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Central D1 Dopamine Receptors
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Book Synopsis Central D1 Dopamine Receptors by : M. J. Goldstein
Download or read book Central D1 Dopamine Receptors written by M. J. Goldstein and published by Springer. This book was released on 2013-11-21 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of a selective D1 dopamine (DA) receptor antagonist SCH 23390 stimulated a number of studies on the functions mediated by central DA receptor subtypes. It was generally assumed that the central D1 DA receptor isa molecular entity whose function awaits further discovery. The papers presented in this volume clearly show that this is no longer the case and that D1 DA receptors have many behavioral fuctions which might be altered in pathological states. A number of papers have recognized the interdependence of the regulatory functions of the D1 DA receptors with D2 and other receptor proteins, and vice versa. The biochemical, pharmacological and morphological characterization of the D1 and D2 DA receptor binding proteins, as well as of DARPP-32, illustrates the complex interactions between various macromolecules. Procedures described for the purification of the D1 and D2 DA receptor subtypes are fundamental for future studies on the mechanisms involved in the coupling of the receptor proteins with signal transducing systems. Several studies in this volume show that D1 DA receptors have behavioral functions and that they are often similar to the responses mediated by D2 DA receptors, but in some instances reflect divergent neuronal activity of both systems. The knowledge of the physiology and biochemistry of the central DA receptor subtypes could lead to the development of a new generation of drugs which ameliorate some mental and neurological dysfunctions without producing severe undesirable side effects.
Book Synopsis Neurobiology of Central D1-Dopamine Receptors by : George Breese
Download or read book Neurobiology of Central D1-Dopamine Receptors written by George Breese and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.
Book Synopsis Neurobiology of Central D1-Dopamine Receptors by : George Breese
Download or read book Neurobiology of Central D1-Dopamine Receptors written by George Breese and published by . This book was released on 1986-09-01 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Central and Peripheral D1 Dopamine Receptors by : C. M. Hollis
Download or read book Central and Peripheral D1 Dopamine Receptors written by C. M. Hollis and published by . This book was released on 1991 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Characterization of D1 Dopamine Receptors in the Central Nervous System by : Ellen Joy Hess
Download or read book Characterization of D1 Dopamine Receptors in the Central Nervous System written by Ellen Joy Hess and published by . This book was released on 1987 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Central and Peripheral Dopamine Receptors by : P.F. Spano
Download or read book Central and Peripheral Dopamine Receptors written by P.F. Spano and published by Springer. This book was released on 1988-11-14 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Insights Into the Role of the Dopamine D1 Receptor in Brain Function by : Mufida El-Ghundi
Download or read book Insights Into the Role of the Dopamine D1 Receptor in Brain Function written by Mufida El-Ghundi and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Dopamine receptors are widely expressed throughout the central and peripheral nervous systems and regulate many key functions of the brain. Five dopamine receptors have so far been cloned and classified into two main classes known as D1-like (D1 and D5) and D2-like (D2, D3 and D4) based on similarity in structure, pharmacology and coupling. Primarily because of the lack of receptor subtype-selective ligands, the precise physiological roles of these individual dopamine receptor subtypes remain unclear. The D 1 receptor subtype is highly expressed in the striatum, nucleus accumbens and prefrontal cortex, brain regions shown to modulate many functions ranging from locomotion to reward, cognition and emotion. To study the potential ' in vivo' role of the dopamine D1 receptor in the regulation of specific brain functions and drug induced behaviors, we used mice lacking the functional D1 receptor gene. In these mice the D1 receptor gene was deleted by means of homologous recombination. Based on the behavioral analysis of D1 receptor-deficient mice, we demonstrate that the D1 receptor is an abundant protein that plays a crucial role in mediating higher brain functions including some aspects of cognition (spatial learning and memory), appetitive motivation (operant responding for sucrose), alcohol seeking behavior and locomotor responses to alcohol and amphetamine. In addition, we have defined, for the first time, a role for the D1 receptor in the normal extinction of conditioned fear responses. However, D1 receptor does not appear to be essential for basal locomotor activity, working memory, sweet-taste preference or acquisition and expression of fear responses. These findings have great importance in furthering the understanding of the role of D1 receptors in brain functions.
Book Synopsis Dopamine in the CNS I by : Gaetano Di Chiara
Download or read book Dopamine in the CNS I written by Gaetano Di Chiara and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Book Synopsis Biology of the NMDA Receptor by : Antonius M. VanDongen
Download or read book Biology of the NMDA Receptor written by Antonius M. VanDongen and published by CRC Press. This book was released on 2008-10-29 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NMDA receptor plays a critical role in the development of the central nervous system and in adult neuroplasticity, learning, and memory. Therefore, it is not surprising that this receptor has been widely studied. However, despite the importance of rhythms for the sustenance of life, this aspect of NMDAR function remains poorly studied. Written
Book Synopsis Dopamine Receptors—Advances in Research and Application: 2013 Edition by :
Download or read book Dopamine Receptors—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dopamine Receptors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Dopamine D1 Receptors in a concise format. The editors have built Dopamine Receptors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Dopamine D1 Receptors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Dopamine Receptors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis The Dopamine Receptors by : Kim Neve
Download or read book The Dopamine Receptors written by Kim Neve and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: As sites of action for drugs used to treat schizophrenia and Parkinson’s disease, dopamine receptors are among the most validated drug targets for neuropsychiatric disorders. Dopamine receptors are also drug targets or potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. Updated from the successful first edition, "The Dopamine Receptors" serves as a reference work on dopamine receptors while also highlighting the areas of research that are most active today. To achieve this goal, authors have written chapters that set a broad area of research in its historical context, rather than focusing on the research output of their own laboratories.
Book Synopsis Medical Biochemistry by : N. V. Bhagavan
Download or read book Medical Biochemistry written by N. V. Bhagavan and published by Academic Press. This book was released on 2002 with total page 1068 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents the fundamentals of biochemistry and related topics for all those pursuing medical or other health-related fields such as clinical chemistry, medical technology, or pharmacology.
Book Synopsis Encyclopedia of Movement Disorders by :
Download or read book Encyclopedia of Movement Disorders written by and published by Academic Press. This book was released on 2010-02-26 with total page 1633 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists
Book Synopsis Molecular Biology of G-protein-coupled Receptors by : Mark R. Brann
Download or read book Molecular Biology of G-protein-coupled Receptors written by Mark R. Brann and published by . This book was released on 1992 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: LESLIE L. IVERSEN The present series of volumes is well timed, as the impact of molecular genetics on pharmacology has been profound, and a comprehensive review of the rapid advances of the past decade is much needed. Since the pioneering work of Dale, Ariens, and others in the early years of this century, much of pharmacology has been founded on the concept of receptors. To begin with, the receptor was conceived of as a "black box," which recognized and transduced the biological effects of neurotransmit ters, hormones, or other biological messengers-and which could also represent a target for man-made drugs. It is only in the last two decades that "molecular pharmacology" has blossomed, first with the advent of radioligand binding techniques and second messenger studies which greatly facilitated the biochemical study of drug-receptor interactions, and latterly with increasing knowledge of the molecular architecture of the receptor proteins themselves. This started with the traditional biochemical approach of isolating and purifying the receptor molecules. This proved to be a task of immense technical difficulty because of the low density of receptors in most biological source tissues, although there were some notable successes, e. g. , the purification of the nicotinic acetylcholine receptor from the electric organ of Torpedo. It was the ap plication of molecular genetics technology during the 1980s, however, which really accelerated progress in this field.
Book Synopsis Dopamine Receptor Agonists by : George Poste
Download or read book Dopamine Receptor Agonists written by George Poste and published by Springer. This book was released on 1984-08 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dopamine, in addition to its importance as a precursor of norepinephrine, is now known to be an important neurotransmitter in regulating functional activities in a number of major organ systems, including the central ner vous system. the cardiovascular system, the kidney, and the gut. Recent advances in our understanding of the functional role of dopamine, its mechanism of action and the pharmacology of dopaminergic agents have occurred on a broad front. The last few years have witnessed significant progress in the identification and classification of central and peripheral dopamine receptors and the factors that affect their responsiveness to inhibitory and stimulatory ligands. These advances have been paralleled by new insights into the contribution of alterations in dopaminergic reg ulation in causing disease and the utility of dopamine agonists and an tagonists as therapeutic modalities. This volume, the first in a series of publications arising from the annual Smith Kline and French Research Symposium on New Horizons in Therapeutics, provides a comprehensive survey of current research on peripheral dopamine receptors and the physiologic and therapeutic con sequences of stimulating pre-and postsynaptic dopamine receptors. Research in dopamine pharmacology mirrors the remarkable ad vances that are occurring in the field of pharmacology at large as a con sequence of the involvement of an ever-larger number of scientific dis ciplines in the study of drug action.
Book Synopsis A Synopsis of Parkinson's Disease by : Md, Frcpc, Frcp (hon), Abdul Qayyum Rana
Download or read book A Synopsis of Parkinson's Disease written by Md, Frcpc, Frcp (hon), Abdul Qayyum Rana and published by BoD – Books on Demand. This book was released on 2014-03-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Parkinsons disease is a disabling neurological condition with both motor and non-motor symptoms for which no cure is available at this stage. This book is unique in covering the most important topics related to Parkinsons disease. Current research and updates about some non-motor symptoms, as well as surgical treatment of Parkinsons disease, in addition to the long term complications of pharmacological treatments have been presented. This book can be used by physicians, researchers and neuroscientists who want to learn new information about these topics related to Parkinsons disease. Authors of the individual chapters are well known in their fields and the book has been edited by a world renowned Parkinsons disease expert.
Book Synopsis Role of Specific Amino Acid Residues in the Intracellular Domains of Human D1 Dopamine Receptors by : Hui Jin
Download or read book Role of Specific Amino Acid Residues in the Intracellular Domains of Human D1 Dopamine Receptors written by Hui Jin and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, over 300 G protein-coupled receptors (GPCR) have been cloned. Much has been learned in the structure-function relationship of these receptors. However, many questions still remain to be solved. D1 dopamine receptor (D1DR) plays an important role in central nervous system and in periphery. The role of specific amino acid residues in the intracellular domains of D1DR was investigated. I demonstrated that the D1DR was palmitoylated at the Cys347 and Cys351. These two cysteines were replaced with alanines both individually and together. The data revealed that palmitoylation was not involved in G coupling. A consensus PKA sequence into the carboxyl tail of D1DR. The data and analysis using the extended ternary complex model demonstrated that the PKA sequence close to the palmitoylation site conferred constitutive desensitization to D1DR. A spontaneous serine mutation of the first intracellular loop caused a constitutive activation of MSH receptor. It was shown that the serine to leucine mutation in the corresponding region of D1DR did not elicit constitutive activation or enhanced receptor-G protein coupling. The significance of the cdc2 phosphorylation site in the second intracellular loop of D1DR was investigated. It was shown that removal of the cdc2 site could abolish D1 receptor internalization, suggesting that this phosphorylation site, in addition to PKA/PKC and GRK sites, might also be involved in agonist-induced receptor internalization. The relationship between receptor density and maximal adenylyl cyclase response was examined. The data revealed that efficacy as measured by the response (maximal activation of adenylyl cyclase) varied with receptor density and reached a saturated state with receptor overpression. All the studies taken together signify that each GPCR may have unique features and should be studied individually. Conclusions obtained from one receptor or a 'prototype' should not be generalized freely to others only on the basis of homologous sequence or common topography.
