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Characterization And Coloning Of An Estrogen Receptor Coactivator
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Book Synopsis Molecular Cloning and Characterization of an Orphan Nuclear Receptor, Estrogen Receptor-related Receptor (ERR) and Its Isoforms, in Noble Rat Prostate by : Ki Lui
Download or read book Molecular Cloning and Characterization of an Orphan Nuclear Receptor, Estrogen Receptor-related Receptor (ERR) and Its Isoforms, in Noble Rat Prostate written by Ki Lui and published by . This book was released on 2003 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization and Coloning of an Estrogen Receptor Coactivator by : Shlomit Halachmi
Download or read book Characterization and Coloning of an Estrogen Receptor Coactivator written by Shlomit Halachmi and published by . This book was released on 1996 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Cloning and General Characterization of Human Estrogen Receptor-apha 36 (ERa36) Gene Promoter by : Yi Zou
Download or read book Molecular Cloning and General Characterization of Human Estrogen Receptor-apha 36 (ERa36) Gene Promoter written by Yi Zou and published by . This book was released on 2006 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis discusses the identificaiton, molecular cloning and initial characterization of the ERa36 promoter.
Book Synopsis Computational Characterization and Prediction of Estrogen Receptor Coactivator Binding Site Inhibitors by : Brian J. Bennion
Download or read book Computational Characterization and Prediction of Estrogen Receptor Coactivator Binding Site Inhibitors written by Brian J. Bennion and published by . This book was released on 2005 with total page 52 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many carcinogens have been shown to cause tissue specific tumors in animal models. The mechanism for this specificity has not been fully elucidated and is usually attributed to differences in organ metabolism. For heterocyclic amines, potent carcinogens that are formed in well-done meat, the ability to either bind to the estrogen receptor and activate or inhibit an estrogenic response will have a major impact on carcinogenicity. Here we describe our work with the human estrogen receptor alpha (hERa) and the mutagenic/carcinogenic heterocyclic amines PhIP, MeIQx, IFP, and the hydroxylated metabolite of PhIP, N2-hydroxy-PhIP. We found that PhIP, in contrast to the other heterocyclic amines, increased cell-proliferation in MCF-7 human breast cancer cells and activated the hERa receptor. We show mechanistic data supporting this activation both computationally by homology modeling and docking, and by NMR confirmation that PhIP binds with the ligand binding domain (LBD). This binding competes with estradiol (E2) in the native E2 binding cavity of the receptor. We also find that other heterocyclic amines and N2-hydroxy-PhIP inhibit ER activation presumably by binding into another cavity on the LBD. Moreover, molecular dynamics simulations of inhibitory heterocyclic amines reveal a disruption of the surface of the receptor protein involved with protein-protein signaling. We therefore propose that the mechanism for the tissue specific carcinogenicity seen in the rat breast tumors and the presumptive human breast cancer associated with the consumption of well-done meat maybe mediated by this receptor activation.
Book Synopsis Molecular Cloning and Characterization of Hagfish Estrogen Receptors by :
Download or read book Molecular Cloning and Characterization of Hagfish Estrogen Receptors written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Interaction Cloning and Structure-function Analysis of the Hormone-binding Domain of the Human Estrogen Receptor by : Sara C. Folta
Download or read book Interaction Cloning and Structure-function Analysis of the Hormone-binding Domain of the Human Estrogen Receptor written by Sara C. Folta and published by . This book was released on 1995 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of the Nuclear Receptor Co-repressor, N-CoR by : Robert Matthew Lavinsky
Download or read book Characterization of the Nuclear Receptor Co-repressor, N-CoR written by Robert Matthew Lavinsky and published by . This book was released on 2000 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogens and Antiestrogens by : Robert Lindsay
Download or read book Estrogens and Antiestrogens written by Robert Lindsay and published by Lippincott Williams & Wilkins. This book was released on 1997 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Selective Estrogen Receptor Modulators by : Andrea Manni
Download or read book Selective Estrogen Receptor Modulators written by Andrea Manni and published by Springer Science & Business Media. This book was released on 2002-01-18 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of co-activators and co-repressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentation reviews the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A tentative approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Book Synopsis Cloning and Characterization of a Specific Associated Protein, ARA70, for Androgen Receptor and the Promoter Study of Androgen Receptor by : Shuyuan Yeh
Download or read book Cloning and Characterization of a Specific Associated Protein, ARA70, for Androgen Receptor and the Promoter Study of Androgen Receptor written by Shuyuan Yeh and published by . This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Estrogen Receptor and Breast Cancer by : Xiaoting Zhang
Download or read book Estrogen Receptor and Breast Cancer written by Xiaoting Zhang and published by Humana Press. This book was released on 2019-11-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of ER by Dr. Elwood Jensen exactly 60 years ago has not only led to the birth of a whole new vital nuclear receptor research field but also made a rapid, direct and lasting impact on the treatment and prevention of breast cancer. Since that landmark discovery, tremendous progress has been made in our understanding of the molecular functions of ER and development of targeted therapies against ER pathways for breast cancer treatment. However, there is currently no book available addressing these discoveries and recent advancement in a historical and systematic fashion. This book is intended to provide comprehensive, most up-to-date information on the history and recent advancement of ER and breast cancer by world renowned leaders in the field. These chapters include the history of the discovery of ER; physiological and pathological roles of ER; recent discovery of ER cistrome, transcriptome and its regulation of noncoding RNAs such as microRNAs and enhancer RNAs in breast cancer; development and clinical practices of the first targeted therapy Tamoxifen and other antiestrogens for breast cancer treatment; structural basis of ER and antiestrogen actions; molecular insights into endocrine resistance; the role of ER mutants, ER-beta and environmental estrogens in breast cancer; and emerging state-of-the-art therapeutic approaches currently in development to overcome treatment resistance and future perspectives. The book will provide undergraduate and graduate students, basic scientists and clinical cancer researchers, residents, fellows, as well as clinicians, oncology educators and the general public a thorough and authoritative review of these exciting topics.
Book Synopsis Estrogens and Antiestrogens I by : Michael Oettel
Download or read book Estrogens and Antiestrogens I written by Michael Oettel and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and antiestrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of publications from which new principles of preventive and therapeutic appli cations of estrogens and antiestrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.
Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2668 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulatory Mechanisms in Transcriptional Signaling by :
Download or read book Regulatory Mechanisms in Transcriptional Signaling written by and published by Academic Press. This book was released on 2009-07-25 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulatory Mechanisms in Transcriptional Signaling, volume of Progress in Molecular Biology and Translational Science, includes in-depth discussion on roles of Chromatin remodeling proteins in nuclear receptor signaling, and the ANCCA regulator in cancer. This important resource, edited by Dr. Debabrata (Debu) Chakravarti, offers research on the progesterone receptor action in leiomyoma and endometrial cancer and emerging roles of the ubiquitin protein system in nuclear hormone receptor signaling to provide the reader with expert discussions of up-to-date research.
Book Synopsis Yen & Jaffe's Reproductive Endocrinology E-Book by : Jerome F. Strauss
Download or read book Yen & Jaffe's Reproductive Endocrinology E-Book written by Jerome F. Strauss and published by Elsevier Health Sciences. This book was released on 2017-12-23 with total page 1379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now celebrating its 40th anniversary, Yen & Jaffe's Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and Antonio R. Gargiulo, keeps you up to date with the latest information on the diagnosis and management of the full range of female and male reproductive disorders. This cornerstone text thoroughly covers both basic science and clinical practice, making it a one-stop reference for all reproductive issues, including impaired fertility, infertility, recurrent pregnancy loss, problems of sexual development, menstrual disturbances, fibroids, endometriosis, female and male reproductive aging, fertility preservation, assisted reproduction technologies including ovarian stimulation and ovulation induction, transgender hormonal treatment, and contraception. Every chapter has been completely revised and updated to reflect important changes in this fast-moving field. - Covers key topics such as the role of genetics in reproductive endocrinology, environmental factors in reproductive endocrinology, and recent advances in surgical procedures. - Features full-color, high-quality illustrations that clearly depict basic anatomic structures, endocrine processes, and cell function and dysfunction. - Provides the knowledge and expertise of global experts who draw on the latest developments in the field to keep you abreast of current science and practice in endocrinology. Coverage includes molecular, cellular, and genetic concepts and their relevance to pathophysiology, diagnosis, and therapy. - Features new bulleted lists under major headings in each chapter for quick, at-a-glance summaries of every section. - Includes a new online video library that highlights surgical procedures, diagnostic imaging, and functional ultrasound imaging. Videos cover Disorders of Sex Development, Endometriosis, Benign Uterine Disorders, Gamete and Embryo Manipulation, and Fertility Preservation. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.
Book Synopsis Nuclear Hormone Receptors by : Malcolm G. Parker
Download or read book Nuclear Hormone Receptors written by Malcolm G. Parker and published by . This book was released on 1991 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.
Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal
Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.
