Contextualizing Systems Biology

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Contextualizing Systems Biology

Author : Martin Döring
Publisher : Springer
ISBN 13 : 3319171062
Total Pages : 316 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Contextualizing Systems Biology by : Martin Döring

Download or read book Contextualizing Systems Biology written by Martin Döring and published by Springer. This book was released on 2015-12-18 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collective monograph aims at contributing to an improved understanding of the epistemic presumptions, sociocultural implications and historically backgrounds of the newly emerging and currently expanding approach of systems biology. In doing so, it offers empirically grounded, valuable and reflexive information about a paradigmatic shift in the biosciences for a wide range of scientists working in the interdisciplinary areas of systems biology, synthetic biology, molecular biology, biology, the philosophy of science, the sociology of science and scientific knowledge, science and technology studies, technology assessment and the like. The authors of this monograph share the theoretical methodological premise that science is a culturally and socially embedded practice which characterizes our culture as a scientific one and at the same time draws its innovative potential from its socio-cultural context. This dialectic relationship lies at the heart of the current development of systems biology which is conceived as a so-called successor of ‘-omics’ research and triggered by high-throughput information technologies. At the same time a need for a holistic conceptualization of complex biological processes emerges. The title Contextualizing Systems Biology suggests that this book analyzes the development and advent of systems biology from different theoretical and methodological perspectives. We investigate a variety of contexts ranging from the analysis of cognitive contexts (such as basic theoretical concepts) to regulative contexts (policies) to the concrete application of a systems biology in the socio-scientific context of a European research project. In empirically analyzing these different and interrelated layers and dimensions of systems biology, the scope of the book goes beyond present attempts to investigate the advent of new approaches in the biological sciences as it frames and assesses systems biology from an interdisciplinary and integrated perspective.

Integration of Omics Approaches and Systems Biology for Clinical Applications

Author : Antonia Vlahou
Publisher : John Wiley & Sons
ISBN 13 : 1119183979
Total Pages : 384 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Integration of Omics Approaches and Systems Biology for Clinical Applications by : Antonia Vlahou

Download or read book Integration of Omics Approaches and Systems Biology for Clinical Applications written by Antonia Vlahou and published by John Wiley & Sons. This book was released on 2018-01-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to the state of the art of omics platforms and all aspects of omics approaches for clinical applications This book presents different high throughput omics platforms used to analyze tissue, plasma, and urine. The reader is introduced to state of the art analytical approaches (sample preparation and instrumentation) related to proteomics, peptidomics, transcriptomics, and metabolomics. In addition, the book highlights innovative approaches using bioinformatics, urine miRNAs, and MALDI tissue imaging in the context of clinical applications. Particular emphasis is put on integration of data generated from these different platforms in order to uncover the molecular landscape of diseases. The relevance of each approach to the clinical setting is explained and future applications for patient monitoring or treatment are discussed. Integration of omics Approaches and Systems Biology for Clinical Applications presents an overview of state of the art omics techniques. These methods are employed in order to obtain the comprehensive molecular profile of biological specimens. In addition, computational tools are used for organizing and integrating these multi-source data towards developing molecular models that reflect the pathophysiology of diseases. Investigation of chronic kidney disease (CKD) and bladder cancer are used as test cases. These represent multi-factorial, highly heterogeneous diseases, and are among the most significant health issues in developed countries with a rapidly aging population. The book presents novel insights on CKD and bladder cancer obtained by omics data integration as an example of the application of systems biology in the clinical setting. Describes a range of state of the art omics analytical platforms Covers all aspects of the systems biology approach—from sample preparation to data integration and bioinformatics analysis Contains specific examples of omics methods applied in the investigation of human diseases (Chronic Kidney Disease, Bladder Cancer) Integration of omics Approaches and Systems Biology for Clinical Applications will appeal to a wide spectrum of scientists including biologists, biotechnologists, biochemists, biophysicists, and bioinformaticians working on the different molecular platforms. It is also an excellent text for students interested in these fields.

An Introduction to Computational Systems Biology

Author : Karthik Raman
Publisher : CRC Press
ISBN 13 : 0429944527
Total Pages : 359 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis An Introduction to Computational Systems Biology by : Karthik Raman

Download or read book An Introduction to Computational Systems Biology written by Karthik Raman and published by CRC Press. This book was released on 2021-05-30 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasises a hands-on approach to modelling Strong emphasis on coding and software tools for systems biology Covers the entire spectrum of modelling, from static networks, to dynamic models Thoughtful exercises to test and enable student understanding of concepts Current chapters on exciting new developments like whole-cell modelling and community modelling

Biosimilar Clinical Development: Scientific Considerations and New Methodologies

Author : Kerry B. Barker
Publisher : CRC Press
ISBN 13 : 1315355906
Total Pages : 196 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Biosimilar Clinical Development: Scientific Considerations and New Methodologies by : Kerry B. Barker

Download or read book Biosimilar Clinical Development: Scientific Considerations and New Methodologies written by Kerry B. Barker and published by CRC Press. This book was released on 2016-11-25 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosimilars have the potential to change the way we think about, identify, and manage health problems. They are already impacting both clinical research and patient care, and this impact will only grow as our understanding and technologies improve. Written by a team of experienced specialists in clinical development, this book discusses various potential drug development strategies, the design and analysis of pharmacokinetics (PK) studies, and the design and analysis of efficacy studies.

Contextualizing Teaching to Improve Learning

Author : Laurinda Leite
Publisher :
ISBN 13 : 9781536118452
Total Pages : 0 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Contextualizing Teaching to Improve Learning by : Laurinda Leite

Download or read book Contextualizing Teaching to Improve Learning written by Laurinda Leite and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the context-based teaching of science and geography as seen by outstanding specialists from several countries around the world. It starts by providing an updated overview on the relevance of the four main physical and natural sciences (biology, chemistry, geology and physics) as well as geography for educating the public irrespective of whether citizens live (or not) in technologically advanced societies. Afterwards, it discusses unique context-based teaching approaches as well as original context-based curriculum and evaluation material tools. Additionally, the book highlights potential relationships between science and geography, which are often seen as independent areas of knowledge, namely in school. By uncovering the similarities between them and by putting in evidence where both areas deal with issues that are relevant for citizens daily lives, the book explores how contexts act as tools to link and give coherence to science and geography as components of everyday life. The worldwide trend towards providing meaningful science education to all, coupled with the concern raised by students disengagement in sciences, namely in technologically advanced societies, put increasingly high demands on the teachers. As shown in this book, contextualized teaching offers unique insights into how teachers can profit from students complicated and interconnected realities. They can use this knowledge to help them learn about the authenticity and relevance of science and geography. In addition, this book also provides directions for future research if the contribution of geography and science to context-based teaching is to be fully explored. Therefore, it is a book designated for researchers, educators and schoolteachers, as it goes from theoretical perspectives to general research-based approaches and ends with practical applications that may make a difference in the 21st century.

Synthetic Biology Handbook

Author : Darren N. Nesbeth
Publisher : CRC Press
ISBN 13 : 1466568488
Total Pages : 328 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Synthetic Biology Handbook by : Darren N. Nesbeth

Download or read book Synthetic Biology Handbook written by Darren N. Nesbeth and published by CRC Press. This book was released on 2016-04-06 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Synthetic Biology Handbook explains the major goals of the field of synthetic biology and presents the technical details of the latest advances made in achieving those goals. Offering a comprehensive overview of the current areas of focus in synthetic biology, this handbook:Explores the standardisation of classic molecular bioscience approaches

Systematic

Author : James R. Valcourt
Publisher : Bloomsbury Publishing USA
ISBN 13 : 1632860317
Total Pages : 289 pages
Book Rating : 4.6/5 (328 download)

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Book Synopsis Systematic by : James R. Valcourt

Download or read book Systematic written by James R. Valcourt and published by Bloomsbury Publishing USA. This book was released on 2017-02-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

Synthetic Biology and Morality

Author : Gregory E. Kaebnick
Publisher : MIT Press
ISBN 13 : 0262519593
Total Pages : 223 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Synthetic Biology and Morality by : Gregory E. Kaebnick

Download or read book Synthetic Biology and Morality written by Gregory E. Kaebnick and published by MIT Press. This book was released on 2013-07-26 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: A range of views on the morality of synthetic biology and its place in public policy and political discourse. Synthetic biology, which aims to design and build organisms that serve human needs, has potential applications that range from producing biofuels to programming human behavior. The emergence of this new form of biotechnology, however, raises a variety of ethical questions—first and foremost, whether synthetic biology is intrinsically troubling in moral terms. Is it an egregious example of scientists “playing God”? Synthetic Biology and Morality takes on this threshold ethical question, as well as others that follow, offering a range of philosophical and political perspectives on the power of synthetic biology. The contributors consider the basic question of the ethics of making new organisms, with essays that lay out the conceptual terrain and offer opposing views of the intrinsic moral concerns; discuss the possibility that synthetic organisms are inherently valuable; and address whether, and how, moral objections to synthetic biology could be relevant to policy making and political discourse. Variations of these questions have been raised before, in debates over other biotechnologies, but, as this book shows, they take on novel and illuminating form when considered in the context of synthetic biology. Contributors John Basl, Mark A. Bedau, Joachim Boldt, John H. Evans, Bruce Jennings, Gregory E. Kaebnick, Ben Larson, Andrew Lustig, Jon Mandle, Thomas H. Murray, Christopher J. Preston, Ronald Sandler

Systems Biology: a Very Short Introduction

Author : Eberhard O. Voit
Publisher : Oxford University Press, USA
ISBN 13 : 0198828373
Total Pages : 161 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Systems Biology: a Very Short Introduction by : Eberhard O. Voit

Download or read book Systems Biology: a Very Short Introduction written by Eberhard O. Voit and published by Oxford University Press, USA. This book was released on 2020-03-26 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology came about as growing numbers of engineers and scientists from other fields created algorithms which supported the analysis of biological data in incredible quantities. Whereas biologists of the past had been forced to study one item or aspect at a time, due to technical and biological limitations, it suddenly became possible to study biological phenomena within their natural contexts. This interdisciplinary field offers a holistic approach to interpreting these processes, and has been responsible for some of the most important developments in the science of human health and environmental sustainability. This Very Short Introduction outlines the exciting processes and possibilities in the new field of systems biology. Eberhard O. Voit describes how it enabled us to learn how intricately the expression of every gene is controlled, how signaling systems keep organisms running smoothly, and how complicated even the simplest cells are. He explores what this field is about, why it is needed, and how it will affect our understanding of life, particularly in the areas of personalized medicine, drug development, food and energy production, and sustainable stewardship of our environments. Throughout he considers how new tools are being provided from the fields of mathematics, computer science, engineering, physics, and chemistry to grasp the complexity of the countless interacting processes in cells which would overwhelm the cognitive and analytical capabilities of the human mind. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Synthetic Biology 2020: Frontiers in Risk Analysis and Governance

Author : Benjamin D. Trump
Publisher : Springer Nature
ISBN 13 : 3030272648
Total Pages : 421 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Synthetic Biology 2020: Frontiers in Risk Analysis and Governance by : Benjamin D. Trump

Download or read book Synthetic Biology 2020: Frontiers in Risk Analysis and Governance written by Benjamin D. Trump and published by Springer Nature. This book was released on 2019-11-28 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology offers powerful remedies for some of the world’s most intractable problems, but these solutions are clouded by uncertainty and risk that few strategies are available to address. The incentives for continued development of this emerging technology are prodigious and obvious, and the public deserves assurances that all potential downsides are duly considered and minimized accordingly. Incorporating social science analysis within the innovation process may impose constraints, but its simultaneous support in making the end products more acceptable to society at large should be considered a worthy trade-off. Contributing authors in this volume represent diverse perspectives related to synthetic biology’s social sciences, and reflect on different areas of risk analysis and governance that have developed for the field. Such perspectives include leading scholarly discussion pertaining to risk assessment, governance, ethics, and communication. The chapters of this volume note that while the first twenty years of synthetic biology development have focused strongly on technological innovation and product development, the next twenty should emphasize the synergy between developers, policymakers, and publics to generate the most beneficial, well governed, and transparent technologies and products possible. Many chapters in this volume provide new data and approaches that demonstrate the feasibility for multi-stakeholder efforts involving policymakers, regulators, industrial developers, workers, experts, and societal representatives to share responsibilities in the production of effective and acceptable governance in the face of uncertain risk probabilities. A full consideration of such perspectives may prevent a world of draconian regulations based on an insufficient or incomplete understanding of the science that underpins synthetic biology, as well as any hesitancy or fear by the public to adopt its eventual products.

Synthetic Biology

Author : Huimin Zhao
Publisher : Academic Press
ISBN 13 : 0123978203
Total Pages : 352 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Synthetic Biology by : Huimin Zhao

Download or read book Synthetic Biology written by Huimin Zhao and published by Academic Press. This book was released on 2013-03-21 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomes Highlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development

Synthetic Biology – Metabolic Engineering

Author : Huimin Zhao
Publisher : Springer
ISBN 13 : 3319553186
Total Pages : 322 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Synthetic Biology – Metabolic Engineering by : Huimin Zhao

Download or read book Synthetic Biology – Metabolic Engineering written by Huimin Zhao and published by Springer. This book was released on 2017-10-27 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Synthetic Biology, 2 Volume Set

Author : Robert A. Meyers
Publisher : John Wiley & Sons
ISBN 13 : 352766856X
Total Pages : 762 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Synthetic Biology, 2 Volume Set by : Robert A. Meyers

Download or read book Synthetic Biology, 2 Volume Set written by Robert A. Meyers and published by John Wiley & Sons. This book was released on 2015-10-19 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: These two volumes contain a selection of updated articles from the acclaimed Meyers Encyclopedia of Molecular Cell Biology and Molecular Medicine, the most authoritative resource in cell and molecular biology, combined with new articles by "founding fathers" in the field. The work is divided into six sections: + Biological Basis + Modeling + Modular Parts and Circuits + Synthetic Genomes + Diseases and Therapeutics + Chemicals Production. Ideally suited as advanced reading for students and postdocs, and with all current research trends covered by an impressive number of leading figures in the field, this is the first choice reference for research institutions.

Philosophy of Systems Biology

Author : Sara Green
Publisher : Springer
ISBN 13 : 3319470000
Total Pages : 265 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Philosophy of Systems Biology by : Sara Green

Download or read book Philosophy of Systems Biology written by Sara Green and published by Springer. This book was released on 2016-12-15 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.

Exploring and Exploiting Genetic Risk for Psychiatric Disorders

Author : Joshua A. Gordon
Publisher : MIT Press
ISBN 13 : 0262547384
Total Pages : 341 pages
Book Rating : 4.2/5 (625 download)

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Book Synopsis Exploring and Exploiting Genetic Risk for Psychiatric Disorders by : Joshua A. Gordon

Download or read book Exploring and Exploiting Genetic Risk for Psychiatric Disorders written by Joshua A. Gordon and published by MIT Press. This book was released on 2023-10-10 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: An edited volume that looks at the state of psychiatric genetics and how to chart a path forward. In this edited collection, experts from psychiatric and statistical genetics, neurobiology, and clinical psychiatry investigate whether and how to pursue the discovery of additional genetic risk factors for mental illnesses. Using the existing knowledge and frameworks of genetic risk factors, they look at how a better understanding of the biology that underlies mental illnesses can improve and enhance the care that patients receive.

Systems Biology

Author : A.K. Konopka
Publisher : CRC Press
ISBN 13 : 1420015125
Total Pages : 258 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Systems Biology by : A.K. Konopka

Download or read book Systems Biology written by A.K. Konopka and published by CRC Press. This book was released on 2006-11-20 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: With extraordinary clarity,the Systems Biology: Principles, Methods, and Concepts focuses on the technical practical aspects of modeling complex or organic general systems. It also provides in-depth coverage of modeling biochemical, thermodynamic, engineering, and ecological systems. Among other methods and concepts based in logic, computer

Emerging Applications of Control and Systems Theory

Author : Roberto Tempo
Publisher : Springer
ISBN 13 : 3319670689
Total Pages : 393 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Emerging Applications of Control and Systems Theory by : Roberto Tempo

Download or read book Emerging Applications of Control and Systems Theory written by Roberto Tempo and published by Springer. This book was released on 2018-02-24 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book celebrates Professor Mathukumalli Vidyasagar’s outstanding achievements in systems, control, robotics, statistical learning, computational biology, and allied areas. The contributions in the book summarize the content of invited lectures given at the workshop “Emerging Applications of Control and Systems Theory” (EACST17) held at the University of Texas at Dallas in late September 2017 in honor of Professor Vidyasagar’s seventieth birthday. These contributions are the work of twenty-eight distinguished speakers from eight countries and are related to Professor Vidyasagar’s areas of research. This Festschrift volume will remain as a permanent scientific record of this event.