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Cancer Immunosurveillance
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Book Synopsis Cancer Immunosurveillance by : Alejandro López-Soto
Download or read book Cancer Immunosurveillance written by Alejandro López-Soto and published by Humana Press. This book was released on 2018-11-22 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest techniques used to study tumor immunology. The chapters in this book detail methodologies for functional analysis and expansion of T lymphocytes for cancer research. The chapters also cover topics such as how single-cell RNA-sequencing can be exploited to dissect immune cell heterogeneity and precursors; isolating and expanding natural killer (NK) cells; evaluating NK cell-mediated anti-tumor killing activity in vitro; immunosurveillance orchestrated by specific immune subsets; use of HLA peptidomics for cancer-exome based identification of tumor neo-antigens; gold standard assessment of immunogenic cell death in oncological mouse models and methods to look at the therapeutic relevance of immune modulation in cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Cancer Immunosurveillance: Methods and Protocols is a valuable resource to aid researchers in better understanding and experimenting in this exciting and developing field.
Book Synopsis Immunological Surveillance by : Macfarlane Burnet
Download or read book Immunological Surveillance written by Macfarlane Burnet and published by Elsevier. This book was released on 2014-05-17 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunological Surveillance
Book Synopsis Cancer Immunotherapy by : Kenneth F. May
Download or read book Cancer Immunotherapy written by Kenneth F. May and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 29 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay of innate and adaptive antitumor immunity dictates the intensity and outcome of the endogenous anticancer response. Stress-induced molecules on tumor cells trigger innate immune reactions, whereas the processing and presentation of tumor-associated antigens evokes adaptive immune recognition. Innate and adaptive antitumor responses may impact tumor development in different ways. In some cases, endogenous reactions suppress tumor formation, while exerting a selective pressure that fosters the emergence of escape variants. Alternatively, some host responses promote tumor cell growth, invasion, and metastasis through the elaboration of inflammatory mediators and cytokines. Investigations have uncovered unique and overlapping roles for innate and adaptive anti tumor immunity, revealing a complex network of interactions among tumor cells, immune elements, and stromal components within the tumor microenvironment, which together shape the direction, quality, and dynamics of the anticancer response.
Book Synopsis Cancer Immunotherapy by : Michele W.L. Teng
Download or read book Cancer Immunotherapy written by Michele W.L. Teng and published by Elsevier Inc. Chapters. This book was released on 2013-06-04 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1957 Burnet and Thomas formulated the cancer immunosurveillance theory by hypothesizing that lymphocytes act as sentinels in recognizing and eliminating continuously arising, nascent transformed cells. Cancer immunosurveillance is one of several important host protection processes that inhibit carcinogenesis and maintain regular cellular homeostasis. More recently, it has been proposed that immunosurveillance primarily functions as a component of a more general process of cancer immunoediting, which involves three phases, elimination (surveillance), equilibrium and escape. These stages have largely been formulated on the basis of experimental data accumulated in mice over the past decade. In parallel, convincing correlative clinical data from human patients have provided unequivocal evidence that cells of the immune system, both innate and adaptive, are required for prevention of cancer. This chapter summarizes the principles of cancer immunoediting and focuses on the relevant clinical data that best support the role of immunity in cancer initiation, growth and spread.
Book Synopsis Immune Surveillance by : Richard T. Smith
Download or read book Immune Surveillance written by Richard T. Smith and published by Elsevier. This book was released on 2012-12-02 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immune Surveillance deals with the issues regarding tumor immunology and surveillance, in which the central theme is all about the life span of the mammalian host that is depleted by the environment with mutagenic agents and solutions. The book is divided into six chapters. It includes discussions on the organization and modulation of cell membrane receptors, as well as the origin and expression of membrane antigens. It also covers the topics on the triggering mechanisms for and effector mechanisms activated by the cellular recognition. These topics analyze and evaluate alternatives for the recognition and destruction mechanisms in the knowledge of cell cooperation and requirements for immune recognition. A chapter provides discourse on a solution for the paradox of thriving tumors based on the demonstrable in vitro host immunity. Another discusses the generation of antibody diversity and the theory of self-tolerance. The last chapter explains the evaluation of the evidence for immune surveillance. This reference will be invaluable to those who specialize in immunology.
Book Synopsis Cancer Immunology and Immunotherapy by : Mansoor M. Amiji
Download or read book Cancer Immunology and Immunotherapy written by Mansoor M. Amiji and published by Elsevier. This book was released on 2021-08-27 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. Nanotechnology-based targeted delivery strategies could improve the delivery efficiency of IO agents as well as provide additional avenues for novel therapeutic and vaccination strategies. Additionally, a number of locally-administered immunogenic scaffolds and therapeutic strategies, such as the use of STING agonist, could benefit from rationally designed biomaterials and delivery approaches. Delivery Technologies for Immuno-Oncology: Volume 1: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Comprehensive treaty covering all aspects of immuno-oncology (IO) Novel strategies for delivery of IO therapeutics and vaccines Forecasting on the future of nanotechnology and drug delivery for IO
Book Synopsis Cytokine Networks and Immunosurveillance in Cancer by : Timothy Chao
Download or read book Cytokine Networks and Immunosurveillance in Cancer written by Timothy Chao and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytokine milieu in the tumor microenvironment plays a key role in modulating the immune response either in favor of or against tumorigenesis. For many tumors, this complex network of cytokine and immune interactions represent a formidable means of escape from immune surveillance. These cytokine networks are particularly important in pancreatic ductal adenocarcinoma (PDA), where a prominent infiltration of immunosuppressive immune populations could be found. Myeloid-derived suppressor cells (MDSCs) have previously been shown to be potent suppressors of anti-tumor immunity in PDA, but the cytokine networks regulating their recruitment to the tumor microenvironment remain incompletely understood. Here, I found that CXCR2 ligand expression is specifically correlated with enrichment of the granulocytic subset of MDSCs (G-MDSCs) in human PDAs. Using a genetically engineered mouse model of PDA, I showed that CXCR2 is required for G-MDSC trafficking to the tumor microenvironment, but not necessary for their systemic differentiation and expansion. The specific lack of G-MDSCs in the tumor microenvironment led to a T cell-dependent inhibition of tumor growth. Expression of CXCR2 ligands in PDA tumor cells can be potently induced by NF-?B activation. These findings describe a cytokine network in PDA where inflammatory signals in the tumor microenvironment drive the expression of CXCR2 ligands and the recruitment of immunosuppressive G-MDSCs. To discover other potentially important cytokine networks, I developed a novel analysis pipeline to reconstruct and compare cytokine networks from whole tumor gene expression data. Using expression of cytolytic genes as a gauge for anti-tumor immune activity, I found that PDA patients with high cytolytic activity have a slight survival advantage compared to those with lower activity. While macrophages were the most influential in tumors with low cytolytic activity, tumors with high cytolytic activity were characterized by increased activity of NK cells, recruitment of B cells, and increased importance of CD8 T cells, CD4 T helper cells, and B cells, among others. I further highlighted the cytokines that might be associated with these immune populations. Therefore, my analysis identified potentially important components of the cytokine network associated with high and low cytolytic activity. Collectively, the work in this thesis suggests that cytokine networks are crucial for maintaining an immunosuppressive microenvironment in cancer. Furthermore, disrupting key components of these networks can tip the balance in favor of cancer immunosurveillance.
Book Synopsis The Biology of Cancer by : Weinberg, Robert A.
Download or read book The Biology of Cancer written by Weinberg, Robert A. and published by W.W. Norton & Company. This book was released on 2013-05-24 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Incorporating the most important advances in the fast-growing field of cancer biology, the text maintains all of its hallmark features. It is admired by students, instructors, researchers, and clinicians around the world for its clear writing, extensive full-color art program, and numerous pedagogical features.
Book Synopsis Rheumatology and Immunology Therapy by : Larry W. Moreland
Download or read book Rheumatology and Immunology Therapy written by Larry W. Moreland and published by Springer Science & Business Media. This book was released on 2004-07-20 with total page 933 pages. Available in PDF, EPUB and Kindle. Book excerpt: Entries in a practical A to Z Format Highly therapy-focused Uniform and clearly arranged entries for ease of reference Comprehensive information on symptoms and therapeutical possibilities of rheumatologic and musculoskeletal diseases as well as drugs Written by leading experts in the field
Book Synopsis Interaction of Immune and Cancer Cells by : Magdalena Klink
Download or read book Interaction of Immune and Cancer Cells written by Magdalena Klink and published by Springer Nature. This book was released on 2022-02-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now, it its second edition, this book summarizes the role of immune cells in tumor suppression and progression. It describes in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. A newly added chapter also focuses on the role of Natural Killer cells in tumor progression. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for researchers and practitioners working or lecturing in the field of cancer research and immunology.
Book Synopsis Tumor Immunosurveillance by Natural Killer Cells by : Rayna Takaki Venook
Download or read book Tumor Immunosurveillance by Natural Killer Cells written by Rayna Takaki Venook and published by . This book was released on 2006 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer cells are an integral component of the innate immune response that can quickly detect and eliminate infected or transformed cells without requiring prior sensitization. It has been demonstrated that NK cells play an important role in tumor immunosurveillance; however, the mechanisms regulating NK cell anti-tumor activity are still not well defined. The work presented in this thesis examines the effects of E1A-mediated transformation, interleukin-2I (IL-21) treatment, and DAP 12-mediated signaling on NK cell-mediated tumor rejection.
Book Synopsis Cancer Immunoprevention by : Florencia McAllister
Download or read book Cancer Immunoprevention written by Florencia McAllister and published by Humana. This book was released on 2022-01-07 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides methods and techniques to further the study of cancer immunoprevention. Chapters describe tumor-associated antigens, cancer immune-preventive vaccines, generation of TILs, development of monoclonal antibodies, immunoprofiling technologies, tissue multispectral imaging techniques, mass cytometry on suspensions, mutiparametric flow cytometry, genomic expression analysis, and proteomic profiling of tumor microenvironment cell populations and metabolic assessment through novel imaging technologies. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Cancer Immunoprevention: Methods and Protocol aims to further understanding, development of interventional active strategies, and immune-interception of cancer.
Download or read book つくって食べよう written by and published by . This book was released on 1986 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Immunology written by Nima Rezaei and published by . This book was released on 2020 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.
Book Synopsis Immune Mediated Diseases by : Michael R Shurin
Download or read book Immune Mediated Diseases written by Michael R Shurin and published by Springer Science & Business Media. This book was released on 2007-09-23 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions from the speakers of the Second IMD Congress (September 10-15, 2007; Moscow, Russia) who were eager to share some of the academic and clinical enthusiasm that defines the IMD meetings. The goal of the International Immune-Mediated Diseases: From Theory to Therapy (IMD) Congress is to bring the world’s best immunologists and clinicians to Moscow.
Book Synopsis Immunoediting, Immunosurveillance, Tumor-induced Immunosuppression and Immunoresistance, Immunomodulation, Immunotherapy, and Immunonutrition in Personalized and Precision Cancer Medicine by : John N. Giannios
Download or read book Immunoediting, Immunosurveillance, Tumor-induced Immunosuppression and Immunoresistance, Immunomodulation, Immunotherapy, and Immunonutrition in Personalized and Precision Cancer Medicine written by John N. Giannios and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer immunoediting is composed of three phases: elimination, equilibrium, and escape. Tumor cells, which successfully navigate these phases, are capable of evading destruction by the immunity system of the host. Furthermore, there are different types of nonimmune surveillance against tumors, including genetic surveillance, which is based on DNA repair and checkpoint control, intracellular surveillance related to apoptosis or type I PCD, intercellular surveillance linked to the tumor microenvironment, and epigenetic surveillance related to the structure of chromatin, and specifically the stringency of imprinting. Circumventing immune destruction is one of the hallmarks of cancer pathogenesis, in addition to evading growth suppressors, deregulating cellular energetics, enabling replicative immortality, inducing angiogenesis, activating invasion and metastasis, sustaining proliferative signaling, and resisting cell death, which may lead to the uncontrollable promotion of tumor burden at the expense of the immune system. Although immunoediting may eliminate tumor cells with alterations in their antigenic epitope profile, many immunoresistant variants escape from the immune system of the host by various immunosuppressive molecular and cellular mechanisms. There are many immunomodulatory effects of targeted therapies that can circumvent tumor-mediated immunosuppression, improving the effector T-cell function, which enhances eradication of targeted tumors. Another even more efficient antitumor strategy consists of combining targeted therapies with immunotherapies, which exert many antitumor synergies. The subsequent complex interplay of targeted anticancer agents and immunotherapy may sensitize tumor cells to immune-mediated eradication with long-lasting immunotherapeutic effects, which may inhibit induction of tumor dormancy. These combinatorial immunotherapies with targeted therapies can be used as neoadjuvants and adjuvant treatments with conventional anticancer strategies, such as surgical debulking, radiation therapy, and chemotherapy. In conventional anticancer treatment, the chemotherapeutic-induced immunosuppression inhibits the anticancer efficiency of cell therapies, which are based on activated lymphocytes for eradication of tumor cells, enhancing susceptibility to infections. The majority of conventional chemotherapeutic agents interfere with hematopoiesis and subsequently with the immune system, affecting the surveillance of cancer cells leading to the promotion of tumor development and growth. Furthermore, cancer surgery causes tremendous alterations in the neuroendocrine, metabolic, and immune systems constituting the stress response, which may lead to infection and cancer recurrence. Generally by using an integrative medicine immunotherapeutic approach, where alternative medicine practice which follows a multitargeted and bidirectional regulation may compensate for deficiencies of conventional orthodox western medicine, which is characterized by specificity, we may achieve a synergistic effect concerning circumvention of tumor-induced immunosuppression and enhancement of antitumor immunomodulation followed by minimization or elimination of side effects, prolonging the survival rate of advanced stage and metastatic cancer patients promoting their quality of life. The key is to treat each cancer patient under a personalized evidence-based medicine approach, which must rely on clinomics, including transcriptomics, genomics, immunomics, lipidomics, glycomics, proteomics, metabolomics, nutrigenomics, and mainly epigenomics whose alterations in their noncoding RNA genes are reversible especially with immunonutrition. The precise immunotherapeutic approach against cancer may act synergistically with conventional anticancer therapies, such as surgery, chemotherapy, and radiotherapy combined with therapies based on molecular targeting, which are tailored for each patient on a pharmacogenomic basis, and they can be combined with nanomedicine for specific molecular targeting and circumvention of biological milieu interactions, which may enhance tremendously therapeutic efficacy with simultaneous reduction of systemic toxicity.
Book Synopsis Innate Immune Regulation and Cancer Immunotherapy by : Rong-Fu Wang
Download or read book Innate Immune Regulation and Cancer Immunotherapy written by Rong-Fu Wang and published by Springer Science & Business Media. This book was released on 2012-02-02 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.
