Clostridial Neurotoxins

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Clostridial Neurotoxins

Author : Cesare Montecucco
Publisher : Springer Science & Business Media
ISBN 13 : 3642851738
Total Pages : 283 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Clostridial Neurotoxins by : Cesare Montecucco

Download or read book Clostridial Neurotoxins written by Cesare Montecucco and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due to intoxication with a protein toxin produced by bacteria of the genus Clostridium. These bacteria and their spores and ubiquitous, and the majority of them do not produce neurotoxins. The selective advantage of producing such potent toxin is still a matter of speculation (see Popoff, this volume). The next major advance was the discovery that tetanus neurotoxin 1 can be converted by formaldehyde treatment to a nonpathogenic but still fully immunogenic form, and that this can be used successfully as a vaccine to prevent tetanus (RAMON and DESCOMBEY 1925). Similar vaccines (toxoids) can be prepared with botulism neurotoxins (see MiDDLEBROOK and BROWN, this volume). The prevention oftetanus by vaccination (see Galatzka and Gasse, this volume) is one of the great successes of basic research coupled with an efficient public medicine service.

Botulinum Neurotoxin and Tetanus Toxin

Author : Lance L. Simpson
Publisher :
ISBN 13 :
Total Pages : 448 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Botulinum Neurotoxin and Tetanus Toxin by : Lance L. Simpson

Download or read book Botulinum Neurotoxin and Tetanus Toxin written by Lance L. Simpson and published by . This book was released on 1989 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Botulinum Neurotoxin and Tetanus Toxin ...

Handbook of Neurotoxicology

Author : Edward J. Massaro
Publisher : Springer Science & Business Media
ISBN 13 : 1592591329
Total Pages : 658 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Handbook of Neurotoxicology by : Edward J. Massaro

Download or read book Handbook of Neurotoxicology written by Edward J. Massaro and published by Springer Science & Business Media. This book was released on 2001-11-12 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.

Clostridial Diseases of Animals

Author : Francisco A. Uzal
Publisher : John Wiley & Sons
ISBN 13 : 1118728408
Total Pages : 356 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Clostridial Diseases of Animals by : Francisco A. Uzal

Download or read book Clostridial Diseases of Animals written by Francisco A. Uzal and published by John Wiley & Sons. This book was released on 2016-05-31 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clostridial Diseases of Animals is the first book to focus on clostridial diseases in domestic and wild animals, offering a comprehensive reference on these common diseases. Provides a single resource for all aspects of clostridial diseases Presents current, comprehensive information with a focus on clinical relevance Covers each disease in depth, including etiology, epidemiology, clinics, gross pathology, histopathology, diagnostics, diagnostic criteria, prophylaxis, control, and treatment Written by the world-leading experts in the field of clostridial diseases in animals Offers photographs and summary tables to support the concepts discussed in the text and aid in recognition

The Clostridia

Author : Julian I. Rood
Publisher : Academic Press
ISBN 13 : 0080542395
Total Pages : 555 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Clostridia by : Julian I. Rood

Download or read book The Clostridia written by Julian I. Rood and published by Academic Press. This book was released on 1997-04-30 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clostridia are a group of bacteria of considerable medical and economic importance and include species responsible for generating the most potent toxins known to humans. The Clostridia: Molecular Biology and Pathogenesis is a unique work, comprising the most complete reference on the clostridia for over 20 years, bringing together the results from some of the most innovative and exciting research in the past decade. Using a principle-oriented rather than taxonomic approach, the results from molecular biology research are placed in the context of their clinical significance, and the disease process as a whole. This state-of-the-art work is truly comprehensive, covering and integrating the diverse topics of genetics, physiology, pathogenesis and cell biology. Written and edited by world-renowned authorities, material is presented to give the reader an up-to-date knowledge of the pathogenic species of this important genus. Background information is followed by details of the genetics, molecular biology, biochemistry and disease mechanisms. The structure, function and mode of action of toxins and other virulence determinants is clearly presented. As such, this work will prove essential for students, teachers, research microbiologists, infectious disease clinicians, toxin specialists, and all those working in medical or veterinary bacteriology, microbial genetics and the pharmaceutical industries. - Covers appropriate medical and veterinary topics - Contains authoritative contributions by international experts - Presents the current state of knowledge and areas for future research - Truly comprehensive--covers topics from molecular biology and physiology

Botulinum and Tetanus Neurotoxins

Author : B. R. Dasgupta
Publisher :
ISBN 13 : 9781475795431
Total Pages : 710 pages
Book Rating : 4.7/5 (954 download)

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Book Synopsis Botulinum and Tetanus Neurotoxins by : B. R. Dasgupta

Download or read book Botulinum and Tetanus Neurotoxins written by B. R. Dasgupta and published by . This book was released on 2014-01-15 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Botulinum Neurotoxins

Author : Andreas Rummel
Publisher : Springer
ISBN 13 : 9783642448898
Total Pages : 0 pages
Book Rating : 4.4/5 (488 download)

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Book Synopsis Botulinum Neurotoxins by : Andreas Rummel

Download or read book Botulinum Neurotoxins written by Andreas Rummel and published by Springer. This book was released on 2015-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Handbook on Clostridia

Author : Peter Duerre
Publisher : CRC Press
ISBN 13 : 113550198X
Total Pages : 1451 pages
Book Rating : 4.1/5 (355 download)

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Book Synopsis Handbook on Clostridia by : Peter Duerre

Download or read book Handbook on Clostridia written by Peter Duerre and published by CRC Press. This book was released on 2005-03-29 with total page 1451 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research ar

Diseases of Swine

Author : Jeffrey J. Zimmerman
Publisher : John Wiley & Sons
ISBN 13 : 1119350859
Total Pages : 1136 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Diseases of Swine by : Jeffrey J. Zimmerman

Download or read book Diseases of Swine written by Jeffrey J. Zimmerman and published by John Wiley & Sons. This book was released on 2019-06-18 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a fully revised Eleventh Edition of the definitive reference to swine health and disease Diseases of Swine has been the definitive reference on swine health and disease for over 60 years. This new edition has been completely revised to include the latest information, developments, and research in the field. Now with full color images throughout, this comprehensive and authoritative resource has been redesigned for improved consistency and readability, with a reorganized format for more intuitive access to information. Diseases of Swine covers a wide range of essential topics on swine production, health, and management, with contributions from more than 100 of the foremost international experts in the field. This revised edition makes the information easy to find and includes expanded information on welfare and behavior. A key reference for anyone involved in the swine industry, Diseases of Swine, Eleventh Edition: Presents a thorough revision to the gold-standard reference on pig health and disease Features full color images throughout the book Includes information on the most current advances in the field Provides comprehensive information on swine welfare and behavior Offers a reorganized format to make the information more accessible Written for veterinarians, academicians, students, and individuals and agencies responsible for swine health and public health, Diseases of Swine, Eleventh Edition is an essential guide to swine health. "The 11th edition of Diseases of Swine continues to serve as the gold-standard resource for anything and everything related to swine herd health...this edition does an outstanding job of keeping up with the advanced diagnostic technologies and the latest research on new or emerging diseases and syndromes...there is no other informational resource that comes close to providing the depth or quality of information on the topic of swine diseases as does this book"

Biological Toxins and Bioterrorism

Author : P. Gopalakrishnakone
Publisher : Springer
ISBN 13 : 9789400758681
Total Pages : 0 pages
Book Rating : 4.7/5 (586 download)

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Book Synopsis Biological Toxins and Bioterrorism by : P. Gopalakrishnakone

Download or read book Biological Toxins and Bioterrorism written by P. Gopalakrishnakone and published by Springer. This book was released on 2015-01-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological toxins are an important part of our world, a reality with which we need to cope, so in parallel with understanding their mechanisms of action and thereby improving our fundamental knowledge, there are successful efforts to utilize them as therapeutics against some debilitating human and animal diseases. In view of the complexity of different types of biotoxins and the broad range of toxin structure, physiology, utility, and countermeasures including regulatory issues, it was thus aimed to compile a book on biotoxins and bioweapons. This reference work in the Toxinology handbook series gathers together knowledge from around the globe about naturally inspired and manufactured biological weapons. The authors describe how they work; how authorities may detect their presence, prevent their use, and diagnose their impacts; and the means by which medical and paramedical professionals may treat victims. Also described are how they have been used to further our knowledge and what insights they have given us into evolutionary and physiological processes. Finally, it is also discussed how these toxins can be used as therapeutics and what the implications of such therapeutics are to their use as biothreat agents. This volume provides a reference accessible to scientists, educators, and medical experts alike with an interest in biotoxins, focusing on the major toxins used as bioweapons. Regulatory agencies will also benefit from the information provided in this book. Some in the intended audience may need to understand how they elicit their effects and how we can defend ourselves against them. Others may be interested in the sometimes colorful histories that surround this subset of biotoxins that can be and, in some cases, have been used as weapons.

Bacterial Signaling

Author : Reinhard Krämer
Publisher : John Wiley & Sons
ISBN 13 : 3527629246
Total Pages : 513 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Bacterial Signaling by : Reinhard Krämer

Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.

Microbial Toxins in Dairy Products

Author : Adnan Y. Tamime
Publisher : John Wiley & Sons
ISBN 13 : 1118756436
Total Pages : 354 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Microbial Toxins in Dairy Products by : Adnan Y. Tamime

Download or read book Microbial Toxins in Dairy Products written by Adnan Y. Tamime and published by John Wiley & Sons. This book was released on 2017-02-06 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Food-borne diseases, including those via dairy products, have been recognised as major threats to human health. The causes associated with dairy food-borne disease are the use of raw milk in the manufacture of dairy products, faulty processing conditions during the heat treatment of milk, post-processing contamination, failure in due diligence and an unhygienic water supply. Dairy food-borne diseases affecting human health are associated with certain strains of bacteria belonging to the genera of Clostridium, Bacillus, Escherichia, Staphylococcus and Listeria, which are capable of producing toxins, plus moulds that can produce mycotoxins such as aflatoxins, sterigmatocytin and ochratoxin. Microbial Toxins in Dairy Products reviews the latest scientific knowledge and developments for detecting and studying the presence of these toxins in dairy products, updating the analytical techniques required to examine bacterial and mould toxins and the potential for contamination of milk as it passes along the food chain, i.e. from 'farm-to-fork'. This comprehensive and accessible collection of techniques will help dairy processors, food scientists, technologists, researchers and students to further minimise the incidences of dairy food-borne illnesses in humans.

Bacterial Protein Toxins

Author : K. Aktories
Publisher : Springer Science & Business Media
ISBN 13 : 3662059711
Total Pages : 713 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Bacterial Protein Toxins by : K. Aktories

Download or read book Bacterial Protein Toxins written by K. Aktories and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 713 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years remarkable progress has been accomplished with respect to our knowledge about bacterial protein toxins. This refers especially to structural aspects of protein toxins but also holds true for genetics, molecular biology and biochemical mechanisms underlying the action of toxins. This volume covers the very current and exciting aspects of up-to-date bacterial toxicology and comprehensively reviews the most important bacterial protein toxins such as the intracellular acting toxins which exhibit enzyme activity, as well as those toxins that interact with cell plasma membranes by damaging the membranes (pore formation) or stimulating cell receptors (superantigens). This is the most current reference work on these important bacterial protein toxins, which are presented from the point of view of different disciplines such as pharmacology, microbiology, cell biology and protein chemistry.

Bacteriological Analytical Manual

Author : United States. Food and Drug Administration. Division of Microbiology
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Bacteriological Analytical Manual by : United States. Food and Drug Administration. Division of Microbiology

Download or read book Bacteriological Analytical Manual written by United States. Food and Drug Administration. Division of Microbiology and published by . This book was released on 1969 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurotoxins and Fillers in Facial Esthetic Surgery

Author : Bradford M. Towne
Publisher : John Wiley & Sons
ISBN 13 : 1119294274
Total Pages : 134 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Neurotoxins and Fillers in Facial Esthetic Surgery by : Bradford M. Towne

Download or read book Neurotoxins and Fillers in Facial Esthetic Surgery written by Bradford M. Towne and published by John Wiley & Sons. This book was released on 2019-03-26 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a detailed, practical guide to incorporating minimally invasive cosmetic surgery into dental practice. Chapters thoroughly examine all aspects of using these materials in practice, and present step-by-step techniques for injecting and placing neurotoxins and fillers, with specific recommendations for product selection and in-depth information on case management. Anatomical drawings and clinical photographs depict the procedures and concepts described. From patient evaluation, treatment planning, and product selection to techniques, managing complications, and marketing the service, Neurotoxins and Fillers in Facial Esthetic Surgery provides a complete resource for using these techniques in practice. Coverage encompasses facial anatomy, neurotoxins, cosmetic fillers, hyaluronic acid dermal fillers, RadiesseTM calcium hydroxylapatite injectable filler, pearls and pitfalls, and how to build your practice. Offers a complete but easy-to-use-reference on all aspects of how to set up a minimally invasive cosmetic facial surgery service within an oral and maxillofacial surgery practice Surveys the range of products available in detail from an objective viewpoint Presents how-to techniques for injecting and placing neurotoxins and fillers Neurotoxins and Fillers in Facial Esthetic Surgery is an essential reference for any oral and maxillofacial surgeon or general dentist wishing to add minimally invasive cosmetic surgery to their repertoire.

Bacterial Toxins

Author : Klaus Aktories
Publisher : John Wiley & Sons
ISBN 13 : 3527614605
Total Pages : 334 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Bacterial Toxins by : Klaus Aktories

Download or read book Bacterial Toxins written by Klaus Aktories and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a survey of well characterized and recently discovered bacterial protein toxins. Leading investigators of the respective toxins review the various molecular mechanisms of action, ranging from toxin-induced ADP-ribosylation up to membrane perforation by pore-forming toxins. Thy also describe the consequences on host physiology before focusing on potential applications as cell biological and pharmacological tools for research and medical applications. Detailed descriptions of the methodology include the engineering and use of modified and chimeric toxins for better performance. A solid introduction to toxin structure and functions, as well as a valuable source of methodology for researchers in molecular biology, pharmacology and experimental medicine.

Bacterial Toxins

Author : Otto Holst
Publisher : Springer Science & Business Media
ISBN 13 : 1592590527
Total Pages : 378 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Bacterial Toxins by : Otto Holst

Download or read book Bacterial Toxins written by Otto Holst and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest of investigators across a broad spectrum of scientific dis- plines has been steadily stimulated by the field of bacterial toxin research, an area that makes use of a large variety of biological, chemical, physicochemical, and medically oriented approaches. Researchers studying bacterial toxins need to be acquainted with all these disciplines in order to work effectively in the field. To date, there has been no published collection offering detailed descr- tions of the techniques and methods needed by researchers operating across the field’sdiverse areas. The present volume Bacterial Toxins: Methods and Pro- cols, is intended to fill this gap. Bacterial Toxins: Methods and Protocols consists of two sections: one on protein toxins (15 chapters) and one on endotoxins (5 chapters). Each s- tion is introduced by an overview article (Chapters 1 and 16). The protocols collected represent state-of-the-art techniques that each have high impact on future bacterial toxin research. All methods are described by authors who have regularly been using the protocol in their own laboratories. Included in each chapter is a brief introduction to the method being described.