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Cardiovascular Genomics New Pathophysiological Concepts
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Book Synopsis Cardiovascular Genomics: New Pathophysiological Concepts by : P.A.F.M. Doevendans
Download or read book Cardiovascular Genomics: New Pathophysiological Concepts written by P.A.F.M. Doevendans and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Four years ago-in December 1997-the first European Science Foundation Workshop on Cardiovascular Specific Gene Expression was held in Maastricht. It was hardly possible to imagine the progress in the field in those four years. In 1997, gene expression was still an art focused on individual genes; in 200 I, many labs have access to micro-array facilities to determine the expression of thousands of genes simultaneously. In 1997, gene expression was an area of fundamental research in basis molecular biology laboratories; in 200 I, clinical cardiovascular research has incorporated gene expression approaches. In 1997, the interpretation of a gene expression experiment was usually straightforward; in 200 I, advanced bioinformatics tools are needed to approach the extreme complexities of genetic control of cell and tissue function. The second symposium in this series is focused on Cardiovascular Genomics. New Pathophysiological Concepts. The organizing committee chose to invite a group of renown scientists and young investigators around four topics of eminent importance in cardiovascular research. These topics reflect the major present-day clinical cardiovascular problems: atherosclerosis, hypertension, arrhythmias and heart failure. In addition to these four disease-driven topics, the workshop has sessions on gene expression methodologies and cellular transplant approaches to cardiovascular disease.
Book Synopsis Cardiovascular Physiology Concepts by : Richard E. Klabunde
Download or read book Cardiovascular Physiology Concepts written by Richard E. Klabunde and published by Lippincott Williams & Wilkins. This book was released on 2020-12-01 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praised for its concise coverage, this highly accessible monograph lays a foundation for understanding the underlying concepts of normal cardiovascular function and offers a welcome alternative to a more mechanistically oriented approach or an encyclopedic physiology text. Clear explanations, ample illustrations and engaging clinical cases and problems provide the perfect guidance for self-directed learning and prepare you to excel in clinical practice.
Book Synopsis Stress Echocardiography by : Thomas H. Marwick
Download or read book Stress Echocardiography written by Thomas H. Marwick and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress Echocardiography - Its Role in the Diagnosis and Evaluation of Coronary Artery Disease - Second Edition by Thomas Marwick is a concise, practical guide for anyone new to the field of stress echocardiography or an excellent summary of the existing evidence base for the experienced user. Dr. W.F. Armstrong described the first edition of this book in his Foreword to the first edition as "a thorough, comprehensive review of the basic and advanced concepts of stress echocardiography. This text represents an excellent starting point for individuals wishing to gain initial familiarity with stress echocardiography and a superb reference source for more experienced investigators and clinicians finding a need to further develop their understanding of the technique and advance its clinical relevance in their laboratories."
Author :Martial G. Bourassa Publisher :Springer Science & Business Media ISBN 13 :9780387295527 Total Pages :520 pages Book Rating :4.2/5 (955 download)
Book Synopsis Antioxidants and Cardiovascular Disease by : Martial G. Bourassa
Download or read book Antioxidants and Cardiovascular Disease written by Martial G. Bourassa and published by Springer Science & Business Media. This book was released on 2006 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic oxidative stress is associated with the aging process and often leads to the development of disorders such as cancer and arterial disease. Cardiovascular conditions in which oxidation damage has been strongly implicated include atherosclerosis, myocardial ischemia and reperfusion, coronary restenosis, diabetes mellitus, and congestive heart failure. Antioxidants and Cardiovascular Disease, Second Edition covers three major topics: 1) the first seven chapters review the oxidative modifcation hypothesis and its close relationship to lipid metabolism and to the pathogenesis of atherosclerosis; 2) the next four chapters describe the different compounds, nutrients and supplements with antioxidant properties and their mechanisms of action; 3) and finallly, the last ten chapters discuss the potential benefits of antioxidants in overall cardiovascular prevention, including hypertension, diabetes mellitus, dyslipidemias, and in the treatment and prevention of specific conditions such as chronic coronary artery disease, restenosis after percutaneous coronary intervention, and chronic heart failure. Antioxidants and Cardiovascular Disease, Second Edition is written by recognized experts in the fields of atherosclerosis, heart failure and antioxidants. It should be of interest to medical students and fellows, researchers, and practicing physicians. There has been rapid progress in our knowledge in this field during the last two to three years. Thus the current reedition appears timely. For instance, this second edition captures several recently reported and published clinical trials as welll as new information on diabetic and hypertensive cardiovascular disease.
Book Synopsis Atlas of Practical Applications of Cardiovascular Magnetic Resonance by : Guillem Pons-Llado
Download or read book Atlas of Practical Applications of Cardiovascular Magnetic Resonance written by Guillem Pons-Llado and published by Springer Science & Business Media. This book was released on 2005-12-28 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Richly illustrated with over 200 illustrations • Contains a Glossary of Terms • Very practical and user-friendly guide
Book Synopsis Mitochondria and the Heart by : José Marín-García
Download or read book Mitochondria and the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have been pivotal in the development of some of the most important ideas in modern biology. Since the discovery that the organelle has its own DNA and specific mutations were found in association with neuromuscular and cardiovascular diseases and with aging, an extraordi-nary number of publications have followed, and the term mitochondrial medicine was coined. Furthermore, our understanding of the multiple roles that mitochondria play in cardiac cell homeostasis opened the door for intensive experimentation to understand the pathogenesis and to find new treatments for cardiovascular diseases. Besides its role in adenosine triphosphate generation, mitochondria regu-late a complex network of cellular interactions, involving (1) generation and detoxification of reactive oxygen species, including superoxide anion, hy-drogen peroxide, and hydroxyl radical; (2) maintenance of the antioxidant glutathione in a reduced state and adequate level of mitochondrial matrix superoxide dismutase; (3) cytoplasmic calcium homeostasis, particularly under conditions of cellular calcium loading; (4) transport of metabolites between cytoplasm and matrix; (5) both programmed (apoptosis) and necrotic cell death; and (6) cell growth and development. It is therefore not surprising that this organelle has come to be the center stage in many current investigations of cardiovascular diseases, aging, and agi- related disease. Concomitant with these advances, an impressive effort is under- way for the development of new tools and methodologies to study mitochondrial structure and function, including powerful ways to visualize, monitor, and alter the organelle function to assess the genetic consequences of these perturbations.
Book Synopsis Clinical Cardiac Electrophysiology in the Young by : Macdonald Dick
Download or read book Clinical Cardiac Electrophysiology in the Young written by Macdonald Dick and published by Springer Science & Business Media. This book was released on 2006-08-13 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the practical aspects of clinical electrophysiology of cardiac arrhythmias in the young as practiced in the Department of Pediatric Cardiology at the University of Michigan. Cardiac arrhythmias in children are often symptomatic as well as frightening to the child patient and parent. This volume is intended as a practical guide for the novice or seasoned physician presented with a child with a cardiac arrhythmia.
Book Synopsis Cardiomyopathies and Heart Failure by : Akira Matsumori
Download or read book Cardiomyopathies and Heart Failure written by Akira Matsumori and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the most up-to-date account of existing knowledge on the subject of cardiomyopathy and heart failure. Its multidisciplinary approach covers cardiovascular medicine; biochemistry; immunology; molecular biology; virology; epidemiology; and clinical medicine. Cardiomyopathies and Heart Failure: -Covers all major investigational and clinical aspects of the topic; -Provides syntheses as well as reviews; -Offers a unique multidisciplinary and international perspective; -Includes an extensive list of references to relevant work; -Targeted towards practicing physicians and basic researchers.
Book Synopsis Interstitial Fibrosis in Heart Failure by : Francisco Villarreal
Download or read book Interstitial Fibrosis in Heart Failure written by Francisco Villarreal and published by Springer Science & Business Media. This book was released on 2005-12-17 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interstitial Fibrosis in Heart Failure, edited by Francisco J. Villarreal, M.D., Ph.D., provides a timely and integrative review of the basics of cardiac extracellular matrix structure. Topics covered include how cardiac remodeling influences its disposition, abundance and function; possible non-invasive techniques for diagnosis; and potential drug-based or molecular therapeutic strategies that may interrupt or even reverse the course of the development of cardiac fibrosis. This resource for both clinicians and scientists aims to cover state-of-the-art findings relevant to cellular and molecular processes underlying cardiac fibrosis including basic elements of structure, function, diagnosis and treatment.
Book Synopsis Hypoplastic Left Heart Syndrome by : Jack Rychik
Download or read book Hypoplastic Left Heart Syndrome written by Jack Rychik and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite approximately 50 years of progress in the management of com plex congenital heart disease, hypoplastic left heart syndrome (HLHS) has been one of the last cardiac malformations to yield to effective surgical treat ment. The surgical therapies for hypoplastic left heart syndrome have evolved by two quite disparate routes. One approach has been the staged reconstruc tion operations utilizing an initial operation pioneered by many but developed by Dr. William Norwood and subsequently modified by many other investigators. The first stage reconstruction operation has been refined and standardized such that the majority of infants now proceed to second and third stage reconstruc tive operations culminating in a Pontan Kreutzer single ventricle physiology. An alternative surgical approach has been the development of neonatal and infant heart transplantation for HLHS. This approach also has had a signifi cant impact on the treatment of HLHS and other cardiac malformations and has been associated with good intermediate term results. Both of the thera peutic approaches devised for treatment of hypoplastic left heart syndrome have been effective and the outcomes are continuing to improve with each.
Book Synopsis Atlas of Non-Invasive Coronary Angiography by Multidetector Computed Tomography by : Guillem Pons-Llado
Download or read book Atlas of Non-Invasive Coronary Angiography by Multidetector Computed Tomography written by Guillem Pons-Llado and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This atlas presents over 160 illustrations, with 116 in color, and illustrates the capacity of multidetector CT for the analysis of the anatomy of the coronary arteries. The multidetector CT scanner speeds diagnosis and treatment of patients. One of its many uses is to perform CT coronary angiography. Multidetector CT provides clear pictures and takes less time than other non-invasive techniques. The book is written by cardiologists and radiologists.
Book Synopsis Aging Issues in Cardiology by : Irene D. Turpie
Download or read book Aging Issues in Cardiology written by Irene D. Turpie and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging Issues in Cardiology provides an overview of the practical clinical areas involved in managing cardiovascular disease in the elderly. This volume will be useful to any physician managing the cardiovascular health of elderly individuals. Topics covered include: -Delirium in Elderly Cardiac Patients, -Depression, - Pharmacologic Issues, - Primary Prevention, - Syncope, - Heart Failure, - Coronary Revascularization.
Book Synopsis Ryanodine Receptors by : Xander H. T. Wehrens
Download or read book Ryanodine Receptors written by Xander H. T. Wehrens and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the ryanodine receptor has emerged as a new and very promising target for the treatment of several cardiovascular disorders, including cardiac arrhythmias and heart failure. This volume is the most current publication devoted to the major intracellular calcium-release channel, the ryanodine receptor. "In this series of brief but informative chapters, the contributions progress from the basic gene family and primary structure, through its 3D structure so far, to its regulation and physiology." David E. Clapham, MD, PhD Professor of Neurobiology and Pediatrics Harvard Medical School Dr. Xander H.T. Wehrens received his M.D. and Ph.D. degrees from Maastricht University in the Netherlands. His research has mainly concentrated on molecular mechanisms of cardiac arrhythmias, in particular in the setting of inherited arrhythmogenic syndromes and congestive heart failure. This work has led to the development of novel anti-arrhythmic therapies. He is currently a research scientist in the Department of Physiology and Cellular Biophysics at the College of Physicians and Surgeons of Columbia University. Dr. Andrew R. Marks is the Chair and Professor of the Department of Physiology and Cellular Biophysics at Columbia University College of Physicians and Surgeons. Dr. Marks' research has focused on understanding how macromolecular signaling complexes regulate ion channel function in muscle and non-muscle systems, and on the regulation of vascular smooth muscle proliferation and migration. His work has contributed new understandings of fundamental mechanisms that regulate muscle contraction that have lead to the discovery of molecular defects that contribute to heart failure and fatal cardiac arrhythmias.
Book Synopsis Hypoxic Pulmonary Vasoconstriction by : Jason X.-J. Yuan
Download or read book Hypoxic Pulmonary Vasoconstriction written by Jason X.-J. Yuan and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complete reference on hypoxic pulmonary vasoconstriction and hypoxia-mediated pulmonary hypertension. Can be utilized by the physician-scientist and researcher in the laboratory as both a technical manual and reference. Designed for clinicians to guide and improve clinical treatment and diagnosis of patients with hypoxia mediated pulmonary vascular disease and right heart failure.
Book Synopsis Valve Surgery at the Turn of the Millennium by : C.H. Peels
Download or read book Valve Surgery at the Turn of the Millennium written by C.H. Peels and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses primarily on aortic and mitral valve disease. Special attention devoted to optimal timing and the role of echocardiography to assess prosthetic valve function and dysfunction. Discusses techniques for aortic valve surgery and choosing valve replacement devices. Part of the series: Developments in Cardiovascular Medicine
Download or read book The Pericardium written by Ralph Shabetai and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many noteworthy advances in our knowledge of the pericardium, its functions and diseases and their relation to heart failure have been made since the first edition of this book appeared in 1981; and no other book that covers in detail the physiology and pathophysiology has since been published. The first edition was favourably received, and I have frequently been asked to write a new edition. My own knowledge in the years that have passed since then, and my clinical and research experience in the field of the subject have both increased. For all these reasons, I decided that the second edition was overdue. The long time that has elapsed between editions necessitated rewriting, rather than simply revising, most of the text. For the same reason, many of the figures are new. Most of the references I have cited appeared in the literature after 1981, but I have retained a number of earlier ones, either because they are classics or, in my opinion, have not yet been bettered. It is my hope that the new edition will be a useful resource for clinicians called upon to manage patients with pericardial disease and for physiologists when the pericardium is relevant to their investigations. I make no apology for the in-depth treatment of the pericardial physiology and pathophysiology throughout the book, for they are the foundation on which diagnosis, hemodynamic and imaging studies, and management must rest.
Book Synopsis Implantable Defibrillator Therapy: A Clinical Guide by : Antonio Pacifico
Download or read book Implantable Defibrillator Therapy: A Clinical Guide written by Antonio Pacifico and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Implantable defibrillators as originally conceived by Michel Mirowski were limited to the detection and automatic termination of ventricular fibrillation. In the original "AID" device, the detection algoritlun sought to distinguish sinus rhytlun from ventricular fibrillation by identifying the "more sinusoidal waveform of ventricular fibrillation. " The therapeutic intervention was elicited only once deadly polymorphic rhythms had developed. It was rapidly learned, however, that ventricular fibrillation is usually preceded by ventricular tachycardia. Mirowski recognized the pivotal importance of developing algoritllms based on heart rate. Ventricular tachycardia detection allowed the successful development of interventions for the termination of ventricular tachyarrhythmias before they degenerated into ventricular fibrillation. Current device therapy no longer confines itself to tlle termination of chaotic rhythms but seeks to prevent them. Diagnostic algorithms moved upward along the chain of events leading to catastrophic rhytlulls. Rate smoothing algorithms were developed to prevent postextrasystolic pauses from triggering ventricular and atrial tachyarrhytlmlias. Beyond the renaissance of ectopy-centered strategies, long-term prevention received increasing attention. Multisite pacing therapies provided by "Arrhythmia Management Devices" were designed to reduce the "arrhytlunia burden" and optimize the synergy of cardiac contraction and relaxation. Clinical evidence now suggests that atrial fibrillation prevention by pacing is feasible and tllat biventricular pacing may be of benefit in selected patients with heart failure. However, these applications of device therapy that generally require ventricular defibrillation backup remain investigational and were not considered in this book.
