Cause Effect Linkages Related To Genotoxicity

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Tumour Site Concordance and Mechanisms of Carcinogenesis

Author : Robert A. Baan
Publisher : International Agency for Research on Cancer
ISBN 13 : 9789283222170
Total Pages : 0 pages
Book Rating : 4.2/5 (221 download)

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Book Synopsis Tumour Site Concordance and Mechanisms of Carcinogenesis by : Robert A. Baan

Download or read book Tumour Site Concordance and Mechanisms of Carcinogenesis written by Robert A. Baan and published by International Agency for Research on Cancer. This book was released on 2019-05-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Scientific Publication reviews the information on cancer sites and mechanistic events for the more than 100 agents classified in Group 1 (carcinogenic to humans) by the IARC Monographs Program. This category of agents is diverse and includes chemicals and chemical mixtures; occupations; metals, dusts, and fibres; radiation; viruses and other biological agents; personal habits; and pharmaceuticals. For the Group 1 agents, there were cross-cutting questions about the relevance to humans of certain cancer sites or mechanistic pathways in animals. This publication is based on a systematic identification and comparison of the cancer sites observed in humans and those observed in experimental animals, and a compilation of mechanistic events for agents known to cause cancer in humans. Relevant information was analyzed on all the agents classified in Group 1 in Monographs up to and including Volume 109, most of which are reviewed in Volume 100A-F. A database of tumor sites seen in humans and animals was used to examine the degree of concordance by use of an anatomically based tumor classification scheme. The analysis of mechanistic aspects of the IARC Group 1 agents focused on 10 key characteristics of human carcinogens developed during the course of this work. Genotoxicity was the most prevalent mechanistic characteristic, consistent with the process of carcinogenesis necessarily involving genomic changes. The IARC concordance database represents a useful source of information for comparing animal and human data with respect to the tumors caused in different species. The results of the mechanistic analysis can provide a basis for future efforts to categorize mechanistic data for carcinogens through a systematic review process. These reviews and analyses were discussed during a two-part Workshop on Tumour Site Concordance and Mechanisms of Carcinogenesis convened by IARC. This Scientific Publication is the report of that Workshop and of subsequent work by the participants, both individually and collectively. This publication also presents a statement of consensus among the Workshop participants, which summarizes the main findings and their implications for human cancer risk assessment.

Ecotoxicology of Explosives

Author : Geoffrey I. Sunahara
Publisher : CRC Press
ISBN 13 : 1420004344
Total Pages : 336 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Ecotoxicology of Explosives by : Geoffrey I. Sunahara

Download or read book Ecotoxicology of Explosives written by Geoffrey I. Sunahara and published by CRC Press. This book was released on 2009-06-01 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Managing sites contaminated with munitions constituents is an international challenge. Although the choice of approach and the use of Ecological Risk Assessment (ERA) tools may vary from country to country, the assurance of quality and the direction of ecotoxicological research are universally recognized as shared concerns. Drawing on a multidiscip

Toxicological Evaluation of Chemical Interactions

Author :
Publisher :
ISBN 13 :
Total Pages : 704 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Toxicological Evaluation of Chemical Interactions by :

Download or read book Toxicological Evaluation of Chemical Interactions written by and published by . This book was released on 1994 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genetic and Molecular Ecotoxicology

Author :
Publisher :
ISBN 13 :
Total Pages : 132 pages
Book Rating : 4.3/5 ( download)

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Book Synopsis Genetic and Molecular Ecotoxicology by :

Download or read book Genetic and Molecular Ecotoxicology written by and published by . This book was released on 1994 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Health Perspectives

Author :
Publisher :
ISBN 13 :
Total Pages : 1724 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Alzheimer's Disease and Advanced Drug Delivery Strategies

Author : Bhupendra Prajapati
Publisher : Elsevier
ISBN 13 : 0443132062
Total Pages : 492 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Alzheimer's Disease and Advanced Drug Delivery Strategies by : Bhupendra Prajapati

Download or read book Alzheimer's Disease and Advanced Drug Delivery Strategies written by Bhupendra Prajapati and published by Elsevier. This book was released on 2023-11-30 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease and Advanced Drug Delivery Strategies compiles under a single volume the most recent advances in drug delivery to the brain as related to AD treatment. The editors recruited scientists from around the world to produce high quality chapters covering not only nanotechnological approaches, but also microsphere, niosomes, and liposomes. Among the topics covered are synthetic molecules, nobiletin, nose to brain delivery, natural biomaterials, cationic nanoformulations, dendrimers, microbubbles, and more. Alzheimer's Disease and Advanced Drug Delivery Strategies is a complete reference for academic and corporate pharma researchers investigating targeted drug delivery to the brain. Medical & Health Sciences researchers would also benefit from understanding the strategies compiled under this volume. Provides insights into how advanced drug delivery systems can be effectively used for the management of Alzheimer’s disease Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems Covers recent perspectives and challenges towards the management and diagnosis of Alzheimer’s Disease

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cause-Effect Linkages II Symposium

Author :
Publisher :
ISBN 13 :
Total Pages : 50 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cause-Effect Linkages II Symposium by :

Download or read book Cause-Effect Linkages II Symposium written by and published by . This book was released on 1991 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment

Author : N. Hadjiliadis
Publisher : Springer Science & Business Media
ISBN 13 : 9401157804
Total Pages : 634 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment by : N. Hadjiliadis

Download or read book Cytotoxic, Mutagenic and Carcinogenic Potential of Heavy Metals Related to Human Environment written by N. Hadjiliadis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental pollution is one of the main problems to confront humanity, with the heavy metals occupying a leading role among the most pernicious pollutants. The metals cause cancer and other sicknesses. Their cytotoxic, mutagenic and carcinogenic potentials are not fully understood, and any thorough investigation demands the combined efforts of scientists drawn from many different disciplines. But the effects of heavy metals are not all negative: some, like cis-DDP, and some ruthenium and tin complexes, have antitumour activity. The idea underlying the present work is therefore to present a multidisciplinary perspective on heavy metals in the environment, affording a better understanding of their action on human organisms and health, aiming to make them less polluting and more environmentally friendly.

In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems

Author : Thomas-Benjamin Seiler
Publisher : Springer Nature
ISBN 13 : 1071623532
Total Pages : 305 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems by : Thomas-Benjamin Seiler

Download or read book In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems written by Thomas-Benjamin Seiler and published by Springer Nature. This book was released on 2022-07-13 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume examines the complex study of the assessment of in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques. Beginning with a section on approaches for chemical analytical and bioanalytical techniques in bioavailability research, the book continues with methods to monitor effects in situ and conduct bioassays to assess the effects of complex environmental samples. It concludes with descriptions of various computational models. Written for the Methods in Pharmacology and Toxicology series, chapters feature the kind of expert implementation advice that leads to greater success in the field. Authoritative and versatile, In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems serves as an ideal guide to aid in tackling the challenge of analyzing and understanding chemical pollution in aquatic systems.

Induced Genotoxicity and Oxidative Stress in Plants

Author : Zeba Khan
Publisher : Springer Nature
ISBN 13 : 9811620741
Total Pages : 227 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Induced Genotoxicity and Oxidative Stress in Plants by : Zeba Khan

Download or read book Induced Genotoxicity and Oxidative Stress in Plants written by Zeba Khan and published by Springer Nature. This book was released on 2021-08-03 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the effects of genotoxic agents causing oxidative stress in plants. The book explores different kind of chemicals which induces genotoxicity, their mechanism of action and effects on plant health. Impacts at the physiological and molecular levels are discussed. The book is of interest to teachers, researchers and plant scientists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences. National and international agricultural scientists will also find this to be a useful read.

Great Lakes - St. Lawrence Research Inventory, 1990/1991

Author : Council of Great Lakes Research Managers
Publisher : [Windsor, Ont.] : International Joint Commission
ISBN 13 :
Total Pages : 136 pages
Book Rating : 4.3/5 (5 download)

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Book Synopsis Great Lakes - St. Lawrence Research Inventory, 1990/1991 by : Council of Great Lakes Research Managers

Download or read book Great Lakes - St. Lawrence Research Inventory, 1990/1991 written by Council of Great Lakes Research Managers and published by [Windsor, Ont.] : International Joint Commission. This book was released on 1992 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genotoxic Effects of Airborne Agents

Author : Raymond R. Tice
Publisher : Springer Science & Business Media
ISBN 13 : 1461334551
Total Pages : 648 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Genotoxic Effects of Airborne Agents by : Raymond R. Tice

Download or read book Genotoxic Effects of Airborne Agents written by Raymond R. Tice and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: For at least 40 years there has been a great interest in the problems created by infectious airborne agents and other toxic sub stances transported through the air. During the Second World War, this problem grew out of the very high incidence of upper respira tory infections appearing in new military recruits who were brought together in very large, open quarters. As a result, very interest ing methods were developed to measure these airborne agents, espe cially bacteria, and some important methods were refined for their control. These methods primarily concentrated on ultraviolet radia tion, propylene glycol and other means to reduce the dust in an en vironment. Because of the specialized circumstances at that time the whole consideration of airborne particles became prominent. Now, with the new strides in the recognition of mutagenic and carcinogenic effects attributed to exposure to airborne chemicals from today's technology, the problem has again become quite promi nent. The development of experimental chambers has made it possible to conduct studies under carefully controlled conditions.

Cellular Effects of Heavy Metals

Author : Gaspar Banfalvi
Publisher : Springer Science & Business Media
ISBN 13 : 9400704283
Total Pages : 348 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cellular Effects of Heavy Metals by : Gaspar Banfalvi

Download or read book Cellular Effects of Heavy Metals written by Gaspar Banfalvi and published by Springer Science & Business Media. This book was released on 2011-03-02 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term “heavy metals” is used as a group name of toxic metals and metalloids (semimetals) causing contaminations and ecotoxicity. In strict chemical sense the density of heavy metals is higher than 5 g/cm3. From biological point of view as microelements they can be divided into two major groups. a. For their physiological function organisms and cells require essential microelements such as iron, chromium (III), cobalt, copper, manganese, molidenium, zinc. b. The other group of heavy metals is toxic to the health or environment. Of highest concern are the emissions of As, Cd, Co, Cu, Hg, Mn, Ni, Pb, Sn, Tl. The toxicity of heavy metals is well known at organizational level, while less attention has been paid to their cellular effects. This book describes the toxicity of heavy metals on microorganisms, yeast, plant and animal cells. Other chapters of the book deal with their genotoxic, mutagenic and carcinogenic effects. The toxicity of several metals touch upon the aspects of environmental hazard, ecosystems and human health. Among the cellular responses of heavy metals irregularities in cellular mechanisms such as gene expression, protein folding, stress signaling pathways are among the most important ones. The final chapters deal with biosensors and removal of heavy metals. As everybody is eating, drinking and exposed to heavy metals on a daily basis, the spirit of the book will attract a wide audience.

Induced Effects Of Genotoxic Agents In Eukaryotic Cells

Author : Toby G Rossman
Publisher : CRC Press
ISBN 13 : 1000162958
Total Pages : 188 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Induced Effects Of Genotoxic Agents In Eukaryotic Cells by : Toby G Rossman

Download or read book Induced Effects Of Genotoxic Agents In Eukaryotic Cells written by Toby G Rossman and published by CRC Press. This book was released on 2020-07-26 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an understanding of the consequences of induced proteins in the toxicological response of cells to chemical and radiation damage to DNA and will be helpful in creating proper mathematical models for extrapolation to low doses and assessing human exposure or cellular injury.

Health Effects of Exposure to Low Levels of Ionizing Radiation

Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council

Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Progress in Inorganic Chemistry

Author : Kenneth D. Karlin
Publisher : John Wiley & Sons
ISBN 13 : 047146144X
Total Pages : 648 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Progress in Inorganic Chemistry by : Kenneth D. Karlin

Download or read book Progress in Inorganic Chemistry written by Kenneth D. Karlin and published by John Wiley & Sons. This book was released on 2003-04-04 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Inorganic Chemistry continues in its tradition of being the most respected forum for exchanging innovative research. This series provides inorganic chemists and materials scientists with a community where critical, authoritative evaluations of advances in every area of the discipline are exchanged. With contributions from internationally renowned chemists, this latest volume offers an in-depth, far-ranging examination of the changing face of the field, providing a tantalizing glimpse of the emerging state of the science.