Cell Adhesion And Invasion In Cancer Metastasis

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Cell Adhesion and Invasion in Cancer Metastasis

Author : Pnina Brodt
Publisher : New York : Springer
ISBN 13 : 9780412101519
Total Pages : 245 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Cell Adhesion and Invasion in Cancer Metastasis by : Pnina Brodt

Download or read book Cell Adhesion and Invasion in Cancer Metastasis written by Pnina Brodt and published by New York : Springer. This book was released on 1996-01-01 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: A critical review of the latest research on the specific cell adhesion molecules involved in the metastatic process. After a summary of concepts in the field, chapters detail findings on the molecular biology and biochemistry of adherins, integrins, selectins and their ligands, and the Ig-like adhesion family, and review the role of proteases and protease inhibitors in regulating the metastatic process and modulating cell adhesion. Includes material on current methods for the analysis of cell invasion. Of interest to novices and experts in tumor biology. Annotation copyright by Book News, Inc., Portland, OR

Cell Adhesion and Invasion Mechanisms in Cancer Metastasis

Author : Pnina Brodt
Publisher : Landes Bioscience
ISBN 13 : 9781570592638
Total Pages : 245 pages
Book Rating : 4.5/5 (926 download)

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Book Synopsis Cell Adhesion and Invasion Mechanisms in Cancer Metastasis by : Pnina Brodt

Download or read book Cell Adhesion and Invasion Mechanisms in Cancer Metastasis written by Pnina Brodt and published by Landes Bioscience. This book was released on 1996-01-01 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Motility in Cancer Invasion and Metastasis

Author : Alan Wells
Publisher : Springer Science & Business Media
ISBN 13 : 1402040091
Total Pages : 360 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cell Motility in Cancer Invasion and Metastasis by : Alan Wells

Download or read book Cell Motility in Cancer Invasion and Metastasis written by Alan Wells and published by Springer Science & Business Media. This book was released on 2006-06-22 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.

Metastasis: From Cell Adhesion and Beyond

Author : Vasiliki Gkretsi
Publisher : Frontiers Media SA
ISBN 13 : 2889459535
Total Pages : 93 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Metastasis: From Cell Adhesion and Beyond by : Vasiliki Gkretsi

Download or read book Metastasis: From Cell Adhesion and Beyond written by Vasiliki Gkretsi and published by Frontiers Media SA. This book was released on 2019-08-22 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook consists of a collection of articles focused on fundamental processes of cancer cell metastasis, such as cell-Extracellular matrix adhesions, epithelial-to-mesenchymal transition (EMT) and lymph node metastasis as well as on upcoming research fields including the effects of biomechanical factors, the use of analytical and statistical tools and experimental techniques to further understand and characterize the invasive and metastatic potential of tumors.

Mechanisms of Invasion and Metastasis

Author : Marc M. Mareel
Publisher : CRC Press
ISBN 13 : 9780849362545
Total Pages : 592 pages
Book Rating : 4.3/5 (625 download)

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Book Synopsis Mechanisms of Invasion and Metastasis by : Marc M. Mareel

Download or read book Mechanisms of Invasion and Metastasis written by Marc M. Mareel and published by CRC Press. This book was released on 1991-04-23 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers important biological, immunological, and molecular information essential for understanding the rationale and results of experiments and clinical observations on cell-cell and cell substrate adhesion; hydrolytic activities, cell motility; immunological and other host elements of the host-tumor ecosystem (at different sites of the metastic process); genetic and epigenetic elements of the acquisition and the expression of invasive phenotypes. 38 tables and 60 computer-drawn figures provide comprehensive overviews, and a methodological chapter emphasizing the differences and similarities between assays and their relevance for natural situations has also been included. Clinical and experimental cancer researchers, as well as as post-graduate students interested in cancer research, will find this book to be an indispensable reference resource.

Cell Adhesion and Cytoskeletal Molecules in Metastasis

Author : Anne E. Cress
Publisher : Springer Science & Business Media
ISBN 13 : 1402051298
Total Pages : 209 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cell Adhesion and Cytoskeletal Molecules in Metastasis by : Anne E. Cress

Download or read book Cell Adhesion and Cytoskeletal Molecules in Metastasis written by Anne E. Cress and published by Springer Science & Business Media. This book was released on 2007-01-20 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights the expression of specific adhesion molecules within human cancer tissues. It details the expression signatures from published DNA microarray and immunohistochemistry studies. Coverage discusses the concept that the alteration of specific adhesion molecules influence the cancer migration ability and cancer damage responses, both features are essential for the survival of an invading tumor cell.

Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention

Author : Wen G. Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 0306483882
Total Pages : 434 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention by : Wen G. Jiang

Download or read book Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.

Cell Invasion

Author : Jyrki Heino
Publisher : CRC Press
ISBN 13 : 1498713165
Total Pages : 179 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Cell Invasion by : Jyrki Heino

Download or read book Cell Invasion written by Jyrki Heino and published by CRC Press. This book was released on 2002-08-01 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an overview of cell invasion. Topics include information on the cellular matrix, cell surface integrins, matrix metalloproteinases and proteinases, and the interplay between protein families.

Electric Cell-Substrate Impedance Sensing and Cancer Metastasis

Author : Wen G. Jiang
Publisher : Springer Science & Business Media
ISBN 13 : 9400749279
Total Pages : 261 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Electric Cell-Substrate Impedance Sensing and Cancer Metastasis by : Wen G. Jiang

Download or read book Electric Cell-Substrate Impedance Sensing and Cancer Metastasis written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2012-09-14 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell based impedance sensing is becoming a new biophysical and cellular technology in cell based analyses. The technology has been used in investigation of cellular growth and death, cell adhesion and migration, cell invasion and cell-cell interactions, cell toxicity, angiogenesis, cell permeability, signal transduction and cellular behaviour under flow conditions. It is a probe free, highly sensitive, and versatile technology platform. Recent development in the technology has also allowed high throughput, automated analyses. It has been widely explored in chemistry, toxicity, cell biology, cancer biology, and other areas of chemistry, medicinal chemistry, life and medical science. Written by experts in the area of cell impedance sensing, including the Nobel Laureate Dr Ivar Giaever, this books covers the background of electric cell-substrate impedance sensing, their applications in cell based investigations, particularly in the area of cancer biology. This book is the first on this technology platform and will be a highly useful reference for molecular and cell biologists, cancer biologists, chemists and biochemists, clinical researchers who work in the areas of cell biology, molecular biology, toxicology, pharmaceutical industry, life science and medical research.

Adhesive Interactions in Normal and Transformed Cells

Author : Yury A. Rovensky
Publisher : Springer Science & Business Media
ISBN 13 : 1617793043
Total Pages : 241 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Adhesive Interactions in Normal and Transformed Cells by : Yury A. Rovensky

Download or read book Adhesive Interactions in Normal and Transformed Cells written by Yury A. Rovensky and published by Springer Science & Business Media. This book was released on 2011-08-31 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adhesive Interactions in Normal and Transformed Cells describes the basic mechanisms of the ability of tissue cells to attach to each other and to the extracellular matrix. These adhesive interactions are pivotal regulators of main cellular functions, such as proliferation, survival and migration. The adhesive interactions are involved in embryonic development, regeneration, and also in inflammation and degeneration processes, which are at the basis of many diseases. Serious alterations in cell adhesion caused by the oncogenic transformation play a key role in cancer invasion and metastasis. This volume provides comprehensive information about structural, mechanistic and signaling aspects of adhesive interactions in both normal and cancer cells in comparison. Integration of such aspects of the adhesive process as structure, relation to cell systems of receptors and cytoskeleton, function, signaling pathways, and the alterations in tumor cells constitutes the strongest point of this work. The results of the long-time author’s research are included in the book. The author was one of pioneers, who used scanning electron microscopy (SEM) to study the cell surface morphology of normal cultured cells and the cells underwent the oncogenic transformation, processes of their attachment to and spreading on the surfaces of a solid substratum, and also surprising ability of the cells to respond to various geometric configurations of the substrata surfaces. Adhesive Interactions in Normal and Transformed Cells has both biological and medical aspects and, therefore, it can be interesting not only for cell biologists, developmental biologists and cancer researchers, but also for physicians. It is intended for researchers, postdocs, undergraduate and graduate students.

Intermolecular Cross-talk in Tumor Metastasis

Author : George G. Skouteris
Publisher : IOS Press
ISBN 13 : 9789051994568
Total Pages : 322 pages
Book Rating : 4.9/5 (945 download)

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Book Synopsis Intermolecular Cross-talk in Tumor Metastasis by : George G. Skouteris

Download or read book Intermolecular Cross-talk in Tumor Metastasis written by George G. Skouteris and published by IOS Press. This book was released on 1999 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis of tumours is a sequence of events taking place after the appearance of a primary tumour. The potency of a tumour to metastasise greatly depends on the molecular interactions between tumour components (cellular differentiation and heterogeneity, surface antigenic determinants etc.) and the micro-environment. The complexity and diversity in the composition of tissue micro-environment is in great extent determining the metastatic behaviour or a primary tumour. Extracellular matrix composition, rearrangement of cytoskeleton, cell antigenicity , expression of metastasis-related novel genes, cell adhesion and novel therapeutical approaches such as blockage of angiogenesis, are the major topics discussed in detail in this volume.

Metastasis of Breast Cancer

Author : R.E. Mansel
Publisher : Springer Science & Business Media
ISBN 13 : 1402058675
Total Pages : 439 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Metastasis of Breast Cancer by : R.E. Mansel

Download or read book Metastasis of Breast Cancer written by R.E. Mansel and published by Springer Science & Business Media. This book was released on 2007-06-17 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.

Attempts to Understand Metastasis Formation I

Author : Ursula Günthert
Publisher : Springer Science & Business Media
ISBN 13 : 3642611079
Total Pages : 302 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Attempts to Understand Metastasis Formation I by : Ursula Günthert

Download or read book Attempts to Understand Metastasis Formation I written by Ursula Günthert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: In metastasis, tumor cells disseminate from the primary lesion and home to secondary organs where they may remain dormant for a long time. Metastasis formation is still the most feared manifestation for tumor patients and clinicians. Although improvements have been made concerning earlier detection and specific therapy, most of the cancer patients still die of distant metastases. The pu-rpose of these three volumes is to review the recent progress in molecular metas tasis research and to attempt to further understand the biol ogy of this multifocal process. With respect to present day molecular biology, the pioneers of metastasis research established the basic concepts of metasta sis formation in the 1970s and 1980s, namely, clonal selection of metastatic cells, heterogeneity of metastatic subpopulations, organ specificity of metastasis and the importance of angio genesis (Fidler, Kripke, Nicolson, Folkman and others). In the 1980s and 1990s, several of the molecules involved were identified and their network interactions elucidated. These three volumes of Current Topics in Microbiology and Immuno logy compile the most recent developments on these meta stasis-related molecules; their interactions, regulation, and ways to interfere with their action. It became evident that metastasis-related molecules are confined to distinct cellular compartments, such as the extracellular space, the cell membrane, the cytoplasmic signalling network, and the nuclear regulatory system. For the complex metastatic cascade, proteolysis and alterations in adhesive functions are the most obvious and thus one of the most thoroughly investigated processes.

New Developments in Metastasis Suppressor Research

Author : Paul Jackson
Publisher : Nova Publishers
ISBN 13 : 9781600216039
Total Pages : 340 pages
Book Rating : 4.2/5 (16 download)

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Book Synopsis New Developments in Metastasis Suppressor Research by : Paul Jackson

Download or read book New Developments in Metastasis Suppressor Research written by Paul Jackson and published by Nova Publishers. This book was released on 2007 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.

Microcirculation in Cancer Metastasis

Author : F. William Orr
Publisher : CRC Press
ISBN 13 : 9780849361548
Total Pages : 326 pages
Book Rating : 4.3/5 (615 download)

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Book Synopsis Microcirculation in Cancer Metastasis by : F. William Orr

Download or read book Microcirculation in Cancer Metastasis written by F. William Orr and published by CRC Press. This book was released on 1991-07-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.

Signal Transduction in Cancer Metastasis

Author : Wen-Sheng Wu
Publisher : Springer Science & Business Media
ISBN 13 : 9048195225
Total Pages : 293 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Signal Transduction in Cancer Metastasis by : Wen-Sheng Wu

Download or read book Signal Transduction in Cancer Metastasis written by Wen-Sheng Wu and published by Springer Science & Business Media. This book was released on 2010-10-04 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.

Cancer Metastasis

Author : Richard G. Vile
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cancer Metastasis by : Richard G. Vile

Download or read book Cancer Metastasis written by Richard G. Vile and published by Wiley-Blackwell. This book was released on 1995-04-25 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise description of the metastasis process and its therapeutic relevance in controlling the clinical outcome of the tumor. Explains why the clinical importance of metastasis could be the most life-threatening element in the tumorigenic procedure.