The Road to Discovery

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ISBN 13 : 9781621821083
Total Pages : 0 pages
Book Rating : 4.8/5 (21 download)

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Book Synopsis The Road to Discovery by : Jan Anthony Witkowski

Download or read book The Road to Discovery written by Jan Anthony Witkowski and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Road to Discovery: A Short History of Cold Spring Harbor Laboratory was published in 2015 to mark the 125th anniversary of Cold Spring Harbor Laboratory. At Cold Spring Harbor, in a bucolic setting on the north shore of New York's Long Island, two interdependent research centers in biology were founded as Charles Darwin's insights into heredity and evolution shook the world of science. Fifty years later, those centers would emerge as a single institution that would cradle another revolution, the new science of molecular biology, and advance to world renown in research and professional education. It is a remarkable story, with a path of progress that was neither simple nor assured. The Road to Discovery traces half a century of changes in name, leadership, governance, and financial fortune. And scientific missteps, most notoriously in eugenics, were triumphed by innovative work in genetics, human metabolism, and cancer. From the 1940s through the 1960s, the Laboratory was home to fundamental discoveries about the nature of genetic material and a cauldron of critical assessment of ideas about genes by sharp-tongued summer visitors. James D. Watson, a junior member of that group, would go on to deduce the structure of DNA with Francis Crick in 1953 and help create the new field of molecular genetics before returning to Cold Spring Harbor as Director 15 years later. As the book shows, his "Bold Plan" would inspire, cajole, and goad into existence an era of expansion, new research directions, and initiatives in conferences, courses, publishing, and education that redefined the scope of the Laboratory. Under Bruce Stillman's leadership, that scope has grown still more, making the Laboratory unique among research institutions worldwide--envied, imitated, but not reproduced. The book's author is the science historian Jan Witkowski. His knowledge of the subject is wide and his affection for it deep. He brings to his task insights that only a decades-long career as a staff member can provide. For over a century, the Laboratory has been influenced by exceptional personalities, outstanding achievements, and dramatic events. The Road to Discovery captures that history in a lively narrative illuminated by vignettes on the importance of individual scientists and their discoveries. Abundantly documented with material from the Laboratory's archives, it is an accessible book that will appeal to anyone interested in the development of biomedical science and biotechnology through the 20th century to the present day.

Cold Spring Harbor

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Publisher : Random House
ISBN 13 : 1407015168
Total Pages : 192 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cold Spring Harbor by : Richard Yates

Download or read book Cold Spring Harbor written by Richard Yates and published by Random House. This book was released on 2010-12-23 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evan Shepard is a young man with a chequered past when he first meets the Drakes, after his car breaks down outside their house. Behind him, he has a troubled adolescence, a failed marriage and a little daughter, but his meeting with the quiet and beautiful Rachel heralds a new start. However, after their swift marriage, things don't work out quite as planned and the stresses of living with Rachel's family, in their shared house in Cold Spring Harbor, begin to take their toll on the new couple.

Lab Ref

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Publisher : CSHL Press
ISBN 13 : 0879698152
Total Pages : 259 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Lab Ref by : Jane Roskams

Download or read book Lab Ref written by Jane Roskams and published by CSHL Press. This book was released on 2002 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The first Lab Ref volume compiled recipes and reference data drawn from a selection of our manuals and was intended to save time and spare frustration." ... "In the same spirit, Lab Ref 2 again assembles in one place a new selection of reference information that should maximize the volume's value in a crowded laboratory environment."--Note.

Experimental Heart

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Publisher :
ISBN 13 :
Total Pages : 382 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Experimental Heart by : Jennifer L. Rohn

Download or read book Experimental Heart written by Jennifer L. Rohn and published by . This book was released on 2009 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: "During his many long nights in the lab, scientist Andy O'Hara has plenty of time to wonder about the mysterious and beautiful Gina, first glimpsed in a lit window across the courtyard. He does not realize she is consumed by her vaccine research, concerned about her biotech company's financial problems, and about to become the prime target of animal rights activists. She is also distracted by a charming pharmaceutical mogul who offers funding for her work and a glamorous escape from her past mistakes." "When Andy finally meets Gina, his monotonous life starts to unravel. Soon he becomes embroiled in an increasingly complex web of deception as he scrambles to discover his rival's true intentions. When Gina abruptly disappears, Andy sets off to find her. But is it too late? Is there a more sinister reason behind Gina's involvement with the company? Is Gina's vaccine all it appears to be? And is Andy ready to acknowledge that there is more to life than work?"--BOOK JACKET.

Phage Display

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Publisher : CSHL Press
ISBN 13 : 0879697407
Total Pages : 724 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Phage Display by : Carlos F. Barbas

Download or read book Phage Display written by Carlos F. Barbas and published by CSHL Press. This book was released on 2001 with total page 724 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phage-display technology has begun to make critical contributions to the study of molecular recognition. DNA sequences are cloned into phage, which then present on their surface the proteins encoded by the DNA. Individual phage are rescued through interaction of the displayed protein with a ligand, and the specific phage is amplified by infection of bacteria. Phage-display technology is powerful but challenging and the aim of this manual is to provide comprehensive instruction in its theoretical and applied so that any scientist with even modest molecular biology experience can effectively employ it. The manual reflects nearly a decade of experience with students of greatly varying technical expertise andexperience who attended a course on the technology at Cold Spring Harbor Laboratory. Phage-display technology is growing in importance and power. This manual is an unrivalled source of expertise in its execution and application.

Methods in Yeast Genetics

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Publisher : CSHL Press
ISBN 13 : 0879697288
Total Pages : 250 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Methods in Yeast Genetics by : David C. Amberg

Download or read book Methods in Yeast Genetics written by David C. Amberg and published by CSHL Press. This book was released on 2005 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.

The Nematode Caenorhabditis Elegans

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Publisher :
ISBN 13 :
Total Pages : 694 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Nematode Caenorhabditis Elegans by : William Barry Wood

Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Telomeres

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Publisher :
ISBN 13 :
Total Pages : 598 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Telomeres by : Titia De Lange

Download or read book Telomeres written by Titia De Lange and published by . This book was released on 2006 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date survey of the current exciting state of telomere biology. Telomeres – specialized structures found at the ends of chromosomes – are essential for maintaining the integrity of chromosomes and their faithful duplication during cell division. Chapters in this volume cover telomere structure and function in a range of organisms, focusing on how they are maintained, their roles in cell division and gene expression, and how deficiencies in these structures contribute to cancers and other diseases and even aging.

Statistics at the Bench

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Publisher :
ISBN 13 :
Total Pages : 188 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Statistics at the Bench by : Martina Bremer

Download or read book Statistics at the Bench written by Martina Bremer and published by . This book was released on 2010 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is a convenient bench companion for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses. Statistical methods most frequently used in publications and reports, as well as guidelines for the interpretation of results, are explained using simple examples with complete instructions for Excel.

Essentials of Glycobiology

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Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)

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Book Synopsis Essentials of Glycobiology by : Ajit Varki

Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.

Houses for Science

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Publisher : CSHL Press
ISBN 13 : 0879694033
Total Pages : 351 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Houses for Science by : Elizabeth L. Watson

Download or read book Houses for Science written by Elizabeth L. Watson and published by CSHL Press. This book was released on 1991-01-01 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Houses for Science traces the unique architectural and scientific evolution of Cold Spring Harbor Laboratory from whaling village, to "summer camp" for biologists, to world-renowned research and educational institution. Situated on Long Island's fabled North Shore, Cold Spring Harbor Laboratory has a one-hundred-year heritage of superlative basic research in genetics and an architectural patrimony that spans nearly two centuries. In Houses for Science architectural historian Elizabeth Watson skillfully integrates the fascinating story of the construction and preservation of this village of science with a chronological account of the history of the Laboratory and the fundamental discoveries made here. Augmenting this account are essays by Nobel laureate James D. Watson on the key advances made in genetics research during the Laboratory's first one hundred years.

Lab Dynamics

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Publisher : CSHL Press
ISBN 13 : 0879698160
Total Pages : 184 pages
Book Rating : 4.8/5 (796 download)

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Book Synopsis Lab Dynamics by : Carl M. Cohen

Download or read book Lab Dynamics written by Carl M. Cohen and published by CSHL Press. This book was released on 2005 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Lab Dynamics is a book about the challenges to doing science and dealing with the individuals involved, including oneself. The authors, a scientist and a psychotherapist, draw on principles of group and behavioral psychology but speak to scientists in their own language about their own experiences. They offer in-depth, practical advice, real-life examples, and exercises tailored to scientific and technical workplaces on topics as diverse as conflict resolution, negotiation, dealing with supervision, working with competing peers, and making the transition from academia to industry." "This is a uniquely valuable contribution to the scientific literature, on a subject of direct importance to lab heads, postdocs, and students. It is also required reading for senior staff concerned about improving efficiency and effectiveness in academic and industrial research."--BOOK JACKET

The P53 Protein

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Publisher :
ISBN 13 : 9781621821335
Total Pages : 0 pages
Book Rating : 4.8/5 (213 download)

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Book Synopsis The P53 Protein by : Guillermina Lozano

Download or read book The P53 Protein written by Guillermina Lozano and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signals that trigger its activation or repression, and its downstream effects on genome stability and the cell cycle that enforce tumor suppression in different cell and tissue types. They also discuss how p53 dysfunction contributes to cancer, exploring the various inherited and somatic mutations in the human TP53 gene, the impact of mutant p53 proteins on tumorigenesis, and the prognostic value and clinical outcomes of these mutations. Drugs that are being developed to respond to tumors harboring aberrant p53 are also described. This book is therefore essential reading for all cancer biologists, cell and molecular biologists, and pharmacologists concerned with the treatment of this disease.

Bioelectronic Medicine

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Publisher : Perspectives Cshl
ISBN 13 : 9781621823025
Total Pages : 350 pages
Book Rating : 4.8/5 (23 download)

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Book Synopsis Bioelectronic Medicine by : Valentin A. Pavlov

Download or read book Bioelectronic Medicine written by Valentin A. Pavlov and published by Perspectives Cshl. This book was released on 2019 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cold Spring Harbor perspectives in medicine."

Symmetry Breaking in Biology

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Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Symmetry Breaking in Biology by : Rong Li

Download or read book Symmetry Breaking in Biology written by Rong Li and published by . This book was released on 2010 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts examine the mechanisms by which cells polarize, divide asymmetrically, and produce asymmetric structures, providing examples from bacteria, yeast, plants, invertebrates, and mammals. Discussion include the molecular basis of polarization, mechanisms, and more.

Translation Mechanisms and Control

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Publisher :
ISBN 13 : 9781621821861
Total Pages : 499 pages
Book Rating : 4.8/5 (218 download)

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Book Synopsis Translation Mechanisms and Control by : Michael B. Mathews

Download or read book Translation Mechanisms and Control written by Michael B. Mathews and published by . This book was released on 2018-09-30 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: A subject collection from Cold Spring Harbor Perspectives in Biology.

CRISPR-Cas

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ISBN 13 : 9781621821304
Total Pages : 0 pages
Book Rating : 4.8/5 (213 download)

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Book Synopsis CRISPR-Cas by : Jennifer A. Doudna

Download or read book CRISPR-Cas written by Jennifer A. Doudna and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas-based techniques are revolutionizing the way geneticists and molecular biologists modify DNA sequences and modulate gene expression in cells and organisms. This laboratory manual presents step-by-step protocols for applying this cutting-edge technology to any system of interest. Contributors describe approaches for de.