Cell Lineage And Fate Determination

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Cell Lineage and Fate Determination

Author : Sally A. Moody
Publisher : Elsevier
ISBN 13 : 0080528783
Total Pages : 661 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Cell Lineage and Fate Determination by : Sally A. Moody

Download or read book Cell Lineage and Fate Determination written by Sally A. Moody and published by Elsevier. This book was released on 1998-10-29 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Lineage and Fate Determination provides a comprehensive view of the mechanisms regulating cell lineage and fate determination in an effort to understand how the fertilized egg is transformed into a complex of specialized tissues. It presents basic information on eight different animal models and recent developmental biological research done in each model. The book provides a focused forum presenting key information for researchers studying various aspects of developmental and cellular biology. Extensive use of tables and black-and-white and color figures helps illustrate each model. The book concludes by discussing future goals for bringing cellular, molecular, and genetic research to clinical applications and tissue replacement therapies. Key Features* Presents eight different animal models* Provides a focused forum on cell fate determination that provides comprehensive and key information for researchers* Illustrates the transitional relationship between researchers and clinicians* Includes the extensive use of tables and color figures

Essays on Developmental Biology Part B

Author : Paul Wassarman
Publisher : Academic Press
ISBN 13 : 0128016167
Total Pages : 916 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Essays on Developmental Biology Part B by : Paul Wassarman

Download or read book Essays on Developmental Biology Part B written by Paul Wassarman and published by Academic Press. This book was released on 2016-03-10 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2016 Current Topics in Developmental Biology (CTDB) will celebrate its 50th or “golden anniversary. To commemorate the founding of CTDB by Aron Moscona (1921-2009) and Alberto Monroy (1913-1986) in 1966, a two-volume set of CTDB (volumes 116 and 117), entitled Essays on Development, will be published by Academic Press/Elsevier in early 2016. The volumes are edited by Paul M. Wassarman, series editor of CTDB, and include contributions from dozens of outstanding developmental biologists from around the world. Overall, the essays provide critical reviews and discussion of developmental processes for a variety of model organisms. Many essays relate the history of a particular area of research, others personal experiences in research, and some are quite philosophical. Essays on Development provides a window onto the rich landscape of contemporary research in developmental biology and should be useful to both students and investigators for years to come. Covers the area of developmental processes for a variety of model organisms International board of authors Part of two 50th Anniversary volumes proving a comprehensive set of reviews edited by Serial Editor Paul M. Wassarman

Cell Fate

Author : Chin-Hsing Annie Lin
Publisher : Frontiers Media SA
ISBN 13 : 2889198529
Total Pages : 104 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Cell Fate by : Chin-Hsing Annie Lin

Download or read book Cell Fate written by Chin-Hsing Annie Lin and published by Frontiers Media SA. This book was released on 2016-06-24 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental question of how an undifferentiated progenitor cell adopts a more specialized cell fate that then contributes to the development of specialized tissues, organs, organ systems and ultimately a unique individual of a given species has intrigued cell and developmental biologists for many years. Advances in molecular and cell biology have enabled investigators to identify genetic and epigenetic factors that contribute to these processes with increasing detail and also to define the various molecular characteristics of each cell fate with greater precision. Understanding these processes have also provided greater insights into disorders in which the normal mechanisms of cell fate determination are altered, such as in cancer and inherited malformations. With these advances have come techniques that facilitate the manipulation of cell fate, which have the potential to revolutionize the field of medicine by facilitating the repair and/or regeneration of diseased organs. Given the rapid advances that are occurring in the field, the articles in this eBook are both relevant and timely. These articles originally appeared online as part of the Research Topic “Cell Fate” overseen by my colleagues Dr. Lin, Dr. Buttitta, Dr. Maves, Dr. Dilworth, Dr. Paladini and myself and have been viewed extensively. Because of their popularity, they are now made available as an eBook, in a more easily downloadable form. Michael T. Chin

Two Perspectives of Cell Fate Determination

Author : Albert C. Huang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (795 download)

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Book Synopsis Two Perspectives of Cell Fate Determination by : Albert C. Huang

Download or read book Two Perspectives of Cell Fate Determination written by Albert C. Huang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell fate determination, the process of transforming a unicellular embryonic cell into lineage-restricted specific tissues of a multicellular organism, is fundamental to the process of development. Following the division of a single zygote, how can seemingly similar neighboring cells ultimately differentiate into disparate cell fates, and maintain their differences? An understanding of this complex and intricate process is important for stem cell-based therapies and treatment of cancer. To provide the necessary conceptual background, we review two complementary perspectives that aid our understanding of the differentiation process -- a systems dynamics level view and a molecular mechanism level view. We introduce the experimental systems, the diverse types of data collected for this work, and computational methods to integrate them to arrive at a coherent model. From a systems dynamics perspective, cell fates can be thought of as attractors in the high dimensional gene regulatory networks. With this view, we designed experiments that identified a class of genes that are "divergent" in their expression during the differentiation process. These genes are associated with neutrophil differentiation and cell cycle progression. Further promoter-based transcription factor binding site analyses reveal enrichment of factors functionally linked to cancer progression and neutrophil differentiation, suggesting a systems dynamics view has the potential to elucidate mechanistic level details. From a molecular mechanistic perspective, we investigate how T-bet, a Th1 lineage defining transcription factor, functionally regulates its target genes. We experimentally determine genome-wide binding locations of T-bet and target genes that it regulates. We find distinct genomic signal patterns for genes that are differentially regulated compared to those that are not. We find that the chromatin-modifying and N-terminal domains of the T-bet protein are necessary for the regulation of T-bet targets. Further, T-bet targets are also differentially regulated in other T helper subtypes. Both perspectives offer unique insights into the differentiation process. Future direction would include methods to combine both perspectives by modeling mechanistic details while keeping track of the larger dynamic "emergent" attractor properties of the network.

Cell Lineage and Embryo Patterning

Author :
Publisher : Elsevier
ISBN 13 : 008048915X
Total Pages : 623 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Cell Lineage and Embryo Patterning by :

Download or read book Cell Lineage and Embryo Patterning written by and published by Elsevier. This book was released on 2000-12-13 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology, both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. This volume brings together current information on the localization and roles of RNAs in cell-lineage determination and subsequent patterning in embryonic development. Guest co-editor Lawrence Etkin is one of the leading researchers in molecular genetics of Xenopus. Key Features * A number of important concepts are discussed, including: * How polarity is established during oogenesis * How germ cell determinants become organized in the establishment of the germ cell lineage * Different strategies used by organisms to establish the germ cell lineage * Similarities and differences between the mechanisms used in embryonic patterning * The mechanisms and machinery by which molecules such as RNA become asymmetrically segregated * The use of similar signaling pathways in patterning of the dorsal-ventral and right-left asymmetries, embryonic germ layers, limb, and nervous system * The link between fundamental biological processes such as RNA translation and localization in the regulation of axis specification

Stem Cells in Reproductive Medicine

Author : Carlos Simón
Publisher : Cambridge University Press
ISBN 13 : 1107034477
Total Pages : 199 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Stem Cells in Reproductive Medicine by : Carlos Simón

Download or read book Stem Cells in Reproductive Medicine written by Carlos Simón and published by Cambridge University Press. This book was released on 2013-07-04 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.

Cell Lineage, Stem Cells, and Cell Determination

Author : Nicole Le Douarin
Publisher : North-Holland
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cell Lineage, Stem Cells, and Cell Determination by : Nicole Le Douarin

Download or read book Cell Lineage, Stem Cells, and Cell Determination written by Nicole Le Douarin and published by North-Holland. This book was released on 1979 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Nematode Caenorhabditis Elegans

Author : William Barry Wood
Publisher :
ISBN 13 :
Total Pages : 694 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Nematode Caenorhabditis Elegans by : William Barry Wood

Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Germ-plasm

Author : August Weismann
Publisher :
ISBN 13 :
Total Pages : 524 pages
Book Rating : 4.:/5 (334 download)

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Book Synopsis The Germ-plasm by : August Weismann

Download or read book The Germ-plasm written by August Weismann and published by . This book was released on 1898 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

Chromatin Regulation of Early Embryonic Lineage Specification

Author : Jason Knott
Publisher : Springer
ISBN 13 : 331963187X
Total Pages : 85 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Chromatin Regulation of Early Embryonic Lineage Specification by : Jason Knott

Download or read book Chromatin Regulation of Early Embryonic Lineage Specification written by Jason Knott and published by Springer. This book was released on 2017-11-23 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Five leaders in the field of mammalian preimplantation embryo development provide their own perspectives on key molecular and cellular processes that mediate lineage formation during the first week of life. The first cell-fate decision involves the formation of the pluripotent inner cell mass (ICM) and extraembryonic trophectoderm (TE). The second cell-fate choice encompasses the transformation of ICM into extraembryonic primitive endoderm (PE) and pluripotent epiblast. The processes, which occur during the period of preimplantation development, serve as the foundation for subsequent developmental events such as implantation, placentation, and gastrulation. The mechanisms that regulate them are complex and involve many different factors operating spatially and temporally over several days to modulate embryonic chromatin structure, impose cellular polarity, and direct distinct gene expression programs in the first cell lineages.

Biology and Pathology of Trophoblast

Author : Ashley Moffett
Publisher : Cambridge University Press
ISBN 13 : 1139452541
Total Pages : 246 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Biology and Pathology of Trophoblast by : Ashley Moffett

Download or read book Biology and Pathology of Trophoblast written by Ashley Moffett and published by Cambridge University Press. This book was released on 2011-08-18 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in 2006, this book provides an in-depth account of trophoblast: the tissue derived from the fertilised egg that nourishes and protects the developing fetus. The cells of the trophoblast have many unique qualities, and exhibit great variability across different species. It has a fascinating role in the development of the placenta and as a regulator during early growth of the embryo. These aspects are all fully covered as well as studies on why it is not rejected by the mother as 'foreign' tissue. Disorders of trophoblast during development also manifest themselves in several clinical conditions during pregnancy, including gestational trophoblastic disease and pre-eclampsia. From stem cells through to epigenetics, implantation and X-chromosome inactivation, there is a lot to be learned about trophoblast, this volume provides a detailed summary of knowledge regarding the subject.

Non-genetic Heterogeneity in Mammalian Cell Fate Determination

Author : Hannan Han-Chun Chang
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (265 download)

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Book Synopsis Non-genetic Heterogeneity in Mammalian Cell Fate Determination by : Hannan Han-Chun Chang

Download or read book Non-genetic Heterogeneity in Mammalian Cell Fate Determination written by Hannan Han-Chun Chang and published by . This book was released on 2008 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cells with extreme high and low Sca-1 also differed in their preference for commitment to the erythroid or myeloid lineage. This difference was reflected in their transcriptomes, which included dramatic differences in basal levels of fate-determining transcription factors. This spontaneous variability in cell-fate priming naturally resolves the old dualism between the "selective" and "instructive" models of cell fate determination, since it provides the variation that is inherently required for selection, allowing differentiation signals to selectively instruct only the responsive subset of cells and influence their gene expression. This insight could be utilized to increase efficiency in attempts to steer stem cell differentiation to a desired fate. Finally, I constructed a mammalian cell system for simultaneous measurement of expression of the lineage-determining transcription factor PU.1 and of its downstream target Mac-1 by fluorescence microscopy. This experimental cell system will enable us to track the origin and propagation of gene expression fluctuations in single, live hematopoietic progenitor cells just undergoing differentiation.

C. Elegans II

Author : Donald L. Riddle
Publisher : Firefly Books
ISBN 13 : 9780879695323
Total Pages : 1252 pages
Book Rating : 4.6/5 (953 download)

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Book Synopsis C. Elegans II by : Donald L. Riddle

Download or read book C. Elegans II written by Donald L. Riddle and published by Firefly Books. This book was released on 1997 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR

Experimental Embryology

Author : Thomas Hunt Morgan
Publisher :
ISBN 13 :
Total Pages : 794 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Experimental Embryology by : Thomas Hunt Morgan

Download or read book Experimental Embryology written by Thomas Hunt Morgan and published by . This book was released on 1927 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimentelle Embryologie.

Patterns in Plant Development

Author : Taylor A. Steeves
Publisher : Cambridge University Press
ISBN 13 : 9780521288958
Total Pages : 410 pages
Book Rating : 4.2/5 (889 download)

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Book Synopsis Patterns in Plant Development by : Taylor A. Steeves

Download or read book Patterns in Plant Development written by Taylor A. Steeves and published by Cambridge University Press. This book was released on 1989-07-28 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patterns in Plant Development offers an introduction to the development of the whole plant.

Cell Fate in Mammalian Development

Author :
Publisher : Academic Press
ISBN 13 : 0128043350
Total Pages : 347 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cell Fate in Mammalian Development by :

Download or read book Cell Fate in Mammalian Development written by and published by Academic Press. This book was released on 2018-02-21 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Fate in Mammalian Development, Volume 128, the latest release in the Current Topics in Developmental Biology series, provides reviews on cell fate in mammalian development. Each chapter is written by an international board of authors, with this release including sections on the Specification of extra-embryonic lineages during mouse pre-implantation development, Cell polarity and fate specification, The circuitry that drives trophectoderm identity, Breaking symmetry and the dynamics of transcription factors directing cell fate specification, Mechanics and cell fate, How physical properties of cells change in development and their effect on cell fate decisions, and more. Provides the authority and expertise of leading contributors from an international board of authors Includes new sections on the specification of extra-embryonic lineages during mouse pre-implantation development, cell polarity and fate specification, the circuitry that drives trophectoderm identity, and more Presents the latest release in the Current Topics in Developmental Biology series