Combination Treatment In Autoimmune Diseases

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Combination Treatment in Autoimmune Diseases

Author : W.B. Harrison
Publisher : Springer Science & Business Media
ISBN 13 : 3662047594
Total Pages : 209 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Combination Treatment in Autoimmune Diseases by : W.B. Harrison

Download or read book Combination Treatment in Autoimmune Diseases written by W.B. Harrison and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: W. B. Harrison, B. A. C. Dijkmans During the last decade intervention has been instituted for all kinds of disease- even in a premorbid state, as early as possible, to control the activity of the disease, to avoid further damage and to maintain quality of life. Apart from the principle 'Treat now, not later", emphasis is laid on aggressive initial therapy. These adagia have influenced in recent times all fields of medicine, from oncology to infectious diseases and also - the topic of the present edition - the "autoimmune diseases". As an example of the latter, rheumatoid arthritis (RA) demonstrates how the attitude of physicians has been changed. From an expectant point of view in the eighties (primum nil nocere) the attitude has been changed, as we approached and entered the new millennium, to initial ag gressive therapy especially in patients with a poor prognosis. Despite the advance of instituting monotherapy with a single optimised disease-modifying anti-rheumatic drug (DMARD) - with methotrexate as prototype agent in RA - adequate disease re mission is not often achieved, and adverse events may well prevent the use of higher dosages of the single agent in question. Therefore, the next step was to combine two or more DMARDs. The choice of combining DMARDs can be purely practical and based upon the anti-rheumatics most used in daily practice, for instance methotrexate and sulphasalazine. The choice of combining drugs can be influenced by different toxicity patterns to avoid cumulative toxicity.

Combination Treatment in Autoimmune Disease

Author : W. B. Harrison
Publisher :
ISBN 13 :
Total Pages : 213 pages
Book Rating : 4.:/5 (248 download)

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Book Synopsis Combination Treatment in Autoimmune Disease by : W. B. Harrison

Download or read book Combination Treatment in Autoimmune Disease written by W. B. Harrison and published by . This book was released on 2001 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polymyositis and Dermatomyositis

Author : Marinos C. Dalakas
Publisher : Butterworth-Heinemann
ISBN 13 : 1483163040
Total Pages : 362 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Polymyositis and Dermatomyositis by : Marinos C. Dalakas

Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.

Combination Therapies

Author : E. Garaci
Publisher : Springer
ISBN 13 : 9781461364726
Total Pages : 313 pages
Book Rating : 4.3/5 (647 download)

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Book Synopsis Combination Therapies by : E. Garaci

Download or read book Combination Therapies written by E. Garaci and published by Springer. This book was released on 2012-10-21 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade many of the key lymphokines, hormones and growth factors that help regulate the immune system have been defined. These molecules, termed biological response modifiers (BRMs) , have been sequenced, synthesized and produced in large enough quantities to test in animals and humans resulting in the development of new approaches to the treatment of human disease, in particular, cancers and infectious diseases. Advances in this area have also led to rethinking therapies against a range of autoimmune disorders and other diseases associated with immune and endocrine imbalances. BRMs currently are being applied clinically as both primary and adjunctive therapy to enhance the effectiveness of traditional treatments by maximizing their activities and to protect critical tissues against intolerable chemotherapeutic and radiation damage. Present constraints against the use of BRMs revolve around the nature of these substances in vivo, where many of their actions and the majority of their interactions and synergies remain to be elucidated. For example, as these molecules are thought to exert their effects locally, the systemic administration of lymphokines, cytokines and growth factors at doses adequate to produce a wanted anti-tumor effect in many instances is intolerably toxic. Efforts to overcome this formidable problem have led scientists to begin to explore the transfer of genes known to encode for these molecules into cells which otherwise inadequately elicit or produce anti-tumor or anti-infective responses.

Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer

Author : Erwan Mortier
Publisher : Frontiers Media SA
ISBN 13 : 288966211X
Total Pages : 202 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer by : Erwan Mortier

Download or read book Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer written by Erwan Mortier and published by Frontiers Media SA. This book was released on 2020-12-11 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Cytokines in Autoimmunity

Author : Fionula M. Brennan
Publisher : Landes Bioscience
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Cytokines in Autoimmunity by : Fionula M. Brennan

Download or read book Cytokines in Autoimmunity written by Fionula M. Brennan and published by Landes Bioscience. This book was released on 1996 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review of the field of cytokines in autoimmunity written by 22 researchers suggesting diverse applications, and building on the successes of recent rheumatoid arthritis clinical trials. The contributors present and review findings on arthritis, diabetes, multiple sclerosis, thyroid disease, Sjogren's syndrome, Lupus, scleroderma, and psoriasis. The final sections concentrate on laboratory and clinical concerns working with "knockout" mice, transgenic mice, and cytokine therapy. Distributed by Chapman and Hall. CiP shows the title as Role of cytokines..... Annotation copyright by Book News, Inc., Portland, OR

Gene Therapy of Autoimmune Disease

Author : Gerald J. Prud'homme
Publisher : Springer
ISBN 13 : 9780306479915
Total Pages : 149 pages
Book Rating : 4.4/5 (799 download)

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Book Synopsis Gene Therapy of Autoimmune Disease by : Gerald J. Prud'homme

Download or read book Gene Therapy of Autoimmune Disease written by Gerald J. Prud'homme and published by Springer. This book was released on 2005-07-13 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune diseases are diverse and responsible for considerable morbidity. Their etiology remains largely unknown, and current therapy with anti-inflammatory drugs is prone to adverse effects, and rarely curative. New therapies with anti-cytokine antibodies or receptors are promising, but require frequent administration of expensive protein drugs. Gene Therapy of Autoimmune Diseases comprehensively reviews research in gene therapy for autoimmune diseases with viral or non-viral vectors. Gene therapy offers the possibility of long-term, continuous delivery of a wide variety of immunosuppressive, anti-inflammatory, or tolerance-inducing agents. Moreover, highly specific genetically modified cells can be produced. This book discusses the most promising avenues in this exciting new field.

Cancer and Autoimmunity

Author : M.E. Gershwin
Publisher : Elsevier
ISBN 13 : 0080528457
Total Pages : 467 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Cancer and Autoimmunity by : M.E. Gershwin

Download or read book Cancer and Autoimmunity written by M.E. Gershwin and published by Elsevier. This book was released on 2000-03-27 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the two disciplines in parallel development for two decades, tumor immunology and transplantation immunology, the latter has thrived and has led to some of the most critical discoveries in immunobiology. The former continues to thwart both scientists and clinicians alike.The goal of immunologists in modern day research is to develop a simple and effective means to manipulate cancer in vivo, possibly encompassing several venues: identifying a phenotypic marker and the use of either active or passive immunization; include the use of passive reagents carrying "warheads" to selectively destroy cancer cells; or altering the basic process of cell survival.This excellent multidiscipline-authored volume presents a theme which has not been well described before. The papers include both basic and clinical science and range from sophisticated molecular biology to little more than phenomenology (e.g. the increased association of cancer in some autoimmune diseases and increased presentation of autoimmune phenomena in malignant condition). This, however, is state-of-the-art.This collection of themes will be of use not only to bench scientists, but also to clinicians who treat patients. The book represents progress at the cutting edge of this discipline, and points the way to further developments in the "black box" of immunology.

Novel Therapeutic Agents for the Treatment of Autoimmune Diseases

Author : Vibeke Strand
Publisher : CRC Press
ISBN 13 : 1482273535
Total Pages : 341 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Novel Therapeutic Agents for the Treatment of Autoimmune Diseases by : Vibeke Strand

Download or read book Novel Therapeutic Agents for the Treatment of Autoimmune Diseases written by Vibeke Strand and published by CRC Press. This book was released on 1996-09-19 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a detailed survey of therapies for autoimmune diseases, exploring the rationale for their use and clinical data regarding their potential benefit.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Mosaic of Autoimmunity

Author : Carlo Perricone
Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mosaic of Autoimmunity by : Carlo Perricone

Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications

Moderate to Severe Psoriasis, Fourth Edition

Author : John Y. M. Koo
Publisher : CRC Press
ISBN 13 : 1482215160
Total Pages : 422 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Moderate to Severe Psoriasis, Fourth Edition by : John Y. M. Koo

Download or read book Moderate to Severe Psoriasis, Fourth Edition written by John Y. M. Koo and published by CRC Press. This book was released on 2014-03-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the dermatology field, this new fourth edition of Moderate-to-Severe Psoriasis discusses the current use of biologics and other pharmacologic and phototherapy treatments for moderate-to-severe psoriasis. Illustrated with high quality color figures, this standalone text emphasizes safe and effective treatments for the psoriasis patient that are perfect for the dermatologist in daily practice. New to this edition are chapters on day treatment programs, new agents, erythrodermic and pustular psoriasis, special populations, and pharmacogenetics.

Modern Immunosuppressives

Author : H. J. Schuurman
Publisher :
ISBN 13 : 9783034883535
Total Pages : 236 pages
Book Rating : 4.8/5 (835 download)

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Book Synopsis Modern Immunosuppressives by : H. J. Schuurman

Download or read book Modern Immunosuppressives written by H. J. Schuurman and published by . This book was released on 2001-06-01 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autoimmune Bullous Diseases

Author : Müzeyyen Gönül
Publisher : BoD – Books on Demand
ISBN 13 : 1789230268
Total Pages : 258 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Autoimmune Bullous Diseases by : Müzeyyen Gönül

Download or read book Autoimmune Bullous Diseases written by Müzeyyen Gönül and published by BoD – Books on Demand. This book was released on 2018-05-09 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune bullous diseases are a group of rare skin diseases characterized by intraepidermal and subepidermal bullae formations due to autoantibodies directed against the structural proteins of the epidermis or the dermal-epidermal junction. Early and correct diagnosis and adequate treatment of autoimmune bullous diseases are important as they cause morbidity and mortality in the affected patients. This book, which gives detailed information about autoimmune bullous diseases, has two sections and nine chapters with sixteen contributing authors. The first section describes the structure and tasks of desmosomes and basement membrane zone, which consist of the major antigens of skin integrity targeted by autoantibodies. The second section is about the epidemiology, etiopathogenesis, mucocutaneous, histopathologic and laboratory findings, and therapy of autoimmune bullous diseases.

SITC’s Guide to Managing Immunotherapy Toxicity

Author : Marc S. Ernstoff, MD
Publisher : Springer Publishing Company
ISBN 13 : 0826172156
Total Pages : 250 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis SITC’s Guide to Managing Immunotherapy Toxicity by : Marc S. Ernstoff, MD

Download or read book SITC’s Guide to Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and published by Springer Publishing Company. This book was released on 2019-03-15 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases

Author : Richard K. Burt
Publisher : CRC Press
ISBN 13 : 1351364766
Total Pages : 687 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases by : Richard K. Burt

Download or read book Hematopoietic Stem Cell Transplantation and Cellular Therapies for Autoimmune Diseases written by Richard K. Burt and published by CRC Press. This book was released on 2021-11-17 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the global progress in medical and scientific research toward converting traditionally chronic autoimmune diseases into a drug-free reversible illness using hematopoietic stem cell transplantation (HSCT) and other cellular therapies such as T regulatory cells (Treg), mesenchymal stromal/stem cells, and chimeric antigen receptor T (CAR T) cells in order to reintroduce sustained immune tolerance. This title provides information on different types of stem cells and immune cells; post-transplant immune regeneration; cellular regulatory requirements; ethical and economic considerations; and the advantages and disadvantages of HSCT in the treatment of a variety of autoimmune diseases versus current conventional treatments. Arranged by disease, the text provides a comprehensive guide to HSCT for all types of autoimmune/immune disorders including monogenetic autoimmune diseases; autoimmune aplastic anemia; neurologic immune diseases including multiple sclerosis, chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, and stiff person syndrome; rheumatologic diseases such as systemic sclerosis and systemic lupus erythematosus; dermatologic diseases such as pemphigus; gastrointestinal disorders such as Crohn’s disease and celiac disease; and immune-mediated endocrinologic disease type I diabetes mellitus. Guidance is provided on the transplantation technique, cell collection and processing, conditioning regimens, infections, and early and late complications. Key Features Outlines therapies and techniques for HSCT for autoimmune diseases Discusses the advantages of HSCT over conventional therapies Reviews the entire process of stem cell therapy from harvest and ethics to indications, efficacy, and regulatory oversight