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Author : Marco Bink
Publisher :
ISBN 13 : 9789054858973
Total Pages : 127 pages
Book Rating : 4.8/5 (589 download)
Download or read book Complex Pedigree Analysis to Detect Quantitative Trait Loci in Dairy Cattle written by Marco Bink and published by . This book was released on 1998* with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fine Mapping Quantitative Trait Loci Affecting Health and Reproduction in US Holstein Cattle on Chromosome 18 written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Continued genetic improvement for milk production has been associated with decreased fertility in US Holstein cattle. A previous study (Ashwell et al., 2004) identified a putative quantitative trait locus (QTL) affecting daughter pregnancy rate at 54 cM on chromosome 18 in one Holstein grandsire family. The goal of this research is to determine the validity of the putative QTL using additional markers and an extended pedigree. Thirteen microsatellite markers located throughout the chromosome were genotyped in 973 animals that were descendants of the original grandsire in which the QTL was identified. Sons of the grandsire as well as six grandson and six great-grandson families of the original grandsire were selected for this study (range of 16 to 169 sons per family). In analysis of the sons using QTL Express, the same putative QTL affecting daughter pregnancy rate was detected and placed at 45 cM. In a joint analysis of thirteen of the largest families, each containing 10 or more sons, a significant QTL for daughter pregnancy rate was detected at 27 cM. QTL affecting daughter pregnancy rate was detected in two additional sub-families (Family II-5 and Family III-2), indicating a putative QTL affecting daughter pregnancy rate is most likely segregating within this pedigree. Across-family analysis also detected putative QTL on chromosome 18 affecting productive life at 35 cM, somatic cell score at 33 cM and percent difficult births at 72 cM. Analysis of individual families identified eight significant putative QTL and six suggestive putative QTL at the chromosome-wise level affecting somatic cell score, productive life, calving ease, percent difficult births, milk yield, fat yield, protein yield and fat percent. A complex pedigree analysis is underway to make full use of statistical power to refine the QTL region affecting fertility. Further verification of the QTL effects identified in this study will allow identification of positional candidate genes to be applied i.
Author : Nicola J. Camp
Publisher : Springer Science & Business Media
ISBN 13 : 1592591760
Total Pages : 362 pages
Book Rating : 4.5/5 (925 download)
Download or read book Quantitative Trait Loci written by Nicola J. Camp and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Quantitative Trait Loci: Methods and Protocols, a panel of highly experienced statistical geneticists demonstrate in a step-by-step fashion how to successfully analyze quantitative trait data using a variety of methods and software for the detection and fine mapping of quantitative trait loci (QTL). Writing for the nonmathematician, these experts guide the investigator from the design stage of a project onwards, providing detailed explanations of how best to proceed with each specific analysis, to find and use appropriate software, and to interpret results. Worked examples, citations to key papers, and variations in method ease the way to understanding and successful studies. Among the cutting-edge techniques presented are QTDT methods, variance components methods, and the Markov Chain Monte Carlo method for joint linkage and segregation analysis.
Author : Joel Ira Weller
Publisher : CABI
ISBN 13 : 1845937341
Total Pages : 288 pages
Book Rating : 4.8/5 (459 download)
Download or read book Quantitative Trait Loci Analysis in Animals written by Joel Ira Weller and published by CABI. This book was released on 2009 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Trait Loci (QTL) is a topic of major agricultural significance for efficient livestock production. This book covers various statistical methods that have been used or proposed for detection and analysis of QTL and marker-and gene-assisted selection in animal genetics and breeding.
Download or read book Mapping Quantitative Trait Loci in Outbred Half-sib Populations written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative trait loci (QTL) mapping in outbred populations faces some challenges unique to the divergent genetic background and complex pedigree relationships. Motivated by a dairy cattle half-sib data set from a grand daughter design, we present in this dissertation a series of endeavors to address various challenges along the analysis flow of QTL mapping. A first step is to infer the haplotypes in sires based on the observed genotypes in sires and his offspring. Our method was shown to outperform peer methods with greater robustness and accuracy yet with fast speed performance. Then in light of adapting the multiple interval mapping method to within-family QTL analysis, we extended the modeling framework by allowing for heteroscedastic residual variances and upgraded the Windows QTL Cartographer accordingly. The advantageous post-analysis result parsing from Windows QTL Cartographer and more importantly, the improved analysis outputs due to more powerful maximum likelihood-based mixture modeling than the least squares regression manifest our efforts in delivering better methodology via practically user friendly software. We further developed a mixed model approach for the purpose of QTL mapping across multiple families that was aimed at modeling QTL effects as both the fixed effect across families and the random effect within families. Our mixed model was shown to encompass similar or higher statistical testing performance on QTL variation than the widely used variance component modeling approach, yet still allowing permutations for obtaining chromosome-wide or genome-wide significance threshold. What's more, the flexibility of our mixed model in constructing alternative hypotheses testing on either fixed or random QTL effects or both was shown to offer interesting insight into the varying sources of signal that would not be unveiled by least squares regression or variance component methods. In concluding our comprehensive approach to QTL linkage mapping in dair.
Author : Mahesh Neupane
Publisher :
ISBN 13 :
Total Pages : 185 pages
Book Rating : 4.:/5 (15 download)
Download or read book Identification of Loci Associated with Economically Important Traits in Cattle written by Mahesh Neupane and published by . This book was released on 2018 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of loci associated with BRD, fertility and polymelia offers new opportunities for producers to select cattle that have improved health and performance.
Author : Richard John Spelman
Publisher :
ISBN 13 : 9789054858966
Total Pages : 190 pages
Book Rating : 4.8/5 (589 download)
Download or read book Detection and Utilisation of Quantitative Trait Loci in Dairy Cattle written by Richard John Spelman and published by . This book was released on 1998* with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jenifer Cruickshank
Publisher :
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.:/5 (89 download)
Download or read book A Narrowed Genome Scan for Quantitative Trait Loci Affecting Twinning Rate and Production Traits in Holstein Cattle written by Jenifer Cruickshank and published by . This book was released on 2003 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lena Andersson-Eklund
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.:/5 (319 download)
Download or read book Genetic Markers and Quantitative Traits in Dairy Cattle written by Lena Andersson-Eklund and published by . This book was released on 1993 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D.C. Rao
Publisher : Academic Press
ISBN 13 : 0080569110
Total Pages : 788 pages
Book Rating : 4.0/5 (85 download)
Download or read book Genetic Dissection of Complex Traits written by D.C. Rao and published by Academic Press. This book was released on 2008-04-23 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occuring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Five sections on the latest advances in complex traits Methods for testing with ethical, legal, and social implications Hot topics include discussions on systems biology approach to drug discovery; using comparative genomics for detecting human disease genes; computationally intensive challenges, and more
Author : Adrienne Britton Kurtz
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.:/5 (57 download)
Download or read book Detection of Quantitative Trait Loci Affecting Milk Production and Health Traits in Dairy Cattle written by Adrienne Britton Kurtz and published by . This book was released on 2001 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Lynch
Publisher : Sinauer Associates Incorporated
ISBN 13 : 9780878934812
Total Pages : 980 pages
Book Rating : 4.9/5 (348 download)
Download or read book Genetics and Analysis of Quantitative Traits written by Michael Lynch and published by Sinauer Associates Incorporated. This book was released on 1998-01 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professors Lynch and Walsh bring together the diverse array of theoretical and empirical applications of quantitative genetics in a work that is comprehensive and accessible to anyone with a rudimentary understanding of statistics and genetics.
Author : Food and Agriculture Organization of the United Nations
Publisher : Food & Agriculture Org.
ISBN 13 : 9789251057179
Total Pages : 498 pages
Book Rating : 4.0/5 (571 download)
Download or read book Marker-assisted Selection written by Food and Agriculture Organization of the United Nations and published by Food & Agriculture Org.. This book was released on 2007 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive description and assessment of the use of marker-assisted selection for increasing the rate of genetic gain in crops, livestock, forestry and fish, including the related policy, FAO's tradition of dealing with issues of importance to agricultural and economic development in a multidisciplinary and cross-sectoral manner.
Author : Andrew H. Paterson
Publisher : CRC Press
ISBN 13 : 9781420049381
Total Pages : 328 pages
Book Rating : 4.0/5 (493 download)
Download or read book Molecular Dissection of Complex Traits written by Andrew H. Paterson and published by CRC Press. This book was released on 2019-09-17 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past 10 years, contemporary geneticists using new molecular tools have been able to resolve complex traits into individual genetic components and describe each such component in detail. Molecular Dissection of Complex Traits summarizes the state of the art in molecular analysis of complex traits (QTL mapping), placing new developments in thi
Author : Cedric Gondro
Publisher : Humana Press
ISBN 13 : 9781627034463
Total Pages : 0 pages
Book Rating : 4.0/5 (344 download)
Download or read book Genome-Wide Association Studies and Genomic Prediction written by Cedric Gondro and published by Humana Press. This book was released on 2013-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the detailed genomic information that is now becoming available, we have a plethora of data that allows researchers to address questions in a variety of areas. Genome-wide association studies (GWAS) have become a vital approach to identify candidate regions associated with complex diseases in human medicine, production traits in agriculture, and variation in wild populations. Genomic prediction goes a step further, attempting to predict phenotypic variation in these traits from genomic information. Genome-Wide Association Studies and Genomic Prediction pulls together expert contributions to address this important area of study. The volume begins with a section covering the phenotypes of interest as well as design issues for GWAS, then moves on to discuss efficient computational methods to store and handle large datasets, quality control measures, phasing, haplotype inference, and imputation. Later chapters deal with statistical approaches to data analysis where the experimental objective is either to confirm the biology by identifying genomic regions associated to a trait or to use the data to make genomic predictions about a future phenotypic outcome (e.g. predict onset of disease). As part of the Methods in Molecular Biology series, chapters provide helpful, real-world implementation advice.
Author : Anne Charmantier
Publisher : Oxford University Press
ISBN 13 : 019967423X
Total Pages : 293 pages
Book Rating : 4.1/5 (996 download)
Download or read book Quantitative Genetics in the Wild written by Anne Charmantier and published by Oxford University Press. This book was released on 2014 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers the expertise of 30 evolutionary biologists from around the globe to highlight how applying the field of quantitative genetics - the analysis of the genetic basis of complex traits - aids in the study of wild populations.
Author : Laurie Piper
Publisher : Cabi
ISBN 13 :
Total Pages : 634 pages
Book Rating : 4.F/5 ( download)
Download or read book The Genetics of Sheep written by Laurie Piper and published by Cabi. This book was released on 1997 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systematics and phylogeny of the sheep;Genetic aspects of domestication, common breeds and their origin; Genetics of colour and hair texture; Genetics of morphological traits and inherited disorders; Biochemical genetics; Molecular genetics of sheep; Molecular genetics of immune molecules; Genetics of disease resistance and vaccine response; Molecular biology and genetics of scrapie in sheep; Cytogenetics: physical chromosome maps; The sheep linkage map; Genetics of behaviour; Biology and genetics of reproduction; Modern reproduction technologies and transgenics; Developmental genetics; Genetic resources and conservation; Genetic improvement of wool production; Genetics of meat quality; Genetics of milk production; Genetic improvement of sheep; Standardized genetic nomenclature for sheep.
