Compartmentalized Signaling and Breast Cancer Cell Proliferation

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Publisher :
ISBN 13 :
Total Pages : 15 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Compartmentalized Signaling and Breast Cancer Cell Proliferation by :

Download or read book Compartmentalized Signaling and Breast Cancer Cell Proliferation written by and published by . This book was released on 2003 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proposal will test a unique hypothesis that Src-family kinases direct the ErbB receptor traffic into an intracellular compartment where proliferation signals are generated. This hypothesis is based on observations that while Cb1 proto-oncoprotein facilitates the down-regulation of ErbB receptors from cell surface and functions as a negative regulator, Src tyrosine kinase enhances paradoxically enhance both the internalization of EGFR and the EGFR-mediated mitogenic signals. The proposed studies will test this hypothesis using mammary epithelial cells made to overexpress EGFR or ErbB2 together with Src. The insights gained from this model system will be directly relevant to a large proportion of breast cancers where ErbB receptors and Src-family kinases are co-overexpressed. Validation of our hypothesis will represent a shift in the current paradigm of normal and aberrant ErbB receptor signaling and may provide novel targets for therapeutic intervention relevant to ErbB-overexpressing breast cancers, which carry a significantly worse prognosis and are frequently hormone-unresponsive.

Signaling the ErbB Receptors in Breast Cancer: Regulation by Compartmentalization of Heterodimetric Receptor Complexes

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Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Signaling the ErbB Receptors in Breast Cancer: Regulation by Compartmentalization of Heterodimetric Receptor Complexes by :

Download or read book Signaling the ErbB Receptors in Breast Cancer: Regulation by Compartmentalization of Heterodimetric Receptor Complexes written by and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: MEKK1 and MEKK4 play a role in the signal transduction pathways of breast cancer cell proliferation, survival, and apoptosis. Treatment with cancer chemotherapeutics, cell stresses, or anoikis activates MEKK1, which stimulates caspase activity. Caspases cleave MEKK1, and this cleavage product of MEKK1 causes apoptosis. I show that expression of the oncogene Akt blocks MEKK1-induced death by 90%. MEKK1-induced caspase activity is strongly inhibited by the expression of Akt to levels below basal. Caspases inhibition by Akt protects cells from cleavage of endogenous MEKK1 to its active form.

The Heterogeneity of Cancer Metabolism

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Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.

Post-Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889715000
Total Pages : 150 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Post-Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease by : Huabo Su

Download or read book Post-Translational Modifications and Compartmentalized Protein Quality Control in Cardiac Muscle and Disease written by Huabo Su and published by Frontiers Media SA. This book was released on 2021-10-18 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systems Biology of Cancer

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Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Tumor Microenvironment Signaling Networks in Pathophysiology and Therapeutics

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Publisher : Frontiers Media SA
ISBN 13 : 2832502873
Total Pages : 248 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Tumor Microenvironment Signaling Networks in Pathophysiology and Therapeutics by : Francesca Pirini

Download or read book Tumor Microenvironment Signaling Networks in Pathophysiology and Therapeutics written by Francesca Pirini and published by Frontiers Media SA. This book was released on 2022-10-19 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 3642168612
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Biomarkers in Breast Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Metastatic Cancer: Clinical and Biological Perspectives

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Publisher : CRC Press
ISBN 13 : 9781587066597
Total Pages : 312 pages
Book Rating : 4.0/5 (665 download)

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Book Synopsis Metastatic Cancer: Clinical and Biological Perspectives by : Rahul Jandial

Download or read book Metastatic Cancer: Clinical and Biological Perspectives written by Rahul Jandial and published by CRC Press. This book was released on 2013-08-08 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most cancer deaths are a result of metastasis. The spread of a primary tumor to colonize neighboring and distant organs is the relentless endgame that defines the neoplastic process. Patients who have been diagnosed with cancer are treated to prevent both the recurrence of the tumor at the site of origin and metastasis that would re-stage them as advanced stage IV cancer. Historically and still with some types of cancer, stage IV is perceived by patients as “terminal.” Fortunately, recent molecular therapies have extended the lives of patients with advanced cancer and reassuringly people living with metastatic disease increasingly visit our clinics. What is the path forward? Given that the consilience of science and medicine is a dynamic art from which therapies arise, it would be misguided to consider any single work adequate at capturing the horizon for research. So with humility we constructed this text as primer for scientists. It begins with a broad introduction to the clinical management of common cancers. This is intended to serve as a foundation for investigators to consider when developing basic science hypotheses. Unquestionably, medical and surgical care of cancer patients reveals biology and dictates how novel therapeutics will ultimately be evaluated in clinical trials. The second section of this text offers provocative and evolving insights that underscore the breadth of science involved in the elucidation of cancer metastasis biology. The text concludes with information that integrates scientific and clinical foundations to highlight translational research. This book serves as a framework for scientists to conceptualize clinical and translational knowledge on the complexity of disease that is metastatic cancer.

Guidance Molecules in Cancer and Tumor Angiogenesis

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Publisher : Academic Press
ISBN 13 : 0123865034
Total Pages : 296 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Guidance Molecules in Cancer and Tumor Angiogenesis by : Ira Daar

Download or read book Guidance Molecules in Cancer and Tumor Angiogenesis written by Ira Daar and published by Academic Press. This book was released on 2012-05-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Guidance molecules in Cancer and cancer angiogenesis". With outstanding and original reviews, this volume covers topics such as Guidance for life, death and neoplasia by netrin receptors, Semaphorin signals tweaking the tumor microenvironment, NOTCH Activation in Human Malignancy, and Essential roles of EphrinB in endothelial cell function and angiogenesis.

Current Frontiers and Perspectives in Cell Biology

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Publisher : BoD – Books on Demand
ISBN 13 : 9535105442
Total Pages : 578 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Current Frontiers and Perspectives in Cell Biology by : Stevo Najman

Download or read book Current Frontiers and Perspectives in Cell Biology written by Stevo Najman and published by BoD – Books on Demand. This book was released on 2012-04-25 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: A numerous internationally renowned authors in the pages of this book present the views of the fields of cell biology and their own research results or review of current knowledge. Chapters are divided into five sections that are dedicated to cell structures and functions, genetic material, regulatory mechanisms, cellular biomedicine and new methods in cell biology. Multidisciplinary and often quite versatile approach by many authors have imposed restrictions of this classification, so it is certain that many chapters could belong to the other sections of this book. The current frontiers, on the manner in which they described in the book, can be a good inspiration to many readers for further improving, and perspectives which are highlighted can be seen in many areas of fundamental biology, biomedicine, biotechnology and other applications of knowledge of cell biology. The book will be very useful for beginners to gain insight into new area, as well as experts to find new facts and expanding horizons.

International Review of Cell and Molecular Biology

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Publisher : Academic Press
ISBN 13 : 012802481X
Total Pages : 299 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis International Review of Cell and Molecular Biology by :

Download or read book International Review of Cell and Molecular Biology written by and published by Academic Press. This book was released on 2015-01-20 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Impact factor for 2013: 4.522. Authored by some of the foremost scientists in the field Provides comprehensive reviews and current advances Wide range of perspectives on specific subjects Valuable reference material for advanced undergraduates, graduate students and professional scientists

Signal Transduction in Cancer Metastasis

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Publisher : Springer Science & Business Media
ISBN 13 : 9048195225
Total Pages : 293 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Signal Transduction in Cancer Metastasis by : Wen-Sheng Wu

Download or read book Signal Transduction in Cancer Metastasis written by Wen-Sheng Wu and published by Springer Science & Business Media. This book was released on 2010-10-04 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Signaling Pathways and Molecular Mediators in Metastasis

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Publisher : Springer Science & Business Media
ISBN 13 : 9400725574
Total Pages : 373 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Signaling Pathways and Molecular Mediators in Metastasis by : Alessandro Fatatis

Download or read book Signaling Pathways and Molecular Mediators in Metastasis written by Alessandro Fatatis and published by Springer Science & Business Media. This book was released on 2012-01-03 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.

Phosphoinositides I: Enzymes of Synthesis and Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 940073011X
Total Pages : 361 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides I: Enzymes of Synthesis and Degradation by : Tamas Balla

Download or read book Phosphoinositides I: Enzymes of Synthesis and Degradation written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-03-14 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Cancer Cell Culture

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Publisher : Humana Press
ISBN 13 : 9781493956579
Total Pages : 502 pages
Book Rating : 4.9/5 (565 download)

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Book Synopsis Cancer Cell Culture by : Ian A. Cree

Download or read book Cancer Cell Culture written by Ian A. Cree and published by Humana Press. This book was released on 2016-08-23 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: With many recent advances, cancer cell culture research is more important than ever before. This timely edition of Cancer Cell Culture: Methods and Protocols covers the basic concepts of cancer cell biology and culture while expanding upon the recent shift in cell culture methods from the generation of new cell lines to the use of primary cells. There are methods to characterize and authenticate cell lines, to isolate and develop specific types of cancer cells, and to develop new cell line models. Functional assays are provided for the evaluation of clonogenicity, cell proliferation, apoptosis, adhesion, migration, invasion, senescence, angiogenesis, and cell cycle parameters. Other methods permit the modification of cells for transfection, drug resistance, immortalization, and transfer in vivo, the co-culture of different cell types, and the detection and treatment of contamination. In this new edition, specific emphasis is placed on safe working practice for both cells and laboratory researchers. These chapters contain the information critical to success – only by good practice and quality control will the results of cancer cell culture improve. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Cancer Cell Culture: Methods and Protocols serves as a practical guide for scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.

Wnt Signaling at the Plasma Membrane: Activation, Regulation and Disease Connection

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Publisher : Frontiers Media SA
ISBN 13 : 2889718808
Total Pages : 212 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Wnt Signaling at the Plasma Membrane: Activation, Regulation and Disease Connection by : Gunes Ozhan

Download or read book Wnt Signaling at the Plasma Membrane: Activation, Regulation and Disease Connection written by Gunes Ozhan and published by Frontiers Media SA. This book was released on 2021-12-30 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: