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Collagen Gels And Matrices For Biomedical Applications
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Book Synopsis Collagen Gels and Matrices for Biomedical Applications by : Madalina Georgiana Albu
Download or read book Collagen Gels and Matrices for Biomedical Applications written by Madalina Georgiana Albu and published by LAP Lambert Academic Publishing. This book was released on 2011-04 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen represents one of the mostly used biomaterials due to its excellent biocompatibility and biodegradability properties. The obtaining of collagen based biomaterials as support for local release of a desired amount of drugs has as motivation their use in the treatment of various skin affections (sores, burns, infections produced by various bacteria) and of soft tissues (periodontal disease, dental extractions). Besides its function as release support, collagen acts as a biological dressing for tissue regeneration. The objective of this work is to obtain last generation local delivery systems containing two antimicrobial drugs in collagenic systems (gels and matrices) to control the drug release for the treatment of different specific diseases: doxycycline - an antibiotic used especially for the treatment of periodontitic disease and tannic acid - an antiseptic for wound treatment. The development of such drug delivery systems bring about both theoretical and practical contributions in the field of biomaterials used as locally controlled drug delivery systems. The biomaterials obtained in this work are in clinical trial being used in medicine and dentistry with good results.
Book Synopsis Extracellular Matrix Proteins: Advances in Research and Application: 2011 Edition by :
Download or read book Extracellular Matrix Proteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 690 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix Proteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Extracellular Matrix Proteins. The editors have built Extracellular Matrix Proteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Extracellular Matrix Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Extracellular Matrix Proteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Soft Matter for Biomedical Applications by : Dr Helena S Azevedo
Download or read book Soft Matter for Biomedical Applications written by Dr Helena S Azevedo and published by Royal Society of Chemistry. This book was released on 2021-06-11 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.
Book Synopsis Extracellular Matrix Proteins—Advances in Research and Application: 2012 Edition by :
Download or read book Extracellular Matrix Proteins—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix Proteins—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Extracellular Matrix Proteins. The editors have built Extracellular Matrix Proteins—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Extracellular Matrix Proteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Extracellular Matrix Proteins—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Studies on Collagen Stability and Mechanical Properties in Tissue Engineering Applications by : Selene Pellizzoni
Download or read book Studies on Collagen Stability and Mechanical Properties in Tissue Engineering Applications written by Selene Pellizzoni and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective: This project aims to measure the stiffness of collagen based gel matrix. This work provides mechanical study of 0.3 % collagen hydrogel monolayer properties under compression. In order to understand how the collagen gel properties change in relation with time and cell concentrations, the mechanical analysis was performed with different cell densities and time rates. They have been analysed before the culture (to report the stiffness characteristics of non-altered collagen gel) and during the culture, with the influence of the cells. Background: Cells are profoundly affected by the physical properties of the environment, including the stiffness of the matrix. The stiffness of cell adhesion substrates is increasingly appreciated as an important mediator of cell behaviour; it can regulate cell signalling broadly, with effects on growth, survival, differentiation and motility. The stiffness of ECM-based collagen gels can be manipulated, and so varied to be suitable for growing cells derived from soft tissues. However, the cells are capable of remodelling the gel, altering its stiffness during culture; this could damage the final culture characteristics, leading to altered cell properties. Methodology: The 0.3 % collagen hydrogel was prepared from collagen type I, obtained from rat tail tendons; it was then placed in the wells of a standard 24-well plate. The collagen gel monolayer was seeded with human hepatoma cells (HepG2) at different densities: 105, 5*104, 2.5*104, 104 and 0.5*104. Before testing the wells, the viability of the cells was ensured with the MTT assay. The normal sample was represented by a single well of collagen hydrogel which was not seeded with cells, but left for the same period of the culture filled with medium in the same incubator as the samples. The confined compression strength was measured through BOSE ElectroForce machine together with the WinTest software. The data acquired were analysed with Matlab software in order to evaluate the Aggregate Modulus (HA), Hydraulic Permeability (k), Coefficient of Permeability and Correlation Coefficient (r). Results and Conclusions: The data showed that the Aggregate Modulus has a general trend of increasing with culture time, except for the collagen gel without cells; the differences between culture durations are statistically significant just for the cases of 0.5*104 and 105 cells per cm2 cultures. Cells grow and increase in number during culture time, indeed cells in gels cultured for one day present a smaller cell concentration than the ones cultured for 5 days. The increase in number can contribute to increase in the Aggregate Modulus, therefore in the stiffness, since, as showed in the literature, the stiffness tends to increase with cells because they add resistance to the gel (Saddiq et al., 2008). It is generally true that cells act to weaken the collagen gel, but the rate in which they make it soft (by causing the secretion of degradative enzymes and by exerting mechanical forces) could be probably lower than the rate of cells growth, in the specific case of HepG2 cells. For this reason, the cell growth effect outweighs the effect of weakness. Seeding cells on collagen gels will usually lead to one of two possible effects on the Aggregate Modulus: the Aggregate Modulus can reduce which will be due to cells weakening the gels or the Aggregate Modulus can increase which can be due to physical presence of cells contributing to higher stiffness measurements. However, for HepG2 cell line, the increase in stiffness seems to be the predominant action. On the other hand, regarding the changes in stiffness during the different cell densities, the data acquired do not show a trend which can be interpreted with logical deductions.
Book Synopsis Collagen Biografts for Tunable Drug Delivery by : Rucha Joshi
Download or read book Collagen Biografts for Tunable Drug Delivery written by Rucha Joshi and published by Springer Nature. This book was released on 2021-01-31 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews collagen-based biomaterials that have been applied broadly to tissue engineering and local drug delivery applications and lays out a landscape for developing a multifunctional biograft material from collagen polymers. The book also discusses current shortcomings in collagen based drug delivery opportunities, including poor mechanical properties, rapid proteolytic degradation, and cursory control over physical properties and molecular release profiles. Finally, a review of application of the collagen biograft materials for promoting neovascularization and tissue regeneration is presented, using examples of established in-vivo chicken egg chorioallantoic membrane (CAM) model. Use of heparin for affinity-based vascular endothelial growth factor (VEGF) retention in collagen constructs is also discussed for promoting neovascularization. Reviews state-of-the-art strategies for drug incorporation and retention in collagen; Covers collagen based material applications for improving vascularization and tissue regeneration; Illustrates how to tailor collagen architecture for soft tissue engineering and controlled drug delivery.
Book Synopsis Biomedical Engineering Fundamentals by : Joseph D. Bronzino
Download or read book Biomedical Engineering Fundamentals written by Joseph D. Bronzino and published by CRC Press. This book was released on 2014-12-17 with total page 1144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering.Biomedical Engineering Fundamentals, the first volume of
Book Synopsis Tissue Engineering and Regenerative Medicine by : Phuc Van Pham
Download or read book Tissue Engineering and Regenerative Medicine written by Phuc Van Pham and published by Springer. This book was released on 2019-08-14 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new series, based on a bi-annual conference and its topics, represents a major contribution to the emerging science of cancer research and regenerative medicine. Each volume brings together some of the most pre-eminent scientists working on cancer biology, cancer treatment, cancer diagnosis, cancer prevention and regenerative medicine to share information on currently ongoing work which will help shape future therapies. These volumes are invaluable resources not only for already active researchers or clinicians but also for those entering these fields, plus those in industry. Tissue Engineering and Regenerative Medicine is a proceedings volume which reflects papers presented at the 3rd bi-annual Innovations in Regenerative Medicine and Cancer Research conference; taken with its companion volume Stem Cells: Biology and Engineering it provides a complete overview of the papers from that meeting of international experts.
Book Synopsis The Biomedical Engineering Handbook by : Joseph D. Bronzino
Download or read book The Biomedical Engineering Handbook written by Joseph D. Bronzino and published by CRC Press. This book was released on 2018-10-03 with total page 5245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive bible for the field of biomedical engineering, this collection of volumes is a major reference for all practicing biomedical engineers and students. Now in its fourth edition, this work presents a substantial revision, with all sections updated to offer the latest research findings. New sections address drugs and devices, personalized medicine, and stem cell engineering. Also included is a historical overview as well as a special section on medical ethics. This set provides complete coverage of biomedical engineering fundamentals, medical devices and systems, computer applications in medicine, and molecular engineering.
Book Synopsis Studies on Ionic Liquids Effect of Collagen Matrices by : V. Tarannu Aafiya S
Download or read book Studies on Ionic Liquids Effect of Collagen Matrices written by V. Tarannu Aafiya S and published by Independent Author. This book was released on 2023-06-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ionic liquids have emerged as an innovative material for various applications due to their unique physicochemical properties. Collagen matrices have been used as a scaffold in tissue engineering and regenerative medicine due to their excellent biocompatibility and biodegradability. The combination of these two materials has attracted much attention in recent years. The studies on ionic liquids effect on collagen matrices have been carried out to investigate the potential applications of these materials. The effects of ionic liquids on collagen matrices have been studied in terms of their chemical modification, physical properties, mechanical properties, rheological properties, swelling behavior, gelation, and crosslinking. The ionic strength of the solution has been shown to play a crucial role in the properties of the collagen matrices. Cytotoxicity studies have been performed to evaluate the biocompatibility of these materials. In vitro and in vivo studies have been carried out to investigate the cell culture, cell proliferation, cell adhesion, cell differentiation, and extracellular matrix formation of the collagen-ionic liquid composite materials. The potential applications of these materials include wound healing, drug delivery, tissue engineering, and regenerative medicine. Electrospinning has been used to produce electrospun fibers and nanofiber scaffolds of collagen-ionic liquid composites for biomedical applications. The surface modification of these materials has also been studied to improve their properties for various biomedical applications. The studies on ionic liquids effect on collagen matrices have the potential to provide new insights into the development of novel materials for various biomedical applications. The chemical synthesis, analytical methods, and characterization of these materials are crucial to understanding the molecular interactions and interfacial phenomena that occur in these systems. The interdisciplinary field of polymer science, polymer chemistry, biophysics, and biomechanics is essential in advancing the development of collagen-ionic liquid composites for various biomedical applications.
Author :Raphael M. Ottenbrite Publisher :Springer Science & Business Media ISBN 13 :144195919X Total Pages :438 pages Book Rating :4.4/5 (419 download)
Book Synopsis Biomedical Applications of Hydrogels Handbook by : Raphael M. Ottenbrite
Download or read book Biomedical Applications of Hydrogels Handbook written by Raphael M. Ottenbrite and published by Springer Science & Business Media. This book was released on 2010-09-05 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hydrogels are networks of polymer chains which can produce a colloidal gel containing over 99 per cent water. The superabsorbency and permeability of naturally occurring and synthetic hydrogels give this class of materials an amazing array of uses. These uses range from wound dressings and skin grafts to oxygen-permeable contact lenses to biodegradable delivery systems for drugs or pesticides and scaffolds for tissue engineering and regenerative medicine. Biomedical Applications of Hydrogels Handbook provides a comprehensive description of this diverse class of materials, covering both synthesis and properties and a broad range of research and commercial applications. The Handbook is divided into four sections: Stimuli-Sensitive Hydrogels, Hydrogels for Drug Delivery, Hydrogels for Tissue Engineering, and Hydrogels with Unique Properties. Key Features: Provides comprehensive coverage of the basic science and applications of a diverse class of materials Includes both naturally occurring and synthetic hydrogels Edited and written by world leaders in the field.
Book Synopsis Polymer Biomaterial Constructs for Regenerative Medicine and Functional Biological Systems by : Linghui Meng
Download or read book Polymer Biomaterial Constructs for Regenerative Medicine and Functional Biological Systems written by Linghui Meng and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of collagen as a biomaterial is currently undergoing a renaissance in the tissue engineering field. The excellent biocompatibility and safety due to its biological characteristics, such as biodegradability and weak antigenicity, make collagen a primary material resource in medical applications. Described herein is work towards the development of novel collagen-based matrices, with additional multi-functionality imparted through a novel in-situ crosslinking approach. The process of electrospinning has become a widely used technique for the creation of fibrous scaffolds for tissue engineering applications due to its ability to rapidly create structures composed of nano-scale polymer fibers closely resembling the architecture of the extracellular matrix (ECM). Collagen-PCL sheath-core bicomponent fibrous scaffolds were fabricated using a novel variation on traditional electrospinning, known as co-axial electrospinning. The results showed that the addition of a synthetic polymer core into collagen nanofibers remarkably increased the mechanical strength of collagen matrices spun from the benign solvent system. A novel single-step, in-situ collagen crosslink approach was developed in order to solve the problems dominating traditional collagen crosslinking methods, such as dimensional shrinking and loss of porous morphology, and to simplify the crosslinking procedure for electrospun collagen scaffolds. The excess amount of NHS present in the crosslinking mixture was found to delay the EDC/collagen coupling reaction in a controlled fashion. Fundamental investigations into the development and characterization of in-situ crosslinked collagen matrices such as fibrous scaffolds, gels and sponges, as well as their biomedical applications including cell culture substrates, wound dressings, drug delivery matrices and bone regeneration substitutes, were performed. The preliminary mice studies indicated that the in-situ crosslinked collagen matrices could be good candidates for wound healing and skin regeneration. Polyelectrolyte fibrous tubes of highly-crosslinked poly (acrylic acid) were fabricated by means of electrospinning as polymer models for functional biological systems, with special attention to the axon cortical layer and its cation-exchange properties. The processing parameters of fiber formation and the reversible phase transitions of PAA tubes according to monovalent-divalent ion exchange in solution were systematically investigated. The results showed that the neutralized PAA tubes were responsive to calcium ions, exhibiting significant shrinkage that could be reversed with a chelator such as citrate. Study of such phase transitions may help to better understand the electrophysiological processes known as nerve excitation and conduction in the nervous system, and the resulting PAA tubes might be used as polymer models of artificial axons for potential tissue engineering and nerve repair applications
Book Synopsis Multifunctional Hydrogels for Biomedical Applications by : Ricardo A. Pires
Download or read book Multifunctional Hydrogels for Biomedical Applications written by Ricardo A. Pires and published by John Wiley & Sons. This book was released on 2022-05-12 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional Hydrogels for Biomedical Applications Comprehensive resource presenting a thorough overview of the biomedical applications of hydrogels This book provides an overview of the development and applications of the clinically relevant hydrogels that are used particularly in tissue engineering, regenerative medicine, and drug delivery. Taking a multidisciplinary approach, it goes through the material from chemistry, materials science, biology, medicine, nanotechnology, and bioengineering points of view. Sample topics covered by the three well-qualified editors include: The design, functions, and developments of hydrogels Proteins and polysaccharides that mimic extracellular matrix Generation and applications of supramolecular hydrogels Design and functions of cell encapsulation systems Multifunctional Hydrogels for Biomedical Applications is a useful all-in-one reference work for materials scientists, polymer chemists, and bioengineers which provides a comprehensive, contemporary understanding of hydrogels and their applications targeting a wide variety of pathologies.
Download or read book Polymeric Gels written by Kunal Pal and published by Woodhead Publishing. This book was released on 2018-06-15 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. - Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks - Analyzes and compares experimental data - Presents in-depth information on the physical properties of polymeric gels using mathematical models - Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances
Book Synopsis Effect of Mechanical Environment on Cell Behavior in Three-dimensional Collagen Matrices by : Mary Ellen Cooke
Download or read book Effect of Mechanical Environment on Cell Behavior in Three-dimensional Collagen Matrices written by Mary Ellen Cooke and published by . This book was released on 2000 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Handbook of the Extracellular Matrix by : F. Raquel Maia
Download or read book Handbook of the Extracellular Matrix written by F. Raquel Maia and published by Springer Nature. This book was released on with total page 1322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Scleroproteins: Advances in Research and Application: 2011 Edition by :
Download or read book Scleroproteins: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scleroproteins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Scleroproteins. The editors have built Scleroproteins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Scleroproteins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Scleroproteins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
