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Characterization Of The Glutathione Transferase Alpha Genes
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Book Synopsis Characterization of the Glutathione Transferase Alpha Genes by : Nasser Fotouhi Ardakani
Download or read book Characterization of the Glutathione Transferase Alpha Genes written by Nasser Fotouhi Ardakani and published by . This book was released on 2000 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The glutathione-S-transferases (GSTs) are a multigene family of enzymes that catalyze the conjugation of glutathione (GSH) with toxic endogenous and xenobiotic compounds including anticancer drugs, as part of detoxification pathways. Our laboratory previously isolated a melphalan resistant rat mammary carcinoma cell-line (MLNr MatB). The in vitro and in vivo studies demonstrated increased GST activity, especially elevated GST alpha class in MLNr cells. At the outset of my work, I examined the nature of the increased GST form in MLNr cells. I cloned the GSTA3 cDNA which is overexpressed in MLNr cells and found that it is identical to the previously described GSTA3 mRNA, suggesting that there is no additional GST alpha gene induced by melphalan. To study the role of the rat GSTA3 gene in chemotherapy resistance, and understand the mechanism of its overexpression in drug resistant tumors, I isolated the entire rGSTA3 subunit gene, including its regulatory regions, from a genomic library and characterized it. The rGSTA3 gene is approximately 15 kb in length and consists of seven exons interrupted by introns of different lengths. The functional activity of its promoter was shown by its ability to drive the expression of a CAT reporter gene in MatB cells, and its activity was greater in melphalan resistant cells. I also presented evidence that rGSTA3 subunit evolved as a duplication of the rGSTA5 subunit gene, increasing the diversification and functional benefits. In addition to drug resistance, I have been examining the implications of GST to carcinogenesis. Epidemiological studies have shown an association between Hepatitis B Virus (HBV) infection and exposure to chemical carcinogens in the incidence of hepatocellular carcinoma (HCC). The exact mechanism of these interactions is not known, but reduced GST activity could increase cellular sensitivity to chemical carcinogens. Semiquantitative RT-PCR revealed that HBV infected cells contain a significant decrease in th" --
Book Synopsis A Molecular Analysis of the Human Alpha Class Glutathione S-transferase Gene Family by : Peter Norford Johnston
Download or read book A Molecular Analysis of the Human Alpha Class Glutathione S-transferase Gene Family written by Peter Norford Johnston and published by . This book was released on 1990 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes with Yet-to-Be Discovered Functions by : Jolán Csiszár
Download or read book Plant Glutathione Transferases: Diverse, Multi-Tasking Enzymes with Yet-to-Be Discovered Functions written by Jolán Csiszár and published by Frontiers Media SA. This book was released on 2019-12-05 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Human Glutathione Transferase Gene GSTM1 Deletion by : Shijie Xu
Download or read book Characterization of the Human Glutathione Transferase Gene GSTM1 Deletion written by Shijie Xu and published by . This book was released on 1996 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Automated DNA Sequencing and Analysis by : Mark D. Adams
Download or read book Automated DNA Sequencing and Analysis written by Mark D. Adams and published by Elsevier. This book was released on 2012-12-02 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely book for DNA researchers, Automated DNA Sequencing and Analysis reviews and assesses the state of the art of automated DNA sequence analysis-from the construction of clone libraries to the developmentof laboratory and community databases. It presents the methodologies and strategies of automated DNA sequence analysis in a way that allows them to be compared and contrasted. By taking a broad view of the process of automated sequence analysis, the present volume bridges the gap between the protocols supplied with instrument and reaction kits and the finalized data presented in the research literature. It will be an invaluable aid to both small laboratories that are interested in taking maximum advantageof automated sequence resources and to groups pursuing large-scale cDNA and genomic sequencing projects. The field of automation in DAN sequencing and analysis is rapidly moving, this book fulfils those needs, reviews the history of the art and provides pointers to future development.
Book Synopsis Characterization of a Zeta Glutathione S-transferase Gene in Wheat by : Zhaohui Ye
Download or read book Characterization of a Zeta Glutathione S-transferase Gene in Wheat written by Zhaohui Ye and published by . This book was released on 1999 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Oxidative Stress and Redox Regulation by : Ursula Jakob
Download or read book Oxidative Stress and Redox Regulation written by Ursula Jakob and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many physiological conditions such as host defense or aging and pathological conditions such as neurodegenerative diseases, and diabetes are associated with the accumulation of high levels of reactive oxygen species and reactive nitrogen species. This generates a condition called oxidative stress. Low levels of reactive oxygen species, however, which are continuously produced during aerobic metabolism, function as important signaling molecules, setting the metabolic pace of cells and regulating processes ranging from gene expression to apoptosis. For this book we would like to recruit the experts in the field of redox chemistry, bioinformatics and proteomics, redox signaling and oxidative stress biology to discuss how organisms achieve the appropriate redox balance, the mechanisms that lead to oxidative stress conditions and the physiological consequences that contribute to aging and disease.
Book Synopsis The Isolation and Characterization of a Gene Coding for Glutathione S-transferase in Musca Domestica by : Robert Fulton
Download or read book The Isolation and Characterization of a Gene Coding for Glutathione S-transferase in Musca Domestica written by Robert Fulton and published by . This book was released on 1996 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis The Science of Flavonoids by : Erich Grotewold
Download or read book The Science of Flavonoids written by Erich Grotewold and published by Springer Science & Business Media. This book was released on 2008 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only book of its kind to provide an overview of the science of flavonoids in plants.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Assessing Genetic Risks by : Institute of Medicine
Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.
Book Synopsis Comprehensive Enzyme Kinetics by : Vladimir Leskovac
Download or read book Comprehensive Enzyme Kinetics written by Vladimir Leskovac and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Welcome to your study of enzyme kinetics, the subject that underlies all enzymology, which in turn underlies all aspects of biochemistry. This text will give you an introduction to a wide range of topics that constitute the modern enzyme kinetics. This textbook is directed at graduate students in biochemistry, chemistry, and life sciences, for advanced courses in enzyme kinetics, enzymology, and enzyme chemistry. For this reason, the whole book is organized in a systematic and scholarly fashion. It is unlikely that the student will be expected to cover everything in the text, but in a later career she or he may find it an invaluable reference for topics that are needed in practice. The concepts, definitions and detailed algebra of enzyme kinetics are laid out in accurate detail. For that reason, this textbook can also serve as a handbook for enzyme kinetics for research workers in the field. The research worker will find it a useful source, which can be used for solving the daily experimental problems in the laboratory. The preparation of the manuscript for this book was under the constant surveillance of W. Wallace Cleland, Professor of Chemical Science at the University of Wisconsin in Madison, and one of the founders of modern enzyme kinetics. Without his help and advice, this bookwould not be possible. Several versions of the manuscript were constantly corrected and improved by Svetlana Professor of Biochemistry at the University of Novi Sad.
Book Synopsis Protein-Protein Interactions by : Weibo Cai
Download or read book Protein-Protein Interactions written by Weibo Cai and published by BoD – Books on Demand. This book was released on 2012-03-30 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Book Synopsis Herbicides and Their Mechanisms of Action by : Andrew H Cobb
Download or read book Herbicides and Their Mechanisms of Action written by Andrew H Cobb and published by Blackwell. This book was released on 2000-12-18 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbicides and their Mechanisms of Action highlights issues in herbicide selectivity. Developed with the input of authors from both academia and industry, this volume delivers a comprehensive and up-to-date treatment of the operation of the selectivity mechanisms of herbicides. Even more, the book discusses real-world effects of herbicides, and the results herbicides bring to bear on the environment. The authors emphasize applied aspects of the subject and concentrate on the developments of the last decade, making the book both practical and timely. With the wide variety of herbicides now available for the selective control of weed growth, it is imperative that scientists acquire a detailed understanding of the scientific bases of these herbicides. Indeed, the most recently developed herbicides work by inhibiting the enzyme systems of specific herbs, thereby retarding the growth of those herbs. For maximum effectiveness it becomes crucial that the active ingredients of these herbicides be efficiently delivered on the desired targets. Providing a state-of-the-art appraisal of this important subject, Herbicides and their Mechanisms of Action is the ideal resource for virtually all researchers and professionals involved in the development, administration, and regulation of herbicides.
Book Synopsis Toxicology of Glutathione Transferases by : Yogesh C. Awasthi
Download or read book Toxicology of Glutathione Transferases written by Yogesh C. Awasthi and published by CRC Press. This book was released on 2006-07-27 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of Glutathione S-Transferase (GST) or Glutathione transferase, studies have probed important questions about its pharmacological and physiological significance. Toxicology of Glutathione Transferases is the only text that details the methods used in GST research. With chapters written by experts who have been involved in
Book Synopsis Glutathione S-Transferases by : Gerard J. Mulder
Download or read book Glutathione S-Transferases written by Gerard J. Mulder and published by CRC Press. This book was released on 1996-05-23 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glutathione s-transferases (GSTs) constitute the most important enzymes protecting human and many other organisms from potentially toxic chemicals, including drugs and carcinogens. This book reviews scientific developments in research of this enzyme.
