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Chemokines In Viral Infections
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Author :Surendran Mahalingam Publisher :Springer Science & Business Media ISBN 13 :9780306482342 Total Pages :140 pages Book Rating :4.4/5 (823 download)
Book Synopsis Chemokines in Viral Infections by : Surendran Mahalingam
Download or read book Chemokines in Viral Infections written by Surendran Mahalingam and published by Springer Science & Business Media. This book was released on 2004-10-14 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past five years, a large number of new chemokines and chemokine receptors have been identified. Alarming progress in the areas of bioinformatics and expressed sequence tag (EST) databases attributed to this development. Recent discoveries provide compelling evidences supporting the roles of these messengers and their receptors in the control of viral infection as well as in aiding virus survival. Chemokines in Viral Infections is the first to provide a comprehensive write up on the various evidences available to date on the interactions between host chemokine system and viral chemokines. This book intends to unravel the chemokine constellation in the context of viral infections, a versatility that was not fully understood five years ago. This book is excellent reading material and will be of interest to research scientists, clinicians and postgraduate students.
Book Synopsis Chemokines and Viral Infection by : Thomas E. Lane
Download or read book Chemokines and Viral Infection written by Thomas E. Lane and published by Springer Science & Business Media. This book was released on 2007-05-30 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines represent a family of over 40 small proteins that, for the most part, are secreted into the environment and function by binding to G protein-coupled receptors (GPCRs) that are expressed on numerous different cell types. When initially identified close to 30 years ago, these molecules were associated with various human inflammatory diseases and it was recognized that expression may be integral in leukocyte recruitment to inflamed tissue. Within a relatively short period of time, early participants within the field determined that these proteins displayed distinct and conserved structural features and exerted potent chemotactic effects on defined lymphocyte subsets. There are now four sub-families of chemokines identified based on defined structural criteria relating to the positional location of conserved cysteine residues within the amino-terminus of the protein. Chemokines are now recognized as important in numerous biological processes ranging from maintaining the organizational integrity of secondary lymphoid tissue to participating in various aspects of both innate and adaptive immune responses following microbial infection.
Book Synopsis Cytokines and Chemokines in Infectious Diseases Handbook by : Malak Kotb
Download or read book Cytokines and Chemokines in Infectious Diseases Handbook written by Malak Kotb and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of what is known about the role of cytokines and chemokines in a variety of human infectious diseases, including gram-negative and -positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide variety of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections.
Book Synopsis Chemokines and Chemokine Receptors During Viral Infections in Man by : Frida Mowafi
Download or read book Chemokines and Chemokine Receptors During Viral Infections in Man written by Frida Mowafi and published by . This book was released on 2007 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemokines and Viral Infection by : Surendran Mahalingham
Download or read book Chemokines and Viral Infection written by Surendran Mahalingham and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Orthopoxviruses by : Frank Fenner
Download or read book The Orthopoxviruses written by Frank Fenner and published by . This book was released on 1989 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Insights Into the Role of Chemokines and Chemokine Receptors During HIV-1 Pathogenesis by : Zahra Folaśade Lompeti Parker
Download or read book Insights Into the Role of Chemokines and Chemokine Receptors During HIV-1 Pathogenesis written by Zahra Folaśade Lompeti Parker and published by . This book was released on 2015 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sexual transmission of HIV-1 is often established by one genetic variant, the transmitted/founder (T/F) virus. T/F HIV-1 may have specific phenotypic properties that are selected for during transmission. To date, the most consistent phenotypic property associated with T/F viruses is use of the chemokine receptor CCR5 as a coreceptor for entry. Small molecule CCR5 antagonists, such as Maraviroc (MVC), inhibit HIV-1 entry by functioning as allosteric inhibitors. These molecules bind within the transmembrane helices of CCR5, inducing a conformational change that prevents the HIV-CCR5 interaction. As with most drugs, HIV-1 has developed strategies to overcome this inhibition. Some viruses develop mutations in the envelope (Env) glycoprotein that enable the use of antagonist-bound CCR5. In Chapter Two, we evaluate 87 CCR5-using viruses to address differences between T/F viruses and viruses isolated from chronically infected individuals (chronic controls-CC) in their ability to mediate entry via varying amounts of CCR5 in the presence of MVC. We demonstrate that CC viruses exhibit partial resistance (PR) to MVC more frequently than T/F viruses, suggesting that T/F and CC HIV-1 differentially utilize CCR5 in a manner that may be biologically important in the context of transmission. Following the discovery of the chemokine receptors CXCR4 and CCR5 as cofactors for HIV-1 entry, it was revealed that their cognate chemokine ligands could inhibit HIV-1 infection in vitro. Multiple cell types have been implicated in secreting chemokines that function to modulate HIV-1 infection. Recently the platelet-derived chemokine PF4 was shown to inhibit HIV-1. However, despite plasma and local concentrations of PF4 being within the range used in these studies, HIV-1 is still able to propagate in vivo. In Chapter Four, we sought to understand the mechanism of action of PF4 and determine it's in vivo relevance. I confirmed and extended previous studies showing that PF4 inhibits infection by HIV-1 and other viruses. However, the inhibitory capacity of PF4 is limited to a defined concentration range, after which inhibition wanes and viral infection is ultimately enhanced at higher chemokine concentrations that are commonly found in vivo. Thus, rather than being a potential anti-viral agent as previously suggested, PF4 may contribute to the hematologic abnormalities commonly seen in HIV-infected individuals by enhancing virus infection in the bone marrow.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemokine Receptors as Drug Targets by : Martine J. Smit
Download or read book Chemokine Receptors as Drug Targets written by Martine J. Smit and published by John Wiley & Sons. This book was released on 2010-12-07 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are hormone-like signaling molecules secreted by cells to signal infection and guide the immune response. Following a decade of basic chemokine research, the pharmaceutical industry has now begun to exploit this crucial signaling pathway for the development of innovative drugs against AIDS, cancer, neural and autoimmune diseases. Here is the first reference focusing on these novel drug development opportunities. Opening with a general introduction on chemokine function and chemokine receptor biology, the second part covers the known implications of these signaling molecules in human diseases, such as cancer, neural disorders, and viral infection, including AIDS. The third part systematically surveys current drug development efforts at targeting individual chemokine receptors, as well as other chemokine interaction partners, including up-to-date reports from the pharmaceutical industry.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author :Amanda E.I. Proudfoot Publisher :Springer Science & Business Media ISBN 13 :1592590586 Total Pages :349 pages Book Rating :4.5/5 (925 download)
Book Synopsis Chemokine Protocols by : Amanda E.I. Proudfoot
Download or read book Chemokine Protocols written by Amanda E.I. Proudfoot and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemokines family of small proteins are involved in numerous b- logical processes ranging from hematopoiesis, angiogenesis, and basal l- kocyte trafficking to the extravasation and tissue infiltration of leukocytes in response to inflammatory agents, tissue damage, and bacterial or viral infection. Chemokines exert their effects through a family of seven G-protein coupled transmembrane receptors. Worldwide interest in the chemokine field surged dramatically early in 1996, with the finding that certain chemokine receptors were the elusive coreceptors, required along with CD4, for HIV infection. Today, though over 40 human chemokines have been described, the n- ber of chemokine receptors lags behind—only 17 human chemokine receptors have been identified so far. What has emerged over the years is that most chemokine receptors bind several distinct ligands, and indeed the majority of chemokines are able to bind to multiple chemokine receptors, explaining to some extent the apparent disparity in the numbers of chemokines and rec- tors. Yet in spite of the apparent redundancy in chemokine/chemokine rec- tor interactions, it is clear that in vivo, spatial, temporal, and indeed cell- and tissue-specific expression of both chemokines and their receptors are imp- tant factors in determining the precise nature of cellular infiltrates in phy- ological and pathological processes.
Author :Alberto Mantovani Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805568614 Total Pages :219 pages Book Rating :4.8/5 (55 download)
Download or read book Chemokines written by Alberto Mantovani and published by Karger Medical and Scientific Publishers. This book was released on 1999-01-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines are a superfamily of small proteins which play a crucial role in immune and inflammatory reactions and in viral infection. They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system. This book provides an overview of the main structural and functional features of chemokines. It presents recent studies which indicate that chemokines regulate the trafficking of dendritic cells and hence the activation of specific immunity and the subsequent orientation of immunity. This volume will be a useful reference for immunologists, virologists, oncologists, pharmacologists and neurobiologists.
Book Synopsis Chemokine Biology - Basic Research and Clinical Application by : Kuldeep Neote
Download or read book Chemokine Biology - Basic Research and Clinical Application written by Kuldeep Neote and published by Springer Science & Business Media. This book was released on 2007-08-08 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemokines play an important role in recruiting inflammatory cells into tissues in response to infection and inflammation. They also play an important role in coordinating the movement of T-cells, B-cells and dentritic cells, necessary to generate an immune response (response to injury, allergens, antigens, invading microorganisms). They selectively attract leukocytes to inflammatory foci, inducing both cell migration and activation. They are involved in various diseases, like atherosclerosis, lung and skin inflammation, multiple sclerosis, or HIV. Volume 2 of this two-volume set discusses the pathophysiology of chemokines. It is divided into two parts: a) chemokines in animal disease models, and b) chemokines as drug targets. Together with volume 1, which discusses the immunobiology of chemokines, both volumes give a comprehensive overview of chemokine biology.
Book Synopsis Persistent Viral Infections by : R. Ahmed
Download or read book Persistent Viral Infections written by R. Ahmed and published by Wiley-Blackwell. This book was released on 1999 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Persistent Viral Infections Edited by Rafi Ahmed Emory Vaccine Center, Atlanta, USA and Irvin S. Y. Chen UCLA School of Medicine, Los Angeles, USA During the past decade much of our attention has focused on diseases associated with viral persistence. Major breakthroughs in immunology, and the advent of molecular approaches to study pathogenesis have increased our understanding of the complex virus-host interactions that occur during viral persistence. Persistent Viral Infections focuses on: * The pathogenesis and immunology of chronic infections * Animal models that provide, or have the potential to provide, major insights This volume will be essential reading for virologists, immunologists, oncologists and neurologists.
Book Synopsis The Chemokine Receptors by : Jeffrey K. Harrison
Download or read book The Chemokine Receptors written by Jeffrey K. Harrison and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, new to The Receptors series, focuses on several areas, including the birth, maturation, and structure of Chemokines; Neutrophil, Dendritic, and Lymphocyte trafficking; and Chemokine Receptors in diseases such as AIDs and lung cancer. In particular the book contains cutting-edge information ranging from basic molecular and cellular mechanisms to physiological and pathological roles of chemokines.
Book Synopsis Chemokines in Disease by : Caroline A. Hébert
Download or read book Chemokines in Disease written by Caroline A. Hébert and published by Springer Science & Business Media. This book was released on 1999-06-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caroline Hébert and a panel of key experimentalists and clinical investigators comprehensively review the state-of-the-art in the chemokine field, ranging from the effects of chemokines and their receptors in retroviral infections, to their role in inflammation, angiogenesis/angiostasis, and tumor cell biology. The book examines in detail fifteen recently identified chemokines and elucidates the role of chemokine function in vivo from animal experiments. Animal models are also used to explore how chemokines operate in a variety of chronic and acute inflammatory diseases and in noninflammatory processes. A detailed review of the emerging role of chemokines in viral biology is also presented, with emphasis on HIV biology and novel therapeutic possibilities. Chemokines in Disease: Biology and Clinical Research summarizes the rapidly expanding knowledge of a dazzling array of chemokines and provides fresh insights into the development of powerful new drugs for treating a wide spectrum of diseases.
Book Synopsis Chemokines, Chemokine Receptors and Disease by : Lisa M. Schwiebert
Download or read book Chemokines, Chemokine Receptors and Disease written by Lisa M. Schwiebert and published by Gulf Professional Publishing. This book was released on 2005-09-02 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the Current Topics in Membranes series discusses the biology of chemokines and their binding partners, chemokine receptors, in normal and disease-related states. Chemokines are small proteins that are important in normal immune responses. Recent research demonstrates a role for these proteins in a variety of diseases such as heart disease, allergy, asthma, and cancer. As a result of the discovery of this link to disease, the topic of chemokines and drugs that block their actions has become an intense are of study. This book presents the topics of chemokines, chemokine receptors, and related pathologies in an integrated manner that provides the reader with a comprehensive and up-to-date knowledge of these topics. Provides a comprehensive overview of the history, molecular biology, cell biology, pharmacology, physiology, and pathophysiology of chemokines and their receptors Each chapter discusses "future directions and unanswered questions" of chemokine biology Serves as a road map for future research
