Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3

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Publisher : National Academies Press
ISBN 13 : 0309225477
Total Pages : 22 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3 by : National Research Council

Download or read book Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3 written by National Research Council and published by National Academies Press. This book was released on 2011-01-01 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2003, the Boston University Medical Center (BUMC) was awarded a $128 million grant from the National Institutes of Health (NIH) to build one of two national maximum-containment laboratory facilities for pathogen research. The National Emerging Infectious Diseases Laboratories (NEIDL) are meant to support the National Institute of Allergy and Infectious Diseases' biodefense research agenda, conducting research to develop new approaches to treating, preventing, and diagnosing a variety of bacterial and viral diseases. The facility includes a biosafety level 4 (BSL-4) containment laboratory housed in a 192,000 square foot building. Although the NEIDL BSL-4 laboratory accounts for only 13 percent of the building's total space, it has been the source of virtually all of the community concern surrounding this project. The location of the facility on Albany Street in Boston's South End, which is an environmental justice community, has been controversial, and there have been numerous public meetings over the plans for the facility as well as three legal actions challenging the project. Continuing Assistance to the National Institutes of Health on Preparation of Additional Risk Assessments for the Boston University NEIDL, Phase 3, the fifth in a series of reports about the proposed facility, provides further technical input on the scope and design of any additional studies that may be needed to assess the risks associated with the siting and operation of the NEIDL. This report presents comments and questions on a "90 percent", or penultimate, draft of the revised risk assessment. According to the report, the "90 percent" draft of the risk assessment is a substantial improvement over past documents reviewed. Additionally, the report makes recommendations to improve the version that is ultimately prepared for public comment.

Laboratory Biorisk Management

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Author :
Publisher : CRC Press
ISBN 13 : 1498749747
Total Pages : 264 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Laboratory Biorisk Management by : Reynolds M. Salerno

Download or read book Laboratory Biorisk Management written by Reynolds M. Salerno and published by CRC Press. This book was released on 2015-12-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades bioscience facilities worldwide have experienced multiple safety and security incidents, including many notable incidents at so-called "sophisticated facilities" in North America and Western Europe. This demonstrates that a system based solely on biosafety levels and security regulations may not be sufficient. Setting the stage for a substantively different approach for managing the risks of working with biological agents in laboratories, Laboratory Biorisk Management: Biosafety and Biosecurity introduces the concept of biorisk management—a new paradigm that encompasses both laboratory biosafety and biosecurity. The book also provides laboratory managers and directors with the information and technical tools needed for its implementation. The basis for this new paradigm is a three-pronged, multi-disciplinary model of assessment, mitigation, and performance (the AMP model). The application of the methodologies, criteria, and guidance outlined in the book helps to reduce the risk of laboratories becoming the sources of infectious disease outbreaks. This is a valuable resource for those seeking to embrace and implement biorisk management systems in their facilities and operations, including the biological research, clinical diagnostic, and production/manufacturing communities.

American Anthrax

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Publisher : Macmillan
ISBN 13 : 1429973153
Total Pages : 337 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis American Anthrax by : Jeanne Guillemin

Download or read book American Anthrax written by Jeanne Guillemin and published by Macmillan. This book was released on 2011-09-13 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Jeanne Guillemin, one of the world's leading experts on anthrax and bioterrorism, the definitive account of the anthrax investigation It was the most complex case in FBI history. In what became a seven-year investigation that began shortly after 9/11—with America reeling from the terror attacks of al Qaeda—virulent anthrax spores sent through the mail killed Bob Stevens, a Florida tabloid photo editor. His death and, days later, the discovery in New York and Washington, D.C. of letters filled with anthrax sent shock waves through the nation. Federal agencies were blindsided by the attacks, which eventually killed five people. Taken off guard, the FBI struggled to combine on-the-ground criminal investigation with progress in advanced bioforensic analyses of the letters' contents. While the criminal eluded justice, disinformation swirled around the letters, erroneously linking them to Iraq's WMD threat and foreign bioterrorism. Without oversight, billions were lavished on biomedical defenses against anthrax and other exotic diseases. Worst of all, faith in federal justice faltered. American Anthrax is a gripping tale of terror, intrigue, madness, and cover-up.

Strengthening the Disaster Resilience of the Academic Biomedical Research Community

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Publisher : National Academies Press
ISBN 13 : 0309462525
Total Pages : 451 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Strengthening the Disaster Resilience of the Academic Biomedical Research Community by : National Academies of Sciences, Engineering, and Medicine

Download or read book Strengthening the Disaster Resilience of the Academic Biomedical Research Community written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-10-20 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: The academic biomedical research community is a hub of employment, economic productivity, and scientific progress. Academic research institutions are drivers of economic development in their local and state economies and, by extension, the national economy. Beyond the economic input that the academic biomedical research community both receives and provides, it generates knowledge that in turn affects society in myriad ways. The United States has experienced and continues to face the threat of disasters, and, like all entities, the academic biomedical research community can be affected. Recent disasters, from hurricanes to cyber-attacks, and their consequences have shown that the investments of the federal government and of the many other entities that sponsor academic research are not uniformly secure. First and foremost, events that damage biomedical laboratories and the institutions that house them can have impacts on the safety and well-being of humans and research animals. Furthermore, disasters can affect career trajectories, scientific progress, and financial stability at the individual and institutional levels. Strengthening the Disaster Resilience of the Academic Biomedical Research Community offers recommendations and guidance to enhance the disaster resilience of the academic biomedical research community, with a special focus on the potential actions researchers, academic research institutions, and research sponsors can take to mitigate the impact of future disasters.

Animal Care and Use Committees

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Publisher :
ISBN 13 :
Total Pages : 50 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Animal Care and Use Committees by : John Timothy Allen

Download or read book Animal Care and Use Committees written by John Timothy Allen and published by . This book was released on 1992 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories

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Publisher : National Academies Press
ISBN 13 : 0309225760
Total Pages : 216 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories by : Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories

Download or read book Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories written by Committee on Anticipating Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories and published by National Academies Press. This book was released on 2012-03-16 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: During July 10-13, 2011, 68 participants from 32 countries gathered in Istanbul, Turkey for a workshop organized by the United States National Research Council on Anticipating Biosecurity Challenges of the Global Expansion of High-containment Biological Laboratories. The United States Department of State's Biosecurity Engagement Program sponsored the workshop, which was held in partnership with the Turkish Academy of Sciences. The international workshop examined biosafety and biosecurity issues related to the design, construction, maintenance, and operation of high-containment biological laboratories- equivalent to United States Centers for Disease Control and Prevention biological safety level 3 or 4 labs. Although these laboratories are needed to characterize highly dangerous human and animal pathogens, assist in disease surveillance, and produce vaccines, they are complex systems with inherent risks. Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories summarizes the workshop discussion, which included the following topics: Technological options to meet diagnostic, research, and other goals; Laboratory construction and commissioning; Operational maintenance to provide sustainable capabilities, safety, and security; and Measures for encouraging a culture of responsible conduct. Workshop attendees described the history and current challenges they face in their individual laboratories. Speakers recounted steps they were taking to improve safety and security, from running training programs to implementing a variety of personnel reliability measures. Many also spoke about physical security, access controls, and monitoring pathogen inventories. Workshop participants also identified tensions in the field and suggested possible areas for action.

Oversight of High-Containment Biological Laboratories

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Author :
Publisher : DIANE Publishing
ISBN 13 : 1437919375
Total Pages : 33 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Oversight of High-Containment Biological Laboratories by : Frank Gottron

Download or read book Oversight of High-Containment Biological Laboratories written by Frank Gottron and published by DIANE Publishing. This book was released on 2009-12 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fed. gov¿t. responded to the 9/11 terrorist attacks and the subsequent anthrax attacks with increased focus on and funding for biodefense. High-containment labs. (HCL) play a critical role in the biodefense effort, offering the hope of better responses to an attack and a better understanding of the threat posed by bioterrorism. However, they also could increase the risk of a biological attack by serving as a potential source of materials or training. Policymakers have become increasingly interested in the oversight of these facilities following reports of accidents, regulatory noncompliance, and community resistance. A key task for policymakers is to define their goals for enhancing oversight of HCL. Illustrations

Biotechnology Research in an Age of Terrorism

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Publisher : National Academies Press
ISBN 13 : 0309089778
Total Pages : 164 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biotechnology Research in an Age of Terrorism by : National Research Council

Download or read book Biotechnology Research in an Age of Terrorism written by National Research Council and published by National Academies Press. This book was released on 2004-03-02 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

The Adaptive Web

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Publisher : Springer Science & Business Media
ISBN 13 : 3540720782
Total Pages : 770 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis The Adaptive Web by : Peter Brusilovski

Download or read book The Adaptive Web written by Peter Brusilovski and published by Springer Science & Business Media. This book was released on 2007-04-24 with total page 770 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art survey provides a systematic overview of the ideas and techniques of the adaptive Web and serves as a central source of information for researchers, practitioners, and students. The volume constitutes a comprehensive and carefully planned collection of chapters that map out the most important areas of the adaptive Web, each solicited from the experts and leaders in the field.

Biomedical Models and Resources

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Publisher : National Academies Press
ISBN 13 : 0309060354
Total Pages : 85 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Biomedical Models and Resources by : National Research Council

Download or read book Biomedical Models and Resources written by National Research Council and published by National Academies Press. This book was released on 1998-02-16 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Printbegrænsninger: Der kan printes 10 sider ad gangen og max. 40 sider pr. session.

Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

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Publisher : Springer Nature
ISBN 13 : 9811581797
Total Pages : 266 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy by : Shabir Ahmad Ganai

Download or read book Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy written by Shabir Ahmad Ganai and published by Springer Nature. This book was released on 2020-11-23 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest developments in the design, synthesis, and molecular mechanism of action of Histone Deacetylase (HDAC) inhibitors in the context of potential cancer therapy. HDAC inhibitors are emerging as promising anticancer drug molecules that promote growth arrest, differentiation and apoptosis of cancer cells with tumor selective toxicity. The book begins with an overview of various epigenetic modifying enzymes that are involved in cancer transition and progression; before exploring the potential of HDACs in cancer treatment. It provides a classification of HDAC inhibitors based on their structural attributes, and addresses HDAC-induced cytotoxicity.. Lastly, it discusses and assesses the rationale behind therapies that combine HDAC inhibitors with other anticancer agents to treat solid tumors. Given its scope, it offers a valuable resource for all researchers, clinicians, and students working in formulation, drug discovery, oncology, and personalized medicine.

EPA-100-B.

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Publisher :
ISBN 13 :
Total Pages : 74 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis EPA-100-B. by :

Download or read book EPA-100-B. written by and published by . This book was released on 2001 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Solid Waste Management: Abstracts from the Literature

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Publisher :
ISBN 13 :
Total Pages : 710 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Solid Waste Management: Abstracts from the Literature by :

Download or read book Solid Waste Management: Abstracts from the Literature written by and published by . This book was released on 1967 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pain in Osteoarthritis

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Publisher : John Wiley & Sons
ISBN 13 : 9780470930557
Total Pages : 320 pages
Book Rating : 4.9/5 (35 download)

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Book Synopsis Pain in Osteoarthritis by : David T. Felson

Download or read book Pain in Osteoarthritis written by David T. Felson and published by John Wiley & Sons. This book was released on 2010-08-03 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative investigation of the sources andtreatment of osteoarthritic joint pain Millions of people throughout the world suffer from osteoarthritis (OA)—a medical condition causing its sufferers excruciating pain that is often disabling. This is the first book to offer clinicians an in-depth understanding of the biological sources of osteoarthritic pain and how they can be treated. Here, a team of leading international authorities has contributed state-of-the-art information on: The Neuroscience of Articular Pain—spinal and peripheral mechanisms of joint pain; experimental models for the study of osteoarthritic pain; inflammatory mediators and nociception in arthritis; phantoms in rheumatology; and more Osteoarthritis and Pain—joint mechanisms and neuromuscular aspects of OA; bone pain and pressure in OA joints; structural correlates of OA pain; and more Treatment of Osteoarthritic Pain—general approaches to treatment; treatments targeting pain receptors; treatments targeting biomechanical abnormalities; and treatments targeting inflammation Whether you're a medical professional, researcher, student, or a generalist or specialist focusing on pain or arthritis, this is your one-stop reference for understanding and treating joint pain in osteoarthritis.

Your Genes, Your Health

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Publisher : Oxford University Press
ISBN 13 : 0199792070
Total Pages : 418 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Your Genes, Your Health by : Aubrey Milunsky

Download or read book Your Genes, Your Health written by Aubrey Milunsky and published by Oxford University Press. This book was released on 2011-10-13 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, Dr. Aubrey Milunsky provides guidance for all who wish to avoid, prevent, or detect genetic disorders in their families. The author describes new advances in many genetic diseases and a cascade of DNA tests that now enable many to secure their health and even save their own lives and those of their loved ones.

Point of Care Ultrasound E-book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323544711
Total Pages : 793 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Point of Care Ultrasound E-book by : Nilam J Soni

Download or read book Point of Care Ultrasound E-book written by Nilam J Soni and published by Elsevier Health Sciences. This book was released on 2019-04-26 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compact, hand-carried ultrasound devices are revolutionizing how healthcare providers practice medicine in nearly every specialty. The 2nd Edition of this BMA-award-winning text features all-new chapters, a greatly expanded video library, and new review questions to keep you fully up to date with the latest technology and its applications. Helps you interpret findings with a peer-reviewed, online video library with more than 1,000 ultrasound videos of normal and pathologic findings. These videos are complemented by anatomical illustrations and text descriptions to maximize learning. Offers new online resources, including over 60 clinical cases and review questions in every chapter. Features fully updated content throughout, plus all-new chapters on hemodynamics, transesophageal echocardiography, transcranial Doppler ultrasound, pediatrics, neonatology, and 2nd/3rd trimester pregnancy. Shares the knowledge and expertise of expert contributors who are internationally recognized faculty from more than 60 institutions. Recipient of British Medical Association’s President's Choice Award and Highly Commended in Internal Medicine at the BMA Medical Book Awards 2015 (first edition).

Actin-Binding Proteins and Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 0387717498
Total Pages : 348 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Actin-Binding Proteins and Disease by : Cris dos Remedios

Download or read book Actin-Binding Proteins and Disease written by Cris dos Remedios and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are scattered reports in the published literature citing relationships between actin, actin-binding proteins and disease. This volume brings this information together for the first time, with a focus on human disorders. The volume is relevant to a wide readership including cell biologists interested in understanding how structural and functional changes in proteins impact on the organism as a whole.