Capillary Electrophoresis Methods for Pharmaceutical Analysis

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Publisher : Elsevier
ISBN 13 : 0080559611
Total Pages : 546 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Capillary Electrophoresis Methods for Pharmaceutical Analysis by : Satinder Ahuja

Download or read book Capillary Electrophoresis Methods for Pharmaceutical Analysis written by Satinder Ahuja and published by Elsevier. This book was released on 2011-08-09 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) is a powerful analytical technique that is widely used in research and development and in quality control of pharmaceuticals. Many reports of highly efficient separations and methods have been published over the past 15 years. CE offers several advantages over high-pressure or high-performance liquid chromatography (HPLC). These include simplicity, rapid analysis, automation, ruggedness, different mechanisms for selectivity, and low cost. Moreover, EC requires smaller sample size and yet offers higher efficiency and thus greater resolution power over HPLC. These characteristics are very attractive in research and development, even more so in pharmaceutical quality control (QC) and stability monitoring (SM) studies. This book will provide busy pharmaceutical scientists a complete yet concise reference guide for utilizing the versatility of CE in new drug development and quality control.- Provides current status and future developments in CE analysis of pharmaceuticals.- Explains how to develop and validate methods.- Includes major pharmaceutical applications including assays and impurity testing.

Capillary Electrophoresis Methods for Pharmaceutical Analysis

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Author :
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 1584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Capillary Electrophoresis Methods for Pharmaceutical Analysis by : George Lunn

Download or read book Capillary Electrophoresis Methods for Pharmaceutical Analysis written by George Lunn and published by Wiley-Interscience. This book was released on 2000-02-21 with total page 1584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electrophoresis Techniques for Pharmaceutical Analysis at your fingertips-A complete, up-to-date library. This invaluable database--also available on CD-ROM--gives you fast, easy access to the growing literature on capillary electrophoresis (CE). Nearly 3,000 abstracts from approximately 900 publications make up this comprehensive library, listing CE techniques for the analysis of more than 700 active pharmaceutical compounds. From acarbose to mephobarbital to zopiclone--a number of procedures are grouped together for each compound. Detailed, precise information lets you replicate methods without referring to original articles as well as customize methods for specific needs. Features include: * Methods for drugs in biological fluids such as blood or urine as well as for bulk and formulated drugs * Name and structure of each target compound as well as molecular weight and formula, CAS registry numbers, and Merck index number * Experimental conditions for each method, including sample preparation, analytical matrix, capillary/capillary instrument model, capillary temperature, interfering compounds, and more * Bibliography of reviews of capillary electrophoresis procedures The CD-ROM additionally combines the four-volume HPLC Methods for Pharmaceutical Analysis with thousands of methods listed for more than 1,300 compounds. This immensely useful reference will save you countless hours of online and library research.

Analysis of Pharmaceuticals by Capillary Electrophoresis

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3322850110
Total Pages : 300 pages
Book Rating : 4.3/5 (228 download)

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Book Synopsis Analysis of Pharmaceuticals by Capillary Electrophoresis by : Kevin D. Altria

Download or read book Analysis of Pharmaceuticals by Capillary Electrophoresis written by Kevin D. Altria and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieser erste Titel einer ganzen Serie von anwendungsbezogenen Handbüchern zur Kapillarelektrophorese beschäftigt sich mit der Analytik von pharmazeutischen Substanzen. Dabei werden verschiedene Techniken praxisnah erläutert. Jeder, der im Labor - ob wissenschaftlich oder praxisnah - mit der Analyse von oft chiralen Pharmazeutika konfrontiert ist, wird viele Hinweise und Tips für seine Arbeit finden.USP: Einzige Monographie zur Analyse von Pharmazeutika mit CE This book describes the current state of the art for the analysis of pharmaceuticals by capillary electrophoresis and contains several hundred references to specific applications and methods. The main purpose of the book is to present the application possibilities of CE an therefore tabulated application data are provided. Chapters of the book are devoted to providing details of individual application areas such as chiral analysis, determination of drug related impurities, determination of drug counter-ions, drug residue monitoring and main component assay. An introductory chapter provides theoretical background to CE an related techniques. A chapter is dedicated to capillary electrochromatography which highlights the importance this technique currently possesses. Successful regulatory acceptance of CE methods is also described. A comprehensive chapter covers method validation aspects. Other chapters include discrete areas such as the use of non-aqueous solvents, forensic applications of CE, the application of experimental designs, determination of drugs in biofluids, and the analysis of vitamins by CE.

Capillary Electrophoresis Methods For Pharmaceutical Analysis

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Author :
Publisher :
ISBN 13 : 9788131219416
Total Pages : 529 pages
Book Rating : 4.2/5 (194 download)

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Book Synopsis Capillary Electrophoresis Methods For Pharmaceutical Analysis by : Ahuja

Download or read book Capillary Electrophoresis Methods For Pharmaceutical Analysis written by Ahuja and published by . This book was released on 2009-01-01 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Capillary Electrophoresis

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Author :
Publisher : CRC Press
ISBN 13 : 1351846736
Total Pages : 396 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Capillary Electrophoresis by : Suvardhan Kanchi

Download or read book Capillary Electrophoresis written by Suvardhan Kanchi and published by CRC Press. This book was released on 2017-08-21 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) has become an established method with widespread recognition as an analytical technique of choice in numerous analytical laboratories, including industrial and academic sectors. Pharmaceutical and biochemical research and quality control are the most important CE applications. This book provides a comparative assessment of related techniques on mode selection, method development, detection, and quantitative analysis and estimation of pharmacokinetic parameters and broadens the understanding of modern CE applications, developments, and prospects. It introduces the fundamentals of CE and clearly outlines the procedures used to mitigate several barriers, such as detection limits, signal detection, changing capillary environment, resolution separation of analytes, and hyphenation of mass spectrometry with CE, for a range of analytical problems. Each chapter outlines a specific electrophoretic variant with detailed instructions and some standard operating procedures. In this respect, the book meets its desired goal of rendering assistance to lovers of electrophoresis.

HPLC Methods for Pharmaceutical Analysis

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Author :
Publisher : Wiley-Interscience
ISBN 13 : 9780471331926
Total Pages : 0 pages
Book Rating : 4.3/5 (319 download)

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Book Synopsis HPLC Methods for Pharmaceutical Analysis by : George Lunn

Download or read book HPLC Methods for Pharmaceutical Analysis written by George Lunn and published by Wiley-Interscience. This book was released on 2000-01-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: HPLC and CE Methods for Pharmaceutical Analysis The complete, up-to-date library at the click of a mouse This invaluable database gives you fast, easy access to more than 13,000 abstracts from the current literature on HPLC and capillary electrophoresis (CE). Incorporating the four-volume HPLC Methods for Pharmaceutical Analysis plus the newly introduced Capillary Electrophoresis for Pharmaceutical Analysis, this CD-ROM features an extensive library of methods used in the analysis of most pharmaceutical compounds. It lists available HPLC techniques for more than 1,300 compounds and CE methods for more than 700 compounds, with a number of techniques described for each compound. Detailed, precise information lets you replicate methods without having to refer to the original publications as well as customize methods for very specific needs. You can instantly locate basic compound information--molecular weight and formula, CAS number, and Merck index number--plus experimental conditions for each method. Complex and substructure searching capabilities let you search the entire database by compound, matrix, HPLC variables, and author--saving you countless hours of online or library research. Minimum system requirements: * IBM-compatible PC 486 * Win95 or higher * CD-ROM drive * 8MB RAM * XXXMB free hard disk space Visit us on the Internet: www.wiley.com

Practical Capillary Electrophoresis

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Author :
Publisher : Academic Press
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Practical Capillary Electrophoresis by : Robert Weinberger

Download or read book Practical Capillary Electrophoresis written by Robert Weinberger and published by Academic Press. This book was released on 2000-02-16 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary zone electrophoresis : basic concepts -- Capillary zone electrophoresis : methods development -- Capillary zone electrophoresis : secondary equilibrium, micelles, cyclodextrins, and related reagents -- Capillary isoelectric focusing -- Size separations in capillary gels and polymer networks -- Capillary electrochromatography -- Injection -- Detection -- Putting it all together.

Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535106570
Total Pages : 211 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis by : Peter Mikuš

Download or read book Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis written by Peter Mikuš and published by BoD – Books on Demand. This book was released on 2012-08-29 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.

Capillary Electrophoresis

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Publisher : Elsevier
ISBN 13 : 0080858600
Total Pages : 615 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Capillary Electrophoresis by : S.F.Y. Li

Download or read book Capillary Electrophoresis written by S.F.Y. Li and published by Elsevier. This book was released on 1992-07-31 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Electrophoresis (CE) has had a very significant impact on the field of analytical chemistry in recent years as the technique is capable of very high resolution separations, requiring only small amounts of samples and reagents. Furthermore, it can be readily adapted to automatic sample handling and real time data processing. Many new methodologies based on CE have been reported. Rapid, reproducible separations of extremely small amounts of chemicals and biochemicals, including peptides, proteins, nucleotides, DNA, enantiomers, carbohydrates, vitamins, inorganic ions, pharmaceuticals and environmental pollutants have been demonstrated. A wide range of applications have been developed in greatly diverse fields, such as chemical, biotechnological, environmental and pharmaceutical analysis.This book covers all aspects of CE, from the principles and technical aspects to the most important applications. It is intended to meet the growing need for a thorough and balanced treatment of CE. The book will serve as a comprehensive reference work. Both the experienced analyst and the newcomer will find the text useful.

Capillary Electrophoresis: Principles and Practice

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Publisher : Springer Science & Business Media
ISBN 13 : 364278058X
Total Pages : 381 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Capillary Electrophoresis: Principles and Practice by : Reinhard Kuhn

Download or read book Capillary Electrophoresis: Principles and Practice written by Reinhard Kuhn and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis (CE) is a brand-new analytical me- thod with the capability of solving many analytical separa- tion problems very fast and economically. This method gives new information about the investigated substances which can- not easily be obtained by other means. CE has become an established method only recently, but will be implemented in almost every analytical laboratory in industry, service units and academia in the near future. The most important fields of CE application are pharmaceutical and biochemical research and quality control. The authors have exhaustive practical experience in the application of CE methods in the pharmaceutical industry and provide the reader with a comprehensive treatment of this method. The main focus is on how to solve problems when applying CE in the laboratory. Physico-chemical theory is only dealt with in depth when necessary to understand the underlying separation mechanisms in order to solve your problems at the analytical bench. An addendum includes tables on the preparation of buffers and recommended further reading.

Pharmaceutical and Biomedical Applications of Capillary Electrophoresis

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Publisher : Elsevier
ISBN 13 : 0080538711
Total Pages : 523 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Pharmaceutical and Biomedical Applications of Capillary Electrophoresis by : S.M. Lunte

Download or read book Pharmaceutical and Biomedical Applications of Capillary Electrophoresis written by S.M. Lunte and published by Elsevier. This book was released on 1996-08-13 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes the theory and applications of Capillary Electrophoresis (CE) in the field of pharmaceutical and biomedical analysis. It is targeted towards users who are intimately involved in analytical problems, especially those which involve small samples. This book presents the technique of capillary electrophoresis from the point of view of the serious hands-on use in the field of pharmaceutical and biomedical analysis. An overview of general theory is presented to acquaint the novice with the fundamental principles. A more theoretical approach is taken in the presentation of electrokinetic chromatography. The next chapter discusses advances in column technologies, the preceding chapters having provided a foundation as to how separations occur. In the next three chapters, recognized experts in their fields present fundamentals and state-of-the-art techniques in the areas of optical, electrochemical and mass spectrometric detection. The major focus of the remaining chapters is on applications. This includes the analysis of pharmaceuticals, amino acids and peptides, macromolecules, nucleosides, nucleotides and oligonucleotides. The use of CE for analysis of small ions and separation of biological particles is also discussed. The issue of sample preparation for analysis by CE is addressed, especially as it relates to clinical analysis.

Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics

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Author :
Publisher : CRC Press
ISBN 13 : 0203912136
Total Pages : 392 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics by : Reinhard H. H. Neubert

Download or read book Affinity Capillary Electrophoresis in Pharmaceutics and Biopharmaceutics written by Reinhard H. H. Neubert and published by CRC Press. This book was released on 2003-01-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference presents the most recent breakthroughs and techniques in affinity capillary electrophoresis (ACE) to measure and determine the physicochemical and thermodynamic parameters of drug compounds. The authors offer strategies to explore and characterize interactions between drugs, drug vehicles, and biological membranes to facilitate devel

Employing Capillary Electrophoresis as a Separation Method for Pharmaceutical Analysis

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Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (591 download)

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Book Synopsis Employing Capillary Electrophoresis as a Separation Method for Pharmaceutical Analysis by : Laura L. Lessard

Download or read book Employing Capillary Electrophoresis as a Separation Method for Pharmaceutical Analysis written by Laura L. Lessard and published by . This book was released on 2004 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary electrophoresis as a technique has many applications in a broad range of fields including forensics, environmental analysis, and biological analysis and as a separation method for samples such as oligonucleotides, peptides, proteins, and pharmaceuticals. The research conducted herein is for the antibiotic pharmaceutical ciprofloxacin HCl and three impurities. Sample stacking was used to overcome the poor limits of detection generally associated with CE, which successfully improved the limits of detection when compared to results from a previous feasibility study. This thesis encompasses three stages: method development, limit of detection determination, and proof of successful method development by analysis of tablets of ciprofloxacin. The method developed is reproducible, yields high resolution, and provides intense signals with respect to the detection generally achievable with capillary electrophoresis. The limits of detection of the impurities were determined to be below 0.05% (by concentration) of that of the active ingredient, and a brief tablet analysis showed that formulated tablets could be analyzed with this method.

Capillary Electrophoresis

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Publisher : Springer Science & Business Media
ISBN 13 : 1588295397
Total Pages : 808 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Capillary Electrophoresis by : Philippe Schmitt-Kopplin

Download or read book Capillary Electrophoresis written by Philippe Schmitt-Kopplin and published by Springer Science & Business Media. This book was released on 2008-02-25 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a selection of current capillary electrophoresis methods used to separate representative types of molecules and particles and in combination with different detection techniques. It includes practical details which are hard to find elsewhere. The volume is intended for beginners in the field and provides an overview of the technique and a starting point for the exploration of the defined literature on different application topics.

Capillary Gel Electrophoresis

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Publisher : Newnes
ISBN 13 : 0080931359
Total Pages : 391 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Capillary Gel Electrophoresis by : Andras Guttman

Download or read book Capillary Gel Electrophoresis written by Andras Guttman and published by Newnes. This book was released on 2021-12-04 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary Gel Electrophoresis and Related Microseparation Techniques covers all theoretical and practical aspects of capillary gel electrophoresis. It also provides an excellent overview of the key application areas of nucleic acid, protein and complex carbohydrate analysis, affinity-based methodologies, micropreparative aspects and related microseparation methods. It not only gives readers a better understanding of how to utilize this technology, but also provides insights into how to determine which method will provide the best technical solutions to particular problems. This book can also serve as a textbook for undergraduate and graduate courses in analytical chemistry, analytical biochemistry, molecular biology and biotechnology courses. - Covers all theoretical and practical aspects of capillary gel electrophoresis - Excellent overview of the key applications of nucleic acid, protein and complex carbohydrate analysis, affinity-based methodologies, micropreparative aspects and related microseparation methods - Teaches readers how to use the technology and select methods that are ideal for fundamental problems - Can serve as a textbook for undergraduate and graduate courses in analytical chemistry, analytical biochemistry, molecular biology and biotechnology courses

Handbook of Capillary Electrophoresis Applications

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Publisher : Springer Science & Business Media
ISBN 13 : 9400915616
Total Pages : 750 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Handbook of Capillary Electrophoresis Applications by : H. Shintani

Download or read book Handbook of Capillary Electrophoresis Applications written by H. Shintani and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 750 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decade, high performance Capillary electrophoresis (HPCE) has emerged as a powerful and versatile separation technique that promises to rival high performance liquid chromatography when applied to the separation of both charged and neutral species. The high speed and high separation efficiency which can be attained using any of the various modes of HPCE has resulted in the increased use of the technique in a range of analytical environments. The procedures are, however, still in the early stages of development and several barriers remain to their adoption as the technique of choice for a range of analytical problems. One such barrier is the selection and optimization of the conditions required to achieve reproducible separations of analytes and it is in this area that this new book seeks to give assistance. The book is written by an international team of authors, drawn from both academic and industrial users, and the manufacturers of instruments. At its heart are a number of tables, divided into specific application areas. These give details of published separations of a wide range of archetypal analytes, the successful separation conditions and the matrix in which they were presented. These tables are based on separations reported since 1992 and are fully referenced to the original literature. The tables are supported by discussions of the problems that a particular area presents and the strategies and solutions adopted to overcome them. The general areas covered are biochemistry, pharmaceutical science, bioscience, ion analysis, food analysis and environmental science.

Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis

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Publisher :
ISBN 13 : 9789155479961
Total Pages : 64 pages
Book Rating : 4.4/5 (799 download)

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Book Synopsis Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis by : Anisa Elhamili

Download or read book Development of Capillary Electrophoresis Methods Coupled to Mass Spectrometry for Biomedical and Pharmaceutical Analysis written by Anisa Elhamili and published by . This book was released on 2011 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: