand (ladder and spiro) organic polymers.

Properties of Polymers

Author : D.W. van Krevelen
Publisher : Elsevier
ISBN 13 : 0444596127
Total Pages : 898 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Properties of Polymers by : D.W. van Krevelen

Download or read book Properties of Polymers written by D.W. van Krevelen and published by Elsevier. This book was released on 2012-12-02 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties of Polymers: Their Correlation with Chemical Structure; Their Numerical Estimation and Prediction from Additive Group Contributions summarizes the latest developments regarding polymers, their properties in relation to chemical structure, and methods for estimating and predicting numerical properties from chemical structure. In particular, it examines polymer electrical properties, magnetic properties, and mechanical properties, as well as their crystallization and environmental behavior and failure. The rheological properties of polymer melts and polymer solutions are also considered. Organized into seven parts encompassing 27 chapters, this book begins with an overview of polymer science and engineering, including the typology of polymers and their properties. It then turns to a discussion of thermophysical properties, from transition temperatures to volumetric and calorimetric properties, along with the cohesive aspects and conformation statistics. It also introduces the reader to the behavior of polymers in electromagnetic and mechanical fields of force. The book covers the quantities that influence the transport of heat, momentum, and matter, particularly heat conductivity, viscosity, and diffusivity; properties that control the chemical stability and breakdown of polymers; and polymer properties as an integral concept, with emphasis on processing and product properties. Readers will find tables that give valuable (numerical) data on polymers and include a survey of the group contributions (increments) of almost every additive function considered. This book is a valuable resource for anyone working on practical problems in the field of polymers, including organic chemists, chemical engineers, polymer processers, polymer technologists, and both graduate and PhD students.

Liquid Crystalline and Mesomorphic Polymers

Author : Valery P. Shibaev
Publisher : Springer Science & Business Media
ISBN 13 : 1461383331
Total Pages : 378 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Liquid Crystalline and Mesomorphic Polymers by : Valery P. Shibaev

Download or read book Liquid Crystalline and Mesomorphic Polymers written by Valery P. Shibaev and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Among the various new directions in modern polymer science, the design and investigation of liquid crystal (LC) polymers have been the ones growing most actively and fruitfully. In spite of that, the possible formation of an anisotropic LC phase was only demonstrated theoretically for the first time in the 1950s by Onsager [1] and Flory [2], and then experimentally verified in the studies with polypeptides solutions. In essence, the studies of these LC lyotropic systems did not deviate from the theme of purely academic interest. It was at the beginning of the 1970s that the experimental "explosion" occurred, when aromatic polyamides were synthesized and their ability to form LC solutions in certain very aggressive solvents was discovered. The search for practical applications of such LC systems was crowned with the successful creation of the new generation of ultrastrong high-modulus ther mostable fibers, such as the Kevlar, due to the high degree of order of the macromolecules in the anisotropic LC state. In fact, these investigations coincided with the swift emergence on the practical "scene" of thermotropic low-molar-mass liquid crystals, with the use of these materials in microelectronics and electro optics (figures and let ters indicators, displays in personal computers, and flat TV, etc.). Polymer scientists also began to develop methods of synthesizing thermotropic LC polymers by incorporating mesogenic fragments in the main (main-chain LC polymers) or side branchings of the macromolecules (side-chain or comb shaped polymers).