Author : Reeti Katoch-Rouse
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (472 download)
Book Synopsis Controlled Reductive Cyclization for the Synthesis of Dihydrobenzofurans by : Reeti Katoch-Rouse
Download or read book Controlled Reductive Cyclization for the Synthesis of Dihydrobenzofurans written by Reeti Katoch-Rouse and published by . This book was released on 2000 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The decalin ring system is a core structural unit in a variety of biologically important natural products, such as arenols and clerodanes. These classes possess either a cis- or trans-fused decalin ring system as well as a characteristic 9-alkyl and an 8,9-dimethyl vicinal arrangement. A concise approach to these systems using a Lewis-acid catalysed Diels Alder reaction, where the 8,9-dimethyl syn arrangement has been set previously, is demonstrated. An efficient and stereocontrolled preparation of appropriately functionalized dienes, which can be further elaborated into the desired Diels Alder precursors, has been carried out using achiral 3,4-dimethoxy cyclopentenone.