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Continuous Processing Of Polymeric Micelles
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Book Synopsis Continuous Processing of Polymeric Micelles by : Anand Gupta
Download or read book Continuous Processing of Polymeric Micelles written by Anand Gupta and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric micelles are nano-particulate core-shell structures that form spontaneously in aqueous solutions of block copolymers composed of hydrophilic and hydrophobic portions when their concentration surpasses the critical micelle concentration (CMC) at a given temperature. They are used as drug delivery systems for highly potent and extremely hydrophobic drugs such as anticancer or anti-inflammatory agents to enhance safety, efficacy, and solubility. Critical quality attributes of polymeric micelles, that tend to govern their destiny in the human body are their size and polydispersity. Ensuring manufacturing consistency for complex drug products such as polymeric nanoparticles is challenging. This can be attributed, in part, to the complex nature of the manufacturing processes and a lack of understanding of critical material attributes such as drug-polymer interactions and critical process parameters such as organic to aqueous phase ratios. Currently, the manufacturing of polymeric micelles in the pharmaceutical industry is via batch processing which has various disadvantages such as scalability, irreproducibility, down-time between batches and other issues leading to product waste, and increased expenses. To overcome potential batch-to-batch variation typically observed using traditional batch manufacturing processes, the current work focused on continuous processing of polymeric micelles and the establishment and assessment of key material attributes and process parameters. A modified continuous processing platform (based on the University of Connecticut prototype liposomal manufacturing platform) was successfully developed and built to produce polymeric micelles. Moreover, this study outlines the relationship between critical independent variables (such as polymer concentration, organic to aqueous flow rate ratios and temperature) and critical quality attributes (such as the size and polydispersity) of polymeric micelles produced by continuous processing. The controlled nanoprecipitation process achieved via co-axial co-flow and radial mixing of jets improved the control and reproducibility of polymeric micelle particle size and polydispersity compared to batch processing. Multiple design of experiments studies were implemented to produce polymeric micelles with controlled size in the range between 15 and 70 nm. Four different molecular weight block copolymers (i.e. PEG-PLA-4kD, and PEG-PCL 7kD, 14kD and 28kD) were investigated to produce polymeric micelles using the turbulent jet co-flow technology. Moreover, curcumin-loaded polymeric micelles, as an example of an API containing polymeric micelles, were produced to establish and validate the continuous processing system. Paclitaxel-loaded polymeric micelles were produced to demonstrate the system's capacity to produce Q1/Q2 equivalent drug product similar to the reference listed drug product: Genexol®PM.
Book Synopsis Polymer Micelles by : Shin-ichi Yusa
Download or read book Polymer Micelles written by Shin-ichi Yusa and published by MDPI. This book was released on 2018-04-20 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Polymer Micelles" that was published in Polymers
Book Synopsis The Role of Polymer/gas Solutions in Continuous Processing of Microcellular Polymers by : Chul Bum Park
Download or read book The Role of Polymer/gas Solutions in Continuous Processing of Microcellular Polymers written by Chul Bum Park and published by . This book was released on 1993 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymeric Drug Delivery Systems by : Glen S. Kwon
Download or read book Polymeric Drug Delivery Systems written by Glen S. Kwon and published by CRC Press. This book was released on 2005-04-12 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
Book Synopsis Polymeric Micelles: Principles, Perspectives and Practices by : Sachin Kumar Singh
Download or read book Polymeric Micelles: Principles, Perspectives and Practices written by Sachin Kumar Singh and published by Springer Nature. This book was released on 2023-04-08 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book thoroughly reviews the advancements in design and applications of Polymeric Micelles (PMs) in drug delivery. It provides information on the synthesis of amphiphilic block copolymers and their types, functional chemistry for targeting and sensing, and biomedical applications. The book further provides the possibilities for designing PMs in a range of drug delivery approaches. The book addresses the molecular parameters of amphiphilic block copolymers that are required for functionalizing PMs for drug delivery applications. Additionally, the book presents recent advances in applications of PMs such as co-delivery, sensing, theranostics, delivery of nucleic acids, and proteins. Towards the end, it discusses different physico-chemical strategies to enhance the stability and drug retention of polymeric micelles and reviews the preclinical and clinical toxicity and immunogenicity-related aspects of polymeric micelles. This book is an invaluable source for academics, research, and industry professionals working in the field of polymeric micelles and drug delivery.
Book Synopsis Introduction to Quality by Design (QbD) by : N. K. Jain
Download or read book Introduction to Quality by Design (QbD) written by N. K. Jain and published by Springer Nature. This book was released on with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Monitoring Polymerization Reactions by : Wayne F. Reed
Download or read book Monitoring Polymerization Reactions written by Wayne F. Reed and published by John Wiley & Sons. This book was released on 2014-01-21 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers new strategies to optimize polymer reactions With contributions from leading macromolecular scientists and engineers, this book provides a practical guide to polymerization monitoring. It enables laboratory researchers to optimize polymer reactions by providing them with a better understanding of the underlying reaction kinetics and mechanisms. Moreover, it opens the door to improved industrial-scale reactions, including enhanced product quality and reduced harmful emissions. Monitoring Polymerization Reactions begins with a review of the basic elements of polymer reactions and their kinetics, including an overview of stimuli-responsive polymers. Next, it explains why certain polymer and reaction characteristics need to be monitored. The book then explores a variety of practical topics, including: Principles and applications of important polymer characterization tools, such as light scattering, gel permeation chromatography, calorimetry, rheology, and spectroscopy Automatic continuous online monitoring of polymerization (ACOMP) reactions, a flexible platform that enables characterization tools to be employed simultaneously during reactions in order to obtain a complete record of multiple reaction features Modeling of polymerization reactions and numerical approaches Applications that optimize the manufacture of industrially important polymers Throughout the book, the authors provide step-by-step strategies for implementation. In addition, ample use of case studies helps readers understand the benefits of various monitoring strategies and approaches, enabling them to choose the best one to match their needs. As new stimuli-responsive and "intelligent" polymers continue to be developed, the ability to monitor reactions will become increasingly important. With this book as their guide, polymer scientists and engineers can take full advantage of the latest monitoring strategies to optimize reactions in both the lab and the manufacturing plant.
Book Synopsis Nanocarrier Drug Delivery Systems by : Prashant L. Pingale
Download or read book Nanocarrier Drug Delivery Systems written by Prashant L. Pingale and published by Walter de Gruyter GmbH & Co KG. This book was released on 2024-09-02 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology can treat diseases by site-specific and target-oriented delivery of precise medicines. Nanomaterials improve the efficacy of drugs and selective diagnosis. The book covers detection and treatment. It explains the use of nanocarriers for a variety of diseases such as cardiovascular and respiratory diseases, cancer, and ulcerative colitis. It includes topical, transdermal, and ocular drug delivery and combined medication delivery.
Download or read book Nutraceuticals written by Dr. Inamuddin and published by Elsevier. This book was released on 2023-03-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutraceuticals: Sources, Processing Methods, Properties, and Applications explores the impact of nutraceutical compounds on human health and their main pharmacological contributions. Organized into three parts, this book addresses nutraceutical production, applications for disease prevention and treatment, and current trends, especially the role of nutraceuticals in cosmeceutical. Nutraceuticals are a class of products that can help people improve their health, reduce the risk of disease, extend their lives, and control the structure and functioning of their bodies. However, due to multiple hurdles that prevent nutraceuticals from circulating in an active form in the body, their use is associated with diminished therapeutic efficacy. Recognizing this problem, the book explores the root of the nutraceutical delivery system and its codelivery methods with a focus on medicines. With contributions from experienced nutraceutical experts, this book serves as a valuable reference for nutrition researchers, food scientists, pharmacologists, and those who are researching and studying in related areas. Discusses nutraceutical applications and compounds and the current trends in this emerging field Explores the production of nutraceuticals Written and edited by experienced researchers in this field
Book Synopsis Discovery, Disruption, and Future Implications of Nanomaterials by : Kaur, Hardeep
Download or read book Discovery, Disruption, and Future Implications of Nanomaterials written by Kaur, Hardeep and published by IGI Global. This book was released on 2024-08-29 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complexities of nanotechnology often hamper the discoveries of nanomaterials and their wide range of applications. Researchers face the challenge of keeping up with the rapid development of new materials and figuring out how they can be most efficiently and safely used. As scientists continue to explore the unique properties of nanoparticles, nanofibers, and other nanostructures, there is a growing need for a comprehensive resource to guide them through this intricate landscape. Discovery, Disruption, and Future Implications of Nanomaterials is a book that provides a curated collection of cutting-edge research and insights into the strategic importance of nanomaterials. It bridges the gap between theory and practice, covering fundamental principles to advanced applications in areas such as biomedicine, electronics, energy, and more. The book focuses on carbon-based materials for water treatment, gene/drug delivery, and nanotechnology's role in various fields, equipping readers with the knowledge to navigate the complexities of nanomaterial development and implementation.
Book Synopsis Process for Continuous Production of Polymers by : W. Hanisch
Download or read book Process for Continuous Production of Polymers written by W. Hanisch and published by . This book was released on 1981 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Melgardt M. de Villiers Publisher :Springer Science & Business Media ISBN 13 :0387776680 Total Pages :681 pages Book Rating :4.3/5 (877 download)
Book Synopsis Nanotechnology in Drug Delivery by : Melgardt M. de Villiers
Download or read book Nanotechnology in Drug Delivery written by Melgardt M. de Villiers and published by Springer Science & Business Media. This book was released on 2008-10-29 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.
Book Synopsis Polymer Colloids by : Rodney Priestley
Download or read book Polymer Colloids written by Rodney Priestley and published by Royal Society of Chemistry. This book was released on 2019-12-02 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Academic and industrial research around polymer-based colloids is huge, driven both by the development of mature technologies, e.g. latexes for coatings, as well as the advancement of new materials and applications, such as building blocks for 2D/3D structures and medicine. Edited by two world-renowned leaders in polymer science and engineering, this is a fundamental text for the field. Based on a specialised course by the editors, this book provides the reader with an invaluable single source of reference. The first section describes formation, explaining basic properties of emulsions and dispersion polymerization, microfluidic approaches to produce polymer-based colloids and formation via directed self-assembly. The next section details characterisation methodologies from microscopy and small angle scattering, to surface science and simulations. The final chapters close with applications, including Pickering emulsions and molecular engineering for materials development. A comprehensive guide to polymer colloids, with contributions by leaders in their respective areas, this book is a must-have for researchers and practitioners working across polymers, soft matter and chemical and molecular engineering.
Book Synopsis Controlled Polymerization and Polymeric Structures by : Akihiro Abe
Download or read book Controlled Polymerization and Polymeric Structures written by Akihiro Abe and published by Springer. This book was released on 2014-07-08 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Polymer Science enjoys a longstanding tradition and good reputation in its community. Each volume is dedicated to a current topic, and each review critically surveys one aspect of that topic, to place it within the context of the volume. The volumes typically summarize the significant developments of the last 5 to 10 years and discuss them critically, presenting selected examples, explaining and illustrating the important principles, and bringing together many important references of primary literature. On that basis, future research directions in the area can be discussed. Advances in Polymer Science volumes thus are important references for every polymer scientist, as well as for other scientists interested in polymer science - as an introduction to a neighboring field, or as a compilation of detailed information for the specialist.
Book Synopsis Pharmaceutical Nanotechnology, 2 Volumes by : Jean Cornier
Download or read book Pharmaceutical Nanotechnology, 2 Volumes written by Jean Cornier and published by John Wiley & Sons. This book was released on 2017-06-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch legt den Schwerpunkt auf konkrete Methoden und die jüngsten Fortschritte bei der Anwendung von Nanotechnologie für die Entwicklung neuer medikamentöser Therapieansätze und die medizinische Diagnostik. Von den Grundlagen der Nanopharmazie, einschließlich Charakterisierung und Herstellungsverfahren, bis hin zur Rolle von Nanopartikeln und Wirkstoffen wird das Fachgebiet umfassend dargestellt. Anwendungsbeispiele beziehen sich auf Fragestellungen bei der Medikamentenentwicklung und die Übertragung auf die klinische Praxis, Marktchancen und Aspekte der industriellen Vermarktung. Die beschriebenen Anwendungen stammen aus der Behandlung von Krebserkrankungen und weiteren wichtigen Therapiebereichen wie Infektionskrankheiten und Dermatologie. Abgerundet wird das Fachbuch durch eine ausführliche Erörterung sicherheitsrelevanter, rechtlicher und gesellschaftlicher Fragen. Geschrieben von einem erstklassigen Team von Herausgebern und Autoren, die zu den führenden Experten in Europa und den USA sowie zu den Pionieren der Nanopharmazie gehören.
Book Synopsis Smart Nanomaterials in Biomedical Applications by : Jin-Chul Kim
Download or read book Smart Nanomaterials in Biomedical Applications written by Jin-Chul Kim and published by Springer Nature. This book was released on 2022-01-19 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the start of 2020, the wrath of pandemic challenged the scientific community to develop more advanced drug delivery approaches for biomedical applications, endowing conventional drugs with additional therapeutic benefits and minimum side effects. Although significant advancements have been done in the field of drug delivery, there is a need to focus towards strategizing novel and improved drug delivery systems that should be convenient and cost-effective to the patients, and simultaneously they should also provide financial benefits to pharmaceutical companies. Controlled drug delivery technology offers ample opportunities and scope for improvising the therapeutic efficacy of drugs via optimizing the drug release rate and time. For this endeavour, smart nanomaterials have served as remarkable candidates for biomedical applications, owing to their ground-breaking properties and design. The development of such nanomaterials requires a broad knowledge related to their physio-chemical properties, molecular structure, mechanisms by which the nanomaterials interact with the cells, and methods by which drugs are released at the site of action. This knowledge must also be allied with the knowledge of signaling crosstalk mechanisms that are modulated by the nanomaterial-drugs composite. It can be anticipated that these emerging drug delivery technologies can facilitate the world to successfully encounter such pandemic outbursts in the future in a cost-effective and time-effective manner. The chapters in this book deal with the advanced technologies and approaches that can benefit advanced students, researchers, and industry experts in developing smart and intelligent nanomaterials for future biomedical applications, and development, manufacturing, and commercialization for controlled and targeted drug delivery.
Book Synopsis Emerging Nanotechnologies in Immunology by : Ranjita Shegokar
Download or read book Emerging Nanotechnologies in Immunology written by Ranjita Shegokar and published by William Andrew. This book was released on 2018-05-17 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanotechnologies in Immunology aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanophamaceuticals currently in the pipeline of S&T development for skin, ocular, and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure.The scientific development of manufactured nanomaterials for drug delivery is increasing rapidly. One of the most prominent applications is topical drug delivery, where cutaneous, ocular, and nasal exposure becomes even more relevant. These targets are the first barrier that nanoparticles encounter when in contact with the human body.The contributors addresses a representative set of the broad spectrum of nanopharmaceuticals currently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue engineered skin substitutes. Regulation and risk is also covered, since the safety of these nanophamaceuticals still represents a barrier to their wide innovative use. Provides the reader with a thorough knowledge of the safety aspects of nanopharmaceuticals which are currently under research Focuses on the characterization and quantification of the nanopharmaceuticals Allows readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects Includes an overview of regulatory aspects related to the R&D of nanopharmaceuticals
