Chirality From Dynamic Kinetic Resolution

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Chirality from Dynamic Kinetic Resolution

Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
ISBN 13 : 1849731977
Total Pages : 319 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Chirality from Dynamic Kinetic Resolution by : Hélène Pellissier

Download or read book Chirality from Dynamic Kinetic Resolution written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2011 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.

Dynamic Stereochemistry of Chiral Compounds

Author : Christian Wolf
Publisher : Royal Society of Chemistry
ISBN 13 : 0854042466
Total Pages : 534 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Dynamic Stereochemistry of Chiral Compounds by : Christian Wolf

Download or read book Dynamic Stereochemistry of Chiral Compounds written by Christian Wolf and published by Royal Society of Chemistry. This book was released on 2008 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.

Chiral Drugs

Author : Guo-Qiang Lin
Publisher : John Wiley & Sons
ISBN 13 : 1118075633
Total Pages : 469 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Chiral Drugs by : Guo-Qiang Lin

Download or read book Chiral Drugs written by Guo-Qiang Lin and published by John Wiley & Sons. This book was released on 2011-08-08 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated view of chiral drugs from concept and synthesisto pharmaceutical properties Chirality greatly influences a drug's biological and pharmacological properties. In an effort to achieve more predictable results from chiral drugs, the Food and Drug Administration now requires that these medicines be as pure as possible, which places great demands on drug synthesis, purification, analysis, and testing. To assist researchers in acquiring the essential knowledge to meet these rigid guidelines, Chiral Drugs focuses on three vital chiral technologies asymmetric synthesis, biocatalytic process, and chiral resolution to offer details on the basic concepts, key developments, and recent trends in chiral drug discovery, along with: The history of chiral drugs development and industrial applications of chiral technologies A section listing twenty-five approved or advanced-trial chiral drugs that lists each drug name, chemical name and properties, a representative synthetic pathway, pharmacological characterizations, and references An interdisciplinary approach combining synthetic organic chemistry, medicinal chemistry, and pharmacology Nearly two-thirds of the drugs on today's market are chiral drugs. Reducing and eliminating their negative characteristics is an ongoing and serious challenge for the pharmaceutical industry. With its well-balanced approach to covering each important aspect of chirality, Chiral Drugs champions important strategies for tipping the medical scale in a positive direction for the production of more effective and safer drugs.

Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT)

Author : Jan-E. Bäckvall
Publisher : Georg Thieme Verlag
ISBN 13 : 3132453781
Total Pages : 544 pages
Book Rating : 4.1/5 (324 download)

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Book Synopsis Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) by : Jan-E. Bäckvall

Download or read book Dynamic Kinetic Resolution (DKR) and Dynamic Kinetic Asymmetric Transformations (DYKAT) written by Jan-E. Bäckvall and published by Georg Thieme Verlag. This book was released on 2022-12-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and applications of DKR and DYKAT DKR and DYKAT are of ever increasing importance in the synthesis of enantiomerically enriched compounds. The preparation of enantiomerically pure compounds is of great importance in society today, in particular in pharmaceutical chemistry and in the agrochemical sector. Kinetic resolution is a popular method for differentiating two enantiomers in a racemic mixture that react at different rates with a chiral catalyst or reagent. The drawback of kinetic resolution is that the yield of one pure enantiomer is limited to a maximum of 50%. To overcome this limitation, an in situ racemization of the starting material can be combined with a kinetic resolution. This combination leads to a so called “dynamic kinetic resolution” (DKR), where the two enantiomers are in equilibrium with one another. The slow-reacting enantiomer will continuously be converted into the fast-reacting one, when the latter is transformed into the enantiomerically pure product. Thus, a racemic starting material can be transformed in catalytic processes into a single isomer of a chiral compound in up to 100% yield. DKR only applies to the resolution of racemic mixtures and the involvement of enantiomers leads to simple kinetics. When diastereomers, either as starting materials or as diastereomeric intermediates, are involved in the resolution process under dynamic conditions (via equilibria between diastereomers), the kinetics is different from DKR. These reactions are classified as “dynamic kinetic asymmetric transformations” (DYKAT). This volume covers the principles of DKR and DYKAT and presents examples of organocatalytic, chemoenzymatic, and transition-metal catalyzed approaches, including applications in the synthesis of complex, biologically active compounds.

Organocatalytic Dynamic Kinetic Resolution

Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
ISBN 13 : 1839165650
Total Pages : 171 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Organocatalytic Dynamic Kinetic Resolution by : Hélène Pellissier

Practical Synthetic Organic Chemistry

Author : Stéphane Caron
Publisher : John Wiley & Sons
ISBN 13 : 1119448859
Total Pages : 850 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Practical Synthetic Organic Chemistry by : Stéphane Caron

Download or read book Practical Synthetic Organic Chemistry written by Stéphane Caron and published by John Wiley & Sons. This book was released on 2020-02-05 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale

Organocatalytic Dynamic Kinetic Resolution

Author : Hélène Pellissier
Publisher : Royal Society of Chemistry
ISBN 13 : 1839166363
Total Pages : 171 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Organocatalytic Dynamic Kinetic Resolution by : Hélène Pellissier

Download or read book Organocatalytic Dynamic Kinetic Resolution written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2022-05-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a classical kinetic resolution, two enantiomers of a racemate are transformed into chiral products at different rates with a maximum theoretical yield of 50%. However, the need to reduce costs and waste in synthesis have led to efforts to develop novel resolution procedures proceeding beyond this 50% limited yield. This has led to the evolution of classical kinetic resolution into dynamic kinetic resolution (DKR), allowing a quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It is only in the last two decades that chiral green organocatalysts have been demonstrated to be capable of promoting DKRs considerably expanding the synthetic scope of the powerful concept of DKR. Collecting all the developments in the field of DKR, this book shows that a wide variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations. It is a great resource for academics and industrialists interested in green enantioselective catalytic reactions.

Stereochemistry and Stereoselective Synthesis

Author : Mihály Nógrádi
Publisher : John Wiley & Sons
ISBN 13 : 352769630X
Total Pages : 280 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Stereochemistry and Stereoselective Synthesis by : Mihály Nógrádi

Download or read book Stereochemistry and Stereoselective Synthesis written by Mihály Nógrádi and published by John Wiley & Sons. This book was released on 2016-06-14 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a well-respected and experienced author, this textbook fills the gap for a concise introduction to the key concepts of organic stereochemistry and the most important classical and modern methods in stereoselective synthesis. The concepts are extensively illustrated in color, with practical examples and question-answer sets to help consolidate the reader's knowledge. In addition, animations are available from the Wiley website. A must-have for students in chemistry, biochemistry, and life sciences, as well as researchers in pharmaceutical and agrochemical companies in need of a quick introduction to the field.

Synthesis of Chiral Amines by Reductive Dynamic Kinetic Resolution

Author : Peichao Zhao
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Synthesis of Chiral Amines by Reductive Dynamic Kinetic Resolution by : Peichao Zhao

Download or read book Synthesis of Chiral Amines by Reductive Dynamic Kinetic Resolution written by Peichao Zhao and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Axially Chiral Compounds

Author : Bin Tan
Publisher : John Wiley & Sons
ISBN 13 : 3527347127
Total Pages : 338 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Axially Chiral Compounds by : Bin Tan

Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.

Enantiomer Separation

Author : Fumio Toda
Publisher : Springer Science & Business Media
ISBN 13 : 1402023375
Total Pages : 334 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Enantiomer Separation by : Fumio Toda

Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.

Fundamentals of Asymmetric Catalysis

Author : Patrick J. Walsh
Publisher : University Science Books
ISBN 13 : 9781891389542
Total Pages : 692 pages
Book Rating : 4.3/5 (895 download)

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Book Synopsis Fundamentals of Asymmetric Catalysis by : Patrick J. Walsh

Download or read book Fundamentals of Asymmetric Catalysis written by Patrick J. Walsh and published by University Science Books. This book was released on 2009-01-02 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.

Discrimination of Mobile Supramolecular Chirality

Author : Ayumi Imayoshi
Publisher : Springer Nature
ISBN 13 : 9811674310
Total Pages : 99 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Discrimination of Mobile Supramolecular Chirality by : Ayumi Imayoshi

Download or read book Discrimination of Mobile Supramolecular Chirality written by Ayumi Imayoshi and published by Springer Nature. This book was released on 2021-11-18 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes a novel concept for molecular recognition. In the field of asymmetric synthesis approaching the mature science, asymmetric discrimination and catalytic synthesis of chiral supramolecules still stand as unsolved problems. The extreme difficulty in asymmetric synthesis of such supramolecules may result from the mobile nature of supramolecular chirality. Here the author shows the first highly enantioselective synthesis of mechanically chiral supramolecules. In the presence of a chiral organocatalyst, a mechanically planar chiral rotaxane was obtained with p erfect enantiopurity (>99% ee) with an excellent selectivity. The dynamic and flexible recognition mode enabled asymmetric synthesis of supramolecules with conformational flexibility and mobility. The recognition mode of the catalyst is a contrast to the traditional static and rigid recognition mode of the typical conventional catalysts. The concept of dynamic molecular recognition will be adopted as a novel concept in a wide range of fields beyond the field of organic chemistry, including material chemistry, biochemistry, and medicinal chemistry.

Green Biocatalysis

Author : Ramesh N. Patel
Publisher : John Wiley & Sons
ISBN 13 : 1118822293
Total Pages : 792 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Green Biocatalysis by : Ramesh N. Patel

Download or read book Green Biocatalysis written by Ramesh N. Patel and published by John Wiley & Sons. This book was released on 2016-06-27 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green Biocatalysis presents an exciting green technology that uses mild and safe processes with high regioselectivity and enantioselectivity. Bioprocesses are carried out under ambient temperature and atmospheric pressure in aqueous conditions that do not require any protection and deprotection steps to shorten the synthetic process, offering waste prevention and using renewable resources. Drawing on the knowledge of over 70 internationally renowned experts in the field of biotechnology, Green Biocatalysis discusses a variety of case studies with emphases on process R&D and scale-up of enzymatic processes to catalyze different types of reactions. Random and directed evolution under process conditions to generate novel highly stable and active enzymes is described at length. This book features: A comprehensive review of green bioprocesses and application of enzymes in preparation of key compounds for pharmaceutical, fine chemical, agrochemical, cosmetic, flavor, and fragrance industries using diverse enzymatic reactions Discussion of the development of efficient and stable novel biocatalysts under process conditions by random and directed evolution and their applications for the development of environmentally friendly, efficient, economical, and sustainable green processes to get desired products in high yields and enantiopurity The most recent technological advances in enzymatic and microbial transformations and cuttingedge topics such as directed evolution by gene shuffling and enzyme engineering to improve biocatalysts With over 3000 references and 800 figures, tables, equations, and drawings, Green Biocatalysis is an excellent resource for biochemists, organic chemists, medicinal chemists, chemical engineers, microbiologists, pharmaceutical chemists, and undergraduate and graduate students in the aforementioned disciplines.

Axially Chiral Compounds

Author : Bin Tan
Publisher : John Wiley & Sons
ISBN 13 : 3527825185
Total Pages : 338 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Axially Chiral Compounds by : Bin Tan

Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-08-16 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.

Non-Metal Catalyzed Synthesis

Author : Yunfei Du
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110985470
Total Pages : 360 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Non-Metal Catalyzed Synthesis by : Yunfei Du

Download or read book Non-Metal Catalyzed Synthesis written by Yunfei Du and published by Walter de Gruyter GmbH & Co KG. This book was released on 2023-12-04 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-metal catalysis may provide new and green methods for obtaining bioactive heterocycles. Many catalysts contain metals, which can be toxic, energy intensive to remove, and require mining of the source materials. By utilizing metal-free catalysts we avoid these issues. This book explores the use of non-metal catalysts when synthesizing various heterocyclic structures with bioactivity.

Comprehensive Organic Chemistry Experiments for the Laboratory Classroom

Author : Carlos A. M. Afonso
Publisher : Royal Society of Chemistry
ISBN 13 : 1849739633
Total Pages : 976 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Comprehensive Organic Chemistry Experiments for the Laboratory Classroom by : Carlos A. M. Afonso

Download or read book Comprehensive Organic Chemistry Experiments for the Laboratory Classroom written by Carlos A. M. Afonso and published by Royal Society of Chemistry. This book was released on 2016-12-16 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: This expansive and practical textbook contains organic chemistry experiments for teaching in the laboratory at the undergraduate level covering a range of functional group transformations and key organic reactions.The editorial team have collected contributions from around the world and standardized them for publication. Each experiment will explore a modern chemistry scenario, such as: sustainable chemistry; application in the pharmaceutical industry; catalysis and material sciences, to name a few. All the experiments will be complemented with a set of questions to challenge the students and a section for the instructors, concerning the results obtained and advice on getting the best outcome from the experiment. A section covering practical aspects with tips and advice for the instructors, together with the results obtained in the laboratory by students, has been compiled for each experiment. Targeted at professors and lecturers in chemistry, this useful text will provide up to date experiments putting the science into context for the students.