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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Joseph A. Marsh
Publisher : Humana
ISBN 13 : 9781493992775
Total Pages : 506 pages
Book Rating : 4.9/5 (927 download)
Download or read book Protein Complex Assembly written by Joseph A. Marsh and published by Humana. This book was released on 2019-04-15 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume details the importance of multiple experimental techniques and computational methods needed to obtain the comprehensive picture of protein complex structure, dynamics and assembly afforded by the emerging field of integrative structural biology. Chapters guide readers through the broad spectrum of approaches required for a complete representation of protein complexes, including expression and purification, experimental characterization of structure and assembly, and computational methods for identifying protein complexes and modelling their assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Protein Complex Assembly: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Author : Krishna Mohan Poluri
Publisher : Springer Nature
ISBN 13 : 9811615942
Total Pages : 346 pages
Book Rating : 4.8/5 (116 download)
Download or read book Protein-Protein Interactions written by Krishna Mohan Poluri and published by Springer Nature. This book was released on 2021-05-19 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the fundamental aspects of protein-protein interactions (PPI), including a detailed account of the energetics and thermodynamics involved in these interactions. It also discusses a number of computational and experimental approaches for the prediction of PPI interactions and reviews their principles, advantages, drawbacks, and the recent developments. Further, it offers structural and mechanistic insights into the formation of protein-protein complexes and maps different PPIs into networks to delineate various pathways that operate at the cellular level. Lastly, it describes computational protein-protein docking techniques and discusses their implications for further experimental research. Given its scope, this book is a valuable resource for students, researchers, scientists, entrepreneurs, and medical/healthcare professionals.
Author : Bertrand Zavidovique
Publisher : World Scientific
ISBN 13 : 9814383287
Total Pages : 328 pages
Book Rating : 4.8/5 (143 download)
Download or read book Science written by Bertrand Zavidovique and published by World Scientific. This book was released on 2012 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book gathers articles that were exposed during the seventh edition of the Workshop ?Data Analysis in Astronomy?. It illustrates a current trend to search for common expressions or models transcending usual disciplines, possibly associated with some lack in the Mathematics required to model complex systems. In that, data analysis would be at the epicentre and a key facilitator of some current integrative phase of Science.It is all devoted to the question of ?representation in Science?, whence its name, IMAGe IN AcTION, and main thrusts Part A: Information: data organization and communication, Part B: System: structure and behaviour, Part C: Data ? System representation. Such a classification makes concepts as ?complexity? or ?dynamics? appear like transverse notions: a measure among others or a dimensional feature among others.Part A broadly discusses a dialogue between experiments and information, be information extracted-from or brought-to experiments. The concept is fundamental in statistics and tailors to the emergence of collective behaviours. Communication then asks for uncertainty considerations ? noise, indeterminacy or approximation ? and its wider impact on the couple perception-action. Clustering being all about uncertainty handling, data set representation appears not to be the only solution: Introducing hierarchies with adapted metrics, a priori pre-improving the data resolution are other methods in need of evaluation. The technology together with increasing semantics enables to involve synthetic data as simulation results for the multiplication of sources.Part B plays with another couple important for complex systems: state vs. transition. State-first descriptions would characterize physics, while transition-first would fit biology. That could stem from life producing dynamical systems in essence. Uncertainty joining causality here, geometry can bring answers: stable patterns in the state space involve constraints from some dynamics consistency. Stable patterns of activity characterize biological systems too. In the living world, the complexity ? i.e. a global measure on both states and transitions ? increases with consciousness: this might be a principle of evolution. Beside geometry or measures, operators and topology have supporters for reporting on dynamical systems. Eventually targeting universality, the category theory of topological thermodynamics is proposed as a foundation of dynamical system understanding.Part C details examples of actual data-system relations in regards to explicit applications and experiments. It shows how pure computer display and animation techniques link models and representations to ?reality? in some ?concrete? virtual, manner. Such techniques are inspired from artificial life, with no connection to physical, biological or physiological phenomena! The Virtual Observatory is the second illustration of the evidence that simulation helps Science not only in giving access to more flexible parameter variability, but also due to the associated data and method storing-capabilities. It fosters interoperability, statistics on bulky corpuses, efficient data mining possibly through the web etc. in short a reuse of resources in general, including novel ideas and competencies. Other examples deal more classically with inverse modelling and reconstruction, involving Bayesian techniques or chaos but also fractal and symmetry.
Author : Eugene V. Koonin
Publisher : Springer Science & Business Media
ISBN 13 : 1475737831
Total Pages : 482 pages
Book Rating : 4.4/5 (757 download)
Download or read book Sequence — Evolution — Function written by Eugene V. Koonin and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequence - Evolution - Function is an introduction to the computational approaches that play a critical role in the emerging new branch of biology known as functional genomics. The book provides the reader with an understanding of the principles and approaches of functional genomics and of the potential and limitations of computational and experimental approaches to genome analysis. Sequence - Evolution - Function should help bridge the "digital divide" between biologists and computer scientists, allowing biologists to better grasp the peculiarities of the emerging field of Genome Biology and to learn how to benefit from the enormous amount of sequence data available in the public databases. The book is non-technical with respect to the computer methods for genome analysis and discusses these methods from the user's viewpoint, without addressing mathematical and algorithmic details. Prior practical familiarity with the basic methods for sequence analysis is a major advantage, but a reader without such experience will be able to use the book as an introduction to these methods. This book is perfect for introductory level courses in computational methods for comparative and functional genomics.
Author : Colin Kleanthous
Publisher : Frontiers in Molecular Biology
ISBN 13 : 9780199637607
Total Pages : 370 pages
Book Rating : 4.6/5 (376 download)
Download or read book Protein-protein Recognition written by Colin Kleanthous and published by Frontiers in Molecular Biology. This book was released on 2000 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Protein-Protein Recognition is to bring together concepts and systems pertaining to protein-protein interactions in a single unifying volume. In the light of the information from the genome sequencing projects and the increase in structural information it is an opportune time totry to make generalizations about how and why proteins form complexes with each other. The emphasis of the book is on heteromeric complexes (complexes in which each of the components can exist in an unbound state) and will use well-studied model systems to explain the processes of formingcomplexes. After an introductory section on the kinetics, thermodynamics, analysis, and classification of protein-protein interactions, weak, intermediate, and high affinity complexes are dealt with in turn. Weak affinity complexes are represented by electron transfer proteins and integrincomplexes. Anti-lysozyme antibodies, the MHC proteins and their interactions with T-cell receptors, and the protein interactions of eukaryotic signal transduction are the systems used to explain complexes with intermediate affinities. Finally, tight binding complexes are represented by theinteraction of protein inhibitors with serine proteases and by nuclease inhibitor complexes. Throughout the chapters common themes are the technologies which have had the greatest impact, how specificity is determined, how complexes are stabilized, and medical and industrial applications.
Author : Monika Fuxreiter
Publisher : Springer Science & Business Media
ISBN 13 : 1461406595
Total Pages : 210 pages
Book Rating : 4.4/5 (614 download)
Download or read book Fuzziness written by Monika Fuxreiter and published by Springer Science & Business Media. This book was released on 2012-03-07 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.
Author : Gerhard Schlosser
Publisher : University of Chicago Press
ISBN 13 : 0226738558
Total Pages : 610 pages
Book Rating : 4.2/5 (267 download)
Download or read book Modularity in Development and Evolution written by Gerhard Schlosser and published by University of Chicago Press. This book was released on 2004-07 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modularity in Development and Evolution offers the first sustained exploration of modules from developmental and evolutionary perspectives. Contributors discuss what modularity is, how it can be identified and modeled, how it originated and evolved, and its biological significance. Covering modules at levels ranging from genes to colonies, the book focuses on their roles not just in structures but also in processes such as gene regulation. Among many exciting findings, the contributors demonstrate how modules can highlight key constraints on evolutionary processes. A timely synthesis of a crucial topic, Modularity in Development and Evolution shows the invaluable insights modules can give into both developmental complexities and their evolutionary origins.
Author : Torsten Schwede
Publisher : World Scientific
ISBN 13 : 9812778780
Total Pages : 790 pages
Book Rating : 4.8/5 (127 download)
Download or read book Computational Structural Biology written by Torsten Schwede and published by World Scientific. This book was released on 2008 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive introduction to Landau-Lifshitz equations and Landau-Lifshitz-Maxwell equations, beginning with the work by Yulin Zhou and Boling Guo in the early 1980s and including most of the work done by this Chinese group led by Zhou and Guo since. The book focuses on aspects such as the existence of weak solutions in multi dimensions, existence and uniqueness of smooth solutions in one dimension, relations with harmonic map heat flows, partial regularity and long time behaviors. The book is a valuable reference book for those who are interested in partial differential equations, geometric analysis and mathematical physics. It may also be used as an advanced textbook by graduate students in these fields.
Author : Volkhard Helms
Publisher : John Wiley & Sons
ISBN 13 : 3527348646
Total Pages : 436 pages
Book Rating : 4.5/5 (273 download)
Download or read book Protein Interactions written by Volkhard Helms and published by John Wiley & Sons. This book was released on 2023-02-06 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental guide to the burgeoning field of protein interactions From enzymes to transcription factors to cell membrane receptors, proteins are at the heart of biological cell function. Virtually all cellular processes are governed by their interactions, with one another, with cell bodies, with DNA, or with small molecules. The systematic study of these interactions is called Interactomics, and research within this new field promises to shape the future of molecular cell biology. Protein Interactions goes beyond any existing guide to protein interactions, presenting the first truly comprehensive overview of the field. Edited by two leading scholars in the field of protein bioinformatics, this book covers all known categories of protein interaction, stable as well as transient, as well as the effect of mutations and post-translational modifications on the interaction behavior. Protein Interactions readers will also find: Introductory chapters on protein structure, conformational dynamics, and protein-protein binding interfaces A data-driven approach incorporating machine learning and integrating experimental data into computational models An outlook on the current challenges in the field and suggestions for future research Protein Interactions will serve as a fundamental resource for novice researchers who want a systematic introduction to interactomics, as well as for experienced cell biologists and bioinformaticians who want to gain an edge in this exciting new field.
Author : Julian J. Eaton-Rye
Publisher : Frontiers Media SA
ISBN 13 : 2889452336
Total Pages : 317 pages
Book Rating : 4.8/5 (894 download)
Download or read book Assembly of the Photosystem II Membrane-Protein Complex of Oxygenic Photosynthesis written by Julian J. Eaton-Rye and published by Frontiers Media SA. This book was released on 2017-08-08 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
Author : Richard A. Kahn
Publisher : Springer Science & Business Media
ISBN 13 : 1402025939
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)
Download or read book ARF Family GTPases written by Richard A. Kahn and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time experts in the area of signalling research with a focus on the ARF family have contributed to the production of a title devoted to ARF biology. A comprehensive phylogenetic analysis of the ARF family, tables of the ARF GEFs and ARF GAPs, and more than a dozen chapters describing them in detail are provided. The impact of the ARF proteins on widely diverse aspects of cell biology and cell signalling can be clearly seen from the activities described; including membrane traffic, lipid metabolism, receptor desensitization, mouse development, microtubule dynamics, and bacterial pathogenesis. Anyone interested in understanding the complexities of cell signalling and the integration of signalling networks will benefit from this volume.
Author : Pierre Pontarotti
Publisher : Springer Science & Business Media
ISBN 13 : 3642207634
Total Pages : 350 pages
Book Rating : 4.6/5 (422 download)
Download or read book Evolutionary Biology – Concepts, Biodiversity, Macroevolution and Genome Evolution written by Pierre Pontarotti and published by Springer Science & Business Media. This book was released on 2011-07-20 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The annual Evolutionary Biology Meetings in Marseilles serve to gather leading scientists, promote the exchange of ideas and encourage the formation of international collaborations. This book contains the most essential contributions presented at the 14th Evolutionary Biology Meeting, which took place in September 2010. It comprises 19 chapters organized according to the following categories: · Evolutionary Biology Concepts · Biodiversity and Evolution · Macroevolution · Genome Evolution Offering an up-to-date overview of recent results in the field of evolutionary biology, this book is an invaluable source of information for scientists, teachers and advanced students.
Author : Ivet Bahar
Publisher : Garland Science
ISBN 13 : 1351815016
Total Pages : 337 pages
Book Rating : 4.3/5 (518 download)
Download or read book Protein Actions: Principles and Modeling written by Ivet Bahar and published by Garland Science. This book was released on 2017-02-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Actions: Principles and Modeling is aimed at graduates, advanced undergraduates, and any professional who seeks an introduction to the biological, chemical, and physical properties of proteins. Broadly accessible to biophysicists and biochemists, it will be particularly useful to student and professional structural biologists and molecular biophysicists, bioinformaticians and computational biologists, biological chemists (particularly drug designers) and molecular bioengineers. The book begins by introducing the basic principles of protein structure and function. Some readers will be familiar with aspects of this, but the authors build up a more quantitative approach than their competitors. Emphasizing concepts and theory rather than experimental techniques, the book shows how proteins can be analyzed using the disciplines of elementary statistical mechanics, energetics, and kinetics. These chapters illuminate how proteins attain biologically active states and the properties of those states. The book ends with a synopsis the roles of computational biology and bioinformatics in protein science.
Author : Michael R. Lynch
Publisher : Oxford University Press
ISBN 13 : 0192847287
Total Pages : 705 pages
Book Rating : 4.1/5 (928 download)
Download or read book Evolutionary Cell Biology written by Michael R. Lynch and published by Oxford University Press. This book was released on 2024-02-22 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Establishes the foundations of the emerging field of evolutionary cell biology, providing a deep and broad coverage of the literature, with many ideas synthesised and presented for the first time.
Author : J. Robin Harris
Publisher : Springer
ISBN 13 : 9811077576
Total Pages : 464 pages
Book Rating : 4.8/5 (11 download)
Download or read book Membrane Protein Complexes: Structure and Function written by J. Robin Harris and published by Springer. This book was released on 2018-02-20 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book contains a compilation of 14 advanced academic chapters dealing with the structure and function of membrane protein complexes. This rapidly advancing important field of study closely parallels those on soluble protein complexes, and viral protein and nucleoprotein complexes. Diverse topics are included in this book, ranging from membrane–bound enzymes to ion channels, proton pumps and photosystems. Data from X-ray crystallography, cryo-electron microscopy and other biophysical and biochemical techniques are presented throughout the book. There is extensive use of colour figures of protein structures. Throughout the book structure and function are closely correlated. The two editors, Egbert Boekema and J. Robin Harris, have worked on aspects of membrane and soluble proteins throughout their scientific careers and also have much publishing experience. The Subcellular Biochemistry series has expanded considerably in recent years, including several related volumes. The theme of protein complexes will be continued within several future volumes, thereby creating encyclopaedic coverage. The chapter topics within this book are particularly relevant to those involved in the biological and biomedical sciences. It is aimed at the advanced undergraduates, postgraduates and established researchers within this broad field. It is hoped that the book will be of interest and use to those involved with the study of cellular membranes and their associated proteins.
Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
