Company Profiles Affinium Pharmaceuticals Ltd

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Polypharmacology in Drug Discovery

Author : Jens-Uwe Peters
Publisher : John Wiley & Sons
ISBN 13 : 1118098137
Total Pages : 542 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Polypharmacology in Drug Discovery by : Jens-Uwe Peters

Download or read book Polypharmacology in Drug Discovery written by Jens-Uwe Peters and published by John Wiley & Sons. This book was released on 2012-01-20 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.

Synthesis of Essential Drugs

Author : Ruben Vardanyan
Publisher : Elsevier
ISBN 13 : 008046212X
Total Pages : 635 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Synthesis of Essential Drugs by : Ruben Vardanyan

Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references

Australian Official Journal of Patents

Author :
Publisher :
ISBN 13 :
Total Pages : 560 pages
Book Rating : 4.:/5 (334 download)

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Book Synopsis Australian Official Journal of Patents by :

Download or read book Australian Official Journal of Patents written by and published by . This book was released on 2003-08-28 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Official Gazette of the United States Patent and Trademark Office

Author :
Publisher :
ISBN 13 :
Total Pages : 802 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Official Gazette of the United States Patent and Trademark Office by :

Download or read book Official Gazette of the United States Patent and Trademark Office written by and published by . This book was released on 2001 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic Engineering News

Author :
Publisher :
ISBN 13 :
Total Pages : 640 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Genetic Engineering News by :

Download or read book Genetic Engineering News written by and published by . This book was released on 2005 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antibiotic Drug Discovery

Author : Steven M Firestine
Publisher : Royal Society of Chemistry
ISBN 13 : 178801149X
Total Pages : 289 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Antibiotic Drug Discovery by : Steven M Firestine

Download or read book Antibiotic Drug Discovery written by Steven M Firestine and published by Royal Society of Chemistry. This book was released on 2017-05-19 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a resurgence of antibiotic drug discovery. This book brings together the relevant information to assess the state-of-the-art. It identifies and elaborates the most recent and compelling strategies for antibiotic drug discovery with a primary focus on new targets, mechanisms and molecular entities. Addressing the need for continued investment in antibiotic drug development, the book provides a point of reference for the rapidly expanding infectious disease research community. In addition to its attention on new targets, the book focusses on the medicinal chemistry and chemistry of the targets. Within this framework, chapters from leading researchers in academia and industry address findings in important areas such as biofilm production, narrow spectrum antibiotics and novel antibacterials from previously uncultured soil bacteria. This book will be a useful resource for postgraduate students and researchers in medicinal chemistry wishing to understand the latest approaches to antibiotic drug discovery.

The Evolving Threat of Antimicrobial Resistance

Author : World Health Organization
Publisher :
ISBN 13 : 9789241503181
Total Pages : 0 pages
Book Rating : 4.5/5 (31 download)

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Book Synopsis The Evolving Threat of Antimicrobial Resistance by : World Health Organization

Download or read book The Evolving Threat of Antimicrobial Resistance written by World Health Organization and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibiotic resistance development is a natural process of adaption leading to a limited lifespan of antibiotics. Unnecessary and inappropriate use of antibiotics favours the emergence and spread of resistant bacteria. A crisis has been building up over decades, so that today common and life-threatening infections are becoming difficult or even impossible to treat. It is time to take much stronger action worldwide to avert an ever increasing health and economic burden. A new WHO publication "The evolving threat of antimicrobial resistance--Options for action" describes examples of policy activities that have addressed AMR in different parts of the world. The aim is to raise awareness and to stimulate further coordinated efforts.

Antibacterial Drug Discovery to Combat MDR

Author : Iqbal Ahmad
Publisher : Springer Nature
ISBN 13 : 9811398712
Total Pages : 673 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Antibacterial Drug Discovery to Combat MDR by : Iqbal Ahmad

Download or read book Antibacterial Drug Discovery to Combat MDR written by Iqbal Ahmad and published by Springer Nature. This book was released on 2019-11-09 with total page 673 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Memory Traces in the Brain

Author : Daniel L. Alkon
Publisher : Cambridge University Press
ISBN 13 : 9780521358675
Total Pages : 206 pages
Book Rating : 4.3/5 (586 download)

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Book Synopsis Memory Traces in the Brain by : Daniel L. Alkon

Download or read book Memory Traces in the Brain written by Daniel L. Alkon and published by Cambridge University Press. This book was released on 1987-12-25 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing the first glimpse of how associative memories are actually established in our brains, this book describes a research strategy for unravelling the mystery of memory and learning. The results of this experimental quest are described at several levels of biological complexity including animal behavior, neural systems, cellular and membrane physiology, and molecular regulation. The amply illustrated text is carefully structured to distinguish between observations and hypotheses, between attractive possibilities and empirical demonstrations. Dr Alkon progresses step-by-step through a series of experimental tests of intuitive conjectures on the nature of learning and memory. The book guides the reader through a scientific detective story that sheds new light on how we learn and how we remember.

The Ring and the Book

Author : Robert Browning
Publisher :
ISBN 13 :
Total Pages : 252 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis The Ring and the Book by : Robert Browning

Download or read book The Ring and the Book written by Robert Browning and published by . This book was released on 1869 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the final of the four volumes published from 1868-1869that make up Robert Browning'sThe Ring and the Book, a long blank-verse poem composed of 12 books and over 20,000 lines. This volume includes the booksThe Pope, GuidoandThe Book and the Ring.

Fieldwork Is Not What It Used to Be

Author : James D. Faubion
Publisher : Cornell University Press
ISBN 13 : 0801463580
Total Pages : 249 pages
Book Rating : 4.8/5 (14 download)

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Book Synopsis Fieldwork Is Not What It Used to Be by : James D. Faubion

Download or read book Fieldwork Is Not What It Used to Be written by James D. Faubion and published by Cornell University Press. This book was released on 2011-10-15 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades anthropologists have been challenged to rethink the nature of ethnographic research, the meaning of fieldwork, and the role of ethnographers. Ethnographic fieldwork has cultural, social, and political ramifications that have been much discussed and acted upon, but the training of ethnographers still follows a very traditional pattern; this volume engages and takes its point of departure in the experiences of ethnographers-in-the-making that encourage alternative models for professional training in fieldwork and its intellectual contexts. The work done by contributors to Fieldwork Is Not What It Used to Be articulates, at the strategic point of career-making research, features of this transformation in progress. Setting aside traditional anxieties about ethnographic authority, the authors revisit fieldwork with fresh initiative. In search of better understandings of the contemporary research process itself, they assess the current terms of the engagement of fieldworkers with their subjects, address the constructive, open-ended forms by which the conclusions of fieldwork might take shape, and offer an accurate and useful description of what it means to become—and to be—an anthropologist today.

Antibiotics

Author : Sergio Sánchez
Publisher : Caister Academic Press Limited
ISBN 13 : 9781908230546
Total Pages : 0 pages
Book Rating : 4.2/5 (35 download)

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Book Synopsis Antibiotics by : Sergio Sánchez

Download or read book Antibiotics written by Sergio Sánchez and published by Caister Academic Press Limited. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 'golden age' for antibiotic discovery, from 1940 until the early 1970s, ushered in a new era in human- and animal-health and the associated dramatic increase in human life expectancies. Indeed, the possibility of eradicating infectious disease seemed feasible. However, it soon became apparent that microorganisms wouldn't be defeated so easily. Their weapon: antibiotic resistance. Today, microbial antibiotic resistance is rapidly exhausting the supply of effective compounds, and this makes the possibility of a global public health disaster seem likely. The urgency of this situation has spawned a plethora of new multi-disciplinary research initiatives looking for novel antibiotics and other antimicrobial agents. In this timely book, respected international experts summarize the most important research to provide a timely overview of the field. Opening chapters define 'antibiotic,' explain why we need new compounds, outline the applications of antibiotics, both old and new, and describe the producing microbes. These are followed by chapters that cover antibiotic resistance, toxicity, overuse, new antimicrobial sources, new targets, novel technologies for antibiotic discovery (e.g. silent gene clusters), lantibiotics, natural antivirals, new macrolide derivatives, and antibiotics in the pipeline. The book will be essential reading for everyone working in antimicrobial research, biotechnology companies, and the pharmaceutical industry, and it is recommended for all microbiology libraries. [Subject: Microbiology, Life Science, Medicine]

Globality

Author : Hal Sirkin
Publisher : Business Plus
ISBN 13 : 0446537438
Total Pages : 226 pages
Book Rating : 4.4/5 (465 download)

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Book Synopsis Globality by : Hal Sirkin

Download or read book Globality written by Hal Sirkin and published by Business Plus. This book was released on 2008-06-11 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: An absolutely stunning -- and scary - wake-up call that reveals how the economic world is about to change dramatically in the next few years as dozens of RDEs ("Rapidly Developing Economies") begin to assert themselves as major economic powers. Globalization is about Americans outsourcing product development and services to other countries. Globality is the next step, where rapidly developing economies from around the world are now competing with us head to head. The authors present a strong case that the economic climate in which we have lived is going to change in unprecedented ways. "...their insights into the competitive battle in emerging markets are so keen." -- William J. Holstein of The New York Times "Many American chief executives, it turns out, are aiming at emerging markets...And they will find many insights into prevailing in those battles in this book." -- William J. Holstein of The New York Times "...for any corporate strategist pondering the challenges and opportunities of globalization, this book is an indispensable guide." -- John Cummings of Business Finance "While the global economy has been a hot topic for at least two decades, it is in constant need of updating ...GLOBALITY...does the job nicely." -- BNET "[This] vividly detailed tome describes the latest shift in globalization from a one-way street of Western domination to an increasingly competitive global playing field, where businesses from once-discounted nations are solidifying their standing." -- CIO Insight "Whatever the next New World Order turns out to be, the advice in GLOBALITY will come in useful, for multinationals and individual workers alike." -- Business Pundit "A smart discourse on how local companies in developing economies, such as China, India and Brazil, are bucking tradition and going for broke on their own terms..." -- BNET "This book is a must-read for leaders of companies in the developed world who want to get into the globality act and stay in it." -- Cecil Johnson, McClatchy-Tribune News "Get ready for a new wave of challengers, 'bursting their way onto the big stage.' So say the three authors of this smart analysis about the latest developments in global competition" -- Andrea Sachs of TIME

Rare and Exotic Orchids

Author : Joel L. Schiff
Publisher : Springer
ISBN 13 : 3319700340
Total Pages : 190 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Rare and Exotic Orchids by : Joel L. Schiff

Download or read book Rare and Exotic Orchids written by Joel L. Schiff and published by Springer. This book was released on 2017-12-08 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprising some 28,000 different species, orchids are by far the largest flowering plant family on Earth. Every year, new species are being uncovered in the wild or created by humans, and so this number has only continued to blossom. This book is intended for those who wish to learn about the multifaceted nature of this amazing plant. It covers many different aspects of orchid study, from its cultural history to its evolutionary development and from its first discoveries to ongoing scientific research. No matter your specialty or level of orchid expertise, you can find in this book new and fascinating facts and stories that will make you gasp, laugh, and read on. Through the many exotic and beautiful pictures permeating these pages, you will come to know something of the infinite diversity of this plant family and at last learn why so many orchid growers and fanatics have embarked on this same endless path. “I was smitten with this book after reading the very first chapter on the history of Orchids...There are plenty of interesting facts to charm your orchid friends and impress even the most studied researcher... All in all a fabulous read that is well illustrated and with a reference section the likes of which I have never seen before with its vast and varied appendices on a slew of subjects. If you are looking for a book that is engaging and educational with lots of good humor thrown in, then this book is for you. I know that I will treasure my copy for years to come.” -- Laura Newton, American Orchid Society Awards Registrar and Accredited Judge, ORCHIDS Magazine (May, 2018) "Joel L. Schiff brings to life not just the science surrounding orchids, but the human process of recognizing, cataloging, and appreciating them...It's this approach, combined with lovely close-up color photos throughout, which makes Rare and Exotic Orchids a recommendation not just for professionals or botany libraries, but for general-interest readers who will enjoy a highly accessible study that invites an in-depth interest in orchids and their importance to human affairs."-- Diane Donovan’s Pick of the Month (April, 2018)

Essays in Pastoral Medicine

Author : Austin O'Malley
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Essays in Pastoral Medicine by : Austin O'Malley

Download or read book Essays in Pastoral Medicine written by Austin O'Malley and published by . This book was released on 1906 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structure-based Drug Discovery

Author : Harren Jhoti
Publisher : Springer
ISBN 13 : 9789048171231
Total Pages : 0 pages
Book Rating : 4.1/5 (712 download)

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Book Synopsis Structure-based Drug Discovery by : Harren Jhoti

Download or read book Structure-based Drug Discovery written by Harren Jhoti and published by Springer. This book was released on 2010-10-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well as other biophysical methods for studying protein/ligand interactions.

Epistasis and the Evolutionary Process

Author : Jason B. Wolf
Publisher : Oxford University Press, USA
ISBN 13 : 9780195128062
Total Pages : 348 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Epistasis and the Evolutionary Process by : Jason B. Wolf

Download or read book Epistasis and the Evolutionary Process written by Jason B. Wolf and published by Oxford University Press, USA. This book was released on 2000 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last two decades, research into epistasis has seen explosive growth and has moved the focus of research in evolutionary genetics from a traditional additive approach. We now know the effects of genes are rarely independent, and to reach a fuller understanding of the process of evolution we need to look at gene interactions as well as gene-environment interactions. This book is an overview of non-additive evolutionary genetics, integrating all work to date on all levels of evolutionary investigation of the importance of epistasis in the evolutionary process in general. It includes a historical perspective on this emerging field, in-depth discussion of terminology, discussions of the effects of epistasis at several different levels of biological organization and combinations of theoretical and experimental approaches to analysis.