Cancer Chemopreventive Agents

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Holland-Frei Cancer Medicine

Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Natural Products for Cancer Chemoprevention

Author : John M. Pezzuto
Publisher : Springer Nature
ISBN 13 : 3030398552
Total Pages : 639 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Natural Products for Cancer Chemoprevention by : John M. Pezzuto

Download or read book Natural Products for Cancer Chemoprevention written by John M. Pezzuto and published by Springer Nature. This book was released on 2020-04-03 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

Cancer Chemoprevention

Author : Gary J. Kelloff
Publisher : Springer Science & Business Media
ISBN 13 : 159259767X
Total Pages : 998 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cancer Chemoprevention by : Gary J. Kelloff

Download or read book Cancer Chemoprevention written by Gary J. Kelloff and published by Springer Science & Business Media. This book was released on 2004-06-04 with total page 998 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM in pocket at end of v. 2 contains a compact e-book version of v. 2.

Pharmacotherapeutic Botanicals for Cancer Chemoprevention

Author : Manish Kumar
Publisher : Springer Nature
ISBN 13 : 9811559996
Total Pages : 344 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Pharmacotherapeutic Botanicals for Cancer Chemoprevention by : Manish Kumar

Download or read book Pharmacotherapeutic Botanicals for Cancer Chemoprevention written by Manish Kumar and published by Springer Nature. This book was released on 2020-07-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

Protease Inhibitors as Cancer Chemopreventive Agents

Author : A.R. Kennedy
Publisher : Springer Science & Business Media
ISBN 13 : 1461528828
Total Pages : 434 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Protease Inhibitors as Cancer Chemopreventive Agents by : A.R. Kennedy

Download or read book Protease Inhibitors as Cancer Chemopreventive Agents written by A.R. Kennedy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protease inhibitors (PIs) are widely distributed in plants and animals, and have a variety of functions, which include preventing digestion of seeds by insects and modifying blood clotting in animals. After it was noted that synthetic and natural inhibitors suppress two-stage carcinogenesis and breast cancer, extensive work investigating PIs as chemopreventive agents was started. PIs are unique in that they interfere with cancer development in a variety of ways, including suppression of oxygen radicals, oncogenes, and metastases. Epidemiologic evidence supports their prevention of major human cancers in populations that consume foods containing them. Their supervised use in humans is on the threshold of development. The epidemiologic discovery of the importance of lentils and other seeds rich in PIs in preventing many human cancers allowed us to look at the action of PIs as chemopreventive agents, as reviewed in Chapter I (Fontham and Correa). Chapter 2 (Kennedy) discusses the role of natural PIs (e. g. , the Bowman-Birk inhibitor) as anticarcinogens and the possible limitations of their use. In Chapter 3 (Kennedy), the transformation of C3HI lOTlh cells caused by carcinogens and promoters is shown to be suppressed by PIs. Bowman (Chapter 4) relates the discovery of inhibitors in soybeans that are distinct from the Kunitz inhibitor, and the occurrence of a similar inhibitor in peanuts and other legumes. Chapter 5 (Birk) is an overview of PIs of plant origin and their role in human nutrition.

Role of Nutraceuticals in Cancer Chemosensitization

Author :
Publisher : Academic Press
ISBN 13 : 0128123745
Total Pages : 400 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Role of Nutraceuticals in Cancer Chemosensitization by :

Download or read book Role of Nutraceuticals in Cancer Chemosensitization written by and published by Academic Press. This book was released on 2017-10-18 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Role of Nutraceuticals in Chemoresistance to Cancer, Volume Two, focuses on nutraceuticals, the compounds derived from natural sources, which are usually multi-targeted as a means to overcome chemoresistance. This book discusses the role of several compounds related to nutraceuticals and chemoresistance, such as curcumin, resveratrol, indole 3-carbinol, tocotrienols, ursolic acid, fisetin, celastrol, gambogic, butein, catechins and silymarin. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use nutraceuticals as a sensitizing agent for chemotherapy. Brings updated information on natural compounds used as specific inhibitors of cell signaling pathways as reviewed by experts in the field Presents experts analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches for the readers to use in their own investigations

Cancer Chemoprevention

Author : Gary J. Kelloff
Publisher : Springer Science & Business Media
ISBN 13 : 1592597688
Total Pages : 537 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cancer Chemoprevention by : Gary J. Kelloff

Download or read book Cancer Chemoprevention written by Gary J. Kelloff and published by Springer Science & Business Media. This book was released on 2008-08-17 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant advances in cancer treatment and measures of neoplastic progression, drug effect (or early detection, overall cancer incidence has increased, pharmacodynamic markers), and markers that measure cancer-associated morbidity is considerable, and overall prognosis as well as predict responses to specific therapy. cancer survival has remained relatively flat over the past All these biomarkers have the potential to greatly augment several decades (1,2). However, new technology the development of successful chemoprevention therapies, allowing exploration of signal transduction pathways, but two specific types of biomarkers will have the most identification of cancer-associated genes, and imaging of immediate impact on successful chemopreventive drug tissue architecture and molecular and cellular function is development—those that measure the risk of developing increasing our understanding of carcinogenesis and cancer invasive life-threatening disease, and those whose mo- progression. This knowledge is moving the focus of cancer lation can “reasonably predict” clinical benefit and, therapeutics, including cancer preventive treatments, to therefore, serve as surrogate endpoints for later-occurring drugs that take advantage of cellular control mechanisms clinical disease. Thus far, the biomarker that best measures to selectively suppress cancer progression. these two phenomena is intraepithelial neoplasia (IEN) Carcinogenesis is now visualized as a multifocal, because it is a near obligate precursor to cancer.

Discovery and Development of Anti-Breast Cancer Agents from Natural Products

Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128212780
Total Pages : 386 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Discovery and Development of Anti-Breast Cancer Agents from Natural Products by : Goutam Brahmachari

Download or read book Discovery and Development of Anti-Breast Cancer Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-06-24 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields. Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. Highlights active agents from natural sources for development as novel anti-cancer agents Features contributions from active researchers and leading experts working in the field Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Medicinal Chemistry of Anticancer Drugs

Author : Carmen Avendaño
Publisher : Elsevier
ISBN 13 : 0444626670
Total Pages : 767 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. Presents information in a clear and concise way using a large number of figures Historical background provides insights on how the process of drug discovery in the anticancer field has evolved Extensive references to primary literature

Discovery and Mechanistic Evaluation of Early Stage Cancer Chemopreventive Agents

Author : Lynda Li Song
Publisher :
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.:/5 (468 download)

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Book Synopsis Discovery and Mechanistic Evaluation of Early Stage Cancer Chemopreventive Agents by : Lynda Li Song

Download or read book Discovery and Mechanistic Evaluation of Early Stage Cancer Chemopreventive Agents written by Lynda Li Song and published by . This book was released on 2000 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phytochemistry of Medicinal Plants

Author : John T. Arnason
Publisher : Springer Science & Business Media
ISBN 13 : 1489917780
Total Pages : 369 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Phytochemistry of Medicinal Plants by : John T. Arnason

Download or read book Phytochemistry of Medicinal Plants written by John T. Arnason and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytochemicals from medicinal plants are receiving ever greater attention in the scientific literature, in medicine, and in the world economy in general. For example, the global value of plant-derived pharmaceuticals will reach $500 billion in the year 2000 in the OECD countries. In the developing countries, over-the-counter remedies and "ethical phytomedicines," which are standardized toxicologically and clinically defined crude drugs, are seen as a promising low cost alternatives in primary health care. The field also has benefited greatly in recent years from the interaction of the study of traditional ethnobotanical knowledge and the application of modem phytochemical analysis and biological activity studies to medicinal plants. The papers on this topic assembled in the present volume were presented at the annual meeting of the Phytochemical Society of North America, held in Mexico City, August 15-19, 1994. This meeting location was chosen at the time of entry of Mexico into the North American Free Trade Agreement as another way to celebrate the closer ties between Mexico, the United States, and Canada. The meeting site was the historic Calinda Geneve Hotel in Mexico City, a most appropriate site to host a group of phytochemists, since it was the address of Russel Marker. Marker lived at the hotel, and his famous papers on steroidal saponins from Dioscorea composita, which launched the birth control pill, bear the address of the hotel.

Cancer Chemopreventive Agents

Author : Gary Kelloff
Publisher :
ISBN 13 :
Total Pages : 276 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Cancer Chemopreventive Agents by : Gary Kelloff

Download or read book Cancer Chemopreventive Agents written by Gary Kelloff and published by . This book was released on 1995 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Chemoprevention

Author : Raymond C. Bergan
Publisher : Springer
ISBN 13 : 9781461356639
Total Pages : 0 pages
Book Rating : 4.3/5 (566 download)

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Book Synopsis Cancer Chemoprevention by : Raymond C. Bergan

Download or read book Cancer Chemoprevention written by Raymond C. Bergan and published by Springer. This book was released on 2012-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a broad overview of topics related to cancer chemoprevention. It provides a review of topics ranging from basic research arenas to clinical trial design, implementation, and interpretation. It covers all key areas necessary for understanding the field of cancer chemoprevention for the interested reader, for individuals wishing to enter this area of investigation, and for individuals seeking guidance in particular areas of research, relating to agent identification, basic science investigations and clinical trials. The genesis of this book is based on the fact that cancer chemoprevention is a relatively new and rapidly evolving field spanning a wide array of disciplines, and forces researchers to address difficult and complex questions whose answers are not readily available. Cancer Chemoprevention provides a ready resource whose importance and intent lie in its ability to gather and solidify disparate data to explicitly outline areas of difficulty and to highlight future areas of important development. It provides broad outlines for current, ongoing and future directions in this area with various target organ sites, written by experts in their respective fields, whose primary research focuses upon that individual field.

Cancer Chemoprevention and Treatment by Diet Therapy

Author : William C.S. Cho
Publisher : Springer Science & Business Media
ISBN 13 : 940076443X
Total Pages : 323 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Cancer Chemoprevention and Treatment by Diet Therapy by : William C.S. Cho

Download or read book Cancer Chemoprevention and Treatment by Diet Therapy written by William C.S. Cho and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading killers in the world and the incidence is increasing, but most cancer patients and cancer survivors suffer much from the disease and its conventional treatments’ side effects. In the past, clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities, but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence. There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field. With this aim, a book series is needed to structurally deliver the knowledge to readers. Throughout the past few years, the cancer chemopreventive potencies and treatment effects of a number of natural dietary agents present in different food sources have been evaluated by various experiments. Some of them have progressed to early clinical trials. This volume is a specialized book presenting the research evidence relevant to the use of specific diet therapy in cancer chemoprevention and treatment. We begin with lessons learned from dietary resveratrol as an effective agent with anticancer properties against malignancies, followed examples of flavonoids from fruits and vegetables in the prevention and treatment of cancer. Evidence for the beneficial influence of diet enriched with flax seed oil and green tea on cancer will be reviewed. Soy food intake may enhance the effects on anticancer treatment for breast cancer, whereas lycopene-rich foods may possess chemopreventive efficacy. There are also discussions on the contribution of the cancer preventive effects of the antioxidant-rich foods and Mediterranean diet. In addition, the modulation of proteasome pathways by nutraceuticals is highlighted. Finally, we close the book with a discussion on the attenuation of cell survival signaling by bioactive phytochemicals in the prevention and therapy cancer.

Cancer Chemoprevention Agents

Author :
Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.:/5 (321 download)

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Book Synopsis Cancer Chemoprevention Agents by :

Download or read book Cancer Chemoprevention Agents written by and published by . This book was released on 1998 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Chemoprevention

Author : Ernest T. Hawk
Publisher :
ISBN 13 :
Total Pages : 543 pages
Book Rating : 4.:/5 (19 download)

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Book Synopsis Cancer Chemoprevention by : Ernest T. Hawk

Download or read book Cancer Chemoprevention written by Ernest T. Hawk and published by . This book was released on 2005 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much progress has been made in discovering and developing agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. In Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention, leading chemopreventives investigators comprehensively describe the exciting methodologies that are accelerating progress in the chemoprevention field and review the state of clinical development of preventive agents in the major human cancer target organs. The authors provide sound guidelines for cancer chemopreventive drug development, detailing general strategies and methods for drug discovery, preclinical efficacy, characterization of precancers, safety evaluation of clinical cohorts, and clinical trial design. Additional chapters address strategies for and the status of chemopreventive agent development in multiple myeloma and cancers of the prostate, breast, lung, colon, bladder, head and neck, esophagus, pancreas, ovary, endometrium, cervix, skin, and liver. The emphasis is on documenting the characterization and application of reliable biomarkers during chemopreventive drug development. Highlights include an elegant approach to identifying chemopreventive agents in natural products, the development of preclinical models for evaluating potential chemopreventive agents, the genomics and proteomics of potential applications, and approaches for determining which populations will likely benefit from chemopreventive intervention. A companion volume, Promising Cancer Chemopreventive Agents, comprehensively surveys those agents that have promise, or have already been successfully used, to treat precancerous conditions or inhibit carcinogenesis. A value-added compact disk containing a companion ebook version of Cancer Chemoprevention, Volume 2: Strategies for Cancer Chemoprevention is included for downloading and use in the reader's PC or PDA. Up-to-date and highly practical, Cancer Chemoprevention, Volumes 1 & 2, offer oncologists, pharmacologists, medicinal chemists, and toxicologists a comprehensive reference survey on the identification of those promising cancer chemopreventive agents that will help stimulate further research and the development of novel approvable drugs.

Targeting Cell Survival Pathways to Enhance Response to Chemotherapy

Author :
Publisher : Academic Press
ISBN 13 : 0128137541
Total Pages : 310 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by :

Download or read book Targeting Cell Survival Pathways to Enhance Response to Chemotherapy written by and published by Academic Press. This book was released on 2018-03-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials